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Non-alcoholic fatty pancreas disease – practices for clinicians Cover

Non-alcoholic fatty pancreas disease – practices for clinicians

Open Access
|Sep 2019

References

  1. 1. ALEMPIJEVIC T., DRAGASEVIC S., ZEC S., POPOVIC D., MILOSAVLJEVIC T. Non-alcoholic fatty pancreas disease. Postgrad Med J 2017; 93(1098):226-230.10.1136/postgradmedj-2016-13454628069746
  2. 2. SMITS M.M., VAN GEENEN E.J.M. The clinical significance of pancreatic steatosis. