Unusual clinical course of trichinellosis with relapse

Paraličová, Z.; Dubinský, P.; Kristian, P.; Jarčuška, P.

doi:10.2478/s11687-013-0123-5

Abstract

During an outbreak of trichinellosis in Eastern Slovakia in 2008, 16 people were hospitalized, including 10 patients having specific anti-Trichinella antibodies. The disease relapse was seen in a 68-year-old woman two weeks after her discharge from hospital, where she was treated with albendazole and prednisone for 10 days. Clinical symptoms of trichinellosis, eosinophilia, elevated CRP and LDH levels were observed again with recorded elevation of aminotransferase levels during the relapse. Herein we discuss a potential cause of unusual relapse of trichinellosis with liver damage in a female patient with type II diabetes mellitus.

References

[1] Dubinský, P., Hurníková, Z., Kinčeková, J., Reiterová, K., Antolová, D., Kerpan, L., Juriš, P, Pliešovský, J. (2008): Decade from the greatest outbreak of trichinellosis in Slovakia. Slov. Vet. J., 33(4): 214–215
Search in Google Scholar
[2] Dupouy-Camet, J., Kociecka, W., Bruschi, F., Bolasfernandez, F., Pozio, E. (2002): Opinion on the diagnosis and treatment of human trichinellosis. Expert Opin. Pharmacother., 3: 1117–1130. DOI: 10.1517/14656566.3.8.1117 http://dx.doi.org/10.1517/14656566.3.8.111710.1517/14656566.3.8.1117
Search in Google Scholar
[3] Gottstein, B., Pozio, E., Nöckler, K. (2009): Epidemiology, diagnosis, treatment, and control of trichinellosis. Clin. Microbiol. Rev., 2009, 22: 127–145. DOI: 10.1128/CMR.00026-08 http://dx.doi.org/10.1128/CMR.00026-0810.1128/CMR.00026-08
Search in Google Scholar
[4] Havassiova, K., Dubinský, P. (1994): Antibody response during the course of human trichinellosis. In: Campbell, W. C., Pozio, E., Bruschi, F. (Eds) Trichinellosis. ISS Press, Rome: 505–510
Search in Google Scholar
[5] Januszkiewicz, J., Kowalczyk, M., Poznanska, H., Wehr, H. (1970): Evaluation of liver involvement in trichinosis. Epidemiol. Rev., 24: 270–278
Search in Google Scholar
[6] Kociecka, W. (2000): Trichinellosis: Human disease, diagnosis and treatment. Vet. Parasitol., 93: 365–383. DOI: 10.1016/S0304-4017(00)00352-6 http://dx.doi.org/10.1016/S0304-4017(00)00352-610.1016/S0304-4017(00)00352-6
Search in Google Scholar
[7] Paraličová, Z., Kinčeková, J., Schréter, I., Jarčuška, P., Dubinský, P. Jr., Porubčin, Š., Pavlinová, J., Kristian, P. (2009): Outbreak of trichinellosis in eastern Slovakia. Helminthologia, 46(4): 209–213. DOI: 10.2478/s11687-009-0039-2 http://dx.doi.org/10.2478/s11687-009-0039-210.2478/s11687-009-0039-2
Search in Google Scholar
[8] Pawlowski, Z. (1967): Adrenal cortext hormones in intestinal trichinellosis. III. Effect of adrenalectomy and hidrocortisone, insulin, alloxan and glucose treatment on elimination of Trichinella spiralis in hooded rats. Acta Parasitol. Pol., 15: 179–189
Search in Google Scholar
[9] Pozio, E., Sacchini, D., Sacchi, L., Tamburini, A., Alberici, F. (2001): Failure of mebendazole in treating Trichinella spiralis infection in humans at the stage of encapsulating larvae. Clin. Infect. Dis., 32: 638–642. DOI: 10.1086/318707 http://dx.doi.org/10.1086/31870710.1086/31870711181129
Search in Google Scholar
[10] Pozio, E., Varese, P., Gomez-Morales, M. A., Croppo, G. P., Pellicia, D., Bruschi, F. (1993): Comparison of human trichinellosis caused by Trichinella spiralis and by Trichinella britovi. Am. J. trop. Med. Hyg., 48: 568–575
Search in Google Scholar
[11] Remig, J., Fröscher, W. (1987): Akute trichinose. Dtsch. med. Wschr., 112: 1855–1859 http://dx.doi.org/10.1055/s-2008-106834210.1055/s-2008-10683423678092
Search in Google Scholar
[12] Reuter, S., Jensen, B., Buttenschoen, K., Kratzer, W., Kern, P. (2000): Benzimidazoles in the treatment of alveolar echinococcosis: a comparative study and review of the literature. J. Antimicrob. Chemother., 46: 451–456. DOI: 10.1093/jac/46.3.451 http://dx.doi.org/10.1093/jac/46.3.45110.1093/jac/46.3.45110980173
Search in Google Scholar
[13] Rodríguez, J. J., De Prada, I., Durán, J. J., Fernández F. B. (2009): The effect of intestinal trichinellosis on oral bioavailability of albendazole in mice. Parasitol Res., 105(1): 65–70. DOI: 10.1007/s00436-009-1365-5 http://dx.doi.org/10.1007/s00436-009-1365-510.1007/s00436-009-1365-519241092
Search in Google Scholar
[14] Schellenberg, R. S., Tan, B. J., Irvine, J. D., Stockdale, D. R., Gajadhar, A. A., Botha, J., Armstrong, C. A., Woods, S. A., Bloudeau, J. M., Mcnab, T. L. (2003): An outbreak of Trichinellosis due to consumption of bear meat infected with Trichinella nativa in 2 northern Saskatchewan communities. J. Infect. Dis., 188: 835–843. DOI: 10.1086/378094 http://dx.doi.org/10.1086/37809410.1086/37809412964114
Search in Google Scholar
[15] Shimoni, Z., Klein, Z., Weiner, P., Assous, M.V., Froom., P. (2007): The use of prednisone in the treatment of trichinellosis. Isr. Med. Assoc. J., 9: 537–539
Search in Google Scholar
[16] Spaldonova, R., Komandarev, S., Tomasovicova, O. (1974). The effect of alloxan diabetes on intestinal and muscle trichinellosis. In: Kim, C. W. (Ed) Trichinellosis. Intext, New York: 149–154
Search in Google Scholar
[17] Turk, M., Kaptan, F., Turker, N., Korkmaz, M., El, S., Ozkaya, D., Ural, S., Vardar, I., Alkan, M. Z., Coskun, N. A., Turker, M., Pozio, E. (2006): Clinical and laboratory aspects of a trichinellosis outbreak in Izmir, Turkey. Parasite, 13: 65–70. DOI: 10.1051/parasite/2006131065 http://dx.doi.org/10.1051/parasite/200613106510.1051/parasite/200613106516605069
Search in Google Scholar
[18] Wakelin, D., Denham, D. A. (1983): The immune response. In: Campbell, W. C. (Ed) Trichinella and trichinosis. Plenum Press, New York and London: 265–308 http://dx.doi.org/10.1007/978-1-4613-3578-8_810.1007/978-1-4613-3578-8_8
Search in Google Scholar
[19] Zentel (2011): Product Information, 8p.
Search in Google Scholar

Unusual clinical course of trichinellosis with relapse

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