Have a personal or library account? Click to login
Wharton’s jelly-mesenchymal stem cells alleviate atopic dermatitis by regulating TXNIP/NLRP3 and HDAC3/TGF-β1 signaling pathway in mice Cover

Wharton’s jelly-mesenchymal stem cells alleviate atopic dermatitis by regulating TXNIP/NLRP3 and HDAC3/TGF-β1 signaling pathway in mice

Open Access
|Nov 2025

References

  1. Sroka-Tomaszewska J, Trzeciak M. Molecular Mechanisms of Atopic Dermatitis Pathogenesis. Int J Mol Sci. 2021;22:4130. DOI: 10.3390/ijms22084130
  2. Schuler CFt, Billi AC, Maverakis E, Tsoi LC, Gudjonsson JE. Novel insights into atopic dermatitis. J Allergy Clin Immunol. 2023;151:1145-1154. DOI: 10.1016/j.jaci.2022.10.023
  3. Zlotnik A, Yoshie O. Chemokines: a new classification system and their role in immunity. Immunity. 2000;12:121-127. DOI: 10.1016/S1074-7613(00)80165-X
  4. Hoffjan S, Stemmler S. On the role of the epidermal differentiation complex in ichthyosis vulgaris, atopic dermatitis and psoriasis. Br J Dermatol. 2007;157:441-449. DOI: 10.1111/j.1365-2133.2007.07999.x
  5. Seto Y, Nakajima H, Suto A, Shimoda K, Saito Y, Nakayama KI, et al. Enhanced Th2 cell-mediated allergic inflammation in Tyk2-deficient mice. J Immunol. 2003;170:1077-1083. DOI: 10.4049/jimmunol.170.2.1077
  6. Manresa MC. Animal Models of Contact Dermatitis: 2,4-Dinitrofluorobenzene-Induced Contact Hypersensitivity. Methods Mol Biol. 2021;2223:87-100. DOI: 10.1007/978-1-0716-1001-5_7
  7. Nagano T, Katase M, Tsumura K. Dietary soyasaponin attenuates 2,4-dinitrofluorobenzene-induced contact hypersensitivity via gut microbiota in mice. Clin Exp Immunol. 2019;195:86-95. DOI: 10.1111/cei.13212
  8. Jang YH, Choi EY, Lee H, Woo J, Park S, Noh Y, et al. Long-Term Use of Oral Corticosteroids and Safety Outcomes for Patients With Atopic Dermatitis. JAMA Netw Open. 2024;7:e2423563. DOI: 10.1001/jamanetworkopen.2024.23563
  9. Pena J, Zameza PA, Pixley JN, Remitz A, Feldman SR. A Comparison of Topical Corticosteroids and Topical Calcineurin Inhibitors for the Treatment of Atopic Dermatitis. J Allergy Clin Immunol Pract. 2023;11:1347-1359. DOI: 10.1016/j.jaip.2023.03.022
  10. Dogra S, Mahajan R, Indian Association of Dermatologists V, Leprologists. Phototherapy for atopic dermatitis. Indian J Dermatol Venereol Leprol. 2015;81:10-15. DOI: 10.4103/0378-6323.148557
  11. Gong Z, Zhao S, Zhou J, Yan J, Wang L, Du X, et al. Curcumin alleviates DSS-induced colitis via inhibiting NLRP3 inflammsome activation and IL-1beta production. Mol Immunol. 2018;104:11-19. DOI: 10.1016/j.molimm.2018.09.004
  12. Nguyen HCB, Adlanmerini M, Hauck AK, Lazar MA. Dichotomous engagement of HDAC3 activity governs inflammatory responses. Nature. 2020;584:286-290. DOI: 10.1038/s41586-020-2576-2
  13. Ghiboub M, Zhao J, Li Yim AYF, Schilderink R, Verseijden C, van Hamersveld PHP, et al. HDAC3 Mediates the Inflammatory Response and LPS Tolerance in Human Monocytes and Macrophages. Front Immunol. 2020;11:550769. DOI: 10.3389/fimmu.2020.550769
