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Figure 7.
Stern-Volmer constant (Ksv), quenching constant (kq), binding constant (Ka) and number of binding sites (n) for interactions between BSA and dinuclear Pd1 and Pd2 complexes_
| complex | Ksv · 105 (M−1) | kq · 1012 (M−1s−1) | Ka · 109 (M−1) | n |
|---|---|---|---|---|
| [{Pd(en)Cl}2 (μ-1,5-nphe)]2+ | (2.80 ± 0.03) | (28 ± 2) | (1.20 ± 0.05) | 1.8 |
| [{Pd(1,3-pd)Cl}2 (μ-1,5-nphe)]2+ | (3.90 ± 0.04) | (39 ± 1) | (1.20 ± 0.02) | 1.8 |
Stern-Volmer constant (Ksv), stability constant (Ka) and number of binding sites (n) of the investigated dinuclear palladium(II) complexes with CT-DNA
| complex | Ksv · 105 (M−1) | Ka · 105 (M−1) | n |
|---|---|---|---|
| [{Pd(en)Cl}2 (μ-1,5-nphe)]2+ | (4.50 ± 0.04) | (8.80 ± 0.02) | 1.7 |
| [{Pd(1,3-pd)Cl}2 (μ-1,5-nphe)]2+ | (2.80 ± 0.06) | (2.50 ± 0.05) | 1.1 |
1H and 13C NMR chemical shifts (δ, ppm) for 1,5-naphthyridine (1,5-nphe), ethylenediamine (en), 1,3-propylenediamine (1,3-pd) and the corresponding dinuclear palladium(II) complexes
| ligand/complex | NMR shifts | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 1H | 13C | ||||||||
| H2, H6 | H4, H8 | H3, H7 | alifatic protons | C2, C6 | C4, C8 | C3, C7 | C4a, C8a | L | |
| 1,5-nphe | 8.57 dd | 7.89 d | 7.48 dd | 154 | 139 | 128 | 144 | ||
| en | 2.64 s (CH2) | 45 (CH2) | |||||||
| Pd1 | 10.21 d | 9.58 d | 8.14 m | 2.76 m (CH2) | 160 | 147 | 130 | 143 | 50 (CH2) |
| 1,3-pd | 1.60 m (H2, CH2) | 29 (C2, CH2) | |||||||
| Pd2 | 10.17 d | 9.55 d | 8.23 m | 1.85 m (H2,CH2) | 160 | 146 | 131 | 143 | 30 (C2, CH2) |
Internal binding constants (Kb), changes in Gibbs energy (ΔG) and hypochromism (H) of the investigated dinuclear palladium(II) complexes, Pd1 and Pd2, with CT-DNA
| complex | Kb · 104 (M−1) | ΔG (kJ/mol) | H |
|---|---|---|---|
| [{Pd(en)Cl}2 (μ-1,5-nphe)]2+ | (7.50 ± 0.05) | −28.93 | 22.42 |
| [{Pd(1,3-pd)Cl}2 (μ-1,5-nphe)]2+ | (4.00 ± 0.03) | −27.31 | 25.77 |