Eruptive Sebaceous Hyperplasia as a Side Effect of Oral Tacrolimus in a Renal Transplant Recipient – A Case Report

Introduction. Eruptive sebaceous hyperplasia is a benign disorder of the sebaceous glands that develops acutely and is often associated with the use of immunosuppressive therapy.

Case report. A 56-year-old patient presented with numerous asymptomatic papules on the face, neck, and back. Due to end-stage renal disease, a cadaveric kidney transplant was performed, followed by immunosuppressive therapy consisting of tacrolimus 3.5 mg/day, sirolimus 0.5 mg twice daily, and prednisone 20 mg/day. Cutaneous lesions developed four months after the initiation of immunosuppressive therapy. Dermoscopic and histopathological findings confirmed the diagnosis of eruptive sebaceous hyperplasia.

Conclusion. This case indicates that eruptive sebaceous hyperplasia may occur in the early post-transplant period in patients after kidney transplantation, particularly following tacrolimus therapy.