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Specific Associations Between Clinical Signs, Immune Cells, Disease Genetic Background and Burden in a Group of Patients with B-Cell Chronic Lymphocytic Leukemia Cover

Specific Associations Between Clinical Signs, Immune Cells, Disease Genetic Background and Burden in a Group of Patients with B-Cell Chronic Lymphocytic Leukemia

Revista Romana de Medicina de Laborator
Volume 22 (2014): Issue 1 (March 2014)
By: Georgiana Emilia Grigore,  Iuliu C. Ivanov,  Mihaela Zlei,  Angela Dăscălescu,  Roxana Popescu,  Tudor Petreuș and  Eugen Carasevici  
Open Access
|Mar 2014

References

  1. 1. Grigore GE, Dascalescu A, Zlei M, Ivanov IC, Danaila C, Petreus T, et al. Rai stage-related changes within T/ NK cell populations from B-CLL patients. Rev Romana Med Lab. 2013;21(3):321-31. DOI: 10.2478/rrlm-2013-003210.2478/rrlm-2013-0032
    Search in Google Scholar
  2. 2. D’Arena G, Guariglia R, La Rocca F, Trino S, Condelli V, De Martino L, et al. Autoimmune Cytopenias in Chronic Lymphocytic Leukemia. Clin Dev Immunol. 2013:730131. DOI: 10.1155/2013/73013110.1155/2013/730131365213123690826
    Search in Google Scholar
  3. 3. Hallek M. State-of-the-art treatment of chronic lymphocytic leukemia. ASH Education Program Book. 2009;2009(1):440-9.10.1182/asheducation-2009.1.44020008230
    Search in Google Scholar
  4. 4. Perez-Andres M, Paiva B, Nieto WG, Caraux A, Schmitz A, Almeida J et al. Human peripheral blood B-cell compartments: A crossroad in B-cell traffic. Cytometry Part B: Clinical Cytometry. 2010;78(S1):S47-S60. DOI: 10.1002/cyto.b.2054710.1002/cyto.b.2054720839338
    Search in Google Scholar
  5. 5. Zenz T, Mertens D, Küppers R, Döhner H, Stilgenbauer S. From pathogenesis to treatment of chronic lymphocytic leukaemia. Nat Rev Cancer. 2010 Jan;10(1):37-50. DOI: 10.1038/nrc276410.1038/nrc276419956173
    Search in Google Scholar
  6. 6. Davids MS, Burger JA. Cell trafficking in chronic lymphocytic leukemia. Open J Hematol. 2012;3(S1).10.13055/ojhmt_3_S1_03.120221340459922844583
    Search in Google Scholar
  7. 7. Caligaris-Cappio F. Role of the microenvironment in chronic lymphocytic leukaemia. British journal of haematology. 2003;123(3):380-8. DOI: 10.1046/j.1365-2141.2003.04679.x10.1046/j.1365-2141.2003.04679.x14616995
    Search in Google Scholar
  8. 8. Ghia P, Strola G, Granziero L, Geuna M, Guida G, Sallusto F, et al. Chronic lymphocytic leukemia B cells are endowed with the capacity to attract CD4+, CD40L+ T cells by producing CCL22. European Journal of Immunology. 2002;32(5):1403-13. DOI: 10.1002/1521-4141(200205)32:5<1403::AID-IMMU1403> 3.0.CO;2-Y
    Search in Google Scholar
  9. 9. Fabris S, Scarciolla O, Morabito F, Cifarelli RA, Dininno C, Cutrona G, et al. Multiplex ligation-dependent probe amplification and fluorescence in situ hybridization to detect chromosomal abnormalities in Chronic lymphocytic leukemia: A comparative study. Genes, Chromosomes and Cancer. 2011;50(9):726-34. DOI: 10.1002/gcc.2089410.1002/gcc.2089421638517
    Search in Google Scholar
  10. 10. Deutsch AJA, Steinbauer E, Hofmann NA, Strunk D, Gerlza T, Beham-Schmid C, et al. Chemokine receptors in gastric MALT lymphoma: loss of CXCR4 and upregulation of CXCR7 is associated with progression to diffuse large B-cell lymphoma. Mod Pathol. 2013 Feb;26(2):182-94.10.1038/modpathol.2012.13422936065
    Search in Google Scholar
