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Evaluating the clinical utility of serum free light chain measurement and reference change value in monitoring monoclonal gammopathy Cover

Evaluating the clinical utility of serum free light chain measurement and reference change value in monitoring monoclonal gammopathy

Open Access
|Jul 2026

References

  1. Tosi P, Tomassetti S, Merli A, Polli V. Serum free light-chain assay for the detection and monitoring of multiple myeloma and related conditions. TherAdvHematol. 2013, 4(1) 37-41 DOI: 10.1177/2040620712466863
  2. Ercan M, Oğuz E, Uysal S, Sezer S, Topçuoğlu C, Yılmaz FM. Ankara Numune Eğitim ve Araştırma Hastanesi immünfiksasyonelektroforezi verilerinin değerlendirilmesi. J ClinExp Invest. 2013;4(2):148-152.
  3. Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in Globocan 2012 Int J Cancer. 2015 Mar 1;136(5):359-86 DOI: 10.1002/ijc.29210
  4. Davids M, Murali M, Kuter D. Serum free light chain analysis. Am J Hematol. 2010;85: 787-790 DOI: 10.1002/ajh.21815
  5. Kuriakose E, Narayanan UnniCheppayil S, Kuzhikandathil Narayanan S, Vasudevan A. A Study on Free Light Chain Assay and Serum Immunofixation Electrophoresis for the Diagnosis of Monoclonal Gammopathies. Indian J ClinBiochem. 2019;34(1):76-81.
  6. Shastri M, Malhotra P, Kaur H, Aggarwal R. Understanding Constraints and Optimization of Serum Immunofixation Electrophoresis and Serum Free Light Chains for Detecting Monoclonal Proteins:A Single-Center Experience. J Lab Physicians. 2023;15(4):518-523. DOI: 10.1055/s-0043-1768684
  7. Bozkurt Yavuz H, Bildirici MA, Yaman H, Karahan SC, Aliyazıcıoğlu Y, Örem A. Reference change value and measurement uncertainty in the evaluation of tumor markers. Scandinavian Journal of Clinical and Laboratory Investigation. 2021 Nov;81(7):601-605. DOI: 10.1080/00365513.2021.1979244
  8. Asberg A, Lian IA, HovOdsæter I, Mikkelsen G. Testing the limits: the diagnostic accuracy of reference change values. Scandinavian Journal of Clinical and Laboratory Investigation. 2021(4);Volume 81, DOI: 10.1080/00365513.2021.1904517
  9. Aarsand AK, Fernandez-Calle P, Webster C, Coskun A, Gonzales-Lao E, Diaz-Garzon J et al.The EFLM Biological Variation Database. https://biologicalvariation.eu/ [Accessed september 2024].
  10. Rajkumar SV, Kyle RA, Therneau TM, Melton LJ, Bradwell AR, Clark RJ, et al. Serum free light chain ratio is an independent risk factor for progression in monoclonal gammopathy of undetermined significance. Blood. 2005 Apr 26;106(3):812-817 DOI: 10.1182/blood-2005-03-1038
  11. Kumar S, Paiva B, Anderson KC, Durie B, Landgren O, Moreau P, et al. International Myeloma Working Group consensus criteria for response and minimal residual disease assessment in multiple myeloma. Lancet Oncol. 2016;Aug;17(8):e328-e346. DOI: 10.1016/S1470-2045(16)30206-6
  12. Ahmed A, Killeen RB. Relapsed and Refractory Multiple Myeloma. StatPearls Publishing; 2024. Available from: https://www.ncbi.nlm.nih.gov/books/NBK592405/.
  13. The National Institute for Health and Care Excellence.Myeloma: diagnosis and management NICE guideline [NG35] Published: 10 February 2016, Last updated:October 2018. https://www.nice.org.uk/guidance/ng35/chapter/recommendations#laboratory-investigations Accessed: September 2024.
  14. Fraser CG, Petersen PH. Desirable standards for laboratory tests if they are to fulfill medical needs. ClinChem. 1993;39:1447 DOI: 10.1093/clinchem/39.7.1447
  15. Ricós C, Cava F, García-Lario JV, Hernández A, Iglesias N, Jiménez CV, et al. The reference change value: a proposal to interpret laboratory reports in serial testing based on biological variation. Scandinavian Journal of Clinical and Laboratory Investigation. 2004;64(3):175-84. DOI: 10.1080/00365510410004885
DOI: https://doi.org/10.2478/rrlm-2026-0019 | Journal eISSN: 2284-5623 | Journal ISSN: 1841-6624
Language: English
Page range: 209 - 212
Submitted on: Jan 24, 2026
Accepted on: Mar 26, 2026
Published on: Jul 11, 2026
In partnership with: Paradigm Publishing Services

© 2026 Soycan Tüner, Hatice Bozkurt Yavuz, Ali Volkan Özdemir, published by Romanian Association of Laboratory Medicine
This work is licensed under the Creative Commons Attribution 4.0 License.