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Exo-D-Mapps Attenuates Production of Inflammatory Cytokines and Promoted Generation of Immunosuppressive Phenotype in Peripheral Blood Mononuclear Cells Cover

Exo-D-Mapps Attenuates Production of Inflammatory Cytokines and Promoted Generation of Immunosuppressive Phenotype in Peripheral Blood Mononuclear Cells

Open Access
|Nov 2019

References

  1. 1. Friedenstein AJ, Petrakova KV, Kurolesova AI, Frolova GP. Heterotopic of bone marrow. Analysis of precursor cells for osteogenic and hematopoietic tissues. Transplantation. 1968; 6: 230-247.10.1097/00007890-196803000-00009
  2. 2. Bieback K, Kern S, Kluter H, Eichler H. Critical parameters for the isolation of mesenchymal stem cells from umbilical cord blood. Stem Cells. 2004; 22: 625-634.10.1634/stemcells.22-4-625
  3. 3. Yanez R, Lamana ML, Garcia-Castro J, Colmenero I, Ramirez M, Bueren JA. Adipose tissue-derived mesenchymal stem cells have in vivo immunosuppressive properties applicable for the control of the graft-versus-host disease. Stem Cells. 2006; 24: 2582-2591.10.1634/stemcells.2006-0228
  4. 4. Anversa P, Perrella MA, Kourembanas S, Choi AM, Loscalzo J. Regenerative pulmonary medicine: potential and promise, pitfalls and challenges. Eur J Clin Invest. 2012; 42: 900-913.10.1111/j.1365-2362.2012.02667.x
  5. 5. Volarevic V, Ljujic B, Stojkovic P, Lukic A, Arsenijevic N, Stojkovic M. Human stem cell research and regenerative medicine-present and future. Br Med Bull. 2011; 99: 155-168.10.1093/bmb/ldr027
  6. 6. Harrell CR, Jankovic MG, Fellabaum C, Volarevic A, Djonov V, Arsenijevic A, Volarevic V. Molecular Mechanisms Responsible for Anti-inflammatory and Immunosuppressive Effects of Mesenchymal Stem Cell-Derived Factors. Adv Exp Med Biol. 2019 Jun 8. doi: 10.1007/5584_2018_306.10.1007/5584_2018_306
  7. 7. Simovic Markovic B, Gazdic M, Arsenijevic A, Jovicic N, Jeremic J, Djonov V, Arsenijevic N, Lukic ML, Volarevic V. Mesenchymal Stem Cells Attenuate Cisplatin-Induced Nephrotoxicity in iNOS-Dependent Manner. Stem Cells Int. 2017; 2017: 1315378.10.1155/2017/1315378
  8. 8. Gazdic M, Simovic Markovic B, Vucicevic L, Nikolic T, Djonov V, Arsenijevic N, Trajkovic V, Lukic ML, Volarevic V. Mesenchymal stem cells protect from acute liver injury by attenuating hepatotoxicity of liver natural killer T cells in an inducible nitric oxide synthase- and indoleamine 2,3-dioxygenase-dependent manner. J Tissue Eng Regen Med. 2018; 12: e1173-e1185.10.1002/term.2452
  9. 9. Simovic Markovic B, Nikolic A, Gazdic M, Nurkovic J, Djordjevic I, Arsenijevic N, Stojkovic M, Lukic ML, Volarevic V. Pharmacological Inhibition of Gal-3 in Mesenchymal Stem Cells Enhances Their Capacity to Promote Alternative Activation of Macrophages in Dextran Sulphate Sodium-Induced Colitis. Stem Cells Int. 2016; 2016: 2640746.10.1155/2016/2640746
  10. 10. Haynesworth SE, Baber MA, Caplan AI. Cytokine expression by human marrow-derived mesenchymal progenitor cells in vitro: Effects of dexamethasone and IL-1α. J Cell Physiol. 1996; 166: 585-92.10.1002/(SICI)1097-4652(199603)166:3<;585::AID-JCP13>3.0.CO;2-6
