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Association of body composition parameters with aortic elastic properties in newly diagnosed type 2 diabetics Cover

Association of body composition parameters with aortic elastic properties in newly diagnosed type 2 diabetics

Romanian Journal of Internal Medicine
Volume 63 (2025): Issue 3 (September 2025)
By: ,  ,  ,  ,  ,  ,   and    
Open Access
|May 2025
Figures & tables

Figures & Tables

Table 1

Comparison of demographic, laboratory and body composition parameters between the groups

Group 1 (n=273)Group 2 (n=139)p
Age (year)50.6 ± 10.244.1 ± 8.6<0.001
Gender (F, n-%)144 – 52.790 – 64.70.020
Obesity (n-%)153 – 562 – 1.4<0.001
Smoking (n-%)99 – 36.362 – 44.60.101
BMI (kg/m2)30.9 ±5.6235.6 ± 2.9<0.001
WC (cm)107.2 ±11.589.1 ±11.3<0.001
HC (cm)109.9 ±11.099.7 ± 7.2<0.001
Waist to Height ratio0.65±0.080.53±0.06<0.001
Waist to Hip ratio0.97±0.060.89±0.08<0.001
TPI18.8±3.914.2±2.0<0.001
VAI4.14±8.351.43±0.85<0.001
BSI0.08±0.050.08±0.020.368
BRI6.74±2.014.12±1.35<0.001
BAI (%)40.3±9.328.5±4.5<0.001
CMI3.86±8.901.01±0.64<0.001
SBP (mm/Hg)138.7 ±19.5120.8 ±15.3<0.001
DBP (mm/Hg)84.2 ±12.573.8 ±12.1<0.001
Heart Rate (/dk)84.9 ±12.878.5±8.5<0.001
Glucose (mg/dL)184.9 ± 79.390.8 ± 7.1<0.001
Urea (mg/dL)27.7 ±8.126.9 ± 8.20.427
Creatinine (mg/dL)0.72 ±0.160.72 ±0.140.837
AST (U/L)21.8 ±13.118.5 ±8.30.025
ALT (U/L)30.2 ±26.817.2 ±11.5<0.001
Total Cholesterol (mg/dL)211.7 ± 58.7194.3 ±37.60.090
HDL (mg/dL)45.2 ±13.956.8 ±13.5<0.001
LDL (mg/dL)127.9 ±40.5117.8 ±33.20.0360
Triglyceride (mg/dL)201.3 ±149.097.5±41.1<0.001
HbA1c (%)8.78 ±2.355.39 ±0.29<0.001
Insulin (mU/L)12.9 ± 8.38.1 ± 4.40.004
Homa-IR5.37 ± 3.721.85 ±1.06<0.001
CRP (mg/L)6.84±6.952.10±2.57<0.001
WBC ( 109 /L)8.05 ±2.326.80 ±1.970.011

[i] Abbrevations: BMI: Body mass index, WC: Waist circumference, HC: Hip circumference, TPI: Tri ponderal index, VAI: Visceral adiposity index, BSI: Body shape index, BRI: Body roundness index, BAI: Body adiposity index, CMI: Cardiometabolic index, SBP: Systolic blood pressure, DBP: Diastolic blood pressure, AST: Aspartate Transaminase, ALT: Alanine Transaminase, LDL: Low Density Lipoprotein, HDL: High Density Lipoprotein, HbA1c: Glycated Hemoglobin, CRP: C-Reactive Protein, , Homa-IR: Homeostatic Model Assessment-Insulin Resistance, WBC: White Blood Cell,

Table 2

Comparison of conventional echo parameters, diastolic and systolic functions, aortic elastic properties in newly diagnosed type 2 DM patients and control groups

Group 1 (n=273)Group 2 (n=139)p
EF (%)62.7 ±2.568.6 ± 1.8<0.001
LVESD (cm)2.58 ±0.432.42 ±0.32<0.001
LVEDD (cm)4.59 ±0.424.51 ±0.380,068
IVS (cm)1.11 ±0.190.85 ±0.14<0.001
PW (cm)1.10 ±0.470.86 ±0.13<0.001
Aortic root diameter (cm)2.70 ±0.332.45 ±0.30<0.001
Left atrium diameter (cm)3.51 ±0.383.12 ±0.38<0.001
Mitral E (m/sec)0.65 ±0.150.72 ±0.17<0.001
Mitral A (m/sec)0.78 ±0.150.668 ±0.16<0.001
Mitral EDT (ms)234.7 ±59.6186.9 ±37.7<0.001
E/A0.87 ±0.291.38 ±0.20<0.001
E/E’ lateral7.63 ±2.546.47 ±1.74<0.001
E/E’ septal10.40 ±2.838.33 ±1.82<0.001
Aortic strain (%)6.53±3.9814.8±6.02<0.001
Aortic stiffness index1.15±0.930.39±0.19<0.001
Aortic distensibility (cm2/dyn1/103)2.61±1.876.56±3.24<0.001

[i] EF: Ejection Fraction, LVESD: Left Ventricular End Systolic Diameter, LVEDD: Left Ventricular End Diastolic Diameter, IVS: Interventicular Septum, PW: Posterior Wall, EDT: E Wave Deceleration Time, E’: Early Diastolic Forward Flow Velocity

Table 3

Spearman correlation of aortic elastic properties with body composition and glycemic parameters

