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D-dimers and ferritin: Expanding the diagnostic panel for cirrhotic ascites evaluation

Open Access
|Jul 2023

References

  1. Runyon BA; AASLD. Introduction to the revised American Association for the Study of Liver Diseases Practice Guideline management of adult patients with ascites due to cirrhosis 2012. Hepatology. 2013 Apr;57(4):1651-3. DOI: 10.1002/hep.26359
  2. Moore KP, Aithal GP. Guidelines on the management of ascites in cirrhosis. Gut. 2006;55 Suppl 6(Suppl 6):vi1-2. DOI: 10.1136/gut.2006.099580
  3. Runyon BA. Low-protein-concentration ascitic fluid is predisposed to spontaneous bacterial peritonitis. Gastroenterology. 1986 Dec;91(6):1343-6. DOI: 10.1016/0016-5085(86)90185-X
  4. Plessier A, Denninger MH, Consigny Y, Pessione F, Francoz C, Durand F, et al. Coagulation disorders in patients with cirrhosis and severe sepsis. Liver Int. 2003 Dec;23(6):440-8. DOI: 10.1111/j.1478-3231.2003.00870.x
  5. Trifonov P, Ivanova I, Papochiev K, Robev B, Nikolov R, Krastev Z. The D- Dimer and Ferritin Silent Life in Ascites: A Pilot Study. Medinform 2023; 10(1):1677-85. DOI: 10.18044/MedInform.2023101.1677
  6. Hu KQ, Yu AS, Tiyyagura L, Redeker AG, Reynolds TB. Hyperfibrinolytic activity in hospitalized cirrhotic patients in a referral liver unit. Am J Gastroenterol. 2001 May;96(5):1581-6. DOI: 10.1111/j.1572-0241.2001.03781.x
  7. Saray A, Mesihovic R, Gornjakovic S, Vanis N, Mehmedovic A, Nahodovic K, et al. Association between high D-dimer plasma levels and ascites in patients with liver cirrhosis. Med Arch. 2012;66(6):372-4. DOI: 10.5455/medarh.2012.66.372-374
  8. Agarwal S, Joyner KA Jr, Swaim MW. Ascites fluid as a possible origin for hyperfibrinolysis in advanced liver disease. Am J Gastroenterol. 2000 Nov;95(11):3218-24. DOI: 10.1111/j.1572-0241.2000.03299.x
  9. Toschi V, Rocchini GM, Motta A, Fiorini GF, Cimminiello C, Violi F, et al. The hyperfibrinolytic state of liver cirrhosis: possible pathogenetic role of ascites. Biomed Pharmacother. 1993;47(8):345-52. DOI: 10.1016/0753-3322(93)90084-X
  10. Kogan AE, Mukharyamova KS, Bereznikova AV, Filatov VL, Koshkina EV, Bloshchitsyna MN, et al. Monoclonal antibodies with equal specificity to D-dimer and high-molecular-weight fibrin degradation products. Blood Coagul Fibrinolysis. 2016 Jul;27(5):542-50. DOI: 10.1097/MBC.0000000000000453
  11. Levitt DG, Levitt MD. Human serum albumin homeostasis: a new look at the roles of synthesis, catabolism, renal and gastrointestinal excretion, and the clinical value of serum albumin measurements. Int J Gen Med. 2016 Jul 15;9:229-55. DOI: 10.2147/IJGM.S102819
  12. Johnson CA, Sobrinho TC, Aziz EM, Rogers SB. Refractory coagulopathy in an infant with loss of clotting proteins into ascitic fluid. Acta Paediatr Scand. 1976 Nov;65(6):773-5. DOI: 10.1111/j.1651-2227.1976.tb18019.x
  13. El Gohary AM, Elyamany AS, Mikhael NL, Mahmoud MG, Tawfik MMR. Serum and ascitic D-dimer in cirrhotic patients with spontaneous bacterial peritonitis. Clin Exp Hepatol. 2021 Jun;7(2):134-140. DOI: 10.5114/ceh.2021.105915
  14. Romanelli R, Cellai A, Lami D,Natucci F, Tosti-Guerra C, Abbate R, et al. D-dimer and fibrinolytic activity in patients with decompensated liver cirrhosis. Digest Liver Dis 2015;47:e33. DOI: 10.1016/j.dld.2015.01.073
  15. Takatori M, Iwabuchi S, Hayashi T, Teramoto T, Tanaka Y,Yoshida Y, et al. Comparative study for coagulation-fibrinolysis parameters between in ascitic fluid and plasma in patients with decompensated liver cirrhosis. Japan J Thromb Hemostasis 1992;3:238-42. DOI: 10.2491/jjsth.3.238
  16. Hoefs J, Barnes T, Halle P. Intraperitoneal coagulation in chronic liver disease ascites. Digestive Diseases and Sciences 1981, 26(6), 518-22. DOI: 10.1007/BF01308100
  17. Kountouras J, Boura P, Tsapas G, Charisis K, Magoula I, Tsakiri I. Value of ascitic fluid ferritin in the differential diagnosis of malignant ascites. Anticancer Research. 1993 Nov-Dec;13(6B):2441-5.
  18. Savaş MC, Abdurrahman K, Halis Ş, Kadri M. Ferritin levels in cirrhotic and malignant ascites. Turkiye Klinikleri J Med Res. 1994;12(6):236-8.
  19. Chiou B, Connor JR. Emerging and Dynamic Biomedical Uses of Ferritin. Pharmaceuticals (Basel). 2018;11(4):124. DOI: 10.3390/ph11040124
DOI: https://doi.org/10.2478/rrlm-2023-0016 | Journal eISSN: 2284-5623 | Journal ISSN: 1841-6624
Language: English
Page range: 191 - 196
Submitted on: Apr 20, 2023
Accepted on: May 22, 2023
Published on: Jul 28, 2023
Published by: Romanian Association of Laboratory Medicine
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2023 Petar Trifonov, Irena Ivanova, Deyan Jelev, Rosen Nikolov, Zahariy Krastev, published by Romanian Association of Laboratory Medicine
This work is licensed under the Creative Commons Attribution 4.0 License.