  11. 11. Caplan AI, Dennis JE. Mesenchymal stem cells as trophic mediators. J Cell Biochem. 2006; 98: 1076-84.10.1002/jcb.2088616619257
  12. 12. Moravej A, Karimi M-H, Geramizadeh B, Azarpira N, Zarnani A-H, Yaghobi R, Khosravi M, Kalani M, Gharesi-Fard B. Mesenchymal stem cells upregulate the expression of PD-L1 but not VDR in dendritic cells. Immunol Invest. 2017; 46: 80-96.10.1080/08820139.2016.122575727736253
  13. 13. Volarevic V, Gazdic M, Simovic Markovic B, Jovicic N, Djonov V, Arsenijevic N. Mesenchymal stem cellderived factors: Immuno-modulatory effects and therapeutic potential. Biofactors. 2017; 43: 633-644.10.1002/biof.137428718997
  14. 14. Harrell CR, Fellabaum C, Jovicic N, Djonov V, Arsenijevic N, Volarevic V. Molecular Mechanisms Responsible for Therapeutic Potential of Mesenchymal Stem Cell-Derived Secretome. Cells. 2019; 8(5). pii: E467. doi: 10.3390/cells8050467.10.3390/cells8050467656290631100966
  15. 15. Mohammadipoor A, Antebi B, Batchinsky AI, Cancio LC. Therapeutic potential of products derived from mesenchymal stem/stromal cells in pulmonary disease. Respir Res. 2018; 19: 218.10.1186/s12931-018-0921-x623477830413158
  16. 16. Hass R, Kasper C, Böhm S, Jacobs R. Different populations and sources of human mesenchymal stem cells (MSC): A comparison of adult and neonatal tissuederived MSC. Cell Commun Signal. 2011; 9: 12.10.1186/1478-811X-9-12311782021569606
  17. 17. Kil K, Choi MY, Kong JS, Kim WJ, Park KH. Regenerative efficacy of mesenchymal stromal cells from human placenta in sensorineural hearing loss. Int J Pediatr Otorhinolaryngol. 2016; 91: 72-81.10.1016/j.ijporl.2016.10.01027863646
  18. 18. Cho JS, Lee J, Jeong DU, Kim HW, Chang WS, Moon J, Chang JW. Effect of Placenta-Derived Mesenchymal Stem Cells in a Dementia Rat Model via Microglial Mediation: a Comparison between Stem Cell Transplant Methods. Yonsei Med J. 2018; 59: 406-415.10.3349/ymj.2018.59.3.406588999329611403
  19. 19. Jiang H, Zhang Y, Tian K, Wang B, Han S. Amelioration of experimental autoimmune encephalomyelitis through transplantation of placental derived mesenchymal stem cells. Sci Rep. 2017; 7: 41837.10.1038/srep41837530125628186117
  20. 20. Roubelakis MG, Pappa KI, Bitsika V, Zagoura D, Vlahou A, Papadaki HA, Antsaklis A, Anagnou NP. Molecular and proteomic characterization of human mesenchymal stem cells derived from amniotic fluid: comparison to bone marrow mesenchymal stem cells. Stem Cells Dev. 2007; 16: 931-952.10.1089/scd.2007.003618047393
  21. 21. Mareschi K, Castiglia S, Sanavio F, Rustichelli D, Muraro M, Defedele D, Bergallo M, Fagioli F. Immunoregulatory effects on T lymphocytes by human mesenchymal stromal cells isolated from bone marrow, amniotic fluid, and placenta. Exp Hematol. 2016; 44: 138-150.e1.10.1016/j.exphem.2015.10.00926577566
  22. 22. Harrell CR, Fellabaum C, Simovic Markovic B, Arsenijevic A, Volarevic V. Therapeutic potential of “Exosomes derived Multiple Allogeneic Proteins Paracrine Signaling: Exosomes d-MAPPS” is based on the effects of exosomes, immunosuppressive and trophic factors. Ser J of Exp Clin Res. 2017; 1: 1.