  14. Li Y, Liu C, Wang G, Wang H, Liu X, Huang C, et al. HDAC3 inhibitor (BRD3308) modulates microglial pyroptosis and neuroinflammation through PPARgamma/NLRP3/GSDMD to improve neurological function after intraventricular hemorrhage in mice. Neuropharmacology. 2023;237:109633. DOI: 10.1016/j. neuropharm.2023.109633
  15. Zhou W, Zeng D, Liu S, Huang Y, Lv F, Zhou W. Histone deacetylase 3 inhibition alleviates 2,4-dinitrochlorobenzene-induced atopic dermatitis via epigenetically upregulating Nrf2/HO-1 signaling pathway. Int Immunopharmacol. 2024;126:111107. DOI: 10.1016/j.intimp.2023.111107
  16. Chang QX, Lyu JL, Wu PY, Wen KC, Chang CC, Chiang HM. Coffea arabica Extract Attenuates Atopic Dermatitis-like Skin Lesions by Regulating NLRP3 Inflammasome Expression and Skin Barrier Functions. Int J Mol Sci. 2023;24:12367 DOI: 10.3390/ijms241512367
  17. Li J, Du X, Mu Z, Han X. Arctiin Alleviates Atopic Dermatitis Against Inflammation and Pyroptosis Through Suppressing TLR4/MyD88/NF-kappaB and NLRP3/Caspase-1/GSDMD Signaling Pathways. J Inflamm Res. 2024;17:8009-8026. DOI: 10.2147/JIR.S484919
  18. Fu X, Liu G, Halim A, Ju Y, Luo Q, Song AG. Mesenchymal Stem Cell Migration and Tissue Repair. Cells. 2019;8:784. DOI: 10.3390/cells8080784
  19. Chen H, Wen X, Liu S, Sun T, Song H, Wang F, et al. Dissecting Heterogeneity Reveals a Unique BAMBI(high) MFGE8(high) Subpopulation of Human UC-MSCs. Adv Sci (Weinh). 2022;10:e2202510. DOI: 10.1002/advs.202202510
  20. Liu T, He Y, Liao Y. Esculentoside A ameliorates DNCB-induced atopic dermatitis by suppressing the ROS-NLRP3 axis via activating the Nrf2 pathway. Clin Exp Pharmacol Physiol. 2023;50:844-854. DOI: 10.1111/1440-1681.13809
  21. Jung H, Son GM, Lee JJ, Park HS. Therapeutic Effects of Tonsil-derived Mesenchymal Stem Cells in an Atopic Dermatitis Mouse Model. In Vivo. 2021;35:845-857. DOI: 10.21873/invivo.12325
  22. Jung N, Kong T, Yu Y, Park H, Lee E, Yoo S, et al. Immunomodulatory Effect of Epidermal Growth Factor Secreted by Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells on Atopic Dermatitis. Int J Stem Cells. 2022;15:311-323. DOI: 10.15283/ijsc21173
  23. Shin TH, Lee BC, Choi SW, Shin JH, Kang I, Lee JY, et al. Human adipose tissue-derived mesenchymal stem cells alleviate atopic dermatitis via regulation of B lymphocyte maturation. Oncotarget. 2017;8:512-522. DOI: 10.18632/oncotarget.13473
  24. Galli SJ, Tsai M. IgE and mast cells in allergic disease. Nat Med. 2012;18:693-704. DOI: 10.1038/nm.2755
  25. Shafi T, Rasool Wani R, Hussain S, Bhat IA, Makhdoomi R, Bashir SA, et al. Investigating dysregulation of TGF-beta1/SMAD3 signaling in atopic dermatitis: a molecular and immunohistochemical analysis. Clin Exp Immunol. 2024;216:192-199. DOI: 10.1093/cei/uxad130
