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Association of body composition parameters with aortic elastic properties in newly diagnosed type 2 diabetics Cover

Association of body composition parameters with aortic elastic properties in newly diagnosed type 2 diabetics

Romanian Journal of Internal Medicine
Volume 63 (2025): Issue 3 (September 2025)
By: Turgut Karabag,  Işil Isel,  Sena Hekimoglu Ustabas,  Şebnem Javadova,  Özgür Can Usta,  Onurcan Turk,  Ahmet Oz and  M Sait Altintas  
Open Access
|May 2025

Figures & Tables

Comparison of conventional echo parameters, diastolic and systolic functions, aortic elastic properties in newly diagnosed type 2 DM patients and control groups

Group 1 (n=273)Group 2 (n=139)p
EF (%)62.7 ±2.568.6 ± 1.8<0.001
LVESD (cm)2.58 ±0.432.42 ±0.32<0.001
LVEDD (cm)4.59 ±0.424.51 ±0.380,068
IVS (cm)1.11 ±0.190.85 ±0.14<0.001
PW (cm)1.10 ±0.470.86 ±0.13<0.001
Aortic root diameter (cm)2.70 ±0.332.45 ±0.30<0.001
Left atrium diameter (cm)3.51 ±0.383.12 ±0.38<0.001
Mitral E (m/sec)0.65 ±0.150.72 ±0.17<0.001
Mitral A (m/sec)0.78 ±0.150.668 ±0.16<0.001
Mitral EDT (ms)234.7 ±59.6186.9 ±37.7<0.001
E/A0.87 ±0.291.38 ±0.20<0.001
E/E’ lateral7.63 ±2.546.47 ±1.74<0.001
E/E’ septal10.40 ±2.838.33 ±1.82<0.001
Aortic strain (%)6.53±3.9814.8±6.02<0.001
Aortic stiffness index1.15±0.930.39±0.19<0.001
Aortic distensibility (cm2/dyn1/103)2.61±1.876.56±3.24<0.001

Linear regression analysis to determine the relation between aortic elastic properties with body composition parameters

Table Multivariate Linear Regression Analysis for Aortic Elasticity Parameters
BStandard ErrorBeta
VariablesDependent variable Aortic stiffnesstP
TPI0.0730.0110.7456.802<0.001
Waist to Hip ratio−24.8549.764−1.882−2.5450.012
BRI−0.1740.083−0.432−2.1050.037
WC (cm)0.2810.0994.1512.8310.005
HC (cm)−0.2550.089−3.177−2.8740.005
Dependent variable Aortic strain
TPI−0.4580.83−0.649−5.537<0.001
VAI−0.7990.418−0.152−1.9110.058
BRI3.1411.6721.0751.8780.062
BAI−0.7250.355−0.796−2.0420.043
WC (cm)−0.5070.232−1.034−2.1830.031
HC (cm)−0.5070.1720.8732.9450.004
Dependent variable Aortic distensibility
TPI−0.2430.042−0.666−5.743<0.001
Waist to Hip ratio74.46940.4981.5071.8390.068
BRI2.2560.9651.4952.3370.021
BAI−0.4990.201−1.061−2.4870.014
WC (cm)−1.0620.462−4.191−2.2970.023
HC (cm)0.9680.4033.2222.4020.018

Comparison of demographic, laboratory and body composition parameters between the groups

