A case of sporadic Creutzfeldt – Jakob disease and discussion on diagnostic biomarkers

Corina Roman-Filip; Aurelian Ungureanu; Dan Filip; Eugen Radu; Ioan-Sorin Zaharie

doi:10.2478/rrlm-2013-0001

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A case of sporadic Creutzfeldt – Jakob disease and discussion on diagnostic biomarkers

Revista Romana de Medicina de Laborator

Volume 21 (2013): Issue 2 (June 2013)

By: Corina Roman-Filip, Aurelian Ungureanu, Dan Filip, Eugen Radu and Ioan-Sorin Zaharie

Open Access

|Jun 2013

Abstract

Creutzfeldt - Jakob disease (CJD) is a rare neurodegenerative disease caused by prions, characterized by a progressive dementia with rapid onset, psychiatric and neurologic symptoms (myoclonus, cerebellar, pyramidal, extrapyramidal and visual signs), with an invariable course to exitus. There are three general forms: sporadic or spontaneous, genetic or familial, and acquired form, including a variant form of CJD. The diagnosis can be confirmed only by histological examination of brain tissue, showing non-inflammatory spongiform changes and neuronal loss. We present the case of a 64 years old male who was admitted in our department for a rapidly progressive cognitive decline, hallucinations and myoclonus. Autopsy brain histology confirmed the diagnosis showing incipient spongiform vacuolization and astrogliosis. This paper illustrates a very rapid course of a sporadic CJD with discussion upon literature regarding the laboratory and pathology biomarkers of diagnosis.

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Articles in this issue

DOI: https://doi.org/10.2478/rrlm-2013-0001 | Journal eISSN: 2284-5623 | Journal ISSN: 1841-6624

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Language: English

Page range: 225 - 230

Published on: Jun 21, 2013

Published by: Romanian Association of Laboratory Medicine

In partnership with: Paradigm Publishing Services

Publication frequency: 4 issues per year

Keywords:

Creutzfeldt - Jakob disease,

prions,

Related subjects:

Microbiology and virology

© 2013 Corina Roman-Filip, Aurelian Ungureanu, Dan Filip, Eugen Radu, Ioan-Sorin Zaharie, published by Romanian Association of Laboratory Medicine
This work is licensed under the Creative Commons License.

Volume 21 (2013): Issue 2 (June 2013)