Have a personal or library account? Click to login
Lupus anticoagulant in children – a confounding factor in diagnosis and targeted therapy Cover

Lupus anticoagulant in children – a confounding factor in diagnosis and targeted therapy

Open Access
|Jul 2021

References

  1. 1. Vivaldi P, Rossetti G, Galli M, Finazzi G. Severe bleeeding due to acquired hypoprothrombinemia-lupus anticoagulant syndrome. Case report and review of literature. Haematologica. 1997;82:345-7.
  2. 2. Pengo V. ISTH guidelines on Lupus Anticoagulant testing. Throm Res. 2012;130:S76-7. DOI: 10.1016/j.thromres.2012.08.28310.1016/j.thromres.2012.08.283
  3. 3. Male C, Lechner K, Eichinger S, Kyrle PA, Kapiotis S, Wank H, et al. Clinical significance of lupus anticoagulants in children. J Pediatrics. 1999;134:199-205. DOI: 10.1016/S0022-3476(99)70416-610.1016/S0022-3476(99)70416-6
  4. 4. Knobe K, Tedgård U, Ek T, Sandström PE, Hillarp A. Lupus anticoagulants in two children-bleeding due to nonphospholipid-dependent antiprothrombin antibodies. Eur J Pediatr. 2012 Sep;171(9):1383-7. DOI: 10.1007/s00431-012-1737-110.1007/s00431-012-1737-1
  5. 5. Gómez-Puerta JA, Cervera R. Diagnosis and classification of the antiphospholipid syndrome. J Auto-immun. Feb-Mar 2014;48-49:20-5. DOI: 10.1016/j.jaut.2014.01.00610.1016/j.jaut.2014.01.006
  6. 6. Desposito F, Arkel Y. Inhibitors of coagulation in children. Crit Rev Oncol Hematol. 1987;7(1):53-69. DOI: 10.1016/S1040-8428(87)80014-810.1016/S1040-8428(87)80014-8
  7. 7. Moore GW. Current Controversies in Lupus Anticoagulant Detection. Antibodies (Basel). 2016 Dec 2;5(4):22. DOI: 10.3390/antib504002210.3390/antib5040022669884631558003
  8. 8. Ames PRJ, Graf M, Archer J, Scarpato N, Iannaccone L. Prolonged activated partial thromboplastin time: Difficulties in discriminating coexistent factor VIII inhibitor and lupus anticoagulant. Clin Appl Thromb Hemost. 2015 Mar;21(2):149-54. DOI: 10.1177/107602961454151610.1177/107602961454151624989713
  9. 9. Kallanagowdar C, Chauhan A, Puertolas MV, Warrier R. Prevalence and Resolution of Lupus Anticoagulant in Children. Ochsner J. 2016;16(2):172-5.
  10. 10. Swadzba J, Iwaniec T, Pulka M, de Laat B, de Groot PG, Musial J. Lupus anticoagulant: Performance of the tests as recommended by the latest ISTH guidelines. J Thromb Haemost. 2011 Sep;9(9):1776-83. DOI: 10.1111/j.1538-7836.2011.04420.x10.1111/j.1538-7836.2011.04420.x21707912
  11. 11. Ames PRJ, Montero D, Archer J. Co-existent Acquired Haemophilia and Lupus Anticoagulant. A Thorny Issue. Indian J Hematol Blood Transfus. 2016 Jun; 32(Suppl 1): 248. DOI: 10.1007/s12288-015-0572-810.1007/s12288-015-0572-8492551427408404
  12. 12. Penmetsa GK, Rodgers GM, Smock KJ. Avoiding errors in the laboratory evaluation of potent lupus anticoagulants. Am J Hematol. 2010 Apr;85(4):272-4. DOI: 10.1002/ajh.2166610.1002/ajh.2166620196174
  13. 13. Wincup C, Ioannou Y. The differences between childhood and adult onset antiphospholipid syndrome. Front Pediatr. 2018 Nov 27;6:362. DOI: 10.3389/fped.2018.0036210.3389/fped.2018.00362627779930542645
  14. 14. Malbora B, Bilaloglu E. Lupus anticoagulant positivity in pediatric patients with prolonged activated partial thromboplastin time: A single-center experience and review of literature. Pediatr Hematol Oncol. 2015;32(7):495-504. DOI: 10.3109/08880018.2015.106530210.3109/08880018.2015.106530226383899
  15. 15. Aguiar CL, Soybilgic A, Avcin T, Myones BL. Pediatric Antiphospholipid Syndrome. Curr Rheum Rep. 2015;17. DOI: 10.1007/s11926-015-0504-510.1007/s11926-015-0504-525854492
  16. 16. Tagariello G, Radossi P, Salviato R, Zardo M, de Valentin L, Basso M, et al. Clinical relevance of isolated prolongation of the activated partial thromboplastin time in a cohort of adults undergoing surgical procedures. Blood Transf. 2017;15:557-61.
