Recent advances in wound healing, tissue repair, regeneration, and scar management: A literature review
References
- Alberts B, Johnson A, Lewis J, Morgan D, Raff M, Roberts K, Walter P. Molecular Biology of the Cell. 6th ed. New York: Garland Science; 2015.
- Lodish H, Berk A, Zipursky SL, et al. Molecular Cell Biology. 8th ed. New York: W.H. Freeman; 2016.
- Martini FH, Nath JL, Bartholomew EF. Fundamentals of Anatomy & Physiology. 11th ed. Pearson Education; 2018.
- Landén NX, Li D, Ståhle M. Transition from acute to chronic wound healing. Cell Mol Life Sci. 2016;73(20):3861-3885. DOI:10.1007/s00018-015-2119-4
- Guo S, DiPietro LA. Factors affecting wound healing. J Dent Res. 2010;89(3):219-229. DOI:10.1177/0022034509359125
- Gurtner GC, Werner S, Barrandon Y, Longaker MT. Wound repair and regeneration. Nature. 2008;453(7193):314-321. DOI:10.1038/nature07039
- Olsson M, Järbrink K, Divakar U, Bajpai S, Upton Z, Schmidtchen A. The humanistic and economic burden of chronic wounds: a systematic review. Wound Repair Regen. 2019;27(1):114-125. DOI:10.1111/wrr.12683
- Frykberg RG, Banks J. Challenges in the treatment of chronic wounds. Adv Wound Care (New Rochelle). 2015;4(9):560-582. DOI:10.1089/wound.2015.0635
- Bayat A, McGrouther DA, Ferguson MWJ. Skin scarring. BMJ. 2003;326(7380):88-92. DOI:10.1136/bmj.326.7380.88
- Gauglitz GG, Korting HC, Pavicic T, Ruzicka T, Jeschke MG. Hypertrophic scarring and keloids: pathomechanisms and current and emerging treatment strategies. Mol Med. 2011;17(1-2):113-125. DOI:10.2119/molmed.2009.00153
- van der Wal MB, Tuinebreijer WE, Bloemen MC, Verhaegen PD, Middelkoop E, van Zuijlen PP. Rasch analysis of the Patient and Observer Scar Assessment Scale (POSAS) in burn scars. Qual Life Res. 2012;21(1):13-23. DOI:10.1007/s11136-011-9924-5
- Furie B, Furie BC. Mechanisms of thrombus formation. N Engl J Med. 2008;359(9):938-949. DOI:10.1056/NEJMra0801082
- Werner S, Grose R. Regulation of wound healing by growth factors and cytokines. Physiol Rev. 2003;83(3):835-870. DOI:10.1152/physrev.2003.83.3.835
- Barrientos S, Stojadinovic O, Golinko MS, Brem H, Tomic-Canic M. Growth factors and cytokines in wound healing. Wound Repair Regen. 2008;16(5):585-601. DOI:10.1111/j.1524-475X.2008.00410.x
- Borregaard N. Neutrophils, from marrow to microbes. Immunity. 2010;33(5):657-670. DOI:10.1016/j.immuni.2010.11.011
- Koh TJ, DiPietro LA. Inflammation and wound healing: the role of the macrophage. Expert Rev Mol Med. 2011;13:e23. DOI:10.1017/S1462399411001943
- Mantovani A, Sica A, Sozzani S, et al. The chemokine system in diverse forms of macrophage activation. Trends Immunol. 2004;25(12):677-686. DOI:10.1016/j.it.2004.09.015
- Eming SA, Krieg T, Davidson JM. Inflammation in wound repair: molecular and cellular mechanisms. J Invest Dermatol. 2007;127(3):514-525. DOI:10.1038/sj.jid.5700701
- Tonnesen MG, Feng XH, Clark RAF. Angiogenesis in wound healing. J Investig Dermatol Symp Proc. 1996;1(1):40-46. DOI:10.1046/j.1087-0024.2000.00014.x
- Fuchs E. The tortoise and the hair: slow-cycling cells in the stem cell race. Cell. 2009;137(5):811-819. DOI:10.1016/j.cell.2009.05.002
