Association between baseline demographic and colorectal carcinoma
| Variables | Colorectal cancer, n(%) | P | OR (CI 95%) | |
|---|---|---|---|---|
| Yes | No | |||
| Gender | ||||
| Male | 38 (63,3) | 28 (46,7) | 0.067 | 1,97 (0,95–4,1) |
| Female | 22 (36,7) | 32 (53,3) | ||
| Age | ||||
| > 55 years old | 37 (61.7) | 21 (35) | 0.003* | 3 (1.42–6.28) |
| < 55 years old | 23 (38.3) | 39 (65) | ||
| Ethnicity | ||||
| Batak | 39 (65) | 35 (58.3) | 0.453 | 1.33 (0.63–2.78) |
| Other | 21 (35) | 25 (41.7) | ||
| Smoking history | ||||
| Moderate + Severe | 24 (40) | 19 (31.7) | 0.341 | 1.44 (0.68–3.05) |
| No + Mild | 36 (60) | 41 (68.3) | ||
| Alcohol history | ||||
| Moderate + Severe | 16 (26.7) | 7 (11.7) | 0.037* | 2.75 (1.04–7.29) |
| No + Mild | 44 (73.3) | 53 (88.3) | ||
Location and Histological Differentiation of CRC
| Variables | n = 60 |
|---|---|
| Location | |
| Proximal colon | 16 (26.7%) |
| Distal colon | 18 (30%) |
| Rectum | 26 (43.3%) |
| Histological differentiation | |
| Well-differentiated | 17 (28.3%) |
| Moderate differentiated | 16 (26.7%) |
| Poor differentiated | 27 (45%) |
Multivariate analysis of factors associated with colorectal cancer
| Variable | B | P | OR (CI 95%) |
|---|---|---|---|
| Age | 1.249 | 0.002* | 3.487 (1.13–5.66) |
| Moderate-severe alcohol consumption | 1.240 | 0.018* | 3,420 (1.07–4.92) |
| CTLA-4 -658C>T allele C polymorphism | |||
| Constant | 1.144 | 0.039* | 2,310 (1.04–4.62) |
| −6.347 |
Baseline Characteristics
| Variables | n = 120 |
|---|---|
| Gender | |
| Male | 66 (55%) |
| Female | 54 (45%) |
| Age (years) | 54.78 ± 9.83 |
| Ethnic | |
| Batak | 74 (61.7%) |
| Others | 46 (38.3%) |
| Smoking history | |
| Moderate to Severe | 43 (35.8%) |
| No to mild | 77 (64.2%) |
| Alcohol consumption | |
| Moderate to Severe | 23 (19.2%) |
| No to mild | 97 (80.8%) |
| CTLA-4 -658T>C polymorphism, n (%) | |
| CC | 16 (13.3%) |
| CT | 15 (12.5%) |
| TT | 89 (74.2%) |
The association between CTLA-4 -658C>T polymorphism and colorectal carcinoma
| CTLA-4-658C>T Polymorphism | Colorectal Cancer | p | OR (CI 95%) | |
|---|---|---|---|---|
| Yes n (%) | No n (%) | |||
| CC | 10 (16.7) | 6 (10) | 0.060 | NA |
| CT | 11 (18.3) | 4 (6.7) | ||
| TT | 39 (65) | 50 (83.3) | ||
| CC+CT | 21 (35) | 10 (16.7) | 0.022* | 2.69 (1.14–6.37) |
| TT | 39 (65) | 50 (83.3) | ||
| CC | 10 (16.7) | 6 (10) | 0.283 | 1.8 (0.61–5.32) |
| CT+TT | 50 (83.3) | 54 (90) | ||
| C Allele | 31 (25.8) | 16 (13.3) | 0.015* | 2.26 (1.16 – 4.41) |
| T Allele | 89 (74.2) | 104 (86.7) | ||