Biological Activity of Au(III) Complexes

Ana S. Stankovic; Marijana P. Kasalovic; Andriana M. Bukonjic; Marina Z. Mijajlovic; Dusan Lj. Tomovic; Milos V. Nikolic

doi:10.2478/sjecr-2019-0050

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Biological Activity of Au(III) Complexes

EABR. Experimental and Applied Biomedical Research

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By: Ana S. Stankovic, Marijana P. Kasalovic, Andriana M. Bukonjic, Marina Z. Mijajlovic, Dusan Lj. Tomovic and Milos V. Nikolic

Open Access

|Nov 2019

Abstract

The earliest therapy use of gold compounds dated in 2500 AD. In 1960s gold compounds were used in the treatment of rheumatoid arthritis, discoid lupus erythematosus, etc. Although the compounds of Au(I) are well-known and used in the modern medicine, new complexes of Au(III) and ligands with different donor atoms are synthetized and examined for their biological (antitumor, antimicrobial) activity. So far conducted studies show that complexes with Au(III) as central metal ions have greater activity compared with free ligands. Future syntheses should be based on the increase of biological activity with complexes that have necessary stability under physiological conditions.

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Articles in this issue

DOI: https://doi.org/10.2478/sjecr-2019-0050 | Journal eISSN: 2956-2090 (formerly 2335-075X, 2956-0454) | Journal ISSN: 2956-0454 (formerly 1820-8665)

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Language: English

Submitted on: Jun 14, 2019

Accepted on: Jun 14, 2019

Published on: Nov 29, 2019

Published by: University of Kragujevac, Faculty of Medical Sciences

In partnership with: Paradigm Publishing Services

Keywords:

gold(I)-complexes,

gold(III)-complexes,

antitumor activity,

antimicrobial activity,

gold nanoparticles

Related subjects:

Medicine,

Clinical medicine,

Clinical medicine, other

© 2019 Ana S. Stankovic, Marijana P. Kasalovic, Andriana M. Bukonjic, Marina Z. Mijajlovic, Dusan Lj. Tomovic, Milos V. Nikolic, published by University of Kragujevac, Faculty of Medical Sciences
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

AHEAD OF PRINT