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The Effect of the Chronic Administration of DPP4-Inhibitors on Systemic Oxidative Stress in Rats with Diabetes Type 2 Cover

The Effect of the Chronic Administration of DPP4-Inhibitors on Systemic Oxidative Stress in Rats with Diabetes Type 2

Open Access
|Nov 2019

References

  1. 1. Rydеn L, Grant PJ, Anker SD, Berne C, Cosentino F, Danchin N, Deaton C, Escaned J, Hammes HP, Huikuri H, Marre M, Marx N, Mellbin L, Ostergren J, Patrono C, Seferovic P, Uva MS, Taskinen MR, Tendera M, Tuomilehto J, Valensi P, Zamorano JL. ESC guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD - summary. Diab Vasc Dis Res. 2014;11(3):133-73.10.1177/147916411452554824800783
  2. 2. Hoch E, Rusu V, Schreiber SL, Florez JC, Jacobs SB, Lander ES. Type 2 diabetes-associated variants disrupt function of SLC16A11, a proton-coupled monocarboxylate transporter, through two distinct mechanisms, Faseb J. 2017; 31.10.1096/fasebj.31.1_supplement.950.2
  3. 3. Cowan J. Overview of Type 2 Diabetes. Essentials of SGLT2 Inhibitors in Diabetes, Springer, 2017.10.1007/978-3-319-43296-0_1
  4. 4. Monnier L, Lapinski H, Colette C. Contributions of fasting and postprandial plasma glucose increments to the overall diurnal hyperglycemia of type 2 diabetic patients: variations with increasing levels of HbA (1c). Diabetes Care 2003; 26:881–5.10.2337/diacare.26.3.88112610053
  5. 5. Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature 2001; 414:813–20.10.1038/414813a11742414
  6. 6. Esposito K, Nappo F, Marfella R, Giugliano G, Giugliano F, Ciotola M, Quagliaro L, Ceriello A, Giugliano D. Inflammatory cytokine concentrations are acutely increased by hyperglycemia in humans: role of oxidative stress. Circulation 2002; 106:2067–72.10.1161/01.CIR.0000034509.14906.AE12379575
  7. 7. Monnier L, Mas E, Ginet C, Michel F, Villon L, Cristol JP, Colette C. Activation of oxidative stress by acute glucose fluctuations compared with sustained chronic hyperglycemia in patients with type 2 diabetes. JAMA 2006; 295:1681–7.10.1001/jama.295.14.168116609090
  8. 8. Omotayo EO, Gurtu S, Sulaiman SA, Wahab MSA, Sirajudeen K, Salleh MSM. Hypoglycemic and antioxidant effects of honey supplementation in streptozotocin-induced diabetic rats, Int. J. Vitam. Nutr. Res. 2010; 80(1):74-82.10.1024/0300-9831/a000008
  9. 9. Maritim AC, Sanders RA, Watkins JB 3rd. Diabetes, oxidative stress, and antioxidants: a review. J Biochem Mol Toxicol. 2003; 17(1):24-38.10.1002/jbt.1005812616644
  10. 10. Nathan DM, Buse JB, Davidson MB, Ferrannini E, Holman RR, Sherwin R, Zinman B. Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care. 2009; 32:193–203.10.2337/dc08-9025260681318945920
  11. 11. Gupta V, Kalra S. Choosing a gliptin. Indian J Endocrinol Metab. 2011; 15:298–308.10.4103/2230-8210.85583319377922029001
  12. 12. Deacon CF. Dipeptidyl peptidase-4 inhibitors in the treatment of type 2 diabetes: a comparative review. Diabetes Obes Metab. 2011; 13:7–18.10.1111/j.1463-1326.2010.01306.x21114598
  13. 13. Blech S, Ludwig-Schwellinger E, Grаfe-Mody EU, Withopf B, Wagner K. The metabolism and disposition of the oral dipeptidyl peptidase-4 inhibitor, linagliptin, in humans. Drug Metab Dispos. 2010; 38:667–78.10.1124/dmd.109.031476
  14. 14. Marfella R, Barbieri M, Grella R, Rizzo MR, Nicoletti GF, Paolisso G. Effects of vildagliptin twice daily vs. sitagliptin once daily on 24-hour acute glucose fluctuations. J Diabetes Complications 2010; 24:79–83.10.1016/j.jdiacomp.2009.01.004
  15. 15. Reed, M.J., Meszaros, K., Entes, L.J., Claypool, M.D., Pinkett, J.G., Gadbois, T.M., and Reaven, G.M. 2000. A new rat model of type 2 diabetes: The fat-fed, streptozotocin-treated rat. Metabolism 49:1390-1394.10.1053/meta.2000.17721
  16. 16. Brondum, E., Nilsson, H., and Aalkjaer, C. 2005. Functional abnormalities in isolated arteries from Goto-Kakizaki and streptozotocin-treated diabetic rat models. Horm. Metab. Res. 37:56-60.10.1055/s-2005-861370
  17. 17. Auclair C, Voisin E (1985). Nitroblue tetrazolium reduction. In: Greenvvald RA (ed) Handbook of methods for oxygen radical research. CRC Press Une, Boca Raton, pp 123–32.
