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Flow Cytometry Analysis of Pparα Receptors in Metabolic Syndrome / Studiul Receptorilor Pparα prin Metoda Citometriei în Flux în Sindromul Metabolic Cover

Flow Cytometry Analysis of Pparα Receptors in Metabolic Syndrome / Studiul Receptorilor Pparα prin Metoda Citometriei în Flux în Sindromul Metabolic

Revista Romana de Medicina de Laborator
Volume 22 (2014): Issue 4 (December 2014)
By: Elena Popa,  Florin Zugun-Eloae,  Mihaela Zlei,  Daniela Jitaru,  Oana Maria Pintilie,  Adorata Elena Coman,  Maria Traian,  Didona Anca Ungureanu and  Eugen Carasevici  
Open Access
|Dec 2014

References

  1. 1. Eckel R, Alberti KGMM, Grundy SM, Zimmet PZ. The metabolic syndrome. The Lancet. 2010;375(9710):181-3. DOI: 10.1016/S0140-6736(09)61794-310.1016/S0140-6736(09)61794-3
    Search in Google Scholar
  2. 2. Kahn R. Metabolic syndrome- what is the clinical usefulness? The Lancet. 2008;371(9628):1892-3. DOI: 10.1016/S0140-6736(08)60731-X10.1016/S0140-6736(08)60731-X
    Search in Google Scholar
  3. 3. Reaven GM. The metabolic syndrome: is this diagnosis necessary? Am J Clin Nutr. 2006; 83(6):1237-7.10.1093/ajcn/83.6.123716762930
    Search in Google Scholar
  4. 4. Gami AS, Witt BJ, Howard DE, Erwin PJ, Gami LA, Somers VK et al. Metabolic Syndrome and Risk of Incident Cardiovascular Events and Death : a systematic review and meta-analysis of longitudinal studies, J Am Coll Cardiol. 2007;49(5):403-4. DOI: 10.1016/j. jacc.2006.09.032
    Search in Google Scholar
  5. 5. International Diabetes Federation. IDF Diabetes Atlas, 6th edn. International Diabetes Federation, Belgium, Brussels, 2013:1-155.
    Search in Google Scholar
  6. 6. World Health Organization. Global Status Report on Noncommunicable Diseases 2010. World Health Organization Geneva, Switzerland, 2011:1-176.
    Search in Google Scholar
  7. 7. Azhar S. Peroxisome proliferator-activated receptors, metabolic syndrome and cardiovascular disease. Future Cardiology.2010;6(5):657-91. DOI: 10.2217/fca.10.8610.2217/fca.10.86324674420932114
    Search in Google Scholar
  8. 8. Cercosimo E, Defronzo RA. Insulin resistance and endothelial dysfunction: the road map to cardiovascular diseases. Diabetes Metab Res Rev. 2006;22(6):423-36. DOI: 10.1002/dmrr.63410.1002/dmrr.63416506274
    Search in Google Scholar
  9. 9. Fruchart JCh. Peroxisome Proliferator-Activated Receptors at the Crossroads of Obesity, Diabetes and Cardiovascular Disease. Journal of American College Cardiology. 2006;48(9):24-32. DOI: 10.1016/j. jacc.2006.04.097
    Search in Google Scholar
  10. 10. Kersten S, Desvergne B, Wahli W. Roles of PPARS in health and disease. Nature. 2000;405(6785):421-4. DOI: 10.1038/3501300010.1038/3501300010839530
    Search in Google Scholar
  11. 11. Ricote M, Valledor AF, Glass CK. Decoding transcriptional programs regulated by PPARs and LXRs in the macrophage: effects on lipid homeostasis, inflammation, and atherosclerosis. Arteriosclerosis, Thrombosis and Vascular Biology. 2004;24(2):230-9. DOI: 10.1161/01.ATV.0000103951.67680.B110.1161/01.ATV.0000103951.67680.B114592855
    Search in Google Scholar
  12. 12. Straus DS, Glass CK. Anti-inflammatory actions of PPAR ligands: new insights on cellular and molecular mechanisms. Trends Immunol. 2007;28(12):551-8. DOI: 10.1016/j.it.2007.09.00310.1016/j.it.2007.09.00317981503
    Search in Google Scholar
  13. 13. Kersten S. Regulation of nutrient metabolism and inflammation. Meyerhof W, Beisiegel U, Joost H-G(Eds), Sensory and Metabolic Control of Energy Balance, Results and Problems in Cell Differentiation 52, Springer- Verlag Berlin Heidelberg, 2010: DOI:10.1007/978-3-642-14426-4_2. DOI: 10.1007/978-3-642-14426-4_210.1007/978-3-642-14426-4_220865368
    Search in Google Scholar
  14. 14. Silverstein R. Inflammation, atherosclerosis, and arterial thrombosis: Role of the scavenger receptor CD36. Cleveland Clinic Journal of Medicine. 2009;76(Suppl 2):S27-S30. DOI: 10.3949/ccjm.76.s2.0610.3949/ccjm.76.s2.06281053019376978
    Search in Google Scholar
  15. 15. Collot -Teixeira S, Martin J, McDermott-Roe C, Poston R, McGregor JL. CD36 and macrophages in atherosclerosis. Cardiovasc Resp. 2007;75(3):468-77. DOI: 10.1016/j.cardiores.2007.03.01010.1016/j.cardiores.2007.03.01017442283