  26. Huang S, Zhou R, Yuan Y, Shen Y. Stigmasterol alleviates airway inflammation in OVA-induced asthmatic mice via inhibiting the TGF-beta1/Smad2 and IL-17A signaling pathways. Aging (Albany NY). 2024;16:6478-6487. DOI: 10.18632/aging.205716
  27. Park HH, Lee S, Yu Y, Yoo SM, Baek SY, Jung N, et al. TGF-beta secreted by human umbilical cord blood-derived mesenchymal stem cells ameliorates atopic dermatitis by inhibiting secretion of TNF-alpha and IgE. Stem Cells. 2020;38:904-916. DOI: 10.1002/stem.3183
  28. Sumiyoshi K, Nakao A, Ushio H, Mitsuishi K, Okumura K, Tsuboi R, et al. Transforming growth factor-beta1 suppresses atopic dermatitis-like skin lesions in NC/Nga mice. Clin Exp Allergy. 2002;32:309-314. DOI: 10.1046/j.1365-2222.2002.01221.x
  29. Alyoussef A. Blocking TGF-beta type 1 receptor partially reversed skin tissue damage in experimentally induced atopic dermatitis in mice. Cytokine. 2018;106:45-53. DOI: 10.1016/j.cyto.2018.02.025
  30. Lian L, Le Z, Wang Z, Chen YA, Jiao X, Qi H, et al. SIRT1 Inhibits High Glucose-Induced TXNIP/NLRP3 Inflammasome Activation and Cataract Formation. Invest Ophthalmol Vis Sci. 2023;64:16. DOI: 10.1167/iovs.64.3.16
  31. Han Y, Xu X, Tang C, Gao P, Chen X, Xiong X, et al. Reactive oxygen species promote tubular injury in diabetic nephropathy: The role of the mitochondrial ros-txnip-nlrp3 biological axis. Redox Biol. 2018;16:32-46. DOI: 10.1016/j.redox.2018.02.013
  32. Wang H, Liu S, Wang Y, Chang B, Wang B. Nod-like receptor protein 3 inflammasome activation by Escherichia coli RNA induces transforming growth factor beta 1 secretion in hepatic stellate cells. Bosn J Basic Med Sci. 2016;16:126-1231. DOI: 10.17305/bjbms.2016.699
  33. Luo DD, Fielding C, Phillips A, Fraser D. Interleukin-1 beta regulates proximal tubular cell transforming growth factor beta-1 signalling. Nephrol Dial Transplant. 2009;24:2655-2665. DOI: 10.1093/ndt/gfp208
  34. Chi Z, Chen S, Xu T, Zhen W, Yu W, Jiang D, et al. Histone Deacetylase 3 Couples Mitochondria to Drive IL-1beta-Dependent Inflammation by Configuring Fatty Acid Oxidation. Mol Cell. 2020;80:43-58. e7. DOI: 10.1016/j.molcel.2020.08.015
  35. Zhang X, Wang J, Xiang S, Zhao L, Lv M, Duan Y, et al. Astragaloside I from Astragalus Attenuates Diabetic Kidney Disease by Regulating HDAC3/Klotho/TGF-beta1 Loop. Am J Chin Med. 2024;52:1795-1817. DOI: 10.1142/S0192415X24500708
DOI: https://doi.org/10.2478/rrlm-2025-0028 | Journal eISSN: 2284-5623 | Journal ISSN: 1841-6624
Language: English
Page range: 241 - 250
Submitted on: May 8, 2025
|
Accepted on: Oct 1, 2025
|
Published on: Nov 6, 2025
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2025 ZhengPing Wu, JiaYi Cai, Ning Li, Di Han, Hong Liu, XinWen Mai, SenYu Chen, ManYu Liao, Peng Zhang, Chi-Ming Liu, published by Romanian Association of Laboratory Medicine
This work is licensed under the Creative Commons Attribution 4.0 License.