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Comparing the anti-inflammatory effects of Simvastatin and Rosuvastatin by measuring IL-1β, IL-6 and TNF-α levels using a murinic caecal ligation and puncture induced sepsis model / Compararea efectelor anti-inflamatoare ale Simvastatinei și Rosuvastatinei măsurând nivelele serice ale IL-1β, IL-6 si TNF-α folosind un model de sepsis la șobolan indus prin ligatură și puncție cecală Cover

Comparing the anti-inflammatory effects of Simvastatin and Rosuvastatin by measuring IL-1β, IL-6 and TNF-α levels using a murinic caecal ligation and puncture induced sepsis model / Compararea efectelor anti-inflamatoare ale Simvastatinei și Rosuvastatinei măsurând nivelele serice ale IL-1β, IL-6 si TNF-α folosind un model de sepsis la șobolan indus prin ligatură și puncție cecală

Revista Romana de Medicina de Laborator
Volume 22 (2014): Issue 4 (December 2014)
By: Mihai Mărginean M,  Sebastian Trancă,  Alina Ardelean-Maghiar (Mărginean),  Dan Dîrzu,  Adina Huțanu,  Oana Platon (Antal) and  Dan Dobreanu  
Open Access
|Dec 2014

References

  1. 1. Dellinger RP, Levy MM, Rhodes A, Annane D, Gerlach H, Opal SM, et al. Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012. Crit Care Med. 2013 Feb;41(2):580-637. DOI: 10.1097/CCM.0b013e31827e83af10.1097/CCM.0b013e31827e83af
    Search in Google Scholar
  2. 2. Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J, Pinsky MR. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med. 2001 Jul;29(7):1303-10. DOI: 10.1097/00003246-200107000-0000210.1097/00003246-200107000-00002
    Search in Google Scholar
  3. 3. Kruger P, Venkatesh B. Are There any Benefits from Statin Treatment for the Septic Patient? Curr Athero scler Rep. 2014 Jan;16(1):378. DOI: 10.1007/s11883-013-0378-910.1007/s11883-013-0378-9
    Search in Google Scholar
  4. 4. Terblanche M, Almog Y, Rosenson R. Statins and sepsis: multiple modifications at multiple levels. Lancet Infect Dis. 2007;7(May):358-68. DOI: 10.1016/ S1473-3099(07)70111-110.1016/S1473-3099(07)70111-1
    Search in Google Scholar
  5. 5. Liao J, Laufs U. Pleiotropic effects of statins. Annu Rev Pharmacol Toxicol. 2005 Jan;45:89-118. DOI: 10.1146/annurev.pharmtox.45.120403.09574810.1146/annurev.pharmtox.45.120403.095748269458015822172
    Search in Google Scholar
  6. 6. Radigan KA, Urich D, Misharin A V, Chiarella SE, Soberanes S, Gonzalez A, et al. The effect of rosuvastatin in a murine model of influenza A infection. PLoS One. 2012 Jan;7(4):1-10. DOI: 10.1371/journal. pone.0035788
    Search in Google Scholar
  7. 7. Araújo-Filho I, Jácome DT, Rêgo ACM, Azevedo IM, Egito EST, Medeiros AC. Effect of the simvastatin in abdominal sepsis of diabetic rats. [Efeito da sinvastatina na sepse abdominal de ratos diabéticos]. Rev Col Bras Cir. 2010 Feb;37(1):39-44. DOI: 10.1590/S0100-6991201000010000910.1590/S0100-6991201000010000920414574
    Search in Google Scholar
  8. 8. Almeida JL, Sampietre SN, Mendonça Coelho AM, Trindade Molan NA, Machado MCC, Monteiro da Cunha JE, et al. Statin pretreatment in experimental acute pancreatitis. J Pancreas. 2008 Jan;9(4):431-9.
