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CALLY index, but not HALP score, is associated with mortality in cirrhosis patients Cover

CALLY index, but not HALP score, is associated with mortality in cirrhosis patients

Open Access
|Feb 2025

References

  1. Heybe MA, Mehta KJ. Role of albumin infusion in cirrhosis-associated complications. Clin Exp Med. 2024 Mar 29;24(1):58. DOI: 10.1007/s10238-024-01315-1
  2. Shekari S, Khonsha F, Rahmati-Yamchi M, Nejabati HR, Mota A. Vanillic Acid and Non-Alcoholic Fatty Liver Disease: A Focus on AMPK in Adipose and Liver Tissues. Curr Pharm Des. 2021;27(46):4686-4692. DOI: 10.2174/13816128276662107011 45438
  3. Hasa E, Hartmann P, Schnabl B. Liver cirrhosis and immune dysfunction. Int Immunol. 2022 Sep 6;34(9):455-466. DOI: 10.1093/intimm/dxac030
  4. Arroyo V, Angeli P, Moreau R, Jalan R, Clària J, Trebicka J, et al. The systemic inflammation hypothesis: Towards a new paradigm of acute decompensation and multiorgan failure in cirrhosis. J Hepatol. 2021 Mar;74(3):670-685. DOI: 10.1016/j. jhep.2020.11.048
  5. Han X, Wang J, Gu H, Guo H, Cai Y, Liao X, Jiang M. Predictive value of serum bile acids as metabolite biomarkers for liver cirrhosis: a systematic review and meta-analysis. Metabolomics. 2022 Jun 27;18(7):43. DOI: 10.1007/s11306-022-01890-y
  6. Asrani SK, Shankar N, da Graca B, Nadim MK, Cardenas A. Role of Novel Kidney Biomarkers in Patients With Cirrhosis and After Liver Transplantation. Liver Transpl. 2022 Mar;28(3):466-482. DOI: 10.1002/lt.26344
  7. Tantia P, Aggarwal P, Acharya S, Kumar S, Kothari M, Kadam A, et al. Exploring Haematological Complications in Cirrhosis of the Liver: A Comprehensive Review. Cureus. 2024 Jul 24;16(7):e65319. DOI: 10.7759/cureus.65319
  8. Park J, Zhao Y, Zhang F, Zhang S, Kwong AC, Zhang Y, et al. IL-6/STAT3 axis dictates the PNPLA3-mediated susceptibility to non-alcoholic fatty liver disease. J Hepatol. 2023 Jan;78(1):45-56. DOI: 10.1016/j.jhep.2022.08.022
  9. Duan Y, Pan X, Luo J, Xiao X, Li J, Bestman PL, Luo M. Association of Inflammatory Cytokines With Non-Alcoholic Fatty Liver Disease. Front Immunol. 2022 May 6;13:880298. DOI: 10.3389/fimmu.2022.880298
  10. Juanola A, Ma AT, de Wit K, Gananandan K, Roux O, Zaccherini G, et al. Novel prognostic biomarkers in decompensated cirrhosis: a systematic review and meta-analysis. Gut. 2023 Dec 7;73(1):156-165. DOI: 10.1136/gutjnl-2023-329923
  11. Ekinci F, Balcik OY, Oktay E, Erdogan AP. HALP Score as a New Prognostic Index in Metastatic Renal Cell Cancer. J Coll Physicians Surg Pak. 2022 Mar;32(3):313-318. DOI: 10.29271/jcpsp.2022.03.313
  12. Shi Y, Shen G, Zeng Y, Ju M, Chen X, He C, et al. Predictive values of the hemoglobin, albumin, lymphocyte and platelet score (HALP) and the modified -Gustave Roussy immune score for esophageal squamous cell carcinoma patients undergoing concurrent chemoradiotherapy. Int Immunopharmacol. 2023 Oct;123:110773. DOI: 10.1016/j.intimp.2023.110773
  13. Smith A, Baumgartner K, Bositis C. Cirrhosis: Diagnosis and Management. Am Fam Physician. 2019 Dec 15;100(12):759-770.
  14. Tapper EB, Parikh ND. Diagnosis and Management of Cirrhosis and Its Complications: A Review. JAMA. 2023 May 9;329(18):1589-1602. DOI: 10.1001/jama.2023.5997
  15. Rudler M, Weiss N, Bouzbib C, Thabut D. Diagnosis and Management of Hepatic Encephalopathy. Clin Liver Dis. 2021 May;25(2):393-417. DOI: 10.1016/j.cld.2021.01.008
  16. Huang DQ, Terrault NA, Tacke F, Gluud LL, Arrese M, Bugianesi E, et al. Global epidemiology of cirrhosis - aetiology, trends and predictions. Nat Rev Gastroenterol Hepatol. 2023 Jun;20(6):388-398. DOI: 10.1038/s41575-023-00759-2
