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The platelet to lymphocyte ratio in heart failure: a comprehensive review Cover

The platelet to lymphocyte ratio in heart failure: a comprehensive review

Open Access
|May 2023

References

  1. PONIKOWSKI, P., VOORS, A.A., ANKER, S.D., BUENO, H., CLELAND, J.G.F.F., COATS, A.J.S.S., et al. 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. Eur. Heart J. 2016;37(27).
  2. REINA-COUTO, M., PEREIRA-TERRA, P., QUELHAS-SANTOS, J., SILVA-PEREIRA, C., ALBINO-TEIXEIRA, A., SOUSA, T. Inflammation in Human Heart Failure: Major Mediators and Therapeutic Targets. Front. Physiol. 2021;12(October).
  3. MURPHY, S.P., KAKKAR, R., MCCARTHY, C.P., JANUZZI, J.L. Inflammation in Heart Failure: JACC State-of-the-Art Review. J. Am. Coll. Cardiol. 2020;75(11):1324–1340.
  4. DELCEA, C., BUZEA, C.A., DAN, G.A. The Neutrophil to Lymphocyte Ratio in Heart Failure: A Comprehensive Review. Rom. J. Intern. Med. 2019;57(4):296–314.
  5. CHUNG, I., LIP, G.Y.H. Platelets and heart failure. Eur. Heart J. 2006;27(22):2623–2631.
  6. AUKRUST, P., UELAND, T., MÜLLER, F., ANDREASSEN, A.K., NORDØY, I., AAS, H., et al. Elevated circulating levels of C-C chemokines in patients with congestive heart failure. Circulation 1998;97(12):1136–1143.
  7. RONDINA, M.T., WEYRICH, A.S., ZIMMERMAN, G.A. Platelets as cellular effectors of inflammation in vascular diseases. Circ. Res. 2013;112(11):1506–19.
  8. DETOPOULOU, P., NOMIKOS, T., FRAGOPOULOU, E., CHRYSOHOOU, C., ANTONOPOULOU, S. Platelet activating factor in heart failure: Potential role in disease progression and novel target for therapy. Curr. Heart Fail. Rep. 2013;10(2):122–129.
  9. SEREBRUANYA, V.L., MCKENZIE, M.E., MEISTERA, A.F., FUZAYLOV, S.Y., GURBEL, P.A., ATAR, D., et al. Whole blood impedance aggregometry for the assessment of platelet function in patients with congestive heart failure (EPCOT trial). Eur. J. Heart Fail. 2002;4(4):461–467.
  10. SEREBRUANY, V.L., MURUGESAN, S.R., POTHULA, A., ATAR, D., LOWRY, D.R., O’CONNOR, C.M., et al. Increased soluble platelet/endothelial cellular adhesion molecule-1 and osteonectin levels in patients with severe congestive heart failure. Independence of disease etiology, and antecedent aspirin therapy. Eur. J. Heart Fail. 1999;1(3):243–249.
  11. ERNE, P., WARDLE, J., SANDERS, J., LEWIS, S.M., MASERI, A. Mean platelet volume and size distribution and their sensitivity to agonists in patients with coronary artery disease and congestive heart failure. Thromb. Haemost. 1988;59(2):259–263.
  12. GURBEL, P.A., GATTIS, W.A., FUZAYLOV, S.F., GAULDEN, L., HASSELBLAD, V., SEREBRUANY, V.L., et al. Evaluation of platelets in heart failure: Is platelet activity related to etiology, functional class, or clinical outcomes?. Am. Heart J. 2002;143(6):1068–1075.
  13. O’CONNOR, C.M., GURBEL, P.A., SEREBRUANY, V.L. Usefulness of soluble and surface-bound P-selectin in detecting heightened platelet activity in patients with congestive heart failure. Am. J. Cardiol. 1999;83(9):1345–1349.
  14. JAFRI, S.M., OZAWA, T., MAMMEN, E., LEVINE, T.B., JOHNSON, C., GOLDSTEIN, S. Platelet function, thrombin and fibrinolytic activity in patients with heart failure. Eur. Heart J. 1993;14(2):205–12.
  15. TOUYZ, R.M., SCHIFFRIN, E.L. Effects of angiotensin II and endothelin-1 on platelet aggregation and cytosolic pH and free Ca2+ concentrations in essential hypertension. Hypertension 1993;22(6):853–62.
  16. VADUGANATHAN, M., GREENE, S.J., BUTLER, J., SABBAH, H.N., SHANTSILA, E., LIP, G.Y.H., et al. The immunological axis in heart failure: Importance of the leukocyte differential. Heart Fail. Rev. 2013;18(6):835–845.