    Search in Google Scholar
  9. 9. Alvarez de Sotomayor M, Vega S, Mingorance C, Marhuenda E, Herrera MD. Effects of HMG-CoA reductase inhibition by simvastatin on vascular dysfunction induced by lipopolysaccharide in rats. Pharmacology. 2008 Jan;82(2):89-96. DOI: 10.1159/00013562910.1159/00013562918509252
    Search in Google Scholar
  10. 10. Hinz J, Gehoff P, Schotola H, Hosseini MT, Didilis VN, Jebran AF, et al. Hemodynamic effects of peri-operative statin therapy in on-pump cardiac surgery patients. J Cardiothorac Surg. 2012 Jan;7:39. DOI: 10.1186/1749-8090-7-3910.1186/1749-8090-7-39339884222533985
    Search in Google Scholar
  11. 11. Al Harbi SA, Tamim HM, Arabi YM. Association between statin therapy and outcomes in critically ill patients: a nested cohort study. BMC Clin Pharmacol. 2011;11(12):1-7.10.1186/1472-6904-11-12319976921819615
    Search in Google Scholar
  12. 12. Christensen S, Thomsen RW, Johansen MB, Pedersen L, Jensen R, Larsen KM, et al. Preadmission statin use and one-year mortality among patients in intensive care - a cohort study. Crit Care. 2010 Jan;14(2):R29. DOI: 10.1186/cc890210.1186/cc8902288713120214779
    Search in Google Scholar
  13. 13. Khan A, Yeung D, Wyatt B, Rafai T, Byant J, Coates A, et al. Effects of statins on postoperative sepsis, systemic inflammatory response syndrome and mortality after colorectal surgery. Crit Care. 2009;13(Suppl 4):P47. DOI: 10.1186/cc810310.1186/cc8103
    Search in Google Scholar
  14. 14. Thomsen RW, Hundborg HH, Johnsen SP, Pedersen L, Sørensen HT, Schønheyder HC, et al. Statin use and mortality within 180 days after bacteremia: a population-based cohort study. Crit Care Med. 2006 Apr;34(4):1080-6. DOI: 10.1097/01. CCM.0000207345.92928.E410.1097/01
    Search in Google Scholar
  15. 15. McAuley DF, Laffey JG, O’Kane CM, Cross M, Perkins GD, Murphy L, et al. Hydroxymethylglutaryl-CoA reductase inhibition with simvastatin in acute lung injury to reduce pulmonary dysfunction (HARP-2) trial: study protocol for a randomized controlled trial. Trials. 2012 Jan;13(1):170. DOI: 10.1186/1745-6215-13-17010.1186/1745-6215-13-170354331622985805
    Search in Google Scholar
  16. 16. Novack V, Eisinger M, Frenkel A, Terblanche M, Adhikari NKJ, Douvdevani A, et al. The effects of statin therapy on inflammatory cytokines in patients with bacterial infections: a randomized double-blind placebo controlled clinical trial. Intensive Care Med. 2009 Jul;35(7):1255-60. DOI: 10.1007/s00134-009-1429-010.1007/s00134-009-1429-019205663
    Search in Google Scholar
  17. 17. Kruger PS, Harward ML, Jones M a, Joyce CJ, Kostner KM, Roberts MS, et al. Continuation of statin therapy in patients with presumed infection: a randomized controlled trial. Am J Respir Crit Care Med. 2011 Mar 15;183(6):774-81. DOI: 10.1164/rccm. 201006-0955OC
    Search in Google Scholar
  18. 18. Patel JM, Snaith C, Thickett DR, Linhartova L, Melody T, Hawkey P, et al. Randomized double-blind placebo- controlled trial of 40 mg/day of atorvastatin in reducing the severity of sepsis in ward patients (ASEPSIS Trial). Crit Care. 2012 Dec 11;16(6):R231. DOI: 10.1186/cc1189510.1186/cc11895367262023232151
    Search in Google Scholar
  19. 19. Kruger P, Bailey M, Bellomo R, Cooper DJ, Harward M, Higgins A, et al. A multicenter randomized trial of atorvastatin therapy in intensive care patients with severe sepsis. Am J Respir Crit Care Med. 2013 Apr;187(7):743-50. DOI: 10.1164/rccm. 201209-1718OC
    Search in Google Scholar
  20. 20. Craig TR, Duffy MJ, Shyamsundar M, McDowell C, O’Kane CM, Elborn JS, et al. A randomized clinical trial of hydroxymethylglutaryl- coenzyme a reductase inhibition for acute lung injury (The HARP Study). Am J Respir Crit Care Med. 2011 Mar 1;183(5):620-6. DOI: 10.1164/rccm.201003-0423OC10.1164/rccm.201003-0423OC20870757
    Search in Google Scholar
  21. 21. Woerndle RH, Maxwell DL. Statins and sepsis: good bullet, disappearing target. J Am Osteopath Assoc. 2008 Sep;108(9):486-90.
