Increasing antioxidant protection during mebendazole and AKβ vitamin complex treatment of experimental trichinellosis in rats

Tolstoy, V.; Lytvynets, A.; Langrová, I.

doi:10.2478/s11687-009-0028-5

Abstract

To enhance the effect of treatment method of Trichinellosis with mebendazole, lipid peroxidation processes (LPP) in blood of Wistar rats experimentally infected with Trichinella spiralis were investigated. In accordance with health condition of infected rats treated with mebendazole and combination of mebendazole and AKβ vitamin complex, dynamics of the main values of the LPP (such as: activity of superoxide dismutase (SOD) and catalase (CAT) in erythrocytes and malonic dialdehyde (MDA) concentration in blood serum) were analyzed. It was concluded that mebendazole amplifies the LPP in rat’s blood. Additional administrations of the AKβ vitamin complex allow improvement of LPP parameters, raising compensatory-adaptive reactions of the host organism and reducing the rate of the experimental animal’s mortality.

References

[1] Akhmedov, D. R. (1994): Clinical and pathogenetic significance of the antioxidative system in infectious diseases. Klin. Med. (Mosk) 72(1): 24–6 (in Russian)
Search in Google Scholar
[2] Bagley, E. (2000): Products of lipid peroxidation as a direct carcinogen. In Oncology 2000, Articles of II Oncologists Meeting of countries of the CIS in the Kiev, p 172 (in Russian)
Search in Google Scholar
[3] Bekish, O. Ia. (1978): Biochemical aspects of pathogenesis in trichinellosis. In Proceedings of the 4th International Congress of Parasitology, Warszawa, Poland, 4: 271–279
Search in Google Scholar
[4] Bekish, O. Ia., Beznos, T. B., Burak, I. I. (1980a): Influence of specific therapy of some helminthic infections on character of allergic reactions in the parasitized ghost organism. In Articles of IX Conference of the Ukrainian Parasitological Society, Kiev. Part I, pp 68–69 (in Russian)
Search in Google Scholar
[5] Bekish, O. Ia., Burak, I. I., Ostreiko, N. N., Zatvornickaia, V. V. (1980b): Way of trichinellosis modeling in various forms of severity. In: Modern methods of struggle against parasitic diseases of agricultural animals. Articles of Republican Scientific-Practical Conference. Minsk, Belorussia, pp 17–18 (in Russian)
Search in Google Scholar
[6] Chistenko, G. N., Vedenko, A. L. (2006): Parasitic disease morbidity in Belorussia. In: Achievements and trends in the development of modern parasitology. Articles of the 5th Republican Scientific-Practical Conference. Vitebsk, Belorussia, pp 21–25 (in Russian)
Search in Google Scholar
[7] Dianzani, M. U. (1992): Free radicals in physiology and pathology. Boll. Soc. Ital. Biol. Sper., 68(8–9): 491–511
Search in Google Scholar
[8] Figallová, V., Prokopič, J. (1987): Effect of vitamins on Trichinella pseudospiralis Garkavi, 1972 infection in mice. Folia Parasit., 34(4): 341–346
Search in Google Scholar
[9] Gavrilov, V.B., Gavrilova, A. R., Mazhul’, L. M. (1987): Methods of determining lipid peroxidation products in the serum using a thiobarbituric acid test. Vopr. Med. Khim., 33: 118–122 (in Russian)
Search in Google Scholar
[10] Halliwell, B. (1991): Drug antioxidant effects. A basis for drug selection? Drugs 42(4): 569–605 http://dx.doi.org/10.2165/00003495-199142040-0000310.2165/00003495-199142040-0000371020571723362
Search in Google Scholar
[11] Harman, D. (1992): Free radical theory of aging: history (a review). EXS, 62: 1–10
Search in Google Scholar
