Have a personal or library account? Click to login
A Case Report of Pediatric Langerhans Cell Histiocytosis: Current Approach and Diagnostic Challenges for Dermatologist Cover

A Case Report of Pediatric Langerhans Cell Histiocytosis: Current Approach and Diagnostic Challenges for Dermatologist

Open Access
|Mar 2021

References

  1. 1. Allen CE, Ladisch S, McClain KL. How I treat Langer-hans cell histiocytosis. Blood. 2015;126(1):26-35.10.1182/blood-2014-12-569301449219525827831
  2. 2. Lau SK, Chu PG, Weiss LM. lmmunohistochemical expression of Langerin in Langerhans cell histiocytosis and non-Langerhans cell histiocytic disorders. Am J Surg Pathol. 2008;32(4):615-9.10.1097/PAS.0b013e31815b212b18277880
  3. 3. Hutter C, Minkov M. Insights into the pathogenesis of Langerhans cell histiocytosis: the development of targeted therapies. Immunotargets Ther. 2016;5:81-91.10.2147/ITT.S91058506685027785447
  4. 4. Tran G, Huynh TN, Paller AS. Langerhans cell histiocytosis: a neoplastic disorder driven by Ras-ERK pathway mutations. J Am Acad Dermatol. 2018;78(3):579-90.10.1016/j.jaad.2017.09.02229107340
  5. 5. Favara BE, Jaffe R. The histopathology of Langerhans cell histiocytosis. Br J Cancer Suppl. 1994;23:S17-23.
  6. 6. Steen AE, Steen KH, Bauer R, Bieber T. Successful treatment of cutaneous Langerhans cell histiocytosis with low-dose methotrexate. Br J Dermatol. 2001;145 (1):137-40.10.1046/j.1365-2133.2001.04298.x11453923
  7. 7. Gadner H, Minkov M, Grois N, Pötschger U, Thiem E, Aricò M, et al. Therapy prolongation improves outcome in multisystem Langerhans cell histiocytosis. Blood. 2013;121(25):5006-14.10.1182/blood-2012-09-45577423589673
  8. 8. Minkov M. An update on the treatment of pediatric-onset Langerhans cell histiocytosis through pharmacotherapy. Expert Opin Pharmacother. 2018;19(3):233-42.10.1080/14656566.2018.142940529355432
  9. 9. Gadner H, Grois N, Pötschger U, Minkov M, Aricò M, Braier J, et al. Improved outcome in multisystem Lang-erhans cell histiocytosis is associated with therapy intensification. Blood. 2008;111(5):2556-62.10.1182/blood-2007-08-10621118089850
  10. 10. Behera B, Malathi M, Prabhakaran N, Divya K, Thappa DM, Srinivas BH. Dermoscopy of Langerhans cell histiocytosis. J Am Acad Dermatol. 2017;76(2S1):S79-81.10.1016/j.jaad.2016.09.04228087041
  11. 11. Kanik-Yuksek S, Ozkaya-Parlakay A, Gulhan B, Ozyoruk D, Karakus E, Cinel G, et al. A rare diagnosis in children: isolated pulmonary Langerhans cell histiocytosis. Clin Respir J. 2018;12(1):355-6.10.1111/crj.1248027067531
  12. 12. Ladisch S. Treating Langerhans cell histiocytosis, globally. Pediatr Blood Cancer. 2018;65(8):e27079.10.1002/pbc.27079
  13. 13. James WD, Berger TG, Elston DM, Neuhaus I. Andrews’ diseases of the skin: clinical dermatology. 12th ed. Edinburgh: Elsevier; 2016. p. 722-5.
  14. 14. Fitzpatrick TB, Goldsmith LA, Wolff K. Fitzpatrick’s dermatology in general medicine. 8th ed. New York: McGraw-Hill. 2012. p. 1782-95.
  15. 15. Hande KR. Etoposide: four decades of development of a topoisomerase II inhibitor. Eur J Cancer. 1998;34(10):1514-21.10.1016/S0959-8049(98)00228-7
  16. 16. Pommier Y, Leo E, Zhang H, Marchand C. DNA topoisomerases and their poisoning by anticancer and antibacterial drugs. Chem Biol. 2010;17(5):421-33.10.1016/j.chembiol.2010.04.012
  17. 17. Pinkus GS, Lones MA, Matsumura F, Yamashiro S, Said JW, Pinkus JL. Langerhans cell histiocytosis: immunohistochemical expression of fascin, a dendritic cell marker. Am J Clin Pathol. 2002;118(3):335-43.10.1309/N2TW-ENRB-1N1C-DWL0
  18. 18. Ravi S. Treatment of adult onset multifocal single system Langerhans cell histiocytosis using single agent induction chemotherapy followed by maintenance oral etoposide and external beam radiotherapy. Int J Sci Res (Ahmedabad). 2016;5(6):74-6.
  19. 19. Felix CA, Blatt J. Etoposide and Langerhans cell histiocytosis: second malignancies, a second look. Pediatr Hematol Oncol. 1999;16(3):183-5.10.1080/088800199277236
  20. 20. Bolognia J, Jorizzo JL, Schaffer JV. Dermatology. 4th ed. Philadelphia: Elsevier Saunders; 2018. p. 1614-20.
  21. 21. Gadner H, Grois N, Arico M, Broadbent V, Ceci A, Jakobson A, et al. A randomized trial of treatment for multisystem Langerhans cell histiocytosis. J Pediatr. 2001;138(5):728-34.10.1067/mpd.2001.111331
  22. 22. Ng Wing Tin S, Martin-Duverneuil N, Idbaih A, Garel C, Ribeiro M, Parker JL, et al. Efficacy of vinblastine in central nervous system Langerhans cell histiocytosis: a nationwide retrospective study. Orphanet J Rare Dis. 2011;6:83.10.1186/1750-1172-6-83
  23. 23. Schmitt AR, Wetter DA, Camilleri MJ, Khan SP, Tollefson MM. Langerhans cell histiocytosis presenting as a blueberry muffin rash. Lancet. 2017;390(10090):155.10.1016/S0140-6736(17)30564-0
Language: English
Page range: 79 - 86
Submitted on: Dec 12, 2019
Accepted on: Mar 31, 2020
Published on: Mar 18, 2021
Published by: Serbian Association of Dermatovenereologists (SAD)
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2021 Irwan Junawanto, Khairuddin Djawad, Sri Rimayani, Farida Tabri, Nurelly N. Waspodo, Faridha Ilyas, Dewa Ayu Supriyantini, published by Serbian Association of Dermatovenereologists (SAD)
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.