  11. 11. Han T, Abdel-Motal UM, Chang D-K, Sui J, Muvaffak A, Campbell J, et al. Human anti-CCR4 minibody gene transfer for the treatment of cutaneous t-cell lymphoma. PloS one. 2012;7(9):e44455. DOI: 10.1371/journal. pone.0044455
    Search in Google Scholar
  12. 12. Chang D-K, Sui J, Geng S, Muvaffak A, Bai M, Fuhlbrigge RC, et al. Humanization of an anti-CCR4 antibody that kills cutaneous T-cell lymphoma cells and abrogates suppression by T-regulatory cells. Molecular Cancer Therapeutics. 2012;11(11):2451-61. DOI: 10.1158/1535-7163.MCT-12-027810.1158/1535-7163.MCT-12-0278349603422869555
    Search in Google Scholar
  13. 13. Ishida T, Ishii T, Inagaki A, Yano H, Kusumoto S, Ri M, et al. The CCR4 as a novel-specific molecular target for immunotherapy in Hodgkin lymphoma. Leukemia. 2006;20(12):2162-8. DOI: 10.1038/sj.leu.240441510.1038/sj.leu.240441517039235
    Search in Google Scholar
  14. 14. Al-haidari Amr A., Syk I, Jirström K, Thorlacius H. CCR4 mediates CCL17 (TARC)-induced migration of human colon cancer cells via RhoA/Rho-kinase signaling. Int J Colorectal Dis. 2013 Nov 1;28(11):1479-87. DOI: 10.1007/s00384-013-1712-y10.1007/s00384-013-1712-y23649168
    Search in Google Scholar
  15. 15. Li J-Y, Ou Z-L, Yu S-J, Gu X-L, Yang C, Chen A-X et al. The chemokine receptor CCR4 promotes tumor growth and lung metastasis in breast cancer. Breast cancer research and treatment. 2012;131(3):837-48. DOI: 10.1007/s10549-011-1502-610.1007/s10549-011-1502-621479551
    Search in Google Scholar
  16. 16. Tsujikawa T, Yaguchi T, Ohmura G, Ohta S, Kobayashi A, Kawamura N, et al. Autocrine and paracrine loops between cancer cells and macrophages promote lymph node metastasis via CCR4/CCL22 in head and neck squamous cell carcinoma. Int J Cancer. 2013 Jun 15;132(12):2755-66. DOI: 10.1002/ijc.2796610.1002/ijc.2796623180648
    Search in Google Scholar
  17. 17. Mahadevan D, Choi J, Cooke L, Simons B, Riley C, Klinkhammer T, et al. Gene Expression and Serum Cytokine Profiling of Low Stage CLL Identify WNT/ PCP, Flt-3L/Flt-3 and CXCL9/CXCR3 as Regulators of Cell Proliferation, Survival and Migration. Hum Genomics Proteomics. 2009;2009:453634. DOI: 10.4061/2009/45363410.4061/2009/453634295862520981323
    Search in Google Scholar
  18. 18. Singh AK, Arya RK, Trivedi AK, Sanyal S, Baral R, Dormond O, et al. Chemokine receptor trio: CXCR3, CXCR4 and CXCR7 crosstalk via CXCL11 and CXCL12. Cytokine Growth Factor Rev. 2013 Feb;24(1):41-9. DOI: 10.1016/j.cytogfr.2012.08.00710.1016/j.cytogfr.2012.08.007417245422989616
    Search in Google Scholar
  19. 19. Mulligan AM, Raitman I, Feeley L, Pinnaduwage D, Nguyen LT, O’Malley FP, et al. Tumoral Lymphocytic Infiltration and Expression of the Chemokine CXCL10 in Breast Cancers from the Ontario Familial Breast Cancer Registry. Clinical Cancer Research. 2013;19(2):336-46. DOI: 10.1158/1078-0432.CCR-11-331410.1158/1078-0432.CCR-11-3314354893823213058
    Search in Google Scholar
  20. 20. Bürkle A, Niedermeier M, Schmitt-Gräff A, Wierda WG, Keating MJ, Burger JA. Overexpression of the CXCR5 chemokine receptor, and its ligand, CXCL13 in B-cell chronic lymphocytic leukemia. Blood. 2007;110(9):3316-25. DOI: 10.1182/ blood-2007-05-08940910.1182/blood-2007-05-08940917652619
    Search in Google Scholar
  21. 21. Okada T, Ngo VN, Ekland EH, Förster R, Lipp M, Littman DR, et al. Chemokine requirements for B cell entry to lymph nodes and Peyer’s patches. The Journal of experimental medicine. 2002;196(1):65-75. DOI: 10.1084/jem.2002020110.1084/jem.20020201219400912093871