    Search in Google Scholar
  22. 22. O’Kane C. Statins and Sepsis: Potential Benefit but More Unanswered Questions. Am J Respir Crit Care Med. 2013;187:672-5. DOI: 10.1164/rccm. 201212-2305ED
    Search in Google Scholar
  23. 23. JR JCMS. Can statins improve outcome in colorectal surgery? Part I. J Coloproctology (Rio Janeiro). 2012;334-8.10.1590/S2237-93632012000300022
    Search in Google Scholar
  24. 24. Gao F, Linhartova L, Johnston AM, Thickett DR. Statins and sepsis. Br J Anaesth. 2008 Mar 1;100(3):288-98. DOI: 10.1093/bja/aem40610.1093/bja/aem40618276651
    Search in Google Scholar
  25. 25. Toscano MG, Ganea D, Gamero AM. Cecal ligation puncture procedure. J Vis Exp. 2011 Jan;(51):1-5.10.3791/2860333984321587163
    Search in Google Scholar
  26. 26. Hubbard WJ, Choudhry M, Schwacha MG, Kerby JD, Rue LW, Bland KI, et al. Cecal ligation and puncture. Shock. 2005 Dec;24 Suppl 1:52-7. DOI: 10.1097/01. shk.0000191414.94461.7e10.1097/01
    Search in Google Scholar
  27. 27. Wichterman KA, Baue AE, Chaudry IH. Sepsis and septic shock--a review of laboratory models and a proposal. J Surg Res. 1980 Aug;29(2):189-201. DOI: 10.1016/0022-4804(80)90037-210.1016/0022-4804(80)90037-2
    Search in Google Scholar
  28. 28. Jekarl DW, Lee S-Y, Lee J, Park Y-J, Kim Y, Park JH, et al. Procalcitonin as a diagnostic marker and IL-6 as a prognostic marker for sepsis. Diagn Microbiol Infect Dis. 2013 Feb 4;75(4):342-7. DOI: 10.1016/j.diagmicrobio. 2012.12.011
    Search in Google Scholar
  29. 29. Lee H. Procalcitonin as a biomarker of infectious diseases. Korean J Intern Med. 2013 May;28(3):285-91. DOI: 10.3904/kjim.2013.28.3.28510.3904/kjim.2013.28.3.285365412323682219
    Search in Google Scholar
  30. 30. Faix JD. Biomarkers of Sepsis. Crit Rev Clin Lab Sci. 2013;50(1):23-36. DOI: 10.3109/10408363.2013.76449010.3109/10408363.2013.764490361396223480440
    Search in Google Scholar
  31. 31. European Union. Directive 2010/63/EU Of The European Parliament And Of The Council of 22 September 2010 on the protection of animals used for scientific purposes. Off J Eur Union. 2010;33-79.
    Search in Google Scholar
  32. 32. University of California. Guidelines for Anesthesia and Analgesia in Laboratory Animals. 2012. p. 1-5.
