Parasitic infections and pregnancy complications

J. Pavlinová; J. Kinčeková; A. Ostró; L. Saksun; Z. Vasilková; A. Königová

doi:10.2478/s11687-011-0002-x

Abstract

Infections of various aetiology during pregnancy present a serious risk factor that can lead to abortion, premature birth, stillbirth, birth of newborn with genetic developmental defects, or seemingly healthy infant that may develop symptoms later in life. A total of 530 sera of patients from gynaecology departments were examined for antibodies against Toxoplasma gondii, Toxocara spp. and Listeria monocytogenes using ELISA (IgG, IgM). In women with habitual abortions we determined up to 42.1 % seroprevalence of IgG antibodies against T. gondii. The prevalence of antibodies was statistically significant (p < 0.0004) when compared to control group (25.1 %). In the patients diagnosed with sterility the prevalence of antibodies (26.3 %) was similar to that of control group. The prevalence of antibodies against Toxocara spp. (5.5 %) and Listeria monocytogenes (2.3 %) in patients with habitual abortions were similar to those of women in the general population.

References

[1] Al-Hamdani, M. M., Mahdi, N. K. (1997): Toxoplasmosis among women with habitual abortion. East. Mediterr. Health J., 3(2): 310–315 10.26719/1997.3.2.310
Search in Google Scholar
[2] Andrade, G. M. Q., Vasconcelos-Santos, D. V., Carellos, E. V. M., Romanelli R. M. C., Vitor R. W. A., Carneiro A. C. A. V., Januario J. N. (2010): Congenital toxoplasmosis from a chronically infected woman with reactivation of retinochoroiditis during pregnancy. J. Pediatr. (Rio J.), 86(1): 85–88. DOI: 10.1590/S0021-75572010000100015 http://dx.doi.org/10.1590/S0021-7557201000010001510.1590/S0021-75572010000100015
Search in Google Scholar
[3] Bálint, O. (2003): Listeriosis. In: Šašinka, M., Nyulassy, Š., Badalík, L.: Vademecum Medici. Martin, SR: Osveta, pp. 1444–1445 (In Slovak)
Search in Google Scholar
[4] Benshushan, A., Tsafrir, A., Arbel, R., Rahav, G., Ariel, I., Rojansky, N. (2002): Listeria infection during pregnancy: a 10 year experience. Isr. Med. Assoc. J., 4(10): 776–780
Search in Google Scholar
[5] Bobić, B., Jevremović, I., Marinković, J., Šibalić, D., Djurkovic-djaković, O. (1998): Risk factors for Toxoplasma infection in a reproductive age female population in the area of Belgrade, Yugoslavia. Eur. J. Epidemiol., 14: 605–610 http://dx.doi.org/10.1023/A:100746122594410.1023/A:1007461225944
Search in Google Scholar
[6] Citterbart, K. (2001): Gynaecology. 1st Edition, Galen. p. 139 (In Czech)
Search in Google Scholar
[7] Čatár, G., Červeň, D., Jalili, N. (1998): Toxoplasma gondii. Bratisl. Lek. Listy, 99, 579–583 (In Slovak)
Search in Google Scholar
[8] Decavalas, G., Papaperopoulou, M., Giannoulaki, E., Tzigounis, V., Kondakis, X. G. (1990): Prevalence of Toxoplasma gondii antibodies in gravidas and recently aborted women and study of risk factors. Eur. J. Epidemiol., 6(2): 223–226 http://dx.doi.org/10.1007/BF0014579810.1007/BF00145798
Search in Google Scholar
[9] Ellner, P. D., Neu H. C. (1992): Understanding infectious disease. Mosby Year Book. St. Louis — Y.B.INC, 343 pp.
Search in Google Scholar
[10] Golledge, C. L., Beaman, M. H. (1990): Toxoplasmosis and pregnancy. Aust. N. Z. J. Obstet. Gynaecol., 30: 32–33. DOI: 10.1111/j.1479-828X.1990.tb03191.x http://dx.doi.org/10.1111/j.1479-828X.1990.tb03191.x10.1111/j.1479-828X.1990.tb03191.x
Search in Google Scholar
[11] Hejlíček, K., Literák, I., Vostalová, E., Křešnička, J. (1999): Antibodies against Toxoplasma gondii in pregnant women of the České Budějovice District. Epidemiol. Mikrobiol. Imunol., 48: 102–105 (In Czech)
Search in Google Scholar
