Detection of anti-protease inhibitors resistance mutations in HCV strains infecting treatment-naïve chronic patients from Romania

Dinu, Sorin; Țârdei, Grațiela; Ceaușu, Emanoil; Florescu, Simin Aysel; Micu, Laurențiu; Ecobici, Alina Monica; Mihăilă, Mariana; Oprișan, Gabriela

doi:10.2478/rrlm-2018-0029

References

1. Chen SL, Morgan TR. The natural history of hepatitis C virus (HCV) infection. Int J Med Sci. 2006;3(2):47-52. DOI: 10.7150/ijms.3.4710.7150/ijms.3.47
Open DOI Search in Google Scholar Back to article
2. Fields BN, Knipe DM, Howley PM. Fields virology. 5th ed. Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins. 2007.
Search in Google Scholar Back to article
3. Smith DB, Bukh J, Kuiken C, Muerhoff AS, Rice CM, Stapleton JT, et al. Expanded classification of hepatitis C virus into 7 genotypes and 67 subtypes: updated criteria and genotype assignment web resource. Hepatology. 2014;59(1):318-27. DOI: 10.1002/hep.2674410.1002/hep.26744
Open DOI Search in Google Scholar Back to article
4. Simmonds P, Becher P, Bukh J, Gould EA, Meyers G, Monath T, et al. ICTV Virus Taxonomy Profile: Flaviviridae. J Gen Virol. 2017;98(1):2-3. DOI: 10.1099/jgv.0.00067210.1099/jgv.0.000672
Open DOI Search in Google Scholar Back to article
5. Smith DB, Becher P, Bukh J, Gould EA, Meyers G, Monath T, et al. Proposed update to the taxonomy of the genera Hepacivirus and Pegivirus within the Flaviviridae family. J Gen Virol. 2016;97(11):2894-907. DOI: 10.1099/jgv.0.00061210.1099/jgv.0.000612
Open DOI Search in Google Scholar Back to article
6. Sherman KE, Flamm SL, Afdhal NH, Nelson DR, Sulkowski MS, Everson GT, et al. Response-guided telaprevir combination treatment for hepatitis C virus infection. N Engl J Med. 2011;365(11):1014-24. DOI: 10.1056/NEJMoa101446310.1056/NEJMoa1014463
Open DOI Search in Google Scholar Back to article
7. Poordad F, McCone J, Jr., Bacon BR, Bruno S, Manns MP, Sulkowski MS, et al. Boceprevir for untreated chronic HCV genotype 1 infection. N Engl J Med. 2011;364(13):1195-206. DOI: 10.1056/NEJMoa101049410.1056/NEJMoa1010494
Open DOI Search in Google Scholar Back to article
8. European Association for Study of Liver. EASL Recommendations on Treatment of Hepatitis C 2015. J Hepatol. 2015;63(1):199-236. DOI: 10.1016/j.jhep.2015.03.02510.1016/j.jhep.2015.03.025
Search in Google Scholar Back to article
9. Macartney MJ, Irish D, Bridge SH, Garcia-Diaz A, Booth CL, McCormick AL, et al. Telaprevir or boceprevir based therapy for chronic hepatitis C infection: development of resistance-associated variants in treatment failure. Antiviral Res. 2014;105:112-7. DOI: 10.1016/j.antiviral.2014.02.01910.1016/j.antiviral.2014.02.019
Open DOI Search in Google Scholar Back to article
10. Sarrazin C. The importance of resistance to direct antiviral drugs in HCV infection in clinical practice. J Hepatol. 2016;64(2):486-504. DOI: 10.1016/j.jhep.2015.09.01110.1016/j.jhep.2015.09.011
Search in Google Scholar Back to article
11. Hezode C, Asselah T, Reddy KR, Hassanein T, Berenguer M, Fleischer-Stepniewska K, et al. Ombitasvir plus paritaprevir plus ritonavir with or without ribavirin in treatment-naive and treatment-experienced patients with genotype 4 chronic hepatitis C virus infection (PEARL-I): a randomised, open-label trial. Lancet. 2015. DOI: 10.1016/S0140-6736(15)60159-310.1016/S0140-6736(15)60159-3