- Grose R, Werner S. Regulation of wound reepithelialization by growth factors and cytokines. Wound Repair Regen. 2004;12(3):241-256. DOI:10.1111/j.1067-1927.2004.012306.x
- Watt FM, Huck WTS. Role of the extracellular matrix in regulating stem cell fate. Nat Rev Mol Cell Biol. 2013;14(8):467-473. DOI:10.1038/nrm3620
- Ogawa R. Keloid and hypertrophic scars are the result of chronic inflammation in the reticular dermis. Wound Repair Regen. 2017;25(5):647-657. DOI:10.1111/wrr.12574
- Nosbaum A, Prevel N, Truong HA, Mehta P, Ettinger M, Scharschmidt TC, et al. Cutting edge: regulatory T cells facilitate cutaneous wound healing. J Immunol. 2016;196(5):2010-2014. DOI:10.4049/jimmunol.1502139
- Ganz T. Defensins: antimicrobial peptides of innate immunity. Nat Rev Immunol. 2003;3(9):710-720. DOI:10.1038/nri1180
- Wulff BC, Parent AE, Meleski MA, DiPietro LA, Schrementi ME, Wilgus TA. Mast cells contribute to scar formation during fetal wound healing. J Invest Dermatol. 2012;132(2):458-465. DOI:10.1038/jid.2011.324
- Hynes RO. The extracellular matrix: not just pretty fibrils. Science. 2009;326(5957):1216-1219. DOI:10.1126/science.1176009
- Jiang D, Liang J, Noble PW. Hyaluronan in tissue injury and repair. Annu Rev Cell Dev Biol. 2007;23:435-461. DOI:10.1146/annurev. cellbio.23.090506.123337
- Campisi J, d’Adda di Fagagna F. Cellular senescence: when bad things happen to good cells. Nat Rev Mol Cell Biol. 2007;8(9):729-740. DOI:10.1038/nrm2233
- Swift ME, Burns AL, Gray KL, DiPietro LA. Age-related alterations in the inflammatory response to dermal injury. J Invest Dermatol. 2001;117(5):1027-1035. DOI:10.1046/j.0022-202x.2001.01539.x
- Brem H, Tomic-Canic M. Cellular and molecular basis of wound healing in diabetes. J Clin Invest. 2007;117(5):1219-1222. DOI:10.1172/JCI32169
- Winter GD. Formation of the scab and the rate of epithelialization of superficial wounds in the skin of the young domestic pig. Nature. 1962;193(4812):293-294. DOI:10.1038/193293a0
- Boateng JS, Matthews KH, Stevens HNE, Eccleston GM. Wound healing dressings and drug delivery systems: a review. J Pharm Sci. 2008;97(8):2892-2923. DOI:10.1002/jps.21210
- McDaniel JC, Browning KK. Smoking, chronic wound healing, and implications for evidence-based practice. J Wound Ostomy Continence Nurs. 2014;41(5):415-423. DOI:10.1097/WON.0000000000000057
- Krasner DL, editor. Chronic Wound Care: The Essentials: A Clinical Source Book for Healthcare Professionals. 1st ed. Malvern, PA: HMP Communications; 2014.
- James GA, Swogger E, Wolcott R, Pulcini E, Secor P, Sestrich J, et al. Biofilms in chronic wounds. Wound Repair Regen. 2008;16(1):37-44. DOI:10.1111/j.1524-475X.2007.00321.x
- Atkin L. Understanding methods of wound debridement. Br J Nurs. 2014;23(Suppl 12):S10-S15. DOI:10.12968/bjon.2014.23.sup12.S10
- Mehta AB, Nadkarni NJ, Patil SP, Godse KV, Gautam M, Agarwal S. Topical corticosteroids in dermatology. Indian J Dermatol Venereol Leprol. 2016;82(4):371-378. DOI:10.4103/0378-6323.178903
- Fisher DA. Adverse effects of topical corticosteroid use. West J Med. 1995;162(2):123-126.
- Demling RH. Nutrition, anabolism, and the wound healing process: an overview. Eplasty. 2009;9:e9.