  23. 23. Miron PM. Preparation, Culture, and Analysis of Amniotic Fluid Samples. Curr Protoc Hum Genet. 2018: e62.10.1002/cphg.6229953168
  24. 24. Meng F, Lowell CA. Lipopolysaccharide (LPS)-induced macrophage activation and signal transduction in the absence of Src-family kinases Hck, Fgr, and Lyn. J Exp Med. 1997; 185: 1661-70.10.1084/jem.185.9.166121962889151903
  25. 25. Volarevic V, Milovanovic M, Ljujic B, Pejnovic N, Arsenijevic N, Nilsson U, Leffler H, Lukic ML. Galectin-3 deficiency prevents concanavalin A-induced hepatitis in mice. Hepatology. 2012; 55: 1954-1964.10.1002/hep.2554222213244
  26. 26. Pejnovic NN, Pantic JM, Jovanovic IP, Radosavljevic GD, Milovanovic MZ, Nikolic IG, Zdravkovic NS, Djukic AL, Arsenijevic NN, Lukic ML. Galectin-3 deficiency accelerates high-fat diet-induced obesity and amplifies inflammation in adipose tissue and pancreatic islets. Diabetes. 2013; 62: 1932-1944.10.2337/db12-0222366161123349493
  27. 27. Volarevic V, Zdravkovic N, Harrell CR, Arsenijevic N, Fellabaum C, Djonov V, Lukic ML, Simovic Markovic B. Galectin-3 Regulates Indoleamine-2,3-dioxygenase-Dependent Cross-Talk between Colon-Infiltrating Dendritic Cells and T Regulatory Cells and May Represent a Valuable Biomarker for Monitoring the Progression of Ulcerative Colitis. Cells. 2019; 8.10.3390/cells8070709667820231336879
  28. 28. Rad F, Ghorbani M, Mohammadi Roushandeh A, Habibi Roudkenar M. Mesenchymal stem cell-based therapy for autoimmune diseases: emerging roles of extracellular vesicles. Mol Biol Rep. 2019; 46: 1533-1549.10.1007/s11033-019-04588-y30623280
  29. 29. Harrell CR, Sadikot R, Pascual J, Fellabaum C, Jankovic MG, Jovicic N, Djonov V, Arsenijevic N, Volarevic V. Mesenchymal Stem Cell-Based Therapy of Inflammatory Lung Diseases: Current Understanding and Future Perspectives. Stem Cells Int. 2019; 2019: 4236973.10.1155/2019/4236973652579431191672
  30. 30. Markovic BS, Kanjevac T, Harrell CR, Gazdic M, Fellabaum C, Arsenijevic N, Volarevic V. Molecular and Cellular Mechanisms Involved in Mesenchymal Stem Cell-Based Therapy of Inflammatory Bowel Diseases. Stem Cell Rev. 2018; 14: 153-165.10.1007/s12015-017-9789-229177796
  31. 31. Gazdic M, Arsenijevic A, Markovic BS, Volarevic A, Dimova I, Djonov V, Arsenijevic N, Stojkovic M, Volarevic V. Mesenchymal Stem Cell-Dependent Modulation of Liver Diseases. Int J Biol Sci. 2017; 13: 1109-1117.10.7150/ijbs.20240566632629104502
  32. 32. Volarevic V, Markovic BS, Gazdic M, Volarevic A, Jovicic N, Arsenijevic N, Armstrong L, Djonov V, Lako M, Stojkovic M. Ethical and Safety Issues of Stem Cell-Based Therapy. Int J Med Sci. 2018; 15: 36-45.10.7150/ijms.21666576573829333086
  33. 33. Gnecchi M, Danieli P, Malpasso G, et al. Paracrine mechanisms of mesenchymal stem cells in tissue repair. Methods Molecular Biol (Clifton, NJ). 2016; 1416: 123-146.10.1007/978-1-4939-3584-0_727236669
  34. 34. Liang X, Ding Y, Zhang Y, et al. Paracrine mechanisms of mesenchymal stem cell-based therapy: current status and perspectives. Cell Transplant. 2014; 23: 1045-1059.10.3727/096368913X66770923676629
  35. 35. Wang A, Brown EG, Lankford L, et al. Placental mesenchymal stromal cells rescue ambulation in ovine myelomeningocele. Stem Cells Transl Med. 2015; 4: 659-669.10.5966/sctm.2014-0296444910325911465
  36. 36. Zamani F, Zare Shahneh F, Aghebati-Maleki L, Baradaran B. Induction of CD14 Expression and Differentiation to Monocytes or Mature Macrophages in Promyelocytic Cell Lines: New Approach. Adv Pharm Bull. 2013; 3: 329-332.
