Association of HLA class II alleles with suicidal behavior in a Transylvanian population

Vuscan, Mihaela Elvira; Vica, Mihaela Laura; Balici, Stefana; Nicula, Gheorghe Zsolt; Rusu, Sergiu Ionica; Siserman, Costel Vasile; Coman, Horia George; Matei, Horea Vladi

doi:10.2478/rrlm-2023-0001

References

1. WHO. Fact sheets: Suicide. 17 June 2021. Available at: https://www.who.int/news-room/fact-sheets/detail/suicide
Search in Google Scholar Back to article
2. Bertolote JM, Fleischmann A. Suicidal behavior prevention: WHO perspectives on research. Am J Med Genet C Semin Med Genet. 2005;133: 8-12. DOI: 10.1002/ajmg.c.3004115645530
Open DOI Search in Google Scholar Back to article
3. Bachmann S. Epidemiology of suicide and the psychiatric perspective. Int J Environ Res Public Health. 2018;15(7): 1425. DOI: 10.3390/ijerph15071425606894729986446
Open DOI Search in Google Scholar Back to article
4. Cosman D. Compendiu de suicidologie. Cluj-Napoca, Romania: Risoprint Publishing House. 2006; ISBN: 973-686-821-4.
Search in Google Scholar Back to article
5. Sokolowski M, Ben-Efraim,YJ, Wasserman J, Wasserman D. Glutamatergic GRIN2B and polyaminergic ODC1 genes in suicide attempts: associations and gene - environment interactions with childhood/adolescent physical assault. Molecular Psychiatry. 2013;18:985-92. DOI: 10.1038/mp.2012.11222850629
Open DOI Search in Google Scholar Back to article
6. De Berardis D, Fornaro M, Valchera A, Cavuto M, Perna G, Di Nicola M, et al. Eradicating suicide at its roots: Preclinical bases and clinical evidence of the efficacy of ketamine in the treatment of suicidal behaviors. Int J Mol Sci. 2018;23;19(10):2888. DOI: 10.3390/ijms19102888621358530249029
Open DOI Search in Google Scholar Back to article
7. Steiner J, Bielau H, Brisch R, Danos P, Ullrich O, Mawrin C, et al. Immunological aspects in the neurobiology of suicide: Elevated microglial density in schizophrenia and depression is associated with suicide. J Psychiatr Res. 2008;42(2):151-7. DOI: 10.1016/j.jpsychires.2006.10.01317174336
Open DOI Search in Google Scholar Back to article
8. Cosman D, Coman H. Melancolia: de la tristeţe la sinucidere (Melancholy: from sadness to suicide). Cluj-Napoca, Romania: Risoprint Publishing House. 2018; ISBN 987-973-53-2253-3
Search in Google Scholar Back to article
9. Ruderfer DM, Walsh CG, Aguirre MW, Tanigawa Y, Ribeiro JD, Franklin JC, et al. Significant shared heritability underlies suicide attempt and clinically predicted probability of attempting suicide. Mol Psychiatry. 2020;25(10):2422-30. DOI: 10.1038/s41380-018-0326-8660950530610202
Open DOI Search in Google Scholar Back to article
10. Wang W, Luo C, Aseltine RH, Wang F, Yan J, Chen K. Suicide risk modeling with uncertain diagnostic records. arXiv preprint arXiv:2009.02597, 2020.
Search in Google Scholar Back to article
11. Niculescu AB, Levey DF, Phalen PL, Le-Niculescu H, Dainton HD, Jain N, et al. Understanding and predicting suicidality using a combined genomic and clinical risk assessment approach. Mol Psychiatry. 2015;20(11):1266-85. DOI: 10.1038/mp.2015.112475910426283638
Open DOI Search in Google Scholar Back to article
12. Kim DJ, Blossom SJ, Delgado PL, Carbajal JM, Caceda R. Examination of pain threshold and neuropeptides in patients with acute suicide risk. Prog Neuropsychopharmacol Biol Psychiatry. 2019;95:109705. DOI: 10.1016/j.pnpbp.2019.109705730951131326514
Open DOI Search in Google Scholar Back to article
13. Nowak G, Ordway GA, Paul IA. Alterations in the N-methyl-D-aspartate (NMDA) receptor complex in the frontal cortex of suicide victims. Brain Res. 1995;675(1-2):157-64. DOI: 10.1016/0006-8993(95)00057-W
Open DOI Search in Google Scholar Back to article
