Have a personal or library account? Click to login
N-acetylcysteine efficacy in patients hospitalized with COVID-19 pneumonia: a systematic review and meta-analysis Cover

N-acetylcysteine efficacy in patients hospitalized with COVID-19 pneumonia: a systematic review and meta-analysis

Open Access
|Mar 2023

References

  1. 1.ALIBERTI S, BRAMBILLA AM, CHALMERS JD, CILLONIZ C, RAMIREZ J, BIGNAMINI A, PRINA E, POLVERINO E, TARSIA P, PESCI A, TORRES A, BLASI F, COSENTINI R. Phenotyping community-acquired pneumonia according to the presence of acute respiratory failure and severe sepsis. Respir Res. 2014 Mar 4;15(1):27.10.1186/1465-9921-15-27401514824593040
  2. 2. SIEMIENIUK RA, BARTOSZKO JJ, ZERAATKAR D, KUM E, QASIM A, MARTINEZ JPD, IZCOVICH A, LAMONTAGNE F, HAN MA, AGARWAL A, AGORITSAS T, AZAB M, BRAVO G, CHU DK, COUBAN R, DEVJI T, ESCAMILLA Z, FOROUTAN F, GAO Y, GE L, GHADIMI M, HEELS-ANSDELL D, HONARMAND K, HOU L, IBRAHIM Q, KHAMIS A, LAM B, MANSILLA C, LOEB M, MIROSHNYCHENKO A, MARCUCCI M, MCLEOD SL, MOTAGHI S, MURTHY S, MUSTAFA RA, PARDO-HERNANDEZ H, RADA G, RIZWAN Y, SAADAT P, SWITZER C, THABANE L, TOMLINSON G, VANDVIK PO, VERNOOIJ RW, VITERI-GARCÍA A, WANG Y, YAO L, ZHAO Y, GUYATT GH, BRIGNARDELLO-PETERSEN R. Drug treatments for COVID-19: living systematic review and network meta-analysis. BMJ. 2020 Jul 30;370:m2980.10.1136/bmj.m2980739091232732190
  3. 3. ASSIMAKOPOULOS SF, MARANGOS M. N-acetyl-cysteine may prevent COVID-19-associated cytokine storm and acute respiratory distress syndrome. Med Hypotheses. 2020;140:109778.10.1016/j.mehy.2020.109778719502832344315
  4. 4. du PREEZ HN, ALDOUS C, KRUGER HG, JOHNSON L. N-Acetylcysteine and Other Sulfur-Donors as a Preventative and Adjunct Therapy for COVID-19. Adv Pharmacol Pharm Sci. 2022;2022:4555490.10.1155/2022/4555490938528535992575
  5. 5. WAN X, WANG W, LIU J, TONG T. Estimating the sample mean and standard deviation from the sample size, median, range and/or interquartile range. BMC Med Res Methodol. 2014;14:135.10.1186/1471-2288-14-135438320225524443
  6. 6. AVDEEV SN, GAYNITDINOVA VV, MERZHOEVA ZM, BERIKKHANOV ZG. N-acetylcysteine for the treatment of COVID-19 among hospitalized patients. J Infect. 2022;84(1):94–118.10.1016/j.jinf.2021.07.003827103134252497
  7. 7. GAYNITDINOVA V.V., AVDEEV S.N., MERZHOEVA Z.M., BERIKKHANOV Z.G., MEDVEDEVA I.V., GORBACHEVA T.L. N-acetylcysteine as a part of complex treatment of moderate COVID-associated pneumonia. PULMONOLOGIYA. 2021;31(1):21–29.10.18093/0869-0189-2021-31-1-21-29
  8. 8. MOUSAPOUR P, HAMIDI FARAHANI R, MOSAED R, ASGARI A, HAZRATI E. Efficacy and safety of acetylcysteine for the prevention of liver injury in COVID-19 intensive care unit patients under treatment with remdesivir. Gastroenterol Hepatol Bed Bench. 2022;15(3):241–248.
  9. 9. TAHER A, LASHGARI M, SEDIGHI L, RAHIMI-BASHAR F, POOROLAJAL J, MEHRPOOYA M. A pilot study on intravenous N-Acetylcysteine treatment in patients with mild-to-moderate COVID19-associated acute respiratory distress syndrome. Pharmacol Rep. 2021;73(6):1650–165910.1007/s43440-021-00296-2819171234114174
