Comparative evaluation of wound healing with different treatments in rats: Cytokine modulation, histological remodeling, and scar outcomes
References
- Baroni A, Buommino E, De Gregorio V, Ruocco E, Ruocco V, Wolf R. Structure and function of the epidermis related to barrier properties. Clin Dermatol. 2012;30(3):257-262. DOI: 10.1016/j. clindermatol.2011.08.007
- Ramos-e-Silva M, de Moura Castro Jacques C. Epidermal barrier function and systemic diseases. Clin Dermatol. 2012;30(3):277-279. DOI: 10.1016/j.clindermatol.2011.08.025
- Proksch E, Brandner JM, Jensen JM. The skin: an indispensable barrier. Exp Dermatol. 2008;17(12):1063-1072. DOI: 10.1111/j.1600-0625.2008.00786.x
- Bayat A, McGrouther DA, Ferguson MWJ. Skin scarring. BMJ. 2003;326:88-92. DOI: 10.1136/bmj.326.7380.88
- Choudhary V, Choudhary M, Bollag WB. Exploring skin wound healing models and the impact of natural lipids on the healing process. Int J Mol Sci. 2024;25:3790. DOI: 10.3390/ijms25073790
- Eming SA, Krieg T, Davidson JM. Inflammation in wound repair: molecular and cellular mechanisms. J Invest Dermatol. 2014;134(9):2350-2356.
- Gurtner GC, Werner S, Barrandon Y, Longaker MT. Wound repair and regeneration. Nature. 2008;453(7193):314-321. DOI: 10.1038/nature07039
- Han G, Ceilley R. Chronic wound healing: a review of current management and treatments. Adv Ther. 2017;34(3):599-610. DOI: 10.1007/s12325-017-0478-y
- Martin P, Nunan R. Cellular and molecular mechanisms of repair in acute and chronic wound healing. Br J Dermatol. 2015;173(2):370-378. DOI: 10.1111/bjd.13954
- Reinke JM, Sorg H. Wound repair and regeneration. Eur Surg Res. 2012;49(1):35-43. DOI: 10.1159/000339613
- Dinarello CA. Immunological and inflammatory functions of the interleukin-1 family. Annu Rev Immunol. 2009;27:519-550. DOI: 10.1146/annurev.immunol.021908.132612
- Ren C, Kumar S, Chanda D, Chen J, Mountz JD, Ponnazhagan S. Therapeutic potential of mesenchymal stem cells producing interferon-alpha in a mouse melanoma lung metastasis model. Stem Cells. 2008 Sep;26(9):2332-2338. DOI: 10.1634/stemcells.2008-0084
- Wynn TA, Vannella KM. Macrophages in tissue repair, regeneration, and fibrosis. Immunity. 2016;44(3):450-462. DOI: 10.1016/j.immuni.2016.02.015
- Dunn LK, Schechter LN. Management of hypertrophic scars and keloids. Plast Reconstr Surg. 2012;130(3):447e-458e.
- Huang L, Wu Z, Liu D, Li G. Hypochlorous acid: an effective and safe alternative approach to control surgical site infections. Front Microbiol. 2020;11:737.
- MacNeil S. Progress and opportunities for tissue-engineered skin. Nature. 2007;445(7130):874-880. DOI: 10.1038/nature05664
- Wang F, Li X, Wang X, Jiang X. Efficacy of topical silicone gel in scar management: A systematic review and meta-analysis of randomised controlled trials. Int Wound J. 2020;17(3):765-773. DOI: 10.1111/iwj.13337
- Partsch H, Mortimer P. Compression for leg wounds. Br J Dermatol. 2015;173(2):359-369. DOI: 10.1111/bjd.13851
- Radford K. Pain management in wound care. Br J Nurs. 2012;21(14 Suppl):S4-S5. DOI: 10.12968/bjon.2012.21.Sup16.S4
- Shih B, Garside E. A systematic review of the effectiveness of silicone in hypertrophic scar and keloid management. J Cutan Aesthet Surg. 2014;7(3):141-146.
