Have a personal or library account? Click to login
Oxidative stress in preeclampsia: A comparative biomarker analysis across body mass index categories Cover

Oxidative stress in preeclampsia: A comparative biomarker analysis across body mass index categories

Open Access
|Nov 2025

References

  1. Wu P, Green M, Myers JE. Hypertensive disorders of pregnancy. BMJ. 2023;381:e071653. DOI: 10.1136/bmj-2022-071653
  2. Rana S, Lemoine E, Granger JP, Karumanchi SA. Preeclampsia: Pathophysiology, Challenges, and Perspectives. Circ Res. 2019;124(7):1094-112. DOI: 10.1161/CIRCRESAHA.118.313276
  3. Afrose D, Alfonso-Sánchez S, McClements L. Targeting oxidative stress in preeclampsia. Hypertension in Pregnancy. 2025;44(1):2445556. DOI: 10.1080/10641955.2024.2445556
  4. Burton GJ, Jauniaux E. Pathophysiology of placental-derived fetal growth restriction. Am J Obstet Gynecol. 2018;218(2s):S745-s61. DOI: 10.1016/j.ajog.2017.11.577
  5. Cindrova-Davies T. Gabor Than Award Lecture 2008: preeclampsia - from placental oxidative stress to maternal endothelial dysfunction. Placenta. 2009;30 Suppl A:S55-65. DOI: 10.1016/j. placenta.2008.11.020
  6. Simon-Szabo Z, Fogarasi E, Nemes-Nagy E, Denes L, Croitoru M, Szabo B. Oxidative stress and peripartum outcomes (Review). Exp Ther Med. 2021;22(1):771. DOI: 10.3892/etm.2021.10203
  7. Harma M, Harma M, Erel O. Increased oxidative stress in patients with hydatidiform mole. Swiss Med Wkly. 2003;133(41-42):563-6. DOI: 10.4414/smw.2003.10397
  8. Arogbokun O, Rosen E, Keil AP, Milne GL, Barrett E, Nguyen R, et al. Maternal Oxidative Stress Biomarkers in Pregnancy and Child Growth from Birth to Age 6. J Clin Endocrinol Metab. 2021;106(5):1427-36. DOI: 10.1210/clinem/dgab018
  9. Onat T, Aydoğan Kırmızı D, Başer E, Ercan M, Demir Çaltekin M, Yalçın S, et al. The relationship between oxidative stress and preeclampsia. The serum ischemia-modified albumin levels and thiol/disulfide homeostasis. Turk J Obstet Gynecol. 2020;17(2):102-7. DOI: 10.4274/tjod.galenos.2020.23682
  10. Ibrahim A, Khoo MI, Ismail EHE, Hussain NHN, Zin AAM, Noordin L, et al. Oxidative stress biomarkers in pregnancy: a systematic review. Reproductive Biology and Endocrinology. 2024;22(1):93. DOI: 10.1186/s12958-024-01259-x
  11. Freire VAF, Melo ADd, Santos HdL, Barros-Pinheiro M. Evaluation of oxidative stress markers in subtypes of preeclampsia: A systematic review and meta-analysis. Placenta. 2023;132:55-67. DOI: 10.1016/j.placenta.2022.12.009
  12. Taravati A, Tohidi F. Comprehensive analysis of oxidative stress markers and antioxidants status in preeclampsia. Taiwanese J Obstet Gynecol. 2018;57(6):779-90. DOI: 10.1016/j. tjog.2018.10.002
  13. Brown MA, Magee LA, Kenny LC, Karumanchi SA, McCarthy FP, Saito S, et al. Hypertensive Disorders of Pregnancy: ISSHP Classification, Diagnosis, and Management Recommendations for International Practice. Hypertension. 2018;72(1):24-43. DOI: 10.1161/HYPERTENSIONAHA.117.10803
  14. Obesity WHOCo, World Health O. Obesity : preventing and managing the global epidemic : report of a WHO consultation. Geneva: World Health Organization; 2000.
  15. Erel O. A novel automated method to measure total antioxidant response against potent free radical reactions. Clin Biochem. 2004;37(2):112-9. DOI: 10.1016/j.clinbiochem.2003.10.014
  16. Erel O. A new automated colorimetric method for measuring total oxidant status. Clin Biochem. 2005;38(12):1103-11. DOI: 10.1016/j.clinbiochem.2005.08.008
