Memantine Therapy as an Augmentation in Treatment-Resistant Depression: A Case Report

Medication	Dose (mg/day)	Start / end time	Dose adjustment	Date/time of dose adjustment
Escitatopram	10	06. March 2019/28. March 2019	NO
Alprazolam	0,75	06. March 2019/28.March 2019	NO
Venlafaxine	75 – 150	29. March 2019/June 2019	YES	Start dose 75 mg 29.03. - 04.04.2019 05.04-08.04. 150mg 08.04 - 06.2019. 75mg
Maprotiline	75 – 100	June2019/September .2019	YES	06.2019-03.09.2019 - 75mg 04.09-17.09. 10mg
Trazodon	100	03. September 2019	YES	03.09-10.09. 50mg
Escitaloprame	10	17. September 2019 / 22. November 2019	YES	17.09 - 24.09 5 mg, and than 10mg
Aripiprazole	5	17. September 2019 / 22. November 2019	NO
Duloxetine	60	22. September 2019 -	YES	22.09-29.09 - 30mg, and than 60mg
Cariprazine	1.5–4.5	05. June 2020 - 09. September 2020	YES	05.06-19.06. 1.5mg; 20.06.-20.07. 3mg; 21.07-09.09. 4,5mg

Table 2.

Effects of Cariprazine therapy
Visit date	MADRS score
30. July 2020	31
12.August 2020	31
19. August 2020	31
26. August 2020	29
09. September 2020	30

Table 3.

Effects of Memantine therapy
Visit date	MADRS score
23. September 2020	16
30. September 2020	13
07. October 2020	11
04. November 2020	9

References

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Articles in this issue

DOI: https://doi.org/10.2478/sjecr-2022-0054 | Journal eISSN: 2956-2090 (formerly 2335-075X, 2956-0454) | Journal ISSN: 2956-0454 (formerly 1820-8665)

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Language: English

Page range: 211 - 216

Submitted on: Aug 30, 2021

Accepted on: Mar 12, 2022

Published on: Dec 31, 2025

Published by: University of Kragujevac, Faculty of Medical Sciences

In partnership with: Paradigm Publishing Services

Keywords:

Major depressive disorder,

treatment-resistant depression,

memantine,

pharmacotherapy

UDC:

616.89-008.454-085:615.21

Related subjects:

Medicine,

Clinical medicine,

Clinical medicine, other

© 2025 Milena Stojkovic, Vladimir Janjic, Nemanja Muric, Nenad Zornic, Vladimir Jakovljevic, Vladimir Zivkovic, Branimir Radmanovic, published by University of Kragujevac, Faculty of Medical Sciences
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Volume 26 (2025): Issue 2 (June 2025)