  17. 17. Li R, Swaelens C, Vandermijnsbrugge F, Cantinieaux B. Applying a direct aPTT ratio (PlatelinLS/ActinFS) permits to identify rapidly and reliably a bleeding-related factor deficiency or a lupus anticoagulant sequential to an isolated prolongation of aPTT in paediatric pre-operative screening. Euro J Haematol. 2016;96:578-85. DOI: 10.1111/ejh.1263410.1111/ejh.1263426179977
  18. 18. Devreese KMJ, Ortel TL, Pengo V, de Laat B. Laboratory criteria for antiphospholipid syndrome: communication from the SSC of the ISTH. J Thromb Haemost. 2018;16:809-13. DOI: 10.1111/jth.1397610.1111/jth.1397629532986
  19. 19. Dreisbach JD, Dreisbach LP, Young DE, Dreisbach PB. Acquired factor VIII inhibitor and lupus anticoagulant presenting with prolonged aPTT: a case report. Grand Rounds. 2010;10:19-24.
  20. 20. Brings HA, Waas JK, McCrae KR, Baele HR, Goldstone J. Successful management of life-threatening hemorrhage in a patient with synchronous lupus anticoagulant and factor VIII inhibitor. J Vasc Surg. 2002 Oct;36(4):853-5. DOI: 10.1067/mva.2002.12733610.1067/mva.2002.12733612368750
  21. 21. Agostini V, Biasoli C, Biguzzi R, Santarelli R, Leoni P. Case Report: Coexistence of Factor VIII Inhibitor and Lupus Anticoagulant. Blood. 2007;110:3948. DOI: 10.1182/blood.V110.11.3948.394810.1182/blood.V110.11.3948.3948
  22. 22. Ballard HS, Nyamuswa G. Life-threatening haemorrhage in a patient with rheumatoid arthritis and a lupus anticoagulant coexisting with acquired auto-antibodies against factor VIII. Br J Rheumatol. 1993 Jun;32(6):515-7. DOI: 10.1093/rheumatology/32.6.51510.1093/rheumatology/32.6.5158508289
  23. 23. Seethala S, Collins NP, Comerci G. An Unusual Etiology for Elevation of Activated Partial Thromboplastin Time (aPTT) in SLE: Acquired Hemophilia and Lupus Anticoagulant. Case Rep Hematol 2013;2013:1-3. DOI: 10.1155/2013/52178510.1155/2013/521785380314024191205
  24. 24. Taher A, Abiad R, Uthman I. Coexistence of lupus anticoagulant and acquired haemophilia in a patient with monoclonal gammopathy of unknown significance. Lupus. 2003;12:854-6. DOI: 10.1191/0961203303lu463cr10.1191/0961203303lu463cr14667103
  25. 25. Tiede A, Werwitzke S, Scharf RE. Laboratory Diagnosis of Acquired Hemophilia A: Limitations, Consequences, and Challenges. Semin Thromb Hemost. 2014 Oct;40(7):803-11. DOI: 10.1055/s-0034-139000410.1055/s-0034-139000425299927
  26. 26. Mustonen P, Lehtonen KV, Javela K, Puurunen M. Persistent antiphospholipid antibody (aPL) in asymptomatic carriers as a risk factor for future thrombotic events: a nationwide prospective study. Lupus. 2014 Dec;23(14):1468-76. DOI: 10.1177/096120331454541010.1177/096120331454541025164304
  27. 27. Sciascia S, Baldovino S, Schreiber K, Solfietti L, Radin M, Cuadrado MJ, et al. Thrombotic risk assessment in antiphospholipid syndrome: The role of new antibody specificities and thrombin generation assay. Clin Mol Allergy. 2016; 14:6. DOI: 10.1186/s12948-016-0043-210.1186/s12948-016-0043-2494736727429595
  28. 28. Radin M, Schreiber K, Costanzo P, Cecchi I, Roccatello D, Baldovino S, et al. The adjusted Global Antiphos-Pholipid Syndrome Score (aGAPSS) for risk stratification in young APS patients with acute myocardial infarction. Int J Cardiol. 2017 Aug 1;240:72-77. DOI: 10.1016/j.ijcard.2017.02.15510.1016/j.ijcard.2017.02.15528385357
DOI: https://doi.org/10.2478/rrlm-2021-0021 | Journal eISSN: 2284-5623 | Journal ISSN: 1841-6624
Language: English
Page range: 287 - 298
Submitted on: Mar 19, 2021
Accepted on: Jun 21, 2021
Published on: Jul 31, 2021
Published by: Romanian Association of Laboratory Medicine
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2021 Cristian Jinca, Margit Serban, Emilia Ursu, Nicoleta Anamaria Pascalau, Oana Belei, Delia Savescu, Mihaela Lelik, Andrei Ioan Munteanu, Andreas Tiede, Smaranda Arghirescu, published by Romanian Association of Laboratory Medicine
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.