Assessment of Interleukin-33 Levels in Patients with Familial Mediterranean Fever

Figures & Tables

	Healthy Controls n=29	Colchicine responsive FMF n=28	Colchicine resistant FMF n=26	p1	p2	p3
Leukocyte, mm³	6340 [2680]	7840 [2400]	7670 [2287]	0.11	0.18	0.97
Neutrophil, mm³	3730 [1830]	4290 [2022]	4435 [2602]	0.20	0.14	0.67
Lymphocyte, mm³	2220 [925]	2230 [752]	2010 [970]	0.40	0.16	0.03
Hemoglobin, g/dL	14.1 ± 1.8	13.5 ± 2.0	13.4 ± 2.1	0.29	0.24	0.87
Thrombocyte, x10³/μL	255 [75]	275 [99]	276 [114]	0.17	0.38	0.84
Creatinine, mg/dL	0.75 [0.23]	0.68 [0.25]	0.82 [4.42]	0.05	0.20	0.02
Albumin, g/dL	4.61 ± 0.32	4.62 ± 0.29	4.29 ± 0.52	0.89	0.008	0.006
ESR, mm/h	14 [8.50]	13 [11.25]	22 [26.75]	0.57	0.002	0.001
CRP, mg/L	3.40 [2.75]	2.90 [3.35]	16 [30.48]	0.18	<0.001	<0.001
IL-33, ng/L	221 [179]	287 [495]	257 [219]	0.006	0.74	0.09

	Colchicine responsive FMF n=28	Colchicine resistant FMF n=26	P
Age, mean ± SD, years	33.3 ± 11.4	35.4 ± 7.6	0.44
Sex, female, n (%)	20 (71%)	9 (35%)	0.007
Age at disease onset, years	21 [12]	21.5 [15.25]	0.71
Duration of disease, years	9 [7]	15 [9]	0.005
Fever, n (%)	16 (57%)	19 (73%)	0.22
Abdominal pain, n (%)	20 (71%)	23 (88%)	0.12
Chest pain, n (%)	14 (50%)	13 (50%)	1.00
Arthritis, n (%)	18 (64%)	19 (73%)	0.48
Skin rash, n (%)	6 (21%)	7 (26%)	0.63
Myalgia, n (%)	10 (35%)	14 (53%)	0.18
Disease severity, ISSF Mild Moderate Severe	23 (82%) 5 (18%) 0 (0%)	2 (8%) 19 (73%) 5 (19%)	<0.001
Colchicine dose, mg/day	1 [0.5]	1.5 [1]	0.22

	n1	n2	Z	p (2-tailed)	Holm p	r (95% CI)
Control vs. Responsive	29	28	−2.754	0.006	0.018	0.365 (0.115–0.571)
Control vs. Resistant	29	26	−0.329	0.742	0.742	0.044 (−0.224–0.306)
Responsive vs. Resistant	28	26	−1.688	0.091	0.182	0.230 (−0.041–0.469)