Table 1:
Peripheral artery disease codes based on the International Classification of Diseases, Tenth Revision.
| Diagnosis | ICD-10 code |
|---|---|
| Atherosclerosis of extremity arteries | I70.2 |
| - unspecified | I70.20 |
| - with intermittent claudication (Fontaine stage IIa) | I70.21 |
| - with rest pain (Fontaine stage IIb) | I70.22 |
| - with ulceration (Fontaine stage III) | I70.23 |
| - with gangrene (Fontaine stage IV) | I70.24 |
| Atherosclerosis of other arteries | I70.8 |
| Generalised and undefined atherosclerosis | I70.9 |
Table 2:
Comorbidity codes based on the International Classification of Diseases, Tenth Revision.
| Diagnosis | ICD-10 codes |
|---|---|
| Coronary artery disease | I20.0 – I25.9 |
| Cerebrovascular disease | I63.0 – I66.9 |
| Aortic aneurysm | I71.0 – I71.9 |
| Diabetes mellitus | E09.21 – E16.9 |
| Arterial hypertension | I10 – I13.9 |
| Dyslipidemia | E78.0 – E78.9 |
| Heart failure | I50.0 – I50.9 |
| Atrial fibrillation | I48 |
| Chronic kidney disease | N10 – N19 |
| Cancer | C00.1 – C96.9; D00.1 – D48.9 |
| COPD/asthma | J44.0 – J46 |
| Dementia | F00.0 – F03; F05.1 |
| Depression | F06.4; F32 – F33.9 |
Table 3:
Annual PAD hospitalisation rates per 100,000 adult population in Slovenia, 2015–2022.
| Year | Total | Fontaine I/II/unspecified PAD | Fontaine III/IV | ||||
|---|---|---|---|---|---|---|---|
| N | Hosp. rate | Age-standardised hosp. rate | N | Hosp. rate | N | Hosp. rate | |
| 2015 | 3,462 | 167.7 | 102.8 | 2,264 | 109.7 | 1,198 | 58.0 |
| 2016 | 3,218 | 154.8 | 95.6 | 2,090 | 100.2 | 1,128 | 54.5 |
| 2017 | 3,459 | 166.4 | 102.8 | 2,285 | 110.1 | 1,174 | 56.8 |
| 2018 | 3,611 | 173.1 | 107.3 | 2,461 | 118.6 | 1,150 | 55.4 |
| 2019 | 3,858 | 183.8 | 113.7 | 2,642 | 125.5 | 1,216 | 58.2 |
| 2020 | 3,102 | 146.5 | 90.8 | 2,076 | 98.7 | 1,026 | 48.8 |
| 2021 | 3,000 | 142.3 | 87.5 | 2,009 | 95.3 | 991 | 47.0 |
| 2022 | 3,429 | 161.3 | 100.1 | 2,284 | 107.1 | 1,145 | 54.2 |
| TOTAL | 27,139 | 162.7 | 99.7 | 18,111 | 108.6 | 9,028 | 54.1 |
Figure 1:
Semiannual (6-month) pattern of peripheral artery disease (PAD) hospitalisation rates per 100,000 population by age group, Slovenia 2015–2022.
Table 4:
Share of episodes (N = 27,139) requiring procedures or ended with an unfavourable outcome in the study of the burden of inpatient PAD, Slovenia 2015–2022.
| Year | Episodes requiring procedures (%) | Episodes ended with an unfavourable outcome (%) | |||
|---|---|---|---|---|---|
| Any procedure | Endovascular | Surgery | Amputation | Death | |
| 2015 | 77.5% | 48.8% | 33.9% | 13.2% | 5.0% |
| 2016 | 76.2% | 50.5% | 32.1% | 11.8% | 4.6% |
| 2017 | 75.9% | 50.5% | 31.6% | 10.0% | 4.0% |
| 2018 | 78.0% | 57.2% | 26.9% | 9.2% | 3.8% |
| 2019 | 78.1% | 54.1% | 30.4% | 9.3% | 3.6% |
| 2020 | 79.7% | 53.4% | 34.0% | 9.6% | 3.4% |
| 2021 | 82.7% | 55.1% | 34.1% | 9.7% | 3.6% |
| 2022 | 80.2% | 53.6% | 32.7% | 7.9% | 3.3% |
Table 5:
Annual cost summary for PAD management, Slovenia 2015–2022.
| Year | Episodes (N) | Total cost (Eur) | Median (Q1–Q3) cost per episode (Eur) |
|---|---|---|---|
| 2015 | 3,462 | 15,677,050.92 | 3389.68 (2116.55–6304.64) |
| 2016 | 3,218 | 13,926,149.84 | 3013.47 (1729.88–6167.16) |
| 2017 | 3,459 | 13,739,039.27 | 2401.98 (1679.99–5603.43) |
| 2018 | 3,611 | 14,704,501.30 | 2544.57 (1781.99–5382.35) |
| 2019 | 3,858 | 17,522,197.99 | 2686.01 (1939.18–5857.11) |
| 2020 | 3,102 | 14,440,400.55 | 3141.08 (1928.60–6287.42) |
| 2021 | 3,000 | 14,588,474.86 | 3775.64 (2001.43–6265.79) |
| 2022 | 3,429 | 17,382,561.56 | 3056.31 (2214.33–7080.68) |
Table 6:
Characteristics of 15,987 patients included in the study of the burden of inpatient PAD, Slovenia 2015–2022.
