Have a personal or library account? Click to login
NUT carcinoma in head and neck region: Case report with literature review Cover

NUT carcinoma in head and neck region: Case report with literature review

Romanian Journal of Rhinology
Volume 13 (2023): Issue 51 (July 2023)
By: Dipti Patil,  Pradipta Patil,  Jaydeep Pol,  Girish Kadkol and  Madhura Phadke  
Open Access
|Jul 2023

References

  1. Zhou L, Yong X, Zhou J, Xu J, Wang C. Clinicopathological analysis of five cases of NUT midline carcinoma, including one with the gingiva. BioMed Res Int. 2020;2020:9791208. DOI: 10.1155/2020/9791208.
    Search in Google ScholarBack to article
  2. Agaimy A, Fonseca I, Martins C, Thway K, Barrette R, Harrington KJ, et al. NUT carcinoma of the salivary glands. Clinicopathologic and molecular analysis of three cases and a survey of NUT expression in salivary gland carcinomas. American J Surg Pathol. 2018;42(7):877-84. DOI: 10.1097/PAS.0000000000001046.
    Search in Google ScholarBack to article
  3. Chau NG, Ma C, Danga K, Al-Sayegh H, Nardi V, Barrette R, et al. An anatomical site and genetic-based prognostic model for patients with nuclear protein in testis (NUT) midline carcinoma: analysis of 124 patients. JNCI Cancer Spectr. 2019;4(2):pkz094. DOI: 10.1093/jncics/pkz094.
    Search in Google ScholarBack to article
  4. Mills AF, Lanfranchi M, Wein RO, Mukand-Cerro I, Pilichowska M, Cowan J, et al. NUT midline carcinoma: a case report with a novel translocation and review of the literature. Head Neck Pathol. 2014;8(2):182-6. DOI: 10.1007/ s12105-013-0479-3.
    Search in Google ScholarBack to article
  5. Liu S, Ferzli G. NUT carcinoma: a rare and devastating neoplasm. BMJ Case Reports. 2018;2018:bcr-2018. DOI: 10.1136/bcr-2018-226526.
    Search in Google ScholarBack to article
  6. Hsieh MS, French CA, Liang CW, Hsiao CH. NUT midline carcinoma: case report and review of the literature. Int J SurgPathol. 2011;19(6):808-12. DOI: 10.1177/1066896909353600.
    Search in Google ScholarBack to article
  7. Shiota H, Barral S, Buchou T, Tan M, Coute Y, Charbonnier G, et al. NUT directs p300-dependent, genome-wide H4 hyperacetylation in male germ cells. Cell Rep. 2018;24(13):3477-87.e6. DOI: 10.1016/j.celrep.2018.08.069.
    Search in Google ScholarBack to article
  8. Napolitano M, Venturelli M, Molinaro E, Toss A. NUT midline carcinoma of the head and neck: current perspectives. Onco Targets Ther. 2019;12:3235-44. DOI: 10.2147/OTT.S173056.
    Search in Google ScholarBack to article
  9. French CA, Rahman S, Walsh EM, Kuhnle S, Grayson AR, Lemieux ME, et al. NSD3-NUT fusion oncoprotein in NUT midline carcinoma: implications for a novel oncogenic mechanism. Cancer Discov. 2014;4(8):928-41. DOI: 10.1158/2159-8209.CD-14-0014.
    Search in Google ScholarBack to article
  10. French CA, Ramirez CL, Kolmakova J, Hickman TT, Cameron MJ, Thyne ME, et al. BRD-NUT oncoproteins: a family of closely related nuclear proteins that block epithelial differentiation and maintain the growth of carcinoma cells. Oncogene. 2008;27(15):2237-42. DOI: 10.1038/sj.onc.1210852.
    Search in Google ScholarBack to article
  11. Alekseyenko AA, Walsh EM, Zee BM, Pakozdi T, Hsi P, Lemieux ME, et al. Ectopic protein interactions within BRD4-chromatin complexes drive oncogenic megadomain formation in NUT midline carcinoma. Proc Natl Acad Sci U S A. 2017;114(21):E4184-92. DOI: 10.1073/pnas.1702086114.
    Search in Google ScholarBack to article
  12. Lee JK, Louzada S, An Y, Kim SY, Kim S, Youk J, et al. Complex chromosomal rearrangements by single catastrophic pathogenesis in NUT midline carcinoma. Ann Oncol. 2017;28(4):890-7. DOI: 10.1093/annonc/mdw686.
    Search in Google ScholarBack to article