Group 1 (n=273)Group 2 (n=139)p
Age (year)50.6 ± 10.244.1 ± 8.6<0.001
Gender (F, n-%)144 – 52.790 – 64.70.020
Obesity (n-%)153 – 562 – 1.4<0.001
Smoking (n-%)99 – 36.362 – 44.60.101
BMI (kg/m2)30.9 ±5.6235.6 ± 2.9<0.001
WC (cm)107.2 ±11.589.1 ±11.3<0.001
HC (cm)109.9 ±11.099.7 ± 7.2<0.001
Waist to Height ratio0.65±0.080.53±0.06<0.001
Waist to Hip ratio0.97±0.060.89±0.08<0.001
TPI18.8±3.914.2±2.0<0.001
VAI4.14±8.351.43±0.85<0.001
BSI0.08±0.050.08±0.020.368
BRI6.74±2.014.12±1.35<0.001
BAI (%)40.3±9.328.5±4.5<0.001
CMI3.86±8.901.01±0.64<0.001
SBP (mm/Hg)138.7 ±19.5120.8 ±15.3<0.001
DBP (mm/Hg)84.2 ±12.573.8 ±12.1<0.001
Heart Rate (/dk)84.9 ±12.878.5±8.5<0.001
Glucose (mg/dL)184.9 ± 79.390.8 ± 7.1<0.001
Urea (mg/dL)27.7 ±8.126.9 ± 8.20.427
Creatinine (mg/dL)0.72 ±0.160.72 ±0.140.837
AST (U/L)21.8 ±13.118.5 ±8.30.025
ALT (U/L)30.2 ±26.817.2 ±11.5<0.001
Total Cholesterol (mg/dL)211.7 ± 58.7194.3 ±37.60.090
HDL (mg/dL)45.2 ±13.956.8 ±13.5<0.001
LDL (mg/dL)127.9 ±40.5117.8 ±33.20.0360
Triglyceride (mg/dL)201.3 ±149.097.5±41.1<0.001
HbA1c (%)8.78 ±2.355.39 ±0.29<0.001
Insulin (mU/L)12.9 ± 8.38.1 ± 4.40.004
Homa-IR5.37 ± 3.721.85 ±1.06<0.001
CRP (mg/L)6.84±6.952.10±2.57<0.001
WBC ( 109 /L)8.05 ±2.326.80 ±1.970.011

Spearman correlation of aortic elastic properties with body composition and glycemic parameters

ASRhoPASIRhoPADRhoP
BMI (kg/m2)−0.365<0.001 0.317<0.001 −0.383<0.001
WC−0.375<0.001 0.320<0.001 −0.390<0.001
HC−0.265<0.001 0.214<0.001 −0.269<0.001
WtHeightR−0.366<0.001 0.316<0.001 −0.384<0.001
WtHipR−0.352<0.001 0.316<0.001 −0.366<0.001
TPI−0.490<0.001 0.456<0.001 −0.516<0.001
VAI−0.383<0.001 0.334<0.001 −0.366<0.001
BSI−0.0100.978 −0.110<0.001 −0.005<0.001
BRI−0.366<0.001 0.318<0.001 −0.385<0.001
BAI−0.361<0.001 0.317<0.001 −0.345<0.001
CMI−0.441<0.001 0.392<0.001 −0.432<0.001
HbA1c (%)−0.471<0.001 0.442<0.001 −0.481<0.001
Glucose−0.474<0.001 0.437<0.001 −0.476<0.001

Binary regression analysis in order to eliminate potential bias in regard to demographic characteristics between the groups

UnivariateMultivariate
OR95% CIP valueOR95% CIP value
Age1.0391.016 – 1.0620.0010.8180.640 – 1.0460.109
Gender, female0.6080.399 – 0.9260.021
Aortic stiffness index1.7291.501 – 1.979<0.0011.8841.295 – 2.7410.001
Aortic strain0.9660.959 – 0.972<0.001
Aortic distensibility0.9310.917 – 0.945<0.001
SBP1.0641.048 – 1.081<0.001
DBP1.0721.051 – 1.093<0.001
WC1.1581.125 – 1.192<0.001
HC1.1361.101 – 1.172<0.001
BMI1.4781.363 – 1.601<0.0011.7521.215 – 2.5260.003
Waist to Height ratio8.9055.695 – 13.923<0.001
Waist to Hip ratio5.0053.434 – 7.293<0.001
VAI3.2482.411 – 4.376<0.001
BRI2.6482.162 – 3.244<0.001
BAI1.3031.191 – 1.425<0.001
DOI: https://doi.org/10.2478/rjim-2025-0010 | Journal eISSN: 2501-062X | Journal ISSN: 1220-4749
Journal RSS Feed
Language: English
Page range: 232 - 241
Submitted on: Feb 3, 2025
|
Published on: May 22, 2025
Published by: N.G. Lupu Internal Medicine Foundation
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year
Keywords:
Type 2 diabetes,
aortic elastic properties,
tri-ponderal mass index
Related subjects:
Medicine,
Clinical medicine,
Internal medicine,
Internal medicine, other,
Cardiology,
Gastroenterology,
Rheumatology

© 2025 Turgut Karabag, Işil Isel, Sena Hekimoglu Ustabas, Şebnem Javadova, Özgür Can Usta, Onurcan Turk, Ahmet Oz, M Sait Altintas, published by N.G. Lupu Internal Medicine Foundation
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

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