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The Effects of Diclofenac and Ibuprofen on Heart Function and Oxidative Stress Markers in the Isolated Rat Heart Cover

The Effects of Diclofenac and Ibuprofen on Heart Function and Oxidative Stress Markers in the Isolated Rat Heart

EABR. Experimental and Applied Biomedical Research
Volume 15 (2014): Issue 1 (March 2014)
By: ,  ,  ,  ,  ,  ,   and    
Open Access
|Apr 2014
References

References

  1. 1. Vane JR, Botting RM. Mechanism of action of antiinflammatory drugs. Int J Tissue React. 1998;20(1):3-15. Review.
    Open DOISearch in Google Scholar
  2. 2. Masferrer JL, Zweifel BS, Manning PT, Hauser SD, Leahy KM, Smith WG, Isakson PC, Seibert K. Selective inhibition of inducible cyclooxygenase 2 in vivo is antiinflammatory and nonulcerogenic. Proc Natl Acad Sci U S A. 1994 Apr 12;91(8):3228-32. PubMed PMID: 8159730; PubMed Central PMCID: PMC43549.
    Open DOISearch in Google Scholar
  3. 3. Pawlosky N. Cardiovascular risk: Are all NSAIDs alike? Can Pharm J (Ott). 2013 Mar;146(2):80-3.
    Open DOISearch in Google Scholar
  4. 4. Santos M, Kunkar V, Garcia-Iturralde P, Tendillo FJ. Meloxicam, a specific COX-2 inhibitor, does not enhance the isoflurane minimum alveolar concentration reduction produced by morphine in the rat. Anesth Analg. 2004 Feb;98(2):359-63.
    Open DOISearch in Google Scholar
  5. 5. Fosbol EL, Folke F, Jacobsen S, Rasmussen JN, Sorensen R, Schramm TK, Andersen SS, Rasmussen S, Poulsen HE, Kober L, Torp-Pedersen C, Gislason GH. Causespecific cardiovascular risk associated with nonsteroidal antiinflammatory drugs among healthy individuals. Circ Cardiovasc Qual Outcomes. 2010 Jul;3(4):395-405.
    Open DOISearch in Google Scholar
  6. 6. Huerta C, Varas-Lorenzo C, Castellsague J, Garcia Rodriguez LA. Non-steroidal anti-inflammatory drugs and risk of first hospital admission for heart failure in the general population. Heart. 2006 Nov;92(11):1610-5. Epub 2006 May 22.
    Open DOISearch in Google Scholar
  7. 7. Gottlieb S. COX 2 inhibitors may increase risk of heart attack. BMJ. 2001 Sep 1;323(7311):471.
    Open DOISearch in Google Scholar
  8. 8. Straino S, Salloum FN, Baldi A et al (2007) Protective effects of parecoxib, a cyclo-oxygenase-2 inhibitor, in postinfarction remodeling in the rat. J Cardiovasc Pharmacol 50:571-577.
    Open DOISearch in Google Scholar
  9. 9. Forstermann U and Munzel T (2006) Endothelial nitric oxide synthase in vascular disease: from marvel to menace. Circulation 113: 1708-1714.
    Open DOISearch in Google Scholar
  10. 10. Griendling KK and FitzGerald GA (2003) Oxidative stress and cardiovascular injury: Part II: animal and human studies. Circulation 108: 2034-2040.
    Open DOISearch in Google Scholar
  11. 11. Li H, Hortmann M, Daiber A, Oelze M, Ostad MA, Schwarz PM, Xu H, Xia N, Kleschyov AL, Mang C, Warnholtz A, Munzel T, Forstermann U. Cyclooxygenase 2-selective and nonselective nonsteroidal antiinflammatory drugs induce oxidative stress by upregulating vascular NADPH oxidases. J Pharmacol Exp Ther. 2008 Sep;326(3):745-53.
    Open DOISearch in Google Scholar