Open DOI Search in Google Scholar Back to article
12. Gheorghe L, Iacob S, Simionov I, Caruntu F, Motoc A, Arama V, et al. A real life boceprevir use in treatment-experienced HCV genotype 1 patients with advanced fibrosis. J Gastrointestin Liver Dis. 2014;23(1):45-50.10.15403/jgld-1278
Search in Google Scholar Back to article
13. Oprisan G, Dinu S, Micu L, Micu G, Ecobici M, Spandole S, et al. Study of genetic and viral markers associated with nonresponse to triple therapy for patients with genotype 1 chronic hepatitis C. International Conference “Education and creativity for a knowledge-based society”, November 17-19, 2016. Bucharest.
Search in Google Scholar Back to article
14. Leblebicioglu H, Arends JE, Ozaras R, Corti G, Santos L, Boesecke C, et al. Availability of hepatitis C diagnostics and therapeutics in European and Eurasia countries. Antiviral Res. 2018;150:9-14. DOI: 10.1016/j.antiviral.2017.12.00110.1016/j.antiviral.2017.12.00129217468
Open DOI Search in Google Scholar Back to article
15. Nițescu M, Vâjâitu C, Săndulescu O, Streinu-Cercel A, Pițigoi D, Preoțescu L, et al. Non-invasive quantification of liver fibrosis regression following successful treatment of chronic hepatitis C with direct acting antivirals. Rev Romana Med Lab. 2017;25(4):355-63. DOI: 10.1515/rrlm-2017-003010.1515/rrlm-2017-0030
Open DOI Search in Google Scholar Back to article
16. Sultana C, Oprisan G, Szmal C, Vagu C, Temereanca A, Dinu S, et al. Molecular epidemiology of hepatitis C virus strains from Romania. J Gastrointestin Liver Dis. 2011;20(3):261-6.
Search in Google Scholar Back to article
17. Sultana C, Oprisan G, Teleman MD, Dinu S, Oprea C, Voiculescu M, et al. Impact of hepatitis C virus core mutations on the response to interferon-based treatment in chronic hepatitis C. World J Gastroenterol. 2016;22(37):8406-13. DOI: 10.3748/wjg.v22.i37.840610.3748/wjg.v22.i37.8406505587127729747
Open DOI Search in Google Scholar Back to article
18. Dinu S, Calistru PI, Ceausu E, Tardei G, Oprisan G. Screening of Protease Inhibitors Resistance Mutations in Hepatitis C Virus Isolates Infecting Romanian Patients Unexposed to Triple Therapy. Roum Arch Microbiol Immunol. 2015;74(1-2):7-17.
Search in Google Scholar Back to article
19. Hall TA. BioEdit: a user-friendly biological sequence alignment editor and analysis program for Windows 95/98/NT. Nucl Acids Symp Ser. 1999;41:95-8.
Search in Google Scholar Back to article
20. Kalaghatgi P, Sikorski AM, Knops E, Rupp D, Sierra S, Heger E, et al. Geno2pheno[HCV] - A Web-based Interpretation System to Support Hepatitis C Treatment Decisions in the Era of Direct-Acting Antiviral Agents. PloS One. 2016;11(5):e0155869. DOI: 10.1371/journal.pone.015586910.1371/journal.pone.0155869487322027196673
Search in Google Scholar Back to article
21. Asselah T, Marcellin P, Schinazi RF. Treatment of hepatitis C virus infection with direct-acting antiviral agents: 100% cure? Liver Int. 2018;38 Suppl 1:7-13. DOI: 10.1111/liv.1367310.1111/liv.13673771351429427484
Open DOI Search in Google Scholar Back to article