[12] Hurníková, Z., Šnábel, V., Pozio, E., Reiterová, K., Hrčková, G., Halásová, D., Dubinský, P. (2005): First record of Trichinella pseudospiralis in the Slovak Republic found in domestic focus. Vet Parasitol. 128(1–2): 91–8 http://dx.doi.org/10.1016/j.vetpar.2004.11.01310.1016/j.vetpar.2004.11.01315725537
Search in Google Scholar
[13] Kociecka, W. (1996): Wlosen krenty i wlosnica. Volumed, Wroclaw
Search in Google Scholar
[14] Kołodziej-Sobocińska, M., Dvorožňáková, E., Dziemian, E. (2006): Trichinella spiralis: macrophage activity and antibody response in chronic murine infection. Exp. Parasitol., 112(1): 52–62 http://dx.doi.org/10.1016/j.exppara.2005.09.00410.1016/j.exppara.2005.09.00416274689
Search in Google Scholar
[15] Kostiuk, V.A., Potapovich, A.I., Kovaleva, Zh.V. (1990): A simple and sensitive method of determination of superoxide dismutase activity based on the reaction of quercetin oxidation. Vopr. Med. Khim., 36: 88–91 (in Russian)
Search in Google Scholar
[16] Mamontova, N. S., Beloborodova, E. I., Tiukalova, L. I. (1994): The determination of Catalase activity in chronic alcoholics. Ter. Arkh., 66(2): 60–63
Search in Google Scholar
[17] Miroshnichenko, O.S. (1992): Biogenesis, physiological role and properties of Catalase. Biopolym. Cell, 8(6): 3–25 10.7124/bc.00033C
Search in Google Scholar
[18] Ozereckovskaya, N. N. (1985): Unsolved problems of trichinosis treatment. In: Articles of All-Union Scientific Conference on human and animal trichinellosis issues in Yerevan, Armennian, pp 19–22 (in Russian)
Search in Google Scholar
[19] Pozio, E. (2007): World distribution of Trichinella spp. infections in animals and humans. Vet. Parasitol., 149: 3–21 http://dx.doi.org/10.1016/j.vetpar.2007.07.00210.1016/j.vetpar.2007.07.00217689195
Search in Google Scholar
[20] Pozio, E., Zarlenga, D. S. (2005): Recent advances on the taxonomy, systematic and epidemiology of Trichinella. Int. J. Parasitol., 35: 1191–1204 http://dx.doi.org/10.1016/j.ijpara.2005.07.01210.1016/j.ijpara.2005.07.01216153648
Search in Google Scholar
[21] Rutkovskaya, Zh. A., Morozkina, T. S. (2006): Influence of different doses of carotenes in “AKβ” on the state of the antioxidant system of the organism of rats. Proceedings of the National Academy of Sciences of Belarus, 2: 59–62
Search in Google Scholar
[22] Senutaite, J. (1990): Biochemical changes on the organism during trichinellosis. Mokslas, Vilnius (in Russian)
Search in Google Scholar
[23] Smirnov, L. D., Suskova, V.S. (1989): Modulation of the immune response by antioxidants (a review). Pharmaceutical Chemistry Journal 23(7): 527–537 (in Russian) http://dx.doi.org/10.1007/BF0076465110.1007/BF00764651
Search in Google Scholar
[24] Tolstoj, V. A., Lytvynets, A., Langrova, I. (2007): Pro-oxidant effects of Mebendazole in albino rats experimentally infected with Trichinella spiralis. Parasitol. Res., 100(6): 1277–1280 http://dx.doi.org/10.1007/s00436-006-0401-y10.1007/s00436-006-0401-y17186274
Search in Google Scholar
[25] Tolstoy, V.A., Butvilovskiy, V.E., Davydov, V.V. (2000): Eosinophilia in rats with experimental trichinello sis durind Mebendazole and anti-oxidant AKβ vitamin complex treatment. In: Tissue helminthiasis: diagnostics, pathogenesis, clinical picture, treatment and epidemiology. Articles of Scientific-Practical Conference. Vitebsk, Belorussia, pp 131–137 (in Russian)
Search in Google Scholar
[26] Vladimirov, Yu. A., Archakov, A.I. (1972): Lipid peroxidation in biological membranes, Nauka, Moscow (in Russian)
Search in Google Scholar

Increasing antioxidant protection during mebendazole and AKβ vitamin complex treatment of experimental trichinellosis in rats

Abstract

Paradigm

My account