  18. 18. Pick E, Keisari Y. A simple colorimetric method for the measurment of hydrogen peroxide produced by cells in culture. J Immunol Methods 1980; 38:161–70.10.1016/0022-1759(80)90340-3
  19. 19. Green LC, Wagner DA, Glogowski J, Skipper PL, Wishnok JS, Tannenbaum SR. Analysis of nitrate, nitrite and [15 N] nitrate in biological fluids. Anal Biochem 1982; 26: 131–138.10.1016/0003-2697(82)90118-X
  20. 20. Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 1979; 95:351–8.10.1016/0003-2697(79)90738-3
  21. 21. Aebi H. Catalase in vitro. Methods in Enzymology. 1984; 105: 121-6.10.1016/S0076-6879(84)05016-3
  22. 22. Beutler E. Superoxide dismutase. In: Beutler E, eds. Red Cell Metabolism. A Manual of Biochemical Methods. Philadelphia, Grune & Stratton:PA; 1984: 83-5.
  23. 23. Beutler E, Duron O, Kelly BM. Improved method for the determination of blood. Glutathione. J Lab Clin Med. 1963; 61: 882–8.
  24. 24. Akash MS, Rehman K, Chen S. Role of inflammatory mechanisms in pathogenesis of type 2 diabetes mellitus. J Cell Biochem. 2013;114(3):525-31.10.1002/jcb.2440222991242
  25. 25. Rehman K, Akash MSH. Mechanism of Generation of Oxidative Stress and Pathophysiology of Type 2 Diabetes Mellitus: How Are They Interlinked? J Cell Biochem. 2017;118(11):3577-85.10.1002/jcb.2609728460155
  26. 26. Flegal KM, Graubard BI, Williamson DF, Gail MH. Cause-specific excess deaths associated with under-weight, overweight, and obesity. JAMA. 2007;298(17):2028-37.10.1001/jama.298.17.2028
  27. 27. Sakuraba H, Mizukami H, Yagihashi N, Wada R, Hanyu C, Yagihashi S. Reduced beta-cell mass and expression of oxidative stress-related DNA damage in the islet of Japanese Type II diabetic patients. Diabetologia. 2002;45(1):85-96.10.1007/s125-002-8248-z
  28. 28. Shin CS, Moon BS, Park KS, Kim SY, Park SJ, Chung MH, Lee HK. Serum 8-hydroxy-guanine levels are increased in diabetic patients. Diabetes Care. 2001;24(4):733-7.10.2337/diacare.24.4.733
  29. 29. Demircan N, Gurel A, Armutcu F, Unalacak M, Aktunc E, Atmaca H. The evaluation of serum cystatin C, malondialdehyde, and total antioxidant status in patients with metabolic syndrome. Med Sci Monit. 2008;14(2):CR97-101.