  12. 12. Barudzic N, Turjacanin-Pantelic D, Zivkovic V, Selakovic D, Srejovic I, Jakovljevic J, Djuric DM, Jakovljevic VLj. The effects of cyclooxygenase and nitric oxide synthase inhibition on oxidative stress in isolated rat heart. Mol Cell Biochem. 2013 Sep;381(1-2):301-11.
    Open DOISearch in Google Scholar
  13. 13. Yarishkin OV, Hwang EM, Kim D, Yoo JC, Kang SS, Kim DR, Shin JH, Chung HJ, Jeong HS, Kang D, Han J, Park JY, Hong SG. Diclofenac, a Non-steroidal Anti-inflammatory Drug, Inhibits L-type Ca Channels in Neonatal Rat Ventricular Cardiomyocytes. Korean J Physiol Pharmacol. 2009 Dec;13(6):437-42.
    Open DOISearch in Google Scholar
  14. 14. McGettigan P, Henry D. Cardiovascular risk and inhibition of cyclooxygenase: a systematic review of the observational studies of selective and nonselective inhibitors of cyclooxygenase 2. JAMA. 2006 Oct 4;296(13):1633-44. Epub 2006 Sep 12. Review.
    Open DOISearch in Google Scholar
  15. 15. de Vries F, Setakis E, van Staa TP. Concomitant use of ibuprofen and paracetamol and the risk of major clinical safety outcomes. Br J Clin Pharmacol. 2010 Sep;70(3):429-38.
    Open DOISearch in Google Scholar
  16. 16. Hernandez-Diaz S, Garcia-Rodriguez LA. Epidemiologic assessment of the safety of conventional nonsteroidal anti- inflammatory drugs. Am J Med. 2001;110:20S-27S.
    Open DOISearch in Google Scholar
  17. 17. Yang ZF, Wang HW, Zheng YQ, Zhang Y, Liu YM, Li CZ. Possible arrhythmiogenic mechanism produced by ibuprofen. Acta Pharmacol Sin. 2008 Apr;29(4):421-9.
    Open DOISearch in Google Scholar
  18. 18. Jakovljević V, Savić M, Kučević I, Djurić A, Ranković A, Radisavljević M, Azanjac A, Djurić DM (2005) The effects of dipyridamole on coronary flow, nitrite outflow and oxidative stress during coronary autoregulation in isolated rat heart. Medicus; 6(2): 57-61.
    Search in Google Scholar
  19. 19. Ohkawa H, Ohishi N, Yagi K (1979) Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95:351-358.
    Open DOISearch in Google Scholar
  20. 20. Auclair C, Voisin E (1985) Nitroblue tetrazolium reduction. In: Greenvvald RA (ed) Handbook of methods for oxygen radical research. CRC Press, Boca Raton, pp 123-132.
    Search in Google Scholar
  21. 21. Pick E, Keisari Y (1980) A simple colorimetric method for the measurement of hydrogen peroxide produced by cells in culture. J Immunol Methods 38:161-170.
    Open DOISearch in Google Scholar
  22. 22. Green LC, Wagner DA, Glogowski J, Skipper PL, Wishnok JS,Tannenbaum SR (1982) Analysis of nitrate, nitrite and [15 N] nitrate in biological fluids. Anal Biochem 126:131-138.
    Open DOISearch in Google Scholar
  23. 23. Zivkovic V, Djuric D, Turjacanin-Pantelic D, Marinkovic Z, Stefanovic D, Srejovic I, Jakovljevic V. The effects of cyclooxygenase and nitric oxide synthase inhibition on cardiodynamic parameters and coronary flow in isolated rat hearts. Exp Clin Cardiol. 2013 Spring;18(2):e102-10.
    Search in Google Scholar
  24. 24. Herbertson MJ, Werner HA, Studer W, Russell JA, Walley KR. Decreased left ventricular contractility during porcine endotoxemia is not prevented by ibuprofen. Crit Care Med. 1996 May;24(5):815-9.
    Open DOISearch in Google Scholar