- Gouin JP, Kiecolt-Glaser JK. The impact of psychological stress on wound healing: methods and mechanisms. Immunol Allergy Clin North Am. 2011;31(1):81-93. DOI:10.1016/j.iac.2010.09.010
- Kiecolt-Glaser JK, Marucha PT, Malarkey WB, Mercado AM, Glaser R. Slowing of wound healing by psychological stress. Lancet. 1995;346(8984):1194-1196. DOI:10.1016/S0140-6736(95)92899-5
- Dallo M, Patel K, Hebert AA. Topical antibiotic treatment in dermatology. Antibiotics (Basel). 2023;12(2):188. DOI:10.3390/antibiotics12020188
- Bigliardi PL, Alsagoff SAL, El-Kafrawi HY, Pyon JK, Wa CTC, Villa MA. Povidone iodine in wound healing: a review of current concepts and practices. Int J Surg. 2017;44:260-268. DOI:10.1016/j.ijsu.2017.06.073
- Rippon MG, Rogers AA, Ousey K. Polyhexamethylene biguanide and its antimicrobial role in wound healing: a narrative review. J Wound Care. 2023;32(1):5-20. DOI:10.12968/jowc.2023.32.1.5
- Fazli MM, Kirketerp-Møller K, Sonne DP, Balchen T, Gundersen G, Jørgensen E, et al. A first-in-human randomized clinical study investigating the safety and tolerability of stabilized hypochlorous acid in patients with chronic leg ulcers. Adv Wound Care (New Rochelle). 2024;13(11):529-541. DOI:10.1089/wound.2024.0040
- Tashkandi H. Honey in wound healing: an updated review. Open Life Sci. 2021;16(1):1091-1100. DOI:10.1515/biol-2021-0084
- Caplan AI. Mesenchymal stem cells: time to correct misconceptions. Stem Cells Transl Med. 2017;6(6):1445-1451. DOI:10.1002/sctm.17-0051
- Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell. 2006;126(4):663-676. DOI:10.1016/j.cell.2006.07.024
- Trounson A, McDonald C. Stem cell therapies in clinical trials: progress and challenges. Cell Stem Cell. 2015;17(1):11-22. DOI:10.1016/j.stem.2015.06.007
- Ahmed EM. Hydrogel: preparation, characterization, and applications: a review. J Adv Res. 2015;6(2):105-121. DOI:10.1016/j.jare.2013.07.006
- O’Brien FJ. Biomaterials & scaffolds for tissue engineering. Mater Today. 2011;14(3):88-95. DOI:10.1016/S1369-7021(11)70058-X
- Badylak SF, Gilbert TW. Immune response to biologic scaffold materials. Semin Immunol. 2008;20(2):109-116. DOI:10.1016/j. smim.2007.11.003
- Pang Q, Yang F, Jiang Z, Wu K, Hou R, Zhu Y. Smart wound dressing for advanced wound management: real-time monitoring and on-demand treatment. Mater Des. 2023;229:111917. DOI:10.1016/j. matdes.2023.111917
- Di Stefano AB, Urrata V, Schilders K, Franza M, Di Leo S, Moschella F, et al. Three-dimensional bioprinting techniques in skin regeneration: current insights and future perspectives. Life (Basel). 2025;15(5):787. DOI:10.3390/life15050787
- Nguyen Thi YV, Ngo AD, Chu DT, Lin SC, Wu CC. RNA therapeutics for regenerative medicine. Prog Mol Biol Transl Sci. 2024;204:163-176. DOI:10.1016/bs.pmbts.2023.12.002
- Chen T, Heller E, Beronja S, Oshimori N, Stokes N, Fuchs E. An RNA interference screen uncovers a new molecule in stem cell self-renewal and long-term regeneration. Nature. 2012;485(7396):104-108. DOI:10.1038/nature10940
- Hsu PD, Lander ES, Zhang F. Development and applications of CRISPR-Cas9 for genome engineering. Cell. 2014;157(6):1262-1278. DOI:10.1016/j.cell.2014.05.010
- Armstrong DG, Lavery LA; Diabetic Foot Study Consortium. Negative pressure wound therapy after partial diabetic foot amputation: a multicentre, randomised controlled trial. Lancet. 2005;366(9498):1704-1710. DOI:10.1016/S0140-6736(05)67695-7
- Avci P, Gupta A, Sadasivam M, Vecchio D, Pam Z, Pam N, et al. Low-level laser (light) therapy in skin. Semin Cutan Med Surg. 2013;32(1):41-52. DOI:10.12788/j.sder.0023
- Saber AA, Saber A. Therapeutic ultrasound: physiological role, clinical applications and precautions. J Surg. 2017;5(3-1):61-69. DOI:10.11648/j.js.s.2017050301.22
- Rajendran SB, Challen K, Wright KL, Hardy JG. Electrical stimulation to enhance wound healing. J Funct Biomater. 2021;12(2):40. DOI:10.3390/jfb12020040
- De A, Sarda A, Gupta S, Das S. Use of artificial intelligence in dermatology. Indian J Dermatol. 2020;65(5):352-357. DOI:10.4103/ijd.IJD_418_20
- Lane ME. Skin penetration enhancers. Int J Pharm. 2013;447(1-2):12-21. DOI:10.1016/j.ijpharm.2013.02.040