  30. 30. Nowotny K, Jung T, Höhn A, Weber D, Grune T. Advanced glycation end products and oxidative stress in type 2 diabetes mellitus. Biomolecules. 2015;5(1):194-222.10.3390/biom5010194
  31. 31. Valko M, Leibfritz D, Moncol J, Cronin MT, Mazur M, Telser J. Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol.2007;39(1):44-84.10.1016/j.biocel.2006.07.001
  32. 32. Asmat U, Abad K, Ismail K. Diabetes mellitus and oxidative stress-A concise review. Saudi Pharm J. 2016;24(5):547-53.10.1016/j.jsps.2015.03.013
  33. 33. Hopps E, Noto D, Caimi G, Averna MR. A novel component of the metabolic syndrome: the oxidative stress. Nutr Metab Cardiovasc Dis. 2010;20(1):72-7.10.1016/j.numecd.2009.06.00219747805
  34. 34. Pеrez-Matute P, Zulet MA, Martínez JA. Reactive species and diabetes: counteracting oxidative stress to improve health. Curr Opin Pharmacol. 2009;9(6):771-9.10.1016/j.coph.2009.08.005
  35. 35. Murakami K, Kondo T, Ohtsuka Y, Fujiwara Y, Shimada M, Kawakami Y. Impairment of glutathione metabolism in erythrocytes from patients with diabetes mellitus. Metabolism. 1989;38(8):753-8.256966110.1016/0026-0495(89)90061-9
  36. 36. Turner RC, Cull CA, Frighi V, Holman RR. Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with type 2 diabetes mellitus: progressive requirement for multiple therapies (UKPDS 49). UK Prospective Diabetes Study (UKPDS) Group. JAMA. 1999;281(21):2005-12.10.1001/jama.281.21.200510359389
  37. 37. Fisman EZ, Motro M, Tenenbaum A. Non-insulin anti-diabetic therapy in cardiac patients: current problems and future prospects. Adv Cardiol. 2008; 45:154-170.10.1159/00011519318230961
  38. 38. Kottenberg E, Thielmann M, Kleinbongard P, Frey UH, Heine T, Jakob H, Heusch G, Peters J. Myocardial protection by remote ischaemic pre-conditioning is abolished in sulphonylurea-treated diabetics undergoing coronary revascularisation. Acta Anaesthesiol Scand. 2014;58(4):453-62.10.1111/aas.1227824548338
  39. 39. Green BD, Flatt PR, Bailey CJ. Dipeptidyl peptidase IV (DPP IV) inhibitors: a newly emerging drug class for the treatment of type 2 diabetes. Diabetes and vascular disease research. 2006; 3(3): 159-65.10.3132/dvdr.2006.02417160910
  40. 40. Tatosian DA, Guo Y, Schaeffer AK, Gaibu N, Popa S, Stoch A, Langdon RB, Kauh EA. Dipeptidyl peptidase-4 inhibition in patients with type 2 diabetes treated with saxagliptin, sitagliptin, or vildagliptin. Diabetes Therapy. 2013; 4(2): 431-42.10.1007/s13300-013-0045-8388931724163113
  41. 41. Sherif IO, Al-Shaalan NH. Vildagliptin Attenuates Hepatic Ischemia/Reperfusion Injury via the TLR4/NF-κB Signaling Pathway. Oxid Med Cell Longev. 2018; 2018:3509091.10.1155/2018/3509091620418230405876
  42. 42. El-Kashef DH, Serrya MS. Sitagliptin ameliorates thioacetamide-induced acute liver injury via modulating TLR4/NF-KB signaling pathway in mice. Life Sci. 2019; 228:266-273.10.1016/j.lfs.2019.05.01931077717
  43. 43. Kelany ME, Hakami TM, Omar AH, Abdallah MA. Combination of Sitagliptin and Insulin against Type 2 Diabetes Mellitus with Neuropathy in Rats: Neuroprotection and Role of Oxidative and Inflammation Stress. Pharmacology. 2016;98(5-6):242-250.10.1159/00044804327449930
  44. 44. Helal MG, Zaki MMAF, Said E. Nephroprotective effect of saxagliptin against gentamicin-induced nephrotoxicity, emphasis on anti-oxidant, anti-inflammatory and anti-apoptic effects. Life Sci. 2018; 208:64-71.10.1016/j.lfs.2018.07.02130012474
  45. 45. Liu Y, Zhang Z, Chen R, Sun J, Chen H. Therapeutic effect of saxagliptin in rat models of nonalcoholic fatty liver and type 2 diabetes. Nan Fang Yi Ke Da Xue Xue Bao. 2014;34(6):862-8.24968846
  46. 46. Refaat R, Sakr A, Salama M, El Sarha A. Combination of Vildagliptin and Pioglitazone in Experimental Type 2 Diabetes in Male Rats. Drug Dev Res. 2016;77(6):300-9.10.1002/ddr.2132427520857
DOI: https://doi.org/10.2478/sjecr-2019-0039 | Journal eISSN: 2956-2090 | Journal ISSN: 2956-0454
Language: English
Page range: 199 - 206
Submitted on: Aug 14, 2019
Accepted on: Aug 17, 2019
Published on: Nov 7, 2019
Published by: University of Kragujevac, Faculty of Medical Sciences
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2019 Stefani Bolevich, Isidora Milosavljevic, Nevena Draginic, Marijana Andjic, Nevena Jeremic, Sergey Bolevich, Peter F Litvitsky, Vladimir Jakovljevic, published by University of Kragujevac, Faculty of Medical Sciences
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.