[12] Hingorani, V., Prakash, O., Chowdhry, P., Kamalam, T. S. (1970): Toxoplasmosis: abortions and stillbirths. Indian J. Med. Res., 58: 967–974
Search in Google Scholar
[13] Huang, Z. P., Huang, Z. J., Guo, H. (1998): Analysis on Toxoplasma gondii infection in the semina of 140 cases of sterility patients. J. Chin. Birth Cont. (Chin.)., 6: 160–161
Search in Google Scholar
[14] Hudeček, R., Krajčovičová, R., Ventruba, P. (2009): Pharmacological possibilities of embryoprotective therapy of infertile women. Klin. Farmakol. Farm., 23(2): 76–82 (In Czech)
Search in Google Scholar
[15] Jirsová, S., Mašata, J., Jech, L., Drbohlav, P., Jaržembovská, M., Pavelková, J., Moosová, M., Řežábek, K., Bencko, V., Zvárová, J. (2009): Levels of chlorinated organic pesticides in follicular liquid of infertile women. Chem. Listy. 103: 589–594 (In Czech)
Search in Google Scholar
[16] Krajčovičová, R., Hudeček, R., Kalvodová, J. (2007): Differential diagnostics and therapy of repeated pregnancy losses. Prakt. Gyn. 11(4): 164–169 (In Czech)
Search in Google Scholar
[17] Langer, H. (1963): Repeated congenital infection with T. gondii. Obstet. Gynaecol., 21: 318–329
Search in Google Scholar
[18] Luft, B. J., Remington, J. S. (1992): Toxoplasmosis encephalitis in AIDS. Clin. Infect. Dis., 15: 211–222
Search in Google Scholar
[19] Mahajan, R. C., Gupta, I., Chhapra, M. B., Gupta, A. N., Devi, P. K., Ganguli, N. K. (1976): Toxoplasmosis — its role in abortion. Indian J. Med. Res., 64(6): 797–800
Search in Google Scholar
[20] Mašta, J., Jedličková, A. (2004): Infections in gynaecology and obstetrics and prinicples of antiinfectious treatment. Praha, CzR: Maxdorf - Jessenius. 371 pp. (In Czech)
Search in Google Scholar
[21] Ondriska, F., Čatár, G., Vozárová, G. (2003): The significance of complement fixation test in clinical diagnosis of toxoplasmosis. Bratisl. Lek. Listy, 104: 189–196
Search in Google Scholar
[22] Ondriska, F., Mikulecký, M. (2002): Larval Toxocarosis in humans. Pediatr. pro Praxi, 5: 213–217 (In Slovak)
Search in Google Scholar
[23] Palička, P., Slabá, H., Zitek, K. (1998): An active approach to influencing the prevalence of Toxoplasmosis in population. Prakt. Gynek., 5(1): 23–27 (In Slovak)
Search in Google Scholar
[24] Qi, R., Su, X. P., Gao, X. L., Liang, X. L. (2005): Toxoplasma infection in males with sterility in Shenyang, China. Zhonghua Nan Ke Xue, 11: 503–504 (In Chinese with English abstract)
Search in Google Scholar
[25] Rappaport, F., Rabinovitz, M., Toaff, R., Krochik, N. (1960): Genital listeriosis as a cause of repeated abortion. Lancet., 1: 1273 http://dx.doi.org/10.1016/S0140-6736(60)92253-410.1016/S0140-6736(60)92253-4
Search in Google Scholar
[26] Reiterová, K., Kinčeková, J., Halásová, D., Miterpá-Ková, M. (2003): Epidemiology and epizootology of toxocarosis. In: Holková, R., Totková, A., Klobušický, M. (Eds) Proceedings „Current problems of human parasitology“. Bratislava: pp. 14–17 (In Slovak)
Search in Google Scholar
[27] Remington, J. S., Newell, J. W., Cavanaugh, E. (1964): Spontaneous Abortion and Chronic Toxoplasma — Report of a case, with isolation of the parasite. Obstet. Gynecol., 24(1): 25–31
Search in Google Scholar
[28] Ross, D. S., Jones, J. L., Lynch, M. F. (2006): Toxoplasmosis, cytomegalovirus, listeriosis, and preconception care. Matern. Child. Health J., 10: 187–191. DOI: 10.10 07/s10995-006-0092-0 http://dx.doi.org/10.1007/s10995-006-0092-010.1007/s10995-006-0092-0
Search in Google Scholar
[29] Řežábek, K. (2008): Infertility Treatment. 4th Edition, Praha, CzR: Grada Publishing, 102 pp. (In Czech)
Search in Google Scholar
[30] Sahwi, S. Y., Zaki, M. S., Haiba, N. Y., Elsaid, O. K., Anwar, M. Y., Abdrabbo, S. A. (1995): Toxoplasmosis as a cause of repeated abortion. Asia Oceania J. Obstet. Gynaecol., 21(2): 145–148 http://dx.doi.org/10.1111/j.1447-0756.1995.tb01087.x10.1111/j.1447-0756.1995.tb01087.x
