Metformin as a Potential Antitumor Agent

Andjela Petrovic; Vladimir Markovic; Veljko Maric; Nevena Gajovic

doi:10.2478/sjecr-2022-0023

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Metformin as a Potential Antitumor Agent

EABR. Experimental and Applied Biomedical Research

AHEAD OF PRINT

By: Andjela Petrovic, Vladimir Markovic, Veljko Maric and Nevena Gajovic

Open Access

|Nov 2022

Abstract

Some recent findings suggest that metformin, an oral antidiabetic drug, may have antitumor properties. Studies have shown that metformin can alter cell metabolism, both tumor and immune cells, which can greatly influence disease outcome. In this review, we discuss the potential mechanisms in which metformin can directly induce apoptosis of tumor cells as well as mechanisms in which metformin can elicit or enhance antitumor immune response.

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Articles in this issue

DOI: https://doi.org/10.2478/sjecr-2022-0023 | Journal eISSN: 2956-2090 (formerly 2335-075X, 2956-0454) | Journal ISSN: 2956-0454 (formerly 1820-8665)

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Language: English

Submitted on: Dec 27, 2021

Accepted on: Feb 19, 2022

Published on: Nov 16, 2022

Published by: University of Kragujevac, Faculty of Medical Sciences

In partnership with: Paradigm Publishing Services

Keywords:

Metformin,

tumor,

antitumor immune response

Related subjects:

Medicine,

Clinical medicine,

Clinical medicine, other

© 2022 Andjela Petrovic, Vladimir Markovic, Veljko Maric, Nevena Gajovic, published by University of Kragujevac, Faculty of Medical Sciences
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

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