    Search in Google Scholar
  22. 22. Malavasi F, Deaglio S, Damle R, Cutrona G, Ferrarini M, Chiorazzi N. CD38 and chronic lymphocytic leukemia: a decade later. Blood. 2011;118(13):3470-8. DOI: 10.1182/blood-2011-06-27561010.1182/blood-2011-06-275610357427521765022
    Search in Google Scholar
  23. 23. Nagira M, Imai T, Yoshida R, Takagi S, Iwasaki M, Baba M, et al. A lymphocyte-specific CC chemokine, secondary lymphoid tissue chemokine (SLC), is a highly efficient chemoattractant for B cells and activated T cells. European Journal of Immunology. 1998;28(5):1516-23. DOI: 10.1002/ (SICI)1521-4141(199805)28:05<1516::AID-IMMU1516> 3.0.CO;2-J10.1002/(SICI)1521-4141(199805)28:05<1516::AID-IMMU1516>3.0.CO;2-J
    Search in Google Scholar
  24. 24. Kunkel EJ, Butcher EC. Plasma-cell homing. Nature Reviews Immunology. 2003;3(10):822-9. DOI: 10.1038/nri120310.1038/nri1203
    Search in Google Scholar
  25. 25. Nannini PR, Borge M, Mikolaitis VC, Abreu C, Morande PE, Zanetti SR, et al. CCR4 expression in a case of cutaneous Richter’s transformation of chronic lymphocytic leukemia (CLL) to diffuse large B-cell lymphoma (DLBCL) and in CLL patients with no skin manifestations. European Journal of Haematology. 2011;87(1):80-6. DOI: 10.1111/j.1600-0609.2011.01613.x10.1111/j.1600-0609.2011.01613.x
    Search in Google Scholar
  26. 26. Kim CH, Rott L, Kunkel EJ, Genovese MC, Andrew DP, Wu L, et al. Rules of chemokine receptor association with T cell polarization in vivo. Journal of Clinical Investigation. 2001;108(9):1331-9. DOI: 10.1172/ JCI20011354310.1172/JCI13543
    Search in Google Scholar
  27. 27. Cózar JM, Canton J, Tallada M, Concha A, Cabrera T, Garrido F, et al. Analysis of NK cells and chemokine receptors in tumor infiltrating CD4 T lymphocytes in human renal carcinomas. Cancer Immunology, Immunotherapy. 2005;54(9):858-66. DOI: 10.1007/s00262-004-0646-110.1007/s00262-004-0646-1
    Search in Google Scholar
  28. 28. Svensson H, Olofsson V, Lundin S, Yakkala C, Björck S, Börjesson L, et al. Accumulation of CCR4+ CTLA-4hi FOXP3+ CD25hi regulatory T cells in colon adenocarcinomas correlate to reduced activation of conventional T cells. PloS one. 2012;7(2):e30695. DOI: 10.1371/journal.pone.003069510.1371/journal.pone.0030695
    Search in Google Scholar
  29. 29. Monserrat J, Ángel Sánchez M, de Paz R, Díaz D, Mur S, Reyes E, et al. Distinctive patterns of naïve/memory subset distribution and cytokine expression in CD4 T lymphocytes in ZAP-70 B-chronic lymphocytic patients. Cytometry Part B: Clinical Cytometry. 2013. DOI: 10.1002/cytob.2112010.1002/cytob.21120
    Search in Google Scholar
  30. 30. Ocana E, Delgado-Perez L, Campos-Caro A, Munoz J, Paz A, Franco R, et al. The prognostic role of CXCR3 expression by chronic lymphocytic leukemia B cells. Haematologica. 2007;92(3):349-56. DOI: 10.3324/haematol. 10649
    Search in Google Scholar
  31. 31. Jones D, Benjamin RJ, Shahsafaei A, Dorfman DM. The chemokine receptor CXCR3 is expressed in a subset of B-cell lymphomas and is a marker of B-cell chronic lymphocytic leukemia. Blood. 2000;95(2):627-32.10.1182/blood.V95.2.627
    Search in Google Scholar
  32. 32. Giuliani N, Bonomini S, Romagnani P, Lazzaretti M, Morandi F, Colla S, et al. CXCR3 and its binding chemokines in myeloma cells: expression of isoforms and potential relationships with myeloma cell proliferation and survival. Haematologica. 2006;91(11):1489-97.
