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Multiplex ligation-dependent probe amplification – a short overview Cover

Multiplex ligation-dependent probe amplification – a short overview

Open Access
|May 2020

References

  1. 1. Schouten J, van Vught P, Galjaard RJ. Multiplex Ligation-Dependent Probe Amplification (MLPA) for Prenatal Diagnosis of Common Aneuploidies. Methods Mol Biol. 2019;1885:161-170. DOI: 10.1007/978-1-4939-8889-1_1110.1007/978-1-4939-8889-1_1130506197
  2. 2. Benard-Slagter A, Zondervan I, De Groot K, Ghazavi F, Sarhadi V, Van Vlierberghe, et al. Digital Multiplex Ligation-Dependent Probe Amplification for Detection of Key Copy Number Alterations in T- and B-Cell Lymphoblastic Leukemia. J Mol Diagn. 2017 ;19(5):659-72. DOI: 10.1016/j.jmoldx.2017.05.00410.1016/j.jmoldx.2017.05.00428736295
  3. 3. Banescu C. Do we really need genetic tests in current practice?. Rev Romana Med Lab. 2019;27(1):9-14. DOI: 10.2478/rrlm-2019-001010.2478/rrlm-2019-0010
  4. 4. MLPA General Protocol (One-Tube), MDP version-007; Issued on 01 March 2019, Available online at www.mlpa.com (Last time accesed on 22.12.2019)
  5. 5. Stuppia L, Antonucci I, Palka G, Gatta V. Use of the MLPA assay in the molecular diagnosis of gene copy number alterations in human genetic diseases. Int J Mol Sci. 2012;13(3):3245-76. DOI: 10.3390/ijms1303324510.3390/ijms13033245331771222489151
  6. 6. Judkins T, Leclair B, Bowles K, Gutin N, Trost J, Mcculloch J, et al. Development and analytical validation of a 25-gene next generation sequencing panel that includes the BRCA1 and BRCA2 genes to assess hereditary cancer risk. BMC Cancer. 2015 2;15:215. DOI: 10.1186/s12885-015-1224-y10.1186/s12885-015-1224-y439168725886519
  7. 7. Lewandowska MA, Czubak K, Klonowska K, Jozwicki W, Kowalewski J, Kozlowski P. The use of a two-tiered testing strategy for the simultaneous detection of small EGFR mutations and EGFR amplification in lung cancer. PLoS One. 2015;10(2):e0117983. DOI: 10.1371/journal.pone.011798310.1371/journal.pone.0117983434223025719557
  8. 8. Klonowska K, Ratajska M, Czubak K, Kuzniacka A, Brozek I, Koczkowska M, et al. Analysis of large mutations in BARD1 in patients with breast and/or ovarian cancer: the Polish population as an example. Sci Rep. 2015;5:10424. DOI: 10.1038/srep1042410.1038/srep10424443996925994375
  9. 9. Vázquez-Reyes A, Bobadilla-Morales L, Barba-barba C, Macías-salcedo G, Serafín-saucedo G, Velázquez-Ri-vera ME, et al. Aneuploidy identification in pre-B acute lymphoblastic leukemia patients at diagnosis by Multiplex Ligation-dependent Probe Amplification (MLPA). Leuk Res. 2017;59:117-23. DOI: 10.1016/j. leukres.2017.05.022
  10. 10. Tripon F, Crauciuc GA, Moldovan VG, Bogliș A, Benedek IJ, Lázár E, et al. Simultaneous FLT3, NPM1 and DNMT3A mutations in adult patients with acute myeloid leukemia - case study. Rev Romana Med Lab. 2019;27(3):245-54. DOI: 10.2478/rrlm-2019-002210.2478/rrlm-2019-0022
  11. 11. Bănescu C, Tripon F, Trifa AP, Crauciuc AG, Bogliș A, Lazar E, et al. Presence of copy number aberration and clinical prognostic factors in patients with acute myeloid leukemia: an analysis of effect modification. Pol Arch Intern Med. 2019;129(12):898-906. DOI: 10.20452/pamw.1509310.20452/pamw.1509331808755
  12. 12. Nouri N, Fazel-Najafabadi E, Salehi M, Hosseinzadeh M, Behnam M, Ghazavi MR, et al. Evaluation of multiplex ligation-dependent probe amplification analysis versus multiplex polymerase chain reaction assays in the detection of dystrophin gene rearrangements in an Iranian population subset. Adv Biomed Res. 2014;3:72. DOI: 10.4103/2277-9175.12586210.4103/2277-9175.125862395079424627880
  13. 13. Zhang X, Xu Y, Liu D, Geng J, Chen S, Jiang Z, et al. A modified multiplex ligation-dependent probe amplification method for the detection of 22q11.2 copy number variations in patients with congenital heart disease. BMC Genomics. 2015; 16:364. DOI: 10.1186/s12864-015-1590-510.1186/s12864-015-1590-5442457425952753
  14. 14. Honjo RS, Dutra RL, Furusawa EA, Zanardo EA, Costa LS, Kulikowski LD, et al. Williams-Beuren Syndrome: A Clinical Study of 55 Brazilian Patients and the Diagnostic Use of MLPA. Biomed Res Int. 2015;2015:903175. DOI: 10.1155/2015/90317510.1155/2015/903175445026926090456
  15. 15. García-Acero M, Moreno-Ni-o O, Suárez-Obando F, Molina M, Manotas MC, Prieto JC et al. Disorders of sex development: Genetic characterization of a patient cohort. Mol Med Rep. 2020;21(1):97-106.
  16. 16. Crauciuc GA, Tripon F, Bogliş A, Fagarasan A, Banescu C. Multiplex ligation dependent probe amplification - A useful, fast and cost-effective method for identification of small supernumerary marker chromosome in children with developmental delay and congenital heart defect. Rev Romana Med Lab. 2018;26(4):461-70. DOI: 10.2478/rrlm-2018-003210.2478/rrlm-2018-0032
  17. 17. Bogliş A, Tripon F, Bănescu C. The utility of molecular genetic techniques in craniosynostosis cases associated with intellectual disability. Rev Romana Med Lab. 2018;26(4):471-7. DOI: 10.2478/rrlm-2018-003310.2478/rrlm-2018-0033
DOI: https://doi.org/10.2478/rrlm-2020-0016 | Journal eISSN: 2284-5623 | Journal ISSN: 1841-6624
Language: English
Page range: 123 - 131
Submitted on: Dec 24, 2019
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Accepted on: Feb 3, 2020
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Published on: May 4, 2020
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2020 Valeriu Moldovan, Elena Moldovan, published by Romanian Association of Laboratory Medicine
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.