22. Bagaglio S, Uberti-Foppa C, Morsica G. Resistance Mechanisms in Hepatitis C Virus: implications for Direct-Acting Antiviral Use. Drugs. 2017;77(10):1043-55. DOI: 10.1007/s40265-017-0753-x10.1007/s40265-017-0753-x28497432
Search in Google Scholar Back to article
23. European Association for the Study of the Liver. EASL Recommendations on Treatment of Hepatitis C 2018. J Hepatol. 2018 Apr 9. pii:S0168-8278(18)31968-8.
Search in Google Scholar Back to article
24. Pawlotsky JM. Hepatitis C Virus Resistance to Direct-Acting Antiviral Drugs in Interferon-Free Regimens. Gastroenterology. 2016;151(1):70-86. DOI: 10.1053/j.gastro.2016.04.00310.1053/j.gastro.2016.04.00327080301
Open DOI Search in Google Scholar Back to article
25. Vidal LL, Soares MA, Santos AF. NS3 protease polymorphisms and genetic barrier to drug resistance of distinct hepatitis C virus genotypes from worldwide treatment-naïve subjects. J Viral Hepat. 2016;23(11):840-849. DOI: 10.1111/jvh.1250310.1111/jvh.1250326775769
Open DOI Search in Google Scholar Back to article
26. Kliemann DA, Tovo CV, da Veiga AB, de Mattos AA, Wood C. Polymorphisms and resistance mutations of hepatitis C virus on sequences in the European hepatitis C virus database. World J Gastroenterol. 2016;22(40):8910-7. DOI: 10.3748/wjg.v22.i40.891010.3748/wjg.v22.i40.8910508379627833382
Open DOI Search in Google Scholar Back to article
27. Sargin Altunok E, Sayan M, Akhan S, Aygen B, Yildiz O, Tekin Koruk S, et al. Protease Inhibitors Drug Resistance Mutations in Turkish Patients with Chronic Hepatitis C. Int J Infect Dis. 2016;50:1-5. DOI: 10.1016/j.ijid.2016.07.00310.1016/j.ijid.2016.07.003
Open DOI Search in Google Scholar Back to article
28. Echeverria N, Betancour G, Gambaro F, Hernandez N, Lopez P, Chiodi D, et al. Naturally occurring NS3 resistance-associated variants in hepatitis C virus genotype 1: Their relevance for developing countries. Virus Res. 2016;223:140-6. DOI: 10.1016/j.virusres.2016.07.00810.1016/j.virusres.2016.07.008
Open DOI Search in Google Scholar Back to article
29. Wyles DL. Resistance to DAAs: When to Look and When It Matters. Curr HIV/AIDS Rep. 2017;14(6):229-37. DOI: 10.1007/s11904-017-0369-510.1007/s11904-017-0369-5
Open DOI Search in Google Scholar Back to article
30. Chevaliez S, Asselah T. Mechanisms of non-response to antiviral treatment in chronic hepatitis C. Clin Res Hepatol Gastroenterol. 2011;35 Suppl 1:S31-41. DOI: 10.1016/S2210-7401(11)70005-510.1016/S2210-7401(11)70005-5
Open DOI Search in Google Scholar Back to article
31. Chen ZW, Li H, Ren H, Hu P. Global prevalence of pre-existing HCV variants resistant to direct-acting antiviral agents (DAAs): mining the GenBank HCV genome data. Sci Rep. 2016;6:20310. DOI: 10.1038/srep2031010.1038/srep20310
Open DOI Search in Google Scholar Back to article
32. Love RA, Parge HE, Wickersham JA, Hostomsky Z, Habuka N, Moomaw EW, et al. The crystal structure of hepatitis C virus NS3 proteinase reveals a trypsin-like fold and a structural zinc binding site. Cell. 1996;87(2):331-42. DOI: 10.1016/S0092-8674(00)81350-110.1016/S0092-8674(00)81350-1
Open DOI Search in Google Scholar Back to article
33. Stempniak M, Hostomska Z, Nodes BR, Hostomsky Z. The NS3 proteinase domain of hepatitis C virus is a zinc-containing enzyme. J Virol. 1997;71(4):2881-6.10.1128/jvi.71.4.2881-2886.19971914149060645