  25. 25. Beamer KC, Daly T, Vargish T. Hemodynamic evaluation of ibuprofen in canine hypovolemic shock. Circ Shock. 1987;23(1):51-7.
    Search in Google Scholar
  26. 26. Kristof A, Husti Z, Koncz I, Kohajda Z, Szel T, Juhasz V, Biliczki P, Jost N, Baczko I, Papp JG, Varro A, Virag L. Diclofenac prolongs repolarization in ventricular muscle with impaired repolarization reserve. PLoS One. 2012;7(12):e53255.
    Open DOISearch in Google Scholar
  27. 27. Blain H, Boileau C, Lapicque F, Nedelec E, Loeuille D, Guillaume C, Gaucher A, Jeandel C, Netter P, Jouzeau JY. Limitation of the in vitro whole blood assay for predicting the COX selectivity of NSAIDs in clinical use. Br J Clin Pharmacol. 2002 Mar;53(3):255-65.
    Open DOISearch in Google Scholar
  28. 28. Varas-Lorenzo C, Riera-Guardia N, Calingaert B, Castellsague J, Salvo F, Nicotra F, Sturkenboom M, Perez- Gutthann S. Myocardial infarction and individual nonsteroidal anti-inflammatory drugs meta-analysis of observational studies. Pharmacoepidemiol Drug Saf. 2013 Apr 25. doi: 10.1002/pds.3437.
    Open DOISearch in Google Scholar
  29. 29. Takayama F, Egashira T, Yamanaka Y. Effect of diclofenac, a non-steroidal anti-inflammatory drug, on lipid peroxidation caused by ischemia-reperfusion in rat liver. Jpn J Pharmacol. 1994 Feb;64(2):71-8.
    Open DOISearch in Google Scholar
  30. 30. Hermann M, Camici G, Fratton A, Hurlimann D, Tanner FC, Hellermann JP, Fiedler M, Thiery J, Neidhart M, Gay RE, Gay S, Luscher TF, Ruschitzka F. Differential effects of selective cyclooxygenase-2 inhibitors on endothelial function in salt-induced hypertension. Circulation. 2003 Nov 11;108(19):2308-11.
    Open DOISearch in Google Scholar
  31. 31. Wilkinson BL, Cramer PE, Varvel NH, Reed-Geaghan E, Jiang Q, Szabo A, Herrup K, Lamb BT, Landreth GE. Ibuprofen attenuates oxidative damage through NOX2 inhibition in Alzheimer’s disease. Neurobiol Aging. 2012 Jan;33(1):197.e21-32.
    Open DOISearch in Google Scholar
  32. 32. Zhao Y, McLaughlin D, Robinson E, Harvey AP, Hookham MB, Shah AM, McDermott BJ, Grieve DJ. Nox2 NADPH oxidase promotes pathologic cardiac remodeling associated with Doxorubicin chemotherapy. Cancer Res. 2010 Nov 15;70(22):9287-97.
    Open DOISearch in Google Scholar
DOI: https://doi.org/10.2478/sjecr-2014-0002 | Journal eISSN: 2956-2090 (formerly 2335-075X, 2956-0454) | Journal ISSN: 2956-0454 (formerly 1820-8665)
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Language: English, Croatian, Slovenian
Page range: 11 - 19
Published on: Apr 23, 2014
Published by: University of Kragujevac, Faculty of Medical Sciences
In partnership with: Paradigm Publishing Services
Keywords:
Diclofenac,
Ibuprofen,
Nonsteroidal antiinflammatory drugs,
Isolated rat heart,
Oxidative stress
Related subjects:
Medicine,
Clinical medicine,
Clinical medicine, other

© 2014 Maja Jevdjevic, Ivan Srejovic, Vladimir Zivkovic, Nevena Barudzic, Anica Petkovic, Jovana Bradic, Dragan Djuric, Vladimir Jakovljevic, published by University of Kragujevac, Faculty of Medical Sciences
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

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