- Sidgwick GP, McGeorge D, Bayat A. A comprehensive evidence-based review on the role of topicals and dressings in the management of skin scarring. Arch Dermatol Res. 2015;307(6):461-477. DOI: 10.1007/s00403-015-1572-0
- Woo KY, Coutts PM. Advanced wound dressings. Wound Healing Skin Integr. 2015;3(2):102-118.
- Zamboni WA, Roth AC, Russell RC. The effect of hyperbaric oxygen on revascularization of a rabbit ear chamber. Plast Reconstr Surg. 2000;105(3):990-996.
- Park JW, Koh YG, Shin SH, Choi Y, Kim W, Yoo HH, et al. Review of scar assessment scales. Med Lasers. 2022;11:1-7. DOI: 10.25289/ML.2022.11.1.1
- Fearmonti R, Bond J, Erdmann D, Levinson H. A review of scar scales and scar measuring devices. Eplasty. 2010;10:e43.
- Choo AMH, Ong YS, Issa F. Scar assessment tools: how do they compare? Front Surg. 2021;8:637821. DOI: 10.3389/fsurg.2021.643098
- Percie du Sert N, Hurst V, Ahluwalia A, Alam S, Avey MT, Baker M, et al. The ARRIVE guidelines 2.0: updated guidelines for reporting animal research. PLoS Biol. 2020;18(7):e3000410. DOI: 10.1371/journal.pbio.3000410
- Rodrigues M, Kosaric N, Bonham CA, Gurtner GC. Wound healing: a cellular perspective. Physiol Rev. 2019;99(1):665-706. DOI: 10.1152/physrev.00067.2017
- Takeo M, Lee W, Ito M. Wound healing and skin regeneration. Cold Spring Harb Perspect Med. 2015;5(1):a023267. DOI: 10.1101/cshperspect.a023267
- Mirza RE, Fang MM, Ennis WJ. Blocking interleukin-1β induces a healing-associated wound macrophage phenotype and improves healing in type 2 diabetes. Diabetes. 2013;62(7):2579-2587. DOI: 10.2337/db12-1450
- Arango Duque G, Descoteaux A. Macrophage cytokines: involvement in immunity and infectious diseases. Front Immunol. 2014;5:491. DOI: 10.3389/fimmu.2014.00491
- Dinarello CA. Interleukin-1 in the pathogenesis and treatment of inflammatory diseases. Blood. 2011;117(14):3720-3732. DOI: 10.1182/blood-2010-07-273417
- Lin ZQ, Kondo T, Ishida Y, Takayasu T, Mukaida N. Essential involvement of IL-6 in the skin wound-healing process as evidenced by delayed wound healing in IL-6-deficient mice. J Leukoc Biol. 2010;88(5):863-875.
- Tonnesen MG, Feng X, Clark RA. Angiogenesis in wound healing. J Invest Dermatol Symp Proc. 2000;5(1):40-46. DOI: 10.1046/j.1087-0024.2000.00014.x
- Madhusudhan DK, Agarwal T, Chatterjee K. Role of growth factors in therapeutic angiogenesis for chronic wound healing. Tissue Eng Regen Med. 2015;12(5):311-325.
- Darby IA, Laverdet B, Bonté F, Desmoulière A. Fibroblasts and myofibroblasts in wound healing. Clin Cosmet Investig Dermatol. 2014;7:301-311. DOI: 10.2147/CCID.S50046
- Hinz B, Phan SH, Thannickal VJ, Prunotto M, Desmoulière A, Varga J, et al. Recent developments in myofibroblast biology: paradigms for connective tissue remodeling. Am J Pathol. 2012 Apr;180(4):1340-55. DOI: 10.1016/j.ajpath.2012.02.004
Language: English
Page range: 179 - 192
Submitted on: Dec 9, 2025
Accepted on: Feb 16, 2026
Published on: Apr 24, 2026
Published by: Romanian Association of Laboratory Medicine
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year
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© 2026 Nino Kuridze, Sophio Giorgadze, Luiza Gabunia, Ketevan Ghambashidze, Nodar Sulashvili, Tamar Didbaridze, Nino Gvajaia, Vasil Kupradze, Levan Ratiani, published by Romanian Association of Laboratory Medicine
This work is licensed under the Creative Commons Attribution 4.0 License.