Search in Google Scholar Back to article
34. Dietz J, Susser S, Berkowski C, Perner D, Zeuzem S, Sarrazin C. Consideration of Viral Resistance for Optimization of Direct Antiviral Therapy of Hepatitis C Virus Genotype 1-Infected Patients. PloS One. 2015;10(8):e0134395. DOI: 10.1371/journal.pone.013439510.1371/journal.pone.0134395455268626317755
Search in Google Scholar Back to article
35. Zhou K, Liang Z, Wang C, Hu F, Ning C, Lan Y, et al. Natural Polymorphisms Conferring Resistance to HCV Protease and Polymerase Inhibitors in Treatment-Naive HIV/HCV Co-Infected Patients in China. PloS One. 2016;11(6):e0157438. DOI: 10.1371/journal.pone.015743810.1371/journal.pone.0157438492040227341031
Search in Google Scholar Back to article
36. Dietz J, Susser S, Vermehren J, Peiffer KH, Grammatikos G, Berger A, et al. Patterns of Resistance-associated Substitutions in Patients With Chronic HCV Infection Following Treatment With Direct-acting Antivirals. Gastroenterology. 2017;154(4):976-988.e4. DOI: 10.1053/j.gastro.2017.11.00710.1053/j.gastro.2017.11.00729146520
Open DOI Search in Google Scholar Back to article
37. Iio E, Shimada N, Abe H, Atsukawa M, Yoshizawa K, Takaguchi K, et al. Efficacy of daclatasvir/asunaprevir according to resistance-associated variants in chronic hepatitis C with genotype 1. J Gastroenterol. 2017;52(1):94-103. DOI: 10.1007/s00535-016-1225-x10.1007/s00535-016-1225-x27236547
Open DOI Search in Google Scholar Back to article
38. Susser S, Welsch C, Wang Y, Zettler M, Domingues FS, Karey U, et al. Characterization of resistance to the protease inhibitor boceprevir in hepatitis C virus-infected patients. Hepatology. 2009;50(6):1709-18. DOI: 10.1002/hep.2319210.1002/hep.2319219787809
Open DOI Search in Google Scholar Back to article
39. Shepherd SJ, Abdelrahman T, MacLean AR, Thomson EC, Aitken C, Gunson RN. Prevalence of HCV NS3 pre-treatment resistance associated amino acid variants within a Scottish cohort. J Clin Virol. 2015;65:50-3. DOI: 10.1016/j.jcv.2015.02.00510.1016/j.jcv.2015.02.005472829825766988
Open DOI Search in Google Scholar Back to article
40. Barnard RJ, Howe JA, Ogert RA, Zeuzem S, Poordad F, Gordon SC, et al. Analysis of boceprevir resistance associated amino acid variants (RAVs) in two phase 3 boceprevir clinical studies. Virology. 2013;444(1-2):329-36. DOI: 10.1016/j.virol.2013.06.02910.1016/j.virol.2013.06.02923876458
Open DOI Search in Google Scholar Back to article
41. Fourati S, Pawlotsky JM. Virologic Tools for HCV Drug Resistance Testing. Viruses. 2015;7(12):6346-59. DOI: 10.3390/v712294110.3390/v7122941469086526690198
Open DOI Search in Google Scholar Back to article
42. Thomson E, Ip CL, Badhan A, Christiansen MT, Adamson W, Ansari MA, et al. Comparison of Next-Generation Sequencing Technologies for Comprehensive Assessment of Full-Length Hepatitis C Viral Genomes. J Clin Microbiol. 2016;54(10):2470-84. DOI: 10.1128/JCM.00330-1610.1128/JCM.00330-16503540727385709
Search in Google Scholar Back to article

Detection of anti-protease inhibitors resistance mutations in HCV strains infecting treatment-naïve chronic patients from Romania

References

Paradigm

My account