    Search in Google Scholar
  33. 33. Trentin L, Agostini C, Facco M, Piazza F, Perin A, Siviero M, et al. The chemokine receptor CXCR3 is expressed on malignant B cells and mediates chemotaxis. Journal of Clinical Investigation. 1999;104(1):115-21. DOI: 10.1172/JCI733510.1172/JCI7335
    Search in Google Scholar
  34. 34. Wong S, Fulcher D. Chemokine receptor expression in B-cell lymphoproliferative disorders. Leukemia & lymphoma. 2004;45(12):2491-6. DOI: 10.1080/1042819041000172344910.1080/10428190410001723449
    Search in Google Scholar
  35. 35. Cambien B, Karimdjee B, Richard-Fiardo P, Bziouech H, Barthel R, Millet M, et al. Organ-specific inhibition of metastatic colon carcinoma by CXCR3 antagonism. British journal of cancer. 2009;100(11):1755-64. DOI: 10.1038/sj.bjc.660507810.1038/sj.bjc.6605078269568519436305
    Search in Google Scholar
  36. 36. Pradelli E, Karimdjee-Soilihi B, Michiels JF, Ricci JE, Millet MA, Vandenbos F, et al. Antagonism of chemokine receptor CXCR3 inhibits osteosarcoma metastasis to lungs. International Journal of Cancer. 2009;125(11):2586-94. DOI: 10.1002/ijc.2466510.1002/ijc.24665277214519544560
    Search in Google Scholar
  37. 37. López-Giral S, Quintana NE, Cabrerizo M, Alfonso- Pérez M, Sala-Valdés M, de Soria VGG, et al. Chemokine receptors that mediate B cell homing to secondary lymphoid tissues are highly expressed in B cell chronic lymphocytic leukemia and non-Hodgkin lymphomas with widespread nodular dissemination. Journal of leukocyte biology. 2004;76(2):462-71. DOI: 10.1189/jlb.120365210.1189/jlb.120365215155773
    Search in Google Scholar
  38. 38. Reif K, Ekland EH, Ohl L, Nakano H, Lipp M, Förster R, et al. Balanced responsiveness to chemoattractants from adjacent zones determines B-cell position. Nature. 2002;416(6876):94-9. DOI: 10.1038/416094a10.1038/416094a11882900
    Search in Google Scholar
  39. 39. Cha Z, Zang Y, Guo H, Rechlic JR, Olasnova LM, Gu H, et al. Association of peripheral CD4+ CXCR5+ T cells with chronic lymphocytic leukemia. Tumour Biol. 2013 Dec;34(6):3579-85. DOI: 10.1007/s13277-013-0937-210.1007/s13277-013-0937-223807677
    Search in Google Scholar
  40. 40. Bystry RS, Aluvihare V, Welch KA, Kallikourdis M, Betz AG. B cells and professional APCs recruit regulatory T cells via CCL4. Nature immunology. 2001;2(12):1126-32. DOI: 10.1038/ni73510.1038/ni73511702067
    Search in Google Scholar
  41. 41. Jadidi-Niaragh F, Yousefi M, Memarian A, Hojjat-Farsangi M, Khoshnoodi J, Razavi SM, et al. Increased Frequency of CD8+ and CD4+ Regulatory T Cells in Chronic Lymphocytic Leukemia: Association with Disease Progression. Cancer investigation. 2013;31(2):121-31. DOI: 10.3109/07357907.2012.75611010.3109/07357907.2012.75611023286587
    Search in Google Scholar
  42. 42. Scrivener S, Goddard R, Kaminski E, Prentice A. Abnormal T-cell function in B-cell chronic lymphocytic leukaemia. Leukemia & lymphoma. 2003;44(3):383-9. DOI: 10.1080/104281902100002999310.1080/104281902100002999312688308