  13. Wang S, Li J, Tong W, Li H, Feng Q, Teng B. Advances in the pathogenesis and treatment of nut carcinoma: a narrative review. Transl Cancer Res. 2020;9(10):6505-15. DOI: 10.21037/tcr-20-1884.
    Search in Google ScholarBack to article
  14. Grayson AR, Walsh EM, Cameron MJ, Godec J, Ashworth T, Ambrose JM, et al. MYC, a downstream target of BRD-NUT, is necessary and sufficient for the blockade of differentiation in NUT midline carcinoma. Oncogene. 2014;33(13):1736-42. DOI: 10.1038/onc.2013.126.
    Search in Google ScholarBack to article
  15. Giridhar P, Mallick S, Kashyap L, Rath GK. Patterns of care and impact of prognostic factors in the outcome of NUT midline carcinoma: a systematic review and individual patient data analysis of 119 cases. Eur Arch Otorhinolaryngol. 2018;275(3):815-21. DOI: 10.1107/s00405-018-4882-y.
    Search in Google ScholarBack to article
  16. do Amparo Veloso Magalhães M, Carvalho Batista NJ, and Grivicich I. Nut mid-line carcinoma: a case report. International Journal of Development Research. 2016;06(10):9719-21.
    Search in Google ScholarBack to article
  17. Wei X, Teng X, Zhang Y, Cheng M, Chen G. Case report: NUT carcinoma in an elderly woman with unique morphology and immunophenotype highlights a diagnostic pitfall. Transl Cancer Res. 2022;11(6):1850-60. DOI: 10.21037/tcr-22-364.
    Search in Google ScholarBack to article
  18. Kakkar A, Antony VM, Irugu DVK, Adhikari N, Jain D. NUT midline carcinoma: a series of five cases, including one with unusual clinical course. Head Neck Pathol. 2018;12(2):230-6. DOI: 10.1007/s12105-017-0858-2.
    Search in Google ScholarBack to article
  19. Minato H, Kobayashi E, Nakada S, Kurose N, Tanaka M, Tanaka Y, et al. Sinonasal NUT carcinoma: clinicopathological and cytogenetic analysis with autopsy findings. Hum Pathol. 2018;71:157-65. DOI: 10.1016/j.humpath.2017.10.011.
    Search in Google ScholarBack to article
  20. Lee T, Cho J, Baek CH, Son YI, Jeong HS, Chung MK, et al. Prevalence of NUT carcinoma in head and neck: Analysis of 362 cases with literature review. Head Neck. 2020;42(5):924-38. DOI: 10.1002/hed.26067.
    Search in Google ScholarBack to article
  21. Vakani PN, Maheshwari J, Maheshwari M, Shah B. Sinonasal NUT midline carcinoma: A new histological entity. Indian J Pathol Microbiol. 2020;63(1):103-5. DOI: 10.4103/IJPM.IJPM_373_19.
    Search in Google ScholarBack to article
  22. Saik WN, Da Forno P, Thway K, Khurram SA. NUT carcinoma arising from the parotid gland: a case report and review of the literature. Head Neck Pathol. 2021;15(3):1064-8. DOI: 10.1007/s12105-020-01254-9.
    Search in Google ScholarBack to article
  23. Patil VM, Toshniwal A, Noronha V, Joshi A, Menon N, Banavali S, et al. NUT midline carcinoma. Clin Oncol (R Coll Radiol). 2019;31(10):732. DOI: 10.1016/j.clon.2019.06.012.
    Search in Google ScholarBack to article
  24. Rajan A. A hard nut to crack: Case report on nut midline carcinoma-a rare sino-nasal malignancy. JMSCR. 2020;8(5):342-5. DOI: 10.18535/jmscr/v8i5.63.
    Search in Google ScholarBack to article
  25. Aryakrishna SL, Kumar R, Rafi M, Mathews A. Nut midline carcinoma-nasal cavity-A case report. JMSCR. 2020;8(6):437-40. DOI: 10.18535/jmscr/v8i6.83.
    Search in Google ScholarBack to article
  26. Patel SA, Singer B, Shen C, Zanation AM, Yarbrough WG, Weiss J. A case of metastatic NUT carcinoma with prolonged response on gemcitabine and nabpaclitaxel. Clin Case Rep. 2021;9:e04616. DOI: 10.1002/ccr3.4616.
    Search in Google ScholarBack to article
  27. Elkhatib SK, Neilsen BK, Sleightholm RL, Baine MJ, Zhen W. A 47-year-old woman with nuclear protein in testis midline carcinoma masquerading as a sinus infection: a case report and review of the literature. J Med Case Reports. 2019;13(1):57. DOI: 10.1186/s13256-019-2015-x.
