Dosing regimen for some of the most common anticholinergic medicines_
| Medicine | Dose and frequency | N of cases |
|---|---|---|
| Diazepam | 2mg daily | 2 |
| 5 mg daily | 2 | |
| 5mg once to three times weekly | 5 | |
| 5 mg twice monthly | 1 | |
| Quetiapine | 25 mg once daily | 7 |
| 100 mg once daily | 1 | |
| 400 mg once daily | 1 | |
| Ranitidine | 150 mg once daily | 8 |
| 300 mg once daily | 1 | |
| Amitriptyline | 25 mg once daily | 4 |
| 25 mg two to three times daily | 2 |
Descriptive statistics_
| Characteristic | |
|---|---|
| Gender N (%) | |
| • Male | 266 (42.8%) |
| • Female | 356 (57.2%) |
| Average age in years (±SD) | 77.2 (±6.2) |
| • Range (years) | 65-101 |
| Number of prescribed medicines N (±SD) | 5.6 (±2.9) |
| Presence of polypharmacy (5 or more medicines) | 374 (60.1%) |
Anticholinergic burden in patients with anticholinergic medicines (N=78)_
| Anticholinergic burden (score) | N (%) of patients with anticholinergic medicines |
|---|---|
| 1 | 54 (69.2%) |
| 2 | 19 (24.4%) |
| 3 | 4 (5.1%) |
| 4 | 1 (1.3%) |
List of anticholinergic medicines in patients with an anticholinergic burden_
| Medicine (ATC code) | N (%) of patients with anticholinergic burden N=78 | % of all enrolled patients N=622 | Anticholinergic burden |
|---|---|---|---|
| Psychotropic medicines (N) | 41 (52.6%) | 6.6% | |
| Diazepam (N05BA01) | 10 (12.8%) | 1.6% | 1 |
| Quetiapine (N05AH04) | 9 (11.5%) | 1.4% | 1 |
| Paroxetine (N06AB05) | 7 (9.0%) | 1.1% | 1 |
| Amitriptilyne (N06AA09) | 6 (7.7%) | 1.0% | 2 |
| Mirtazapine (N06AX11) | 4 (5.1%) | 0.6% | 1 |
| Citalopram (N06AB04) | 4 (5.1%) | 0.6% | 1 |
| Fentanyl (N02AB03) | 2 (2.6%) | 0.3% | 1 |
| Olanzapine (N05AH03) | 2 (2.6%) | 0.3% | 1 |
| Carbamazepine (N03AF01) | 2 (2.6%) | 0.3% | 1 |
| Fluoxetine (N06AB03) | 2 (2.6%) | 0.3% | 1 |
| Risperidone (N05AX08) | 2 (2.6%) | 0.3% | 1 |
| Promazine (N05AA03) | 1 (1.3%) | 0.2% | 1 |
| Clozapine (N05AH02) | 1 (1.3%) | 0.2% | 2 |
| Lithim (N05AN01) | 1 (1.3%) | 0.2% | 1 |
| Trazodone (N06AX05) | 1 (1.3%) | 0.2% | 1 |
| Alimentary tract and metabolism medicines (A) | 11 (14.1%) | 1.8% | |
| Ranitidine (A02BA02) | 8 (10.3%) | 1.3% | 1 |
| Domperidone (A03FA03) | 3 (3.8%) | 0.5% | 1 |
| Respiratory system and allergy medicines (R) | 11 (14.1%) | 1.8% | |
| Loratadine (R06AX13) | 4 (5.1%) | 0.6% | 1 |
| Cetirizine (R06AE07) | 3 (3.8%) | 0.5% | 1 |
| Fexofenadine (R06AX26) | 2 (2.6%) | 0.3% | 1 |
| Theophylline (R03DA04) | 2 (2.6%) | 0.3% | 1 |
| Musculo-skeletal system medicines (M) | 6 (7.7%) | 1.0% | |
| Tizanidine (M03BX02) | 6 (7.7.%) | 1.0% | 2 |
| Genitourinary system medicines (G) | 5 (6.4%) | 0.8% | |
| Darifenacin (G04BD10) | 3 (3.8%) | 0.5% | 2 |
| Tolterodine (G04BD07) | 2 (2.6%) | 0.3% | 2 |
| Cardiovascular system medicines (C) | 1 (1.3%) | 0.2% | |
| Disopyramide (C01BA03) | 1 (1.3%) | 0.2% | 1 |