    Search in Google Scholar
  43. 43. Damle RN, Temburni S, Calissano C, Yancopoulos S, Banapour T, Sison C, et al. CD38 expression labels an activated subset within chronic lymphocytic leukemia clones enriched in proliferating B cells. Blood. 2007;110(9):3352-9. DOI: 10.1182/ blood-2007-04-08383210.1182/blood-2007-04-083832220090817684154
    Search in Google Scholar
  44. 44. Zucchetto A, Benedetti D, Tripodo C, Bomben R, Dal Bo M, Marconi D, et al. CD38/CD31, the CCL3 and CCL4 chemokines, and CD49d/vascular cell adhesion molecule-1 are interchained by sequential events sustaining chronic lymphocytic leukemia cell survival. Cancer research. 2009;69(9):4001-9. DOI: 10.1158/0008-5472.CAN-08-417310.1158/0008-5472.CAN-08-417319383907
    Search in Google Scholar
  45. 45. Herishanu Y, Pérez-Galán P, Liu D, Biancotto A, Pittaluga S, Vire B, et al. The lymph node microenvironment promotes B-cell receptor signaling, NF-κB activation, and tumor proliferation in chronic lymphocytic leukemia. Blood. 2011;117(2):563-74. DOI: 10.1182/ blood-2010-05-28498410.1182/blood-2010-05-284984303148020940416
    Search in Google Scholar
  46. 46. Palamarchuk A, Efanov A, Nazaryan N, Santanam U, Alder H, Rassenti L, et al. 13q14 deletions in CLL involve cooperating tumor suppressors. Blood. 2010;115(19):3916-22. DOI: 10.1182/ blood-2009-10-24936710.1182/blood-2009-10-249367286956020071661
    Search in Google Scholar
  47. 47. Ouillette P, Collins R, Shakhan S, Li J, Li C, Shedden K, et al. The prognostic significance of various 13q14 deletions in chronic lymphocytic leukemia. Clinical Cancer Research. 2011;17(21):6778-90. DOI: 10.1158/1078-0432.CCR-11-078510.1158/1078-0432.CCR-11-0785320700121890456
    Search in Google Scholar
  48. 48. Del Giudice I, Rossi D, Chiaretti S, Marinelli M, Tavolaro S, Gabrielli S, et al. NOTCH1 mutations in+ 12 chronic lymphocytic leukemia (CLL) confer an unfavorable prognosis, induce a distinctive transcriptional profiling and refine the intermediate prognosis of+ 12 CLL. Haematologica. 2012;97(3):437-41. DOI: 10.3324/haematol.2011.060129 10.3324/haematol.2011.060129329160022207691
    Search in Google Scholar
DOI: https://doi.org/10.2478/rrlm-2014-0004 | Journal eISSN: 2284-5623 | Journal ISSN: 1841-6624
Journal RSS Feed
Language: English
Page range: 79 - 92
Published on: Mar 25, 2014
Published by: Romanian Association of Laboratory Medicine
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year
Keywords:
B-CLL,
genetic lesions,
microenvironment
Related subjects:
Life sciences,
Molecular biology,
Biochemistry,
Human biology,
Microbiology and virology

© 2014 Georgiana Emilia Grigore, Iuliu C. Ivanov, Mihaela Zlei, Angela Dăscălescu, Roxana Popescu, Tudor Petreuș, Eugen Carasevici, published by Romanian Association of Laboratory Medicine
This work is licensed under the Creative Commons License.

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