    Search in Google Scholar
  33. 33. Merx MW, Liehn E a, Janssens U, Lütticken R, Schrader J, Hanrath P, et al. HMG-CoA reductase inhibitor simvastatin profoundly improves survival in a murine model of sepsis. Circulation. 2004 Jun 1;109(21):2560 DOI:10.1161/01.CIR.0000129774.09737.5B10.1161/01.CIR.0000129774.09737.5B15123521
    Search in Google Scholar
  34. 34. French E, Vandewoude S, Granowski J, Maul D. Assessment of pain in laboratory animals. Contemp Top. 2000;39(85).
    Search in Google Scholar
  35. 35. Leach M. Pain assessment in laboratory animals using behaviour and facial expressions. 2011.
    Search in Google Scholar
  36. 36. Sotocinal SG, Sorge RE, Zaloum A, Tuttle AH, Martin LJ, Wieskopf JS, et al. The Rat Grimace Scale: a partially automated method for quantifying pain in the laboratory rat via facial expressions. Mol Pain. 2011 Jan;7(1):55. DOI: 10.1186/1744-8069-7-5510.1186/1744-8069-7-55316360221801409
    Search in Google Scholar
  37. 37. Giusti-Paiva A, Martinez MR, Felix JVC, da Rocha MJA, Carnio EC, Elias LLK, et al. Simvastatin decreases nitric oxide overproduction and reverts the impaired vascular responsiveness induced by endotoxic shock in rats. Shock. 2004 Mar;2 (3):271-5. DOI: 10.1097/10. shk.0000115756.74059.ce
    Search in Google Scholar
  38. 38. Leary S, Underwood W, Anthony R, Cartner S. AVMA Guidelines for the Euthanasia of Animals: 2013 Edition [Internet]. 2013.
    Search in Google Scholar
  39. 39. Hernandez TL, Capell WH, Wolfe P, Gerard LA, Eckel RH. Time course of C-reactive protein reduction with simvastatin therapy in patients with type 2 diabetes mellitus. Am J Cardiol. 2006 Dec 15;98(12):1656-9. DOI: 10.1016/j.amjcard.2006.07.04710.1016/j.amjcard.2006.07.04717145229
    Search in Google Scholar
  40. 40. Plenge JK, Hernandez TL, Weil KM, Poirier P, Grunwald GK, Marcovina SM, et al. Simvastatin lowers C-reactive protein within 14 days: an effect independent of low-density lipoprotein cholesterol reduction. Circulation. 2002 Oct 17;106(12):1447-52. DOI: 10.1161/01.CIR.0000029743.68247.3110.1161/01.CIR.0000029743.68247.31
    Search in Google Scholar
  41. 41. Yende S, Milbrandt E, Kellum J. Understanding the potential role of statins in pneumonia and sepsis. Crit Care Med. 2011;39(8):1871-8. DOI: 10.1097/ CCM.0b013e31821b8290 10.1097/CCM.0b013e31821b8290313980421516038
    Search in Google Scholar
DOI: https://doi.org/10.2478/rrlm-2014-0037 | Journal eISSN: 2284-5623 | Journal ISSN: 1841-6624
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Language: English
Page range: 439 - 450
Submitted on: Jun 2, 2014
Accepted on: Oct 21, 2014
Published on: Dec 30, 2014
Published by: Romanian Association of Laboratory Medicine
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year
Keywords:
sepsis,
experimental model,
rat,
HMG-CoA reductase,
Simvastatin,
Rosuvastatin,
interleukins,
cytokines
Related subjects:
Life sciences,
Molecular biology,
Biochemistry,
Human biology,
Microbiology and virology

© 2014 Mihai Mărginean M, Sebastian Trancă, Alina Ardelean-Maghiar (Mărginean), Dan Dîrzu, Adina Huțanu, Oana Platon (Antal), Dan Dobreanu, published by Romanian Association of Laboratory Medicine
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

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