    Search in Google Scholar
  16. 16. Herzenberg LA, Parks D, Sahaf B, Roederer M, Herzenberg LA. The history and future of the fluorescence activated cell sorter and flow cytometry: a view from Stanford. Clin Chem. 2002;48(10):1819-27.10.1093/clinchem/48.10.1819
    Search in Google Scholar
  17. 17. Sheikholeslami MR, Jilani I, Keating M, Uyeji J, Chen K, Kantarjian H et al. Variations in the detection of ZAP-70 in chronic lymphocytic leukemia: Comparison with IgV (H) mutation analysis. Cytometry B Clin Cytom. 2006;70(4):270-5. DOI: 10.1002/cyto.b.2013410.1002/cyto.b.2013416906585
    Search in Google Scholar
  18. 18. Butts CL, Shukair SA, Duncan KM, Harris CW, Belyavskaia E, Sternberg EM . Evaluation of steroid hormone receptor protein expression in intact cells using flow cytometry. Nucl Recept Signal. 2007; DOI:10.1621/nrs.05007. DOI: 10.1621/nrs.0500710.1621/nrs.05007194807217710123
    Search in Google Scholar
  19. 19. Christensen R. Testing Fisher, Neyman, Pearson and Bayes. American Statistician. 2005; 59(2):121-6. DOI: 10.1198/000313005X2087110.1198/000313005X20871
    Search in Google Scholar
  20. 20. Kreiner S, Christensen KB. Analysis of Local Dependence and Multi-dimensionality in Graphical Loglinear Rasch Models. Communications in Statistics - Theory and Methods. 2004;33(6):1239-76. DOI: 10.1081/STA-12003014810.1081/STA-120030148
    Search in Google Scholar
  21. 21. Der G, Everitt B. Statistical Analysis of Medical Data Using SAS. Boca Raton, Fl. Chapman Hall/CRC Press, 2005:1-440.10.1201/9781420057225
    Search in Google Scholar
  22. 22. Lee M, Saver JL, Towfighi A, Chow J, Ovbiagele B. Efficacy of fibrates for cardiovascular risk reduction in persons with atherogenic dyslipidemia: A meta-analysis Atherosclerosis. 2011;217(2):492-8.
    Search in Google Scholar
  23. 23. Zandbergen F, Plutzky J. PPARα in atherosclerosis and inflammation. Biochim Biophys Acta. 2007;1771(8):972-82. DOI: 10.1016/j. bbalip.2007.04.021
    Search in Google Scholar
  24. 24. Hansson GK. Inflammation, atherosclerosis, and coronary artery disease. N. Engl. J. Med. 2005; 352(16):1685-95. DOI: 10.1056/NEJMra04343010.1056/NEJMra04343015843671
    Search in Google Scholar
  25. 25. Wu D, Molofsky AB, Liang HE, Ricardo-Gonzales RR, Jouihan HA, Bando JK et al. Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis. Science. 2011;332(6026):243-47. DOI: 10.1126/science.120147510.1126/science.1201475314416021436399
    Search in Google Scholar
  26. 26. Lee BC, Lee J. Cellular and molecular players in adipose tissue inflammation in the development of obesity-induced insulin resistance. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2014;1842(3):446-62. DOI: 10.1016/j.bbadis.2013.05.01710.1016/j.bbadis.2013.05.017380025323707515
    Search in Google Scholar
  27. 27. Jacobsen E, Helmers R, Lee J, Lee N. The expanding role(s) of eosinophils in health and disease. Blood. 2012;120(19):3882-90. DOI: 10.1182/ blood-2012-06-33084510.1182/blood-2012-06-330845
    Search in Google Scholar
  28. 28. Woerly G, Honda K, Loyens M,. Papin J P, Auwerx J, Staels B et al. Peroxisome proliferator-activated receptors alpha and gamma down-regulate allergic inflammation and eosinophil activation. J Exp Med. 2003;198(3):411-21. DOI: 10.1084/jem.2002138410.1084/jem.20021384
    Search in Google Scholar
  29. 29. D’Amore S, Vacca M, Graziano G, D’Orazio A, Cariello M, Martelli N et al. Nuclear receptors expression chart in peripheral blood mononuclear cells identifies patients with Metabolic Syndrome. Biochim Biophys Acta. 2013;1832(12):2289-301. DOI: 10.1016/j.bbadis.2013.09.00610.1016/j.bbadis.2013.09.006
    Search in Google Scholar
  30. 30. Faiola B, Peterson RA, Bordelon R, Brodie TA, Cummings CA, Romach EH et al. PPAR alpha, more than PPAR delta, Mediates the Hepatic and Skeletal Muscle Alterations Induced by the PPAR Agonist GW0742.Toxicol. Sci. 2008;105(2):384-94. DOI: 10.1093/toxsci/ kfn130
    Search in Google Scholar