| Characteristic | Category | N (%) / Me (Q1–Q3) |
|---|---|---|
| SEVERITY OF PAD | ||
| Fontaine stage | Unspecified | 2,301 (14.4%) |
| Fontaine IIa | 1,125 (7.0%) | |
| Fontaine IIb | 7,522 (47.1%) | |
| Fontaine III | 2,085 (13.0%) | |
| Fontaine IV | 2,954 (18.5%) | |
| RISK FACTORS | ||
| Sex | Male | 9,600 (60.1%) |
| Age (years) | 72 (64–81) | |
| COMORBIDITIES | ||
| Coronary artery disease | Present | 1,209 (7.6%) |
| Cerebrovascular disease | Present | 335 (2.1%) |
| Aortic aneurysm | Present | 149 (0.9%) |
| Diabetes mellitus | Present | 3,006 (18.8%) |
| Arterial hypertension | Present | 5,577 (34.9%) |
| Dyslipidemia | Present | 3,294 (20.6%) |
| Heart failure | Present | 867 (5.4%) |
| Atrial fibrillation | Present | 1,356 (8.5%) |
| Chronic kidney disease | Present | 1,372 (8.6%) |
| Cancer | Present | 399 (2.5%) |
| COPD/asthma | Present | 575 (3.6%) |
| Dementia | Present | 396 (2.5%) |
| Depression | Present | 57 (0.4%) |
Table 7:
Results of univariate logistic regression analysis of the association between presence of CLI and patients' risk factors/comorbidities in 15,987 patients in the study of the burden of inpatient PAD, Slovenia 2015–2022.
| Characteristic | Category | NCLI / Ncat (%) / Me (Q1–Q3) | OR | 95% CI | p-value |
|---|---|---|---|---|---|
| RISK FACTORS | |||||
| Sex | female | 2,288/6,387 (35.8%) | 1.00 | ||
| male | 2,751/9,600 (28.7%) | 0.72 | 0.67, 0.77 | < 0.001 | |
| Age (years) | 79 (69, 85) | 1.06 | 1.06, 1.07 | < 0.001 | |
| COMORBIDITIES | |||||
| Coronary artery | no | 4,685/14,778 (31.7%) | 1.00 | ||
| disease | yes | 354/1,209 (29.3%) | 0.89 | 0.78, 1.01 | 0.081 |
| Cerebrovascular | no | 4,937/15,652 (31.5%) | 1.00 | ||
| disease | yes | 102/335 (30.4%) | 0.95 | 0.75, 1.20 | 0.670 |
| Abdominal aortic | no | 5,016/15,838 (31.7%) | 1.00 | ||
| aneurysm | yes | 23/149 (15.4%) | 0.39 | 0.25, 0.60 | < 0.001 |
| Diabetes mellitus | no | 3,700/12,981 (28.5%) | 1.00 | ||
| yes | 1,339/3,006 (44.5%) | 2.01 | 1.86, 2.19 | < 0.001 | |
| Arterial | no | 3,182/10,410 (30.6%) | 1.00 | ||
| hypertension | yes | 1,857/5,577 (33.3%) | 1.13 | 1.06, 1.22 | < 0.001 |
| Hyperlipidemia | no | 4,243/12,693 (33.4%) | 1.00 | ||
| yes | 796/3,294 (24.2%) | 0.63 | 0.58, 0.69 | < 0.001 | |
| Heart failure | no | 4,492/15,120 (29.7%) | 1.00 | ||
| yes | 547/867 (63.1%) | 4.04 | 3.51, 4.67 | < 0.001 | |
| Atrial fibrillation | no | 4,355/14,631 (29.8%) | 1.00 | ||
| yes | 684/1,356 (50.4%) | 2.40 | 2.15, 2.69 | < 0.001 | |
| Chronic kidney | no | 4,319/14,615 (29.6%) | 1.00 | ||
| disease | yes | 720/1,372 (52.5%) | 2.63 | 2.35, 2.94 | < 0.001 |
| Cancer | no | 4,847/15,588 (31.1%) | 1.00 | ||
| yes | 192/399 (48.1%) | 2.06 | 1.68, 2.51 | < 0.001 | |
| COPD | no | 4,872/15,412 (31.6%) | 1.00 | ||
| yes | 167/575 (29.0%) | 0.89 | 0.74, 1.06 | 0.193 | |
| Dementia | no | 4,745/15,591 (30.4%) | 1.00 | ||
| yes | 294/396 (74.2%) | 6.59 | 5.27, 8.31 | < 0.001 | |
| Depression | no | 5,020/15,930 (31.5%) | 1.00 | ||
| yes | 19/57 (33.3%) | 1.09 | 0.61, 1.86 | 0.768 |