  17. Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem. 1979;95(2):351-8. DOI: 10.1016/0003-2697(79)90738-3
  18. Redman CW, Sargent IL. Placental stress and pre-eclampsia: a revised view. Placenta. 2009;30 Suppl A:S38-42. DOI: 10.1016/j. placenta.2008.11.021
  19. Sánchez-Aranguren LC, Prada CE, Riaño-Medina CE, Lopez M. Endothelial dysfunction and preeclampsia: role of oxidative stress. Front Physiol. 2014;5:372. DOI: 10.3389/fphys.2014.00372
  20. Burton GJ, Jauniaux E. Oxidative stress. Best Pract Res Clin Obstet Gynaecol. 2011;25(3):287-99. DOI: 10.1016/j. bpobgyn.2010.10.016
  21. Myatt L, Cui X. Oxidative stress in the placenta. Histochem Cell Biol. 2004;122(4):369-82. DOI: 10.1007/s00418-004-0677-x
  22. Duhig K, Chappell LC, Shennan AH. Oxidative stress in pregnancy and reproduction. Obstet Med. 2016;9(3):113-6. DOI: 10.1177/1753495X16648495
  23. Gupta S, Aziz N, Sekhon L, Agarwal R, Mansour G, Li J, et al. Lipid peroxidation and antioxidant status in preeclampsia: a systematic review. Obstet Gynecol Surv. 2009;64(11):750-9. DOI: 10.1097/OGX.0b013e3181bea0ac
  24. Phoswa WN, Khaliq OP. The Role of Oxidative Stress in Hypertensive Disorders of Pregnancy (Preeclampsia, Gestational Hypertension) and Metabolic Disorder of Pregnancy (Gestational Diabetes Mellitus). Oxid Med Cell Longev. 2021;2021:5581570. DOI: 10.1155/2021/5581570
  25. Roberts JM, Hubel CA. The two stage model of preeclampsia: variations on the theme. Placenta. 2009;30 Suppl A(Suppl A):S32-7. DOI: 10.1016/j.placenta.2008.11.009
  26. Furukawa S, Fujita T, Shimabukuro M, Iwaki M, Yamada Y, Nakajima Y, et al. Increased oxidative stress in obesity and its impact on metabolic syndrome. J Clin Invest. 2004;114(12):1752-61. DOI: 10.1172/JCI200421625
  27. Mutlu-Türkoglu U, Ademoglu E, Ibrahimoglu L, Aykaç-Toker G, Uysal M. Imbalance between lipid peroxidation and antioxidant status in preeclampsia. Gynecol Obstet Invest. 1998;46(1):37-40. DOI: 10.1159/000009994
  28. Denison FC, Roberts KA, Barr SM, Norman JE. Obesity, pregnancy, inflammation, and vascular function. Reproduction. 2010;140(3):373-85. DOI: 10.1530/REP-10-0074
  29. Hung TH, Burton GJ. Hypoxia and reoxygenation: a possible mechanism for placental oxidative stress in preeclampsia. Taiwan J Obstet Gynecol. 2006;45(3):189-200. DOI: 10.1016/S1028-4559(09)60224-2
  30. Jauniaux E, Poston L, Burton GJ. Placental-related diseases of pregnancy: Involvement of oxidative stress and implications in human evolution. Hum Reprod Update. 2006;12(6):747-55. DOI: 10.1093/humupd/dml016
  31. Llurba E, Gratacós E, Martín-Gallán P, Cabero L, Dominguez C. A comprehensive study of oxidative stress and antioxidant status in preeclampsia and normal pregnancy. Free Radic Biol Med. 2004;37(4):557-70. DOI: 10.1016/j.freeradbiomed.2004.04.035
  32. Mao J, Sun H, Shen Q, Zou C, Yang Y, Du Q. Impact of pre-pregnancy body mass index on preeclampsia. Front Med (Lausanne). 2025;12:1529966. DOI: 10.3389/fmed.2025.1529966
DOI: https://doi.org/10.2478/rrlm-2025-0024 | Journal eISSN: 2284-5623 | Journal ISSN: 1841-6624
Language: English
Page range: 227 - 232
Submitted on: Aug 6, 2025
|
Accepted on: Sep 3, 2025
|
Published on: Nov 6, 2025
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2025 Suat Çakina, Emine Sevinc Postacı, Fatma Beyazıt, published by Romanian Association of Laboratory Medicine
This work is licensed under the Creative Commons Attribution 4.0 License.