The Clinical Outcome and Therapeutic Treatment of a Patient with Double Seronegative Myasthenia Gravis

We reported a case of a 22-year-old male patient with swallowing difficulties and double vision. He was diagnosed on the basis of a positive pharmacological test, damage to the postsynaptic neuromuscular junction and computed tomography of the thorax. Tests for antibodies targeted to acetylcholine receptors and to muscle-specific tyrosine kinase were negative. A partial improvement in neurological findings following treatment with pyridostigmine bromide, cyclosporine and methylprednisolone was notedadministered. Th e patient responded favourably to plasma exchange with a withdrawal of all clinical symptoms, confirming the hypothesis that humoral factors may underlie the pathogenesis of double-negative MG .