  37. 37. Xu Y, Liu Y, Yang C, Kang L, Wang M, Hu J, He H, Song W, Tang H. Macrophages transfer antigens to dendritic cells by releasing exosomes containing deadcell-associated antigens partially through a ceramidedependent pathway to enhance CD4(+) T-cell responses. Immunology. 2016; 149: 157-171.10.1111/imm.12630501167927278624
  38. 38. Hirahara K, Nakayama T. CD4+ T-cell subsets in inflammatory diseases: beyond the Th1/Th2 paradigm. Int Immunol. 2016; 28: 163-171.10.1093/intimm/dxw006488988626874355
  39. 39. Mills KH. Induction, function and regulation of IL-17-producing T cells. Eur J Immunol. 2008; 38: 2636-2649.10.1002/eji.20083853518958872
  40. 40. Bunte K, Beikler T. Th17 Cells and the IL-23/IL-17 Axis in the Pathogenesis of Periodontitis and Immune-Mediated Inflammatory Diseases. Int J Mol Sci. 2019; 20.10.3390/ijms20143394667906731295952
  41. 41. Chehimi M, Vidal H, Eljaafari A. Pathogenic Role of IL-17-Producing Immune Cells in Obesity, and Related Inflammatory Diseases. J Clin Med. 2017; 6.10.3390/jcm6070068553257628708082
  42. 42. Harrell CR, Simovic Markovic B, Fellabaum C, Arsenijevic A, Djonov V, Arsenijevic N, Volarevic V. Therapeutic Potential of Mesenchymal Stem Cell-Derived Exosomes in the Treatment of Eye Diseases. Adv Exp Med Biol. 2018; 1089: 47-57.10.1007/5584_2018_21929774506
  43. 43. Wang D, Huang S, Yuan X, Liang J, Xu R, Yao G, Feng X, Sun L. The regulation of the Treg/Th17 balance by mesenchymal stem cells in human systemic lupus erythematosus. Cell Mol Immunol. 2017; 14: 423-431.10.1038/cmi.2015.89542308426435067
  44. 44. Luz-Crawford P, Kurte M, Bravo-Alegría J, Contreras R, Nova-Lamperti E, Tejedor G, Noël D, Jorgensen C, Figueroa F, Djouad F, Carrión F. Mesenchymal stem cells generate a CD4+CD25+Foxp3+ regulatory T cell population during the differentiation process of Th1 and Th17 cells. Stem Cell Res Ther. 2013; 4: 65.10.1186/scrt216370689823734780
  45. 45. Tannetta D, Dragovic R, Alyahyaei Z, Southcombe J. Extracellular vesicles and reproduction-promotion of successful pregnancy. Cell Mol Immunol. 2014; 11: 548-563.10.1038/cmi.2014.42422083524954226
DOI: https://doi.org/10.2478/sjecr-2019-0045 | Journal eISSN: 2956-2090 | Journal ISSN: 2956-0454
Language: English
Page range: 75 - 82
Submitted on: Aug 14, 2019
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Accepted on: Aug 31, 2019
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Published on: Nov 25, 2019
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2019 Carl Randall Harrell, Bojana Simovic Markovic, Crissy Fellabaum, Dragica Miloradovic, Aleksandar Acovic, Dragana Miloradovic, Nebojsa Arsenijevic, Vladislav Volarevic, published by University of Kragujevac, Faculty of Medical Sciences
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.