ASRhoPASIRhoPADRhoP
BMI (kg/m2)−0.365<0.0010.317<0.001−0.383<0.001
WC−0.375<0.0010.320<0.001−0.390<0.001
HC−0.265<0.0010.214<0.001−0.269<0.001
WtHeightR−0.366<0.0010.316<0.001−0.384<0.001
WtHipR−0.352<0.0010.316<0.001−0.366<0.001
TPI−0.490<0.0010.456<0.001−0.516<0.001
VAI−0.383<0.0010.334<0.001−0.366<0.001
BSI−0.0100.978−0.110<0.001−0.005<0.001
BRI−0.366<0.0010.318<0.001−0.385<0.001
BAI−0.361<0.0010.317<0.001−0.345<0.001
CMI−0.441<0.0010.392<0.001−0.432<0.001
HbA1c (%)−0.471<0.0010.442<0.001−0.481<0.001
Glucose−0.474<0.0010.437<0.001−0.476<0.001

[i] Abbrevations: BMI: Body mass index, WC: Waist circumference, HC: Hip circumference, TPI: Tri ponderal index, VAI: Visceral adiposity index, BSI: Body shape index, BRI: Body roundness index, BAI: Body adiposity index, CMI: Cardiometabolic index

Table 4

Binary regression analysis in order to eliminate potential bias in regard to demographic characteristics between the groups

UnivariateMultivariate
OR95% CIP valueOR95% CIP value
Age1.0391.016 – 1.0620.0010.8180.640 – 1.0460.109
Gender, female0.6080.399 – 0.9260.021
Aortic stiffness index1.7291.501 – 1.979<0.0011.8841.295 – 2.7410.001
Aortic strain0.9660.959 – 0.972<0.001
Aortic distensibility0.9310.917 – 0.945<0.001
SBP1.0641.048 – 1.081<0.001
DBP1.0721.051 – 1.093<0.001
WC1.1581.125 – 1.192<0.001
HC1.1361.101 – 1.172<0.001
BMI1.4781.363 – 1.601<0.0011.7521.215 – 2.5260.003
Waist to Height ratio8.9055.695 – 13.923<0.001
Waist to Hip ratio5.0053.434 – 7.293<0.001
VAI3.2482.411 – 4.376<0.001
BRI2.6482.162 – 3.244<0.001
BAI1.3031.191 – 1.425<0.001

[i] Abbrevations: SBP: Systolic blood pressure, DBP: Diastolic blood pressure, BMI: Body mass index, WC: Waist circumference, HC: Hip circumference, TPI: Tri ponderal index, VAI: Visceral adiposity index, BSI: Body shape index, BRI: Body roundness index, BAI: Body adiposity index, CMI: Cardiometabolic index

Table 5

Linear regression analysis to determine the relation between aortic elastic properties with body composition parameters

Table Multivariate Linear Regression Analysis for Aortic Elasticity Parameters
BStandard ErrorBeta
VariablesDependent variableAortic stiffnesstP
TPI0.0730.0110.7456.802<0.001
Waist to Hip ratio−24.8549.764−1.882−2.5450.012
BRI−0.1740.083−0.432−2.1050.037
WC (cm)0.2810.0994.1512.8310.005
HC (cm)−0.2550.089−3.177−2.8740.005
Dependent variableAortic strain
TPI−0.4580.83−0.649−5.537<0.001
VAI−0.7990.418−0.152−1.9110.058
BRI3.1411.6721.0751.8780.062
BAI−0.7250.355−0.796−2.0420.043
WC (cm)−0.5070.232−1.034−2.1830.031
HC (cm)−0.5070.1720.8732.9450.004
Dependent variableAortic distensibility
TPI−0.2430.042−0.666−5.743<0.001
Waist to Hip ratio74.46940.4981.5071.8390.068
BRI2.2560.9651.4952.3370.021
BAI−0.4990.201−1.061−2.4870.014
WC (cm)−1.0620.462−4.191−2.2970.023
HC (cm)0.9680.4033.2222.4020.018

[i] Abbrevations: BMI: Body mass index, WC: Waist circumference, HC: Hip circumference, TPI: Tri ponderal index, VAI: Visceral adiposity index, BSI: Body shape index, BRI: Body roundness index, BAI: Body adiposity index, CMI: Cardiometabolic index

DOI: https://doi.org/10.2478/rjim-2025-0010 | Journal eISSN: 2501-062X (formerly 1220-4749) | Journal ISSN: 1220-4749
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Language: English, Romanian
Page range: 232 - 241
Submitted on: Feb 3, 2025
Published on: May 22, 2025
Published by: N.G. Lupu Internal Medicine Foundation
In partnership with: Paradigm Publishing Services
Keywords:
Type 2 diabetes,
aortic elastic properties,
tri-ponderal mass index
Related subjects:
Medicine,
Clinical medicine,
Internal medicine,
Internal medicine, other,
Cardiology,
Gastroenterology,
Rheumatology

© 2025 Turgut Karabag, Işil Isel, Sena Hekimoglu Ustabas, Şebnem Javadova, Özgür Can Usta, Onurcan Turk, Ahmet Oz, M Sait Altintas, published by N.G. Lupu Internal Medicine Foundation
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Volume 63 (2025): Issue 3 (September 2025)
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