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Can laboratory assays for measurement of cellular DNA damage and its repair be useful for prediction of cancer and prognosis? Cover

Can laboratory assays for measurement of cellular DNA damage and its repair be useful for prediction of cancer and prognosis?

By: William Au  
Open Access
|May 2018

References

  1. 1. Au WW, Salama SA, Sierra-Torres CH. Functional characterization of polymorphism in DNA repair genes using cytogenetic challenge assays. Environ Health Persp. 2003;111;1843-50. DOI: 10.1289/ehp.663210.1289/ehp.6632124174714630517
  2. 2. Luzhna L, Kathiria P, Kovalchuk O. Micronuclei in genotoxicity assessment: from genetics to epigenetics and beyond. Front genet. 2013;4:131. DOI: 10.3389/fgene.2013.0013110.3389/fgene.2013.00131370815623874352
  3. 3. Au WW, Salama SA. Cytogenetic challenge assays for assessment of DNA repair capacities. In: Methods in Molecular Biology: DNA Repair Protocols: Mammalian Systems. 2nd Edition. Edited by: DS Henderson, Humana Press, Totowa, NJ., 2005; Chapter 3, 25-42.10.1385/1-59259-973-7:025
  4. 4. Nikolova T, Dvorak M, Jung F, Adam I, Krämer E, Gerhold-Ay A, Kaina B. The γH2AX Assay for Genotoxic and Nongenotoxic Agents: Comparison of H2AX Phosphorylation with Cell Death Response, Toxicol Sci. 2014;140(1):103-17. DOI: 10.1093/toxsci/kfu06610.1093/toxsci/kfu06624743697
  5. 5. Rukirawat M, Cebulska-Wasilewska A, Au WW. Evidence for exposure-induced DNA repair abnormality is indicative of health and genetic risk, Int J Hygiene Env Health. 2013;216:566-73. DOI: 10.1016/j.ijheh.2013.03.00310.1016/j.ijheh.2013.03.00323545294
  6. 6. Fu XJ, Shi XJ, Lin K, Lin R, Huang WH, Zhang GJ, Au WW. Environmental and DNA repair risk factors for breast cancer in Southern China. Int J Hygiene Env Health. 2015;218:313-318. DOI: 10.1016/j.ijheh.2015.01.00110.1016/j.ijheh.2015.01.00125616561
DOI: https://doi.org/10.2478/rrlm-2018-0014 | Journal eISSN: 2284-5623 | Journal ISSN: 1841-6624
Language: English
Page range: 141 - 144
Published on: May 17, 2018
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2018 William Au, published by Romanian Association of Laboratory Medicine
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.