    Search in Google ScholarBack to article
  28. Albrecht T, Harms A, Roessler S, Goeppert B. NUT carcinoma in a nutshell: A diagnosis to be considered more frequently. Pathol Res Pract. 2019;215(6):152347. DOI: 10.1016/j.prp.2019.01.043.
    Search in Google ScholarBack to article
  29. Klijanienko J, Le Tourneau C, Rodriguez J, Caly M, theocharis S. Cytological features of NUT midline carcinoma arising in sino-nasal tract and parotid gland: Report of two new cases and review of the literature. Diagn Cytopathol. 2016;44(9):753-6. DOI: 10.1002/dc.23506.
    Search in Google ScholarBack to article
  30. Arimizu K, Hirano G, Makiyama C, Matsuo M, Sasaguri T, Makiyama A. NUT carcinoma of the nasal cavity that responded to a chemotherapy regimen for Ewing’s sarcoma family of tumors: a case report. BMC Cancer. 2018;18:1134. DOI: 10.1186/s12885-018-5087-x.
    Search in Google ScholarBack to article
  31. Seim NB, Philips RHW, Schoenfield L, Teknos TN, Rocco JW, Agrawal A, et al. NUT midline carcinoma of the sublingual gland: Clinical presentation and review. Head Neck Pathol. 2017;11(4):460-8. DOI: 10.1007/s12105-017-0809-y.
    Search in Google ScholarBack to article
  32. Oliveira LJC, Gongora ABL, Latancia MT, Barbosa FG, Gregorio JVAM, Testagrossa LA, et al. The first report of molecular characterized BRD4-NUT carcinoma in Brazil: a case report. J Med Case Rep. 2019;13:279. DOI: 10.1186/ s13256-019-2213-6.
    Search in Google ScholarBack to article
  33. D’Souza JN, Notz G, Bogdasarian RN, Cognetti DM, Curry JM, Rosen MR, et al. Orbital involvement by NUT midline carcinoma. Ophthalmic Plast Reconstr Surg. 2015;31(6):e147-50. DOI: 10.1097/IOP.0000000000000179.
    Search in Google ScholarBack to article
  34. Ding T, Wang Y, Zhao T, Xu Z, Gao W, Cui Z, et al. NUT midline carcinoma in the right orbit: a case report. Cancer Biol Ther. 2019;20(8):1091-6. DOI: 10.1080/15384047.2019.1598761.
    Search in Google ScholarBack to article
  35. Maher OM, Christensen AM, Yedururi S, Bell D, Tarek N. Histone deacetylase inhibitor for NUT midline carcinoma. Pediatr Blood Cancer. 2015;62(4):715-7. DOI: 10.1002/pbc.25350.
    Search in Google ScholarBack to article
  36. Storck S, Kennedy AL, Marcus KJ, Teot L, Vaughn J, Gnekow AK, et al. Pediatric NUT-midline carcinoma: Therapeutic success employing a sarcoma based multimodal approach. Pediatr Hematol Oncol. 2017;34(4):231-7. DOI: 10.1080/08880018.2017.1363839.
    Search in Google ScholarBack to article
  37. Andreasen S, French CA, Josiassen M, Hahn CH, Kiss K. NUT carcinoma of the sublingual gland. Head Neck Pathol. 2016;10(3):362-6. DOI: 10.1007/s12105-015-0672-7.
    Search in Google ScholarBack to article
  38. Mertens F, Wiebe T, Adlercreutz C, Mandahl N, French CA. Successful treatment of a child with t(15;19)-positive tumor. Pediatr Blood Cancer. 2007;49(7):1015-7. DOI: 10.1102/pbc.20755.
    Search in Google ScholarBack to article
DOI: https://doi.org/10.2478/rjr-2023-0020 | Journal eISSN: 2393-3356 | Journal ISSN: 2069-6523
Journal RSS Feed
Language: English
Page range: 129 - 139
Submitted on: Mar 28, 2023
Accepted on: Jun 23, 2023
Published on: Jul 26, 2023
Published by: Romanian Rhinologic Society
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year
Keywords:
NUT,
midline,
carcinoma,
squamous,
head and neck
Related subjects:
Medicine,
Clinical medicine,
Clinical medicine, other,
Surgery,
Surgery, other,
Otorhinolaryngology,
Speech, voice and paediatric hearing disorders,
Oromaxillofacial surgery

© 2023 Dipti Patil, Pradipta Patil, Jaydeep Pol, Girish Kadkol, Madhura Phadke, published by Romanian Rhinologic Society
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Previous articleVolume 13 (2023): Issue 51 (July 2023)Next article