Abstract
We studied experimental lagochilascariosis in male and female mice of four strains. The survival ratio and number of larvae recovered varied: B10.A and C57BL/6 mice had the highest number of larvae 90 days after infection and the lowest survival ratio at 345 days of infection. BALB/c mice had an intermediate survival ratio and number of larvae. A/J mice had the lowest number of larvae and the highest survival ratio. Our findings suggest that resistance to Lagochilascaris minor is not linked to the H-2a region because both susceptible B10.A and resistant A/J mice express the H-2a haplotype. However, the pattern of mortality and larvae recovered that we observed in C57BL/6 mice, which possess the same genetic background as B10.A, indicates that the background genotype does affect the outcome of lagochilascariosis in mice. This study demonstrates that the genetic background, but not H-2a or sex, determine the outcome of lagochilascariosis in mice.