  17. A, C., V, B., A, N., A, C., P, T.-B. Administration to Mouse of Endotoxin From Gram-Negative Bacteria Leads to Activation and Apoptosis of T Lymphocytes. Eur. J. Immunol. 1998;28(2).
  18. HUEHNERGARTH, K. V, MOZAFFARIAN, D., SULLIVAN, M.D., CRANE, B.A., WILKINSON, C.W., LAWLER, R.L., et al. Usefulness of Relative Lymphocyte Count as an Independent Predictor of Death / Urgent Transplant in Heart Failure 2005;95:10–13.
  19. MAISEL, A.S., KNOWLTON, K.U., FOWLER, P., REARDEN, A., ZIEGLER, M.G., MOTULSKY, H.J., et al. Adrenergic control of circulating lymphocyte subpopulations. Effects of congestive heart failure, dynamic exercise, and terbutaline treatment. J. Clin. Invest. 1990;85(2):462–7.
  20. THOMSON, S.P., MCMAHON, L.J., NUGENT, C.A. Endogenous cortisol: A regulator of the number of lymphocytes in peripheral blood. Clin. Immunol. Immunopathol. 1980;17(4):506–514.
  21. HURDLE, A.D., GYDE, O.H., WILLOUGHBY, J.M. Occurrence of lymphopenia in heart failure. J. Clin. Pathol. 1966;19(1):60–64.
  22. BALTA, S., OZTURK, C. The platelet-lymphocyte ratio: A simple, inexpensive and rapid prognostic marker for cardiovascular events. Platelets 2015;26(7):680–681.
  23. DURMUS, E., KIVRAK, T., GERIN, F., SUNBUL, M., SARI, I., ERDOGAN, O. Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio are Predictors of Heart Failure. Arq. Bras. Cardiol. 2015;(June 2012):606–613.
  24. YE, G., CHEN, Q., CHEN, X., LIU, Y., YIN, T., MENG, Q., et al. The prognostic role of platelet-to-lymphocyte ratio in patients with acute heart failure: A cohort study. Sci. Rep. 2019;9(1):1–8.
  25. DELCEA, C., BUZEA, C.A., VIJAN, A., DRAGHICI, A., STOICHITOIU, L.E., DAN, G.A., et al. Comparative role of hematological indices for the assessment of in-hospital outcome of heart failure patients. Scand. Cardiovasc. J. 2021;55(4).
  26. ARFSTEN, H., CHO, A., PRAUSMÜLLER, S., SPINKA, G., NOVAK, J., GOLIASCH, G., et al. Inflammation-Based Scores as a Common Tool for Prognostic Assessment in Heart Failure or Cancer. Front. Cardiovasc. Med. 2021;8(October):1–10.
  27. DAHLEN, B., SCHULZ, A., GÖBEL, S., TRÖBS, S.O., SCHWUCHOW-THONKE, S., SPRONK, H.M., et al. The impact of platelet indices on clinical outcome in heart failure: results from the MyoVasc study. ESC Hear. Fail. 2021;8(4):2991–3001.
  28. TAMAKI, S., NAGAI, Y., SHUTTA, R., MASUDA, D. Combination of Neutrophil-to-Lymphocyte and Platelet-to- Lymphocyte Ratios as a Novel Predictor of Cardiac Death in Patients With Acute Decompensated Heart Failure With Preserved Left Ventricular Ejection Fraction: A Multicenter Study. J. Am. Heart Assoc. 2023;12(1):e026326.
  29. UÇAR, F.M., AÇAR, B., GUL, M., ÖZEKE, Ö., AYDOGDU, S. The association between platelet/lymphocyte ratio and coronary artery disease severity in asymptomatic low ejection fraction patients. Korean Circ. J. 2016;46(6):821–826.
  30. SUN, X.P., LI, J., ZHU, W.W., LI, D.B., CHEN, H., LI, H.W., et al. Impact of Platelet-to-Lymphocyte Ratio on Clinical Outcomes in Patients with ST-Segment Elevation Myocardial Infarction. Angiology 2016;68(4):346–353.
  31. INTAN, R.E., ALKAFF, F.F., OKTAVIONO, Y.H., NUGRAHA, R.A., OCTORA, T.N., JONATAN, M., et al. Retrospective Study of the Association Between Platelet-to-Lymphocyte Ratio in Patients with Acute Coronary Syndrome on Admission to a Rural Referral Center in East Java, Indonesia, and the Incidence of New Symptomatic Heart Failure at 6 Months. Med. Sci. Monit. 2022;28:1–9.