  10. 10. de ALENCAR JCG, MOREIRA CL, MÜLLER AD, et al. Double-blind, Randomized, Placebo-controlled Trial With N-acetylcysteine for Treatment of Severe Acute Respiratory Syndrome Caused by Coronavirus Disease 2019 (COVID-19). Clin Infect Dis. 2021;72(11):e736–e741.
  11. 11. IZQUIERDO JL, SORIANO JB, GONZÁLEZ Y, et al. Use of N-Acetylcysteine at high doses as an oral treatment for patients hospitalized with COVID-19. Sci Prog. 2022;105(1):368504221074574.10.1177/00368504221074574879575535084258
  12. 12. ASSIMAKOPOULOS SF, ARETHA D, KOMNINOS D, et al. N-acetyl-cysteine reduces the risk for mechanical ventilation and mortality in patients with COVID-19 pneumonia: a two-center retrospective cohort study. Infect Dis (Lond). 2021;53(11):847–854.10.1080/23744235.2021.194567534182881
  13. 13. FAVERIO P, REBORA P, ROSSI E, et al. Impact of N-acetyl-l-cysteine on SARS-CoV-2
  14. 14. KHOONSARI M, ZAMANI F, KARBALAIE NIYA M H, HEMMASI G, AJDARKOSH H, et al. Liver Enzymes and Inpatient Deaths in COVID-19 Hospitalized Patients. Hepat Mon. 2020;20(11):e109076.10.5812/hepatmon.109076
  15. 15. CARRILLO HERNANDEZ-RUBIO J, SANCHEZ-CARPINTERO ABAD M, YORDI LEON A, et al. Outcomes of an intermediate respiratory care unit in the COVID-19 pandemic. PLoS One. 2020;15(12):e0243968.10.1371/journal.pone.0243968774398533326484
  16. 16. TSERMPINI EE, GLAMOČLIJA U, ULUCAN-KARNAK F, REDENŠEK TRAMPUŽ S, DOLŽAN V. Molecular Mechanisms Related to Responses to Oxidative Stress and Antioxidative Therapies in COVID-19: A Systematic Review. Antioxidants (Basel). 2022;11(8):1609.10.3390/antiox11081609940544436009328
  17. 17. du PREEZ HN, ALDOUS C, KRUGER HG, JOHNSON L. N-Acetylcysteine and Other Sulfur-Donors as a Preventative and Adjunct Therapy for COVID-19. Adv Pharmacol Pharm Sci. 2022;2022:4555490.10.1155/2022/4555490938528535992575
  18. 18. JIANG C, ZOU J, LV Q, YANG Y. Systematic review and meta-analysis of the efficacy of N-acetylcysteine in the treatment of acute exacerbation of chronic obstructive pulmonary disease. Ann Palliat Med. 2021;10(6):6564–6576.10.21037/apm-21-113834237968
  19. 19. POOLE P, SATHANANTHAN K, FORTESCUE R. Mucolytic agents versus placebo for chronic bronchitis or chronic obstructive pulmonary disease. Cochrane Database Syst Rev. 2019;5(5):CD001287.10.1002/14651858.CD001287.pub6652742631107966
DOI: https://doi.org/10.2478/rjim-2023-0001 | Journal eISSN: 2501-062X | Journal ISSN: 1220-4749
Language: English
Page range: 41 - 52
Submitted on: Dec 12, 2022
Published on: Mar 16, 2023
Published by: N.G. Lupu Internal Medicine Foundation
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2023 Themistoklis Paraskevas, Anastasios Kantanis, Iosif Karalis, Christos Michailides, Vasileios Karamouzos, Ioanna Koniari, Charalampos Pierrakos, Dimitrios Velissaris, published by N.G. Lupu Internal Medicine Foundation
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.