- Zhao L, Chen J, Bai B, Song G, Zhang J, Yu H, et al. Topical drug delivery strategies for enhancing drug effectiveness by skin barriers, drug delivery systems and individualized dosing. Front Pharmacol. 2024;14:1333986. DOI:10.3389/fphar.2023.1333986
- Vogt A, Wischke C, Neffe AT, Ma N, Alexiev U, Lendlein A. Nanocarriers for drug delivery into and through the skin-do existing technologies match clinical challenges? J Control Release. 2016;242:3-15. DOI:10.1016/j.jconrel.2016.07.027
- Baumann LS, Spencer J. The effects of topical vitamin E on the cosmetic appearance of scars. Dermatol Surg. 1999;25(4):311-315. DOI:10.1046/j.1524-4725.1999.08237.x
- Mustoe TA, Cooter RD, Gold MH, Hobbs FDR, Ramelet AA, Shakespeare PG, et al. International clinical recommendations on scar management. Plast Reconstr Surg. 2002;110(2):560-571. DOI:10.1097/00006534-200208000-00031
- Gold MH, Berman B, Clementoni MT, Gauglitz GG, Nahai F, Murcia C. Updated international clinical recommendations on scar management: part 1 - evaluating the evidence. Dermatol Surg. 2014;40(8):817-824. DOI:10.1111/dsu.0000000000000049
- Wang F, Li X, Wang X, Jiang X. Efficacy of topical silicone gel in scar management: a systematic review and meta-analysis of randomised controlled trials. Int Wound J. 2020;17(3):765-773. DOI:10.1111/iwj.13337
- Hosnuter M, Payasli C, Isikdemir A, Tekerekoglu B. The effects of onion extract on hypertrophic and keloid scars. J Wound Care. 2007;16(6):251-254. DOI:10.12968/jowc.2007.16.6.27070
- Yang X, Lohsiriwat V, Chang FCS, et al. Real-world management of abnormal scarring using topical silicone gel: expert consensus and case series from the Asian SCARS Expert Group. Drugs Context. 2023;12:2023-4-3. DOI:10.7573/dic.2023-4-3
- Del Rosso JQ, Bhatia N. Status report on topical hypochlorous acid: clinical relevance of specific formulations, potential modes of action, and study outcomes. J Clin Aesthet Dermatol. 2018;11(11):36-39.
- Gold MH, Andriessen A, Bhatia AC, Bitter P Jr, Chilukuri S, Cohen JL, et al. Topical stabilized hypochlorous acid: the future gold standard for wound care and scar management in dermatologic and plastic surgery procedures. J Cosmet Dermatol. 2020;19(2):270-277. DOI:10.1111/jocd.13280
- Sakarya S, Günay N, Karakulak M, Ertugrul B. Hypochlorous acid: an ideal wound care agent with powerful microbicidal, antibiofilm, and wound healing potency. Wounds. 2014;26(12):342-350.
- Burian EA, Sabah L, Kirketerp-Møller K, Gundersen G, Ågren MS. Effect of stabilized hypochlorous acid on re-epithelialization and bacterial bioburden in acute wounds: a randomized controlled trial in healthy volunteers. Acta Derm Venereol. 2022;102:adv00727. DOI:10.2340/actadv.v102.1624
- Kuridze N, Gabunia L, Ghambashidze K, Lobzhanidze K, Mtvarelishvili G, Avagimyan A, Kaladze T. Optimizing skin wound healing outcomes: a comparative analysis of cytokine response and tissue remodeling after treatment with polysiloxane-siloxane, silicone, betamethasone, and heparin-based preparations. World Med J Biomed Sci. 2024;1(12):112-125.
- Kuridze N, Gabunia L, Ghambashidze K, Rtveladze T, Iosebidze T, Gvishani M, Shoshiashvili V. Comparative analysis of different methods of treatment on pro-inflammatory cytokines and the skin wound healing outcomes. Acta Sci Med Sci. 2025;9(1):57-64. DOI:10.31080/ASMS.2024.09.1991
- Kuridze N, Gabunia L, Ghambashidze K, Giorgadze S, Pkhaladze M. The skin wounds and effects of Epicyn, Flosteron and Contractubex on IL-1 and IL-6 cytokines in the dynamic of healing process. World Med J Biomed Sci. 2024;1(4):90-98.
Language: English
Page range: 259 - 268
Submitted on: Mar 2, 2026
Accepted on: Jun 24, 2026
Published on: Jul 11, 2026
Published by: Romanian Association of Laboratory Medicine
In partnership with: Paradigm Publishing Services
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© 2026 Nino Kuridze, Luiza Gabunia, Nino Gogokhia, Ketevan Ghambashidze, Sophio Giorgadze, Gvantsa Janigashvili, Nino Gvajaia, Levan Ratiani, published by Romanian Association of Laboratory Medicine
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