  31. 31. Kim CS, Park HS, Kawada T, Kim J-H, Lim D, Hubbard NE et al. Circulating levels of MCP-1 and IL-8 are elevated in human obese subjects and associated with obesity related parameters. International Journal of Obesity. 2006;30(9):1347-55. DOI: 10.1038/ sj.ijo.080325910.1038/sj.ijo.0803259
    Search in Google Scholar
  32. 32. Pasceri V, Chang J, Willerson J, Yeh ETH. Modulation of C-Reactive Protein-Mediated Monocyte Chemoattractant Protein-1 Induction in Human Endothelial Cells by Anti Atherosclerosis Drugs. Circulation. 2001;103(21):2531-4. DOI: 10.1161/01.CIR.103.21.253110.1161/01.CIR.103.21.2531
    Search in Google Scholar
  33. 33. Dragomir E, Tircol M, Manduteanu I, Voinea M, Simionescu M. Aspirin and PPAR-alpha activators inhibit monocyte chemoattractant protein-1 expression induced by high glucose concentration in human endothelial cells. Vascul Pharmacol. 2006;44(6):440-9. DOI: 10.1016/j.vph.2006.02.00610.1016/j.vph.2006.02.006
    Search in Google Scholar
  34. 34. Christiansen T, Richelsen B and Bruun JM. Monocyte chemoattractant protein-1 is produced in isolated adi pocytes, associated with adiposity and reduced after weight loss in morbid obese subjects. International Journal of Obesity. 2005;29(1):146-50. DOI: 10.1038/ sj.ijo.080283910.1038/sj.ijo.0802839
    Search in Google Scholar
  35. 35. Fu J, Gaetani S, Oveisi F, Verme JL, Serrano A. Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-α. Nature. 2003;425(6953):90-3. DOI: 10.1038/nature0192110.1038/nature01921
    Search in Google Scholar
  36. 36. Vohl MC, Lepage P, Gaudet D, Brewer CG, Bétard C, Perron P et al. Molecular scanning of the human PPARa gene: association of the L162v mutation with hyperapobetalipoproteinemia.Lipid Res. 2000;41(6):945-52.10.1016/S0022-2275(20)32037-X
    Search in Google Scholar
  37. 37. Perreault M, Zulyniak MA, Badoud F, Stephenson S, Badawi A, Buchholz A et al. A distinct fatty acid profile underlies the reduced inflammatory state of metabolically healthy obese individuals. PLoSOne. 2014; 9(2):e88539. DOI: 10.1371/journal.pone.0088539. DOI: 10.1371/journal.pone.008853910.1371/journal.pone.0088539391977724520395
    Search in Google Scholar
  38. 38. Tsimihodimos V, Miltiadous G , Daskalopoulou SS, Mikhailidis DP, Elisaf MS. Fenofibrate: Metabolic and Pleiotropic Effects. Current Vascular Pharmacology, 2005; (1):87-98 DOI: 10.2174/157016105277394210.2174/157016105277394215638786
    Search in Google Scholar
  39. 39. Wilson J, Duan R, El-Marakby A, Alhashim A and Lee DL. Peroxisome Proliferator Activated Receptor-α Agonist Slows the Progression of Hypertension, Attenuates Plasma Interleukin-6 Levels and Renal Inflammatory Markers in Angiotensin II Infused Mice. PPAR Research.2012; DOI:10.1155/2012/645969. DOI: 10.1155/2012/64596910.1155/2012/645969340581822848208
    Search in Google Scholar
  40. 40. Han J. Hajjar DP, Febbraio M, Nicholson AC. Native and modified low density lipoproteins increase the functional expression of the macrophage class B scavenger receptor, CD36. J. Biol. Chem.1997;272(34):21654-9. DOI: 10.1074/jbc.272.34.2165410.1074/jbc.272.34.216549261189
    Search in Google Scholar
  41. 41. Gautam S, Banerjee M. The macrophage Ox- LDL receptor, CD36 and its association with type II diabetes mellitus. Molecular genetics and metabolism. 2011;10 (4):389-98. DOI: 10.1016/j. ymgme.2010.12.012
    Search in Google Scholar
DOI: https://doi.org/10.2478/rrlm-2014-0036 | Journal eISSN: 2284-5623 | Journal ISSN: 1841-6624
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Language: English
Page range: 427 - 438
Submitted on: Jun 15, 2014
Accepted on: Oct 3, 2014
Published on: Dec 30, 2014
Published by: Romanian Association of Laboratory Medicine
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year
Keywords:
PPARα,
metabolic syndrome,
leukocytes,
eosinophyls
Related subjects:
Life sciences,
Molecular biology,
Biochemistry,
Human biology,
Microbiology and virology

© 2014 Elena Popa, Florin Zugun-Eloae, Mihaela Zlei, Daniela Jitaru, Oana Maria Pintilie, Adorata Elena Coman, Maria Traian, Didona Anca Ungureanu, Eugen Carasevici, published by Romanian Association of Laboratory Medicine
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

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