  17. GBD 2017 Cirrhosis Collaborators. The global, regional, and national burden of cirrhosis by cause in 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet Gastroenterol Hepatol. 2020 Mar;5(3):245-266.
  18. Wang MJ, Zhang HL, Chen F, Guo XJ, Liu QG, Hou J. The double-edged effects of IL-6 in liver regeneration, aging, inflammation, and diseases. Exp Hematol Oncol. 2024 Jun 18;13(1):62. DOI: 10.1186/s40164-024-00527-1
  19. Wang LL, Wei TT, Yin JR, Qin BD, Ma N, Tang QQ, et al. Red blood cell distribution width and mean platelet volume are potential prognostic indices for patients with primary biliary cirrhosis. Clin Chem Lab Med. 2017 May 1;55(6):e127-e129. DOI: 10.1515/cclm-2016-0680
  20. Ma R, Okugawa Y, Shimura T, Yamashita S, Sato Y, Yin C, et al. Clinical implications of C-reactive protein-albumin-lymphocyte (CALLY) index in patients with esophageal cancer. Surg Oncol. 2024 Apr;53:102044. DOI: 10.1016/j.suronc.2024.102044
  21. Sakurai K, Kubo N, Hasegawa T, Nishimura J, Iseki Y, Nishii T, et al. Clinical significance of the CALLY index in patients with gastric cancer undergoing gastrectomy. World J Surg. 2024 Nov;48(11):2749-2759. DOI: 10.1002/wjs.12357
  22. Wang W, Gu J, Liu Y, Liu X, Jiang L, Wu C, et al. Pre-Treatment CRP-Albumin-Lymphocyte Index (CALLY Index) as a Prognostic Biomarker of Survival in Patients with Epithelial Ovarian Cancer. Cancer Manag Res. 2022 Sep 19;14:2803-2812. DOI: 10.2147/CMAR.S359968
  23. Takeda Y, Sugano H, Okamoto A, Nakano T, Shimoyama Y, Takada N, et al. Prognostic usefulness of the C-reactive protein-albumin-lymphocyte (CALLY) index as a novel biomarker in patients undergoing colorectal cancer surgery. Asian J Surg. 2024 Aug;47(8):3492-3498. DOI: 10.1016/j.asjsur.2024.03.054
  24. Zhuang J, Wang S, Wang Y, Wu Y, Hu R. Prognostic Value of CRP-Albumin-Lymphocyte (CALLY) Index in Patients Undergoing Surgery for Breast Cancer. Int J Gen Med. 2024 Mar 15;17:997-1005. DOI: 10.2147/IJGM.S447201
  25. Özdemir S, Özkan A. The Importance of the CALLY Index as a Non-Invasive Prognostic Biomarker in SARS-CoV-2 Infected Patients: An Analytical Study: CALLY Index in SARS-CoV-2 Infection. Medical Science and Discovery.2023; 10(7):443-448. DOI: 10.36472/msd. v10i7.967
  26. Zhao Z, Xu L. Prognostic significance of HALP score and combination of peripheral blood multiple indicators in patients with early breast cancer. Front Oncol. 2023 Dec 12;13:1253895. DOI: 10.3389/fonc.2023.1253895
  27. Ozturk U, Nergiz S, Ozturk O. “The association between HALP score and infection in acute ischemic stroke patients”. J Stroke Cerebrovasc Dis. 2024 Nov;33(11):107929. DOI: 10.1016/j. jstrokecerebrovasdis.2024.107929
  28. Yaman M, Orak M, Durgun HM, Tekin V, Ülgüt ŞG, Belek S, et al. The prognostic value of HALP score and sPESI in predicting in-hospital mortality in patients with pulmonary thromboembolism. Postgrad Med J. 2024 Sep 20:qgae124. DOI: 10.1093/postmj/qgae124
  29. Li W, Yan Y, Cui X, Bian J, Yuan L, Wang G. Exploring the association between hemoglobin, albumin, lymphocyte, and platelet score and all-cause mortality among middle-aged and older patients with osteoarthritis. J Investig Med. 2024 Oct 16:10815589241273682. DOI: 10.1177/10815589241273682
DOI: https://doi.org/10.2478/rrlm-2025-0007 | Journal eISSN: 2284-5623 | Journal ISSN: 1841-6624
Language: English
Page range: 29 - 34
Submitted on: Dec 8, 2024
Accepted on: Jan 26, 2025
Published on: Feb 6, 2025
Published by: Romanian Association of Laboratory Medicine
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2025 Günay Yıldız, Cihan Bedel, Ökkeş Zortuk, Fatih Selvi, Yusuf Karanci, published by Romanian Association of Laboratory Medicine
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.