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The Effects of Selective Serotonin Reuptake Inhibitors on Motility of Peripheral Smooth Muscles Cover

The Effects of Selective Serotonin Reuptake Inhibitors on Motility of Peripheral Smooth Muscles

EABR. Experimental and Applied Biomedical Research
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By: Jovana Z. Milosavljevic,  Marko Folic,  Slobodan Jankovic,  Miloš N. Milosavljevic,  Milica Milentijevic and  Srdjan M. Stefanovic  
Open Access
|Nov 2024

Figures & Tables

Summary of the effects of SSRIs on the smooth muscle cells and ion channels

DrugIntestinal smooth musclesVascular smooth musclesGastric smooth muscle cellsIsthmus of human Fallopian tubeAmpulla of human Fallopian tubehERG channelsKv channels of coronary arteries of rabbits
FluoxetineRelaxationDilation of isolated skeletal muscle arterioles and small rat cerebral arteriesContractionDoes not show a statistically significant effectDoes not show a statistically significant effectUnknownUnknown
Paroxetine

  • Contraction in clinical studies on humans

  • Relaxation of of the smooth muscle cells of the ileum of rabbits

Does not show a statistically significant effectIncreasing gastric accommodationContractionDoes not show a statistically significant effectUnknownUnknown
CitalopramRelaxationDilatationContractionDoes not show a statistically significant effectDoes not show a statistically significant effectUnknownUnknown
EscitalopramUnknownVasoconstriction of vascular smooth muscle cells of rabbit coronary arteriesUnknownDoes not show a statistically significant effectContractionInhibitionInhibition
SertralineUnknownVasoconstriction of vascular smooth muscle cells of rabbit coronary arteriesDoes not show a statistically significant effectDoes not show a statistically significant effectDoes not show a statistically significant effectUnknownInhibition
FluxoxamineUnknownVasoconstriction of vascular smooth muscle cells of rabbit coronary arteriesUnknownUnknownUnknownInhibitionInhibition
DapoxetineUnknownUnknownUnknownUnknownUnknownUnknownInhibition
DOI: https://doi.org/10.2478/sjecr-2020-0031 | Journal eISSN: 2956-2090 | Journal ISSN: 2956-0454
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Language: English
Submitted on: Mar 18, 2020
Accepted on: Mar 19, 2020
Published on: Nov 29, 2024
Published by: University of Kragujevac, Faculty of Medical Sciences
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year
Keywords:
Selective serotonin reuptake inhibitors,
fluoxetine,
paroxetine,
citalopram,
escitalopram,
sertraline,
fluvoxamine,
dapoxetine,
smooth muscle cells
Related subjects:
Medicine,
Clinical medicine,
Clinical medicine, other

© 2024 Jovana Z. Milosavljevic, Marko Folic, Slobodan Jankovic, Miloš N. Milosavljevic, Milica Milentijevic, Srdjan M. Stefanovic, published by University of Kragujevac, Faculty of Medical Sciences
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

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