Search in Google Scholar
[31] Sharf, M., Eibschitz, I., Eylan, E. (1973): Latent toxoplasmosis and pregnancy. Obstet. Gynecol., 42(3): 349–354
Search in Google Scholar
[32] Schlosserová, K., Ondriska, F., Halgoš, J., Beladičová, V., Valentová, D. (2007): Current situation of toxocarosis occurrence in Bratislava. In Holková, R., Tomo, I., Totková, A., Klobušický M. (Eds) Proceedings “Current Problems of Human Parasitology” from http://www.fmed.uniba.sk/fileadmin/user_upload/editors/ustavy/parazitologia/Schlosserova....pdf (In Slovak)
Search in Google Scholar
[33] Silveira, C. A. M., Ferreiea, R., Muccioll, C., Nussenblatt, R., Belfort-jr, R. (2003): Toxoplasmosis transmitted to a newborn from the mother infected 20 years earlier. Am. J. Ophthalmol., 136: 370–371 http://dx.doi.org/10.1016/S0002-9394(03)00191-010.1016/S0002-9394(03)00191-0
Search in Google Scholar
[34] Singh, N. (1998): Status of Toxoplasma antibodies in recurrent fetal loss in U.A.E. women. Indian J. Pediatr., 65: 891–897 http://dx.doi.org/10.1007/BF0283135710.1007/BF0283135710773955
Search in Google Scholar
[35] Southern, P. M. (1972): Habitual abortion and toxoplasmosis. Is there a relationship? Obstet. Gynecol., 39: 45–47
Search in Google Scholar
[36] Stray-pedersen, B., Lorentzen-styr, A. M. (1977): Uterine toxoplasma infections and repeated abortions. Am. J. Obstet. Gynecol., 128(7): 716–721 10.1016/0002-9378(77)90709-8
Search in Google Scholar
[37] Strhársky, J., Klement, C., Hrubá, F. (2009): Seroprevalence of Toxoplasma gondii antibodies in the Slovak Republic. Folia Microbiol., 54(6): 553–558. DOI: 10.1007/s12223-009-0081-y http://dx.doi.org/10.1007/s12223-009-0081-y10.1007/s12223-009-0081-y20140726
Search in Google Scholar
[38] Studeničová, C., Benčaiová, G., Holková, R. (2006): Seroprevalence of Toxoplasma gondii antibodies in a healthy population from Slovakia. Eur. J. Intern. Med., 17(7): 470–473. DOI: 10.1016/j.ejim.2006.07.007 http://dx.doi.org/10.1016/j.ejim.2006.07.00710.1016/j.ejim.2006.07.00717098589
Search in Google Scholar
[39] Svobodová, V., Literák, I. (1998): Prevalence of IgM and IgG antibodies to Toxoplasma gondii in blood donors in the Czech Republic. Eur. J. Epidemiol., 14: 803–805. DOI: 10.1023/A:1007589422080 http://dx.doi.org/10.1023/A:100758942208010.1023/A:1007589422080
Search in Google Scholar
[40] Štork, A. (1981): Medical Textbook, Vol. 1. A-L. Praha, CzR: Avicenum: pp. 972–974 (In Czech)
Search in Google Scholar
[41] Terpsidis, K. I., Papazahariadou, M. G., Taitzoglou, I. A., Papaioannou, N. G., Georgiadis, M. P., Theodoridis, I. T. (2009): Toxoplasma gondii: Reproductive parameters in experimentally infected male rats. Exp. Parasitol., 121(3): 238–241. DOI: 10.1016/j.exppara.2008.11.006 http://dx.doi.org/10.1016/j.exppara.2008.11.00610.1016/j.exppara.2008.11.00619063884
Search in Google Scholar
[42] Tomolová, Z., Zmrhal, J., Hradec, D. (2004): Gynaecological Listeriosis as a cause of septic disease of newborns. Prakt. Gyn., 3: 19–21 (In Czech)
Search in Google Scholar
[43] Turbadkar, D., Mathur, M., Rele, M. (2003): Seroprevalence of torch infection in bad obstetric history. Indian J. Med. Microbiol., 21: 108–110
Search in Google Scholar
[44] Wilson, C. B., Remington, J. S. (1987): Toxoplasmosis. In: Textbook of Pediatric Infectious Diseases. 2nd Ed.,Vol. II., Philadelphia: W.B. Saunders Comp., pp. 2067–2078
Search in Google Scholar
[45] Wong, S. Y., Remington, J. S. (1994): Toxoplasmosis in pregnancy. Clin. Infect. Dis., 18: 853–862
Search in Google Scholar

Parasitic infections and pregnancy complications

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