  32. POURAFKARI, L., WANG, C.K., TAJLIL, A., AFSHAR, A.H., SCHWARTZ, M., NADER, N.D. Platelet-lymphocyte ratio in prediction of outcome of acute heart failure. Biomark. Med. 2018;12(1):63–70.
  33. TURCATO, G., SANCHIS-GOMAR, F., CERVELLIN, G., ZORZI, E., SIVERO, V., SALVAGNO, G.L., et al. Evaluation of neutrophil-lymphocyte and platelet-lymphocyte ratios as predictors of 30-day mortality in patients hospitalized for an episode of acute decompensated heart failure. J. Med. Biochem. 2019;38(4):452–460.
  34. TABAN SADEGHI, M., ESGANDARIAN, I., NOURI-VASKEH, M., GOLMOHAMMADI, A., RAHVAR, N., TEIMOURIZAD, A. Role of circulatory leukocyte based indices in short-term mortality of patients with heart failure with reduced ejection fraction. Med. Pharm. Reports 2020;93(4):351–356.
  35. YAO, C., WANG, L., SHI, F., CHEN, R., LI, B., LIU, W., et al. Optimized combination of circulating biomarkers as predictors of prognosis in AECOPD patients complicated with heart failure. Int. J. Med. Sci. 2021;18(7):1592–1599.
  36. HEIDARPOUR, M., BASHIRI, S., VAKHSHOORI, M., HESHMAT-GHAHDARIJANI, K., KHANIZADEH, F., FERDOWSIAN, S., et al. The association between platelet-to-lymphocyte ratio with mortality among patients suffering from acute decompensated heart failure. BMC Cardiovasc. Disord. 2021;21(1):454.
  37. HUANG, W.M., CHENG, H.M., HUANG, C.J., GUO, C.Y., LU, D.Y., LEE, C.W., et al. Hemographic indices are associated with mortality in acute heart failure /692/4019/592/75/74 /692/4019/592/75/230 article. Sci. Rep. 2017;7(1):1–9.
  38. DEMIR, M., DUYULER, P.T., GURAY, U., CELIK, M.C. Platelet to Lymphocyte Ratio on Admission and Prognosis in Patients with Acute Cardiogenic Pulmonary Edema. J. Emerg. Med. 2018;55(4):465–471.
  39. SIEDLECKI, Ł., SZYGUŁA-JURKIEWICZ, B., SZCZUREK, W., PYKA, Ł., NIEDZIELA, J., GĄSIOR, M. Mortality risk factors in patients with advanced heart failure and diabetes mellitus. Kardiol. Pol. 2019;77(6):604–609.
  40. BALCI, K.G., BALCI, M.M., SEN, F., CANPOLAT, U., AKBOGA, M.K., UNAL, S., et al. The role of baseline indirect inflammatory markers in prediction of response to cardiac resynchronisation therapy. Kardiol. Pol. 2016;74(2):119–126.
  41. BAZOUKIS, G., SAPLAOURAS, A., LETSAS, K.P., YEUNG, C., XYDONAS, S., KARAMICHALAKIS, N., et al. The association of hematological indices with the response to cardiac resynchronization therapy: A single-center study. Hippokratia 2019;23(3):118–125.
  42. BALCI, K.G., BALCI, M.M., ARSLAN, U., AÇAR, B., MADEN, O., SELCUK, H., et al. Increased platelet-to-lymphocyte ratios and low relative lymphocyte counts predict appropriate shocks in heart failure patients with ICDs. Acta Cardiol. Sin. 2016;32(5):542–549.
  43. SEROPIAN, I.M., ROMEO, F.J., PIZARRO, R., VULCANO, N.O., POSATINI, R.A., MARENCHINO, R.G., et al. Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio as predictors of survival after heart transplantation. ESC Hear. Fail. 2018;5(1):149–156.
DOI: https://doi.org/10.2478/rjim-2023-0006 | Journal eISSN: 2501-062X | Journal ISSN: 1220-4749
Language: English
Page range: 84 - 97
Submitted on: Feb 7, 2023
Published on: May 8, 2023
Published by: N.G. Lupu Internal Medicine Foundation
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2023 Caterina Delcea, Cătălin Adrian Buzea, Ancuța Elena Vîjan, Elisabeta Bădilă, Gheorghe-Andrei Dan, published by N.G. Lupu Internal Medicine Foundation
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.