The X-chromosome-linked immunodeficiency determines an improved course of murine lagochilascariosis

Prudente, M.; Lino-Junior, R.; Carvalhaes, M.

doi:10.2478/s11687-009-0038-3

Abstract

Lagochilascaris minor is the causative agent of lagochilascariosis, a disease that affects the neck region causing exudative abscesses with eggs, adult parasites and L3/L4 larvae within purulent exudates. Nowadays, mice are considered intermediate hosts for the parasite. To determine the pattern of infection in B1 cell-defective mice, experimental lagochilascariosis was studied in BALB/c and X-chromosome-linked immunodeficient (Xid) mice. BALB.xid infected mice showed higher survival ratios and less intense lung lesions than BALB/c mice. Serum levels of IL-10 was higher in BALB/c infected mice when compared to BALB.xid animals; however, serum levels of IFNγ, in control and infected BALB.xid mice, were statistically different from that seen in BALB/c mice. We discuss the participation of B1 cells and their cytokines in the resistance to infection.

References

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The X-chromosome-linked immunodeficiency determines an improved course of murine lagochilascariosis

Abstract

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