14. Schizophrenia Psychiatric Genome-Wide Association Study (GWAS) Consortium.. Genome-wide association study identifies five new schizophrenia loci. Nature genetics. 2011;43(10), 969-76. DOI: 10.1038/ng.940330319421926974
Open DOI Search in Google Scholar Back to article
15. Scott LJ, Muglia P, Kong XQ, Guan W, Flickinger M, Upmanyu R, et al. Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry. Proc Natl Acad Sci USA. 2009;106(18):7501-6. DOI: 10.1073/pnas.0813386106267863919416921
Open DOI Search in Google Scholar Back to article
16. McGuffin P, Marusic A, Farmer A. What can psychiatric genetics offer suicidology? Crisis. 2001;22(2):61-5. DOI: 10.1027//0227-5910.22.2.6111727895
Open DOI Search in Google Scholar Back to article
17. Clayden RC, Zaruk A, Meyre D, Thabane L, Samaan Z. The association of attempted suicide with genetic variants in the SLC6A4 and TPH genes depends on the definition of suicidal behavior: a systematic review and meta-analysis. Transl Psychiatry. 2012;2(10):e166. DOI: 10.1038/tp.2012.96356582623032942
Open DOI Search in Google Scholar Back to article
18. Salamon H, Klitz W, Easteal S, Gao X, Erlich HA, Fernandez-Viña M, et al. Evolution of HLA class II molecules: Allelic and amino acid site variability across populations. Genetics. 1999;152(1):393-4. DOI: 10.1093/genetics/152.1.393146058710224269
Open DOI Search in Google Scholar Back to article
19. Matei HV, Vica ML, Siserman CV. Association between HLA class II alleles and hepatitis B virus infection in Transylvania, Romania. Immunol Invest. 2018;47(7):735-44. DOI: 10.1080/08820139.2018.148983229979894
Open DOI Search in Google Scholar Back to article
20. Joshi PK, Pirastu N, Kentistou KA, Fischer K, Hofer E, Schraut KE, et al. Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity. Nat Commun. 2017;8:910. DOI: 10.1038/s41467-017-00934-5571501329030599
Open DOI Search in Google Scholar Back to article
21. Teng JL, Chen X, Chen J, Ting Zeng T, He L, Li M, et al. The amino acid variants in HLA II molecules explain the major association with adult-onset Still’s disease in the Han Chinese population. J Autoimmun. 2021;116:102562. DOI: 10.1016/j.jaut.2020.10256233168359
Open DOI Search in Google Scholar Back to article
22. Debnath M, Berk M, Leboyer M, Tamouza R. The MHC/HLA gene complex in major psychiatric disorders: Emerging roles and implications. Curr Behav Neurosci Rep. 2018;5(2):179-88. DOI: 10.1007/s40473-018-0155-8
Open DOI Search in Google Scholar Back to article
23. Tamouza R, Krishnamoorthy R, Leboyer M. Understanding the genetic contribution of the human leukocyte antigen system to common major psychiatric disorders in a world pandemic context. Brain Behav Immun. 2021;91:731-9. DOI: 10.1016/j.bbi.2020.09.033753466133031918
Open DOI Search in Google Scholar Back to article
24. Glanville KP, Coleman JR, Hanscombe KB, Euesden J, Choi SW, Purves KL, et al. Classical human leukocyte antigen alleles and C4 haplotypes are not significantly associated with depression. Biol. Psychiatry. 2020;87(5): 419-30. DOI: 10.1016/j.biopsych.2019.06.031700104031570195
Open DOI Search in Google Scholar Back to article
25. Le Clerc S, Lombardi L, Baune BT, Amare AT, Schubert KO, Hou L, et al. HLADRB1 and HLADQB1 genetic diversity modulates response to lithium in bipolar affective disorders. Sci. Rep. 2021;11:17823. DOI: 10.1038/s41598-021-97140-7842648834497278
Open DOI Search in Google Scholar Back to article
26. Astbury S, Reynolds CJ, Butler DK, Muñoz-Sandoval DC, Lin KM, Pieper FP, et al. HLA-DR polymorphism in SARS-CoV-2 infection and susceptibility to symptomatic COVID-19. Immunology. 2022;166(1), 68-77. DOI: 10.1111/imm.13450911135035156709
Open DOI Search in Google Scholar Back to article
27. Lorente L, Martín MM, Franco A. HLA genetic polymorphisms and prognosis of patients with COVID-19. Medicina Intensiva. 2021; Volume 45, Issue 2, Pages 96-103, ISSN 0210-5691. DOI: 10.1016/j.medin.2020.08.004790537632988645
Open DOI Search in Google Scholar Back to article
28. Sher L. The impact of the COVID-19 pandemic on suicide rates. Oxford University Press, available at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313777/pdf/hcaa202.pdf. 2020. DOI: 10.1093/qjmed/hcaa202731377732539153
Open DOI Search in Google Scholar Back to article
29. Zalsman G, Stanley B, Szanto K, Clarke DE, Carli V, Mehlum L. Suicide in the time of COVID-19: review and recommendations. Arch Suicide Res. 2020;24(4), 477-82. DOI: 10.1080/13811118.2020.1830242891152933200946
Open DOI Search in Google Scholar Back to article
30. Vuscan, ME, Buciuta A, Vica ML, Balici S, Rusu SI, Siserman CV, et al. Impact of the COVID-19 Pandemic on the Suicidal Behavior in Romania. Arch Suicide Res. 2022;1-11. DOI: 10.1080/13811118.2021.202205235040366
Open DOI Search in Google Scholar Back to article
31. Matei HV, Vică ML, Ciucă I, Coman HG, Nicula GZ, Siserman CV. Correlations among the HLA-DQB1 alleles and suicidal behavior. J Forensic Sci. 2020;65 113. DOI: 10.1111/1556-4029.1416631408207
Open DOI Search in Google Scholar Back to article
32. Sayeh A, Cheikh CB, Mrad M, Lakhal N, Gritli N, Galelli S, et al. Association of HLA-DR/DQ polymorphisms with schizophrenia in Tunisian patients. Ann Saudi Med, 2014;34(6):503-507. DOI: 10.5144/0256-4947.2014.503607457925971824
Open DOI Search in Google Scholar Back to article
33. Hollar DW. Risk for intentional violent death associated with HLA genotypes: a preliminary survey of deceased American organ donors. Genetica, 2009;137:253-264. DOI: 10.1007/s10709-009-9369-819495996
Open DOI Search in Google Scholar Back to article
34. Irish Schizophrenia Genomics Consortium, & Wellcome Trust Case Control Consortium 2. Genome-wide association study implicates HLA-C* 01: 02 as a risk factor at the major histocompatibility complex locus in schizophrenia. Biol. Psychiatry. 2012;72(8):620-8. DOI: 10.1016/j.biopsych.2012.05.035352946722883433
Open DOI Search in Google Scholar Back to article
35. Tamouza R, Oliveira J, Etain B, Bengoufa D, Hamdani N, Manier C, et al. HLA genetics in bipolar disorder. Acta Psychiatr Scand. 2018;138(5), 464-71. DOI: 10.1111/acps.1291229869414
Open DOI Search in Google Scholar Back to article
36. Bennabi M, Gaman A, Delorme R, Boukouaci W, Manier C, Scheid I, et al. HLA-class II haplotypes and autism spectrum disorders. Scientific reports. 2018;8(1):1-8. DOI: 10.1038/s41598-018-25974-9595593729769579
Open DOI Search in Google Scholar Back to article
37. Vică, ML, Matei HV, Bondor CI, Nicula GZ, Siserman CV, Loga L, et al. HLA polymorphisms and haplotype diversity in Transylvania, Romania. J. Immunol. Res. 2019;1342762. DOI: 10.1155/2019/1342762701225832083138
Open DOI Search in Google Scholar Back to article
38. Lennon JC. Machine learning algorithms for suicide risk: a premature arms race? Gen. Psychiatry. 2020;33:e100269. DOI: 10.1136/gpsych-2020-100269753405133089067
Open DOI Search in Google Scholar Back to article
39. Bentley KH, Zuromski KL, Fortgang RG, Madsen EM, Kessler D, Lee H, et al. Implementing Machine Learning Models for Suicide Risk Prediction in Clinical Practice: Focus Group Study With Hospital Providers. JMIR Form Res. 2022 Mar 11;6(3):e30946. DOI: 10.2196/30946895699635275075
Open DOI Search in Google Scholar Back to article

Association of HLA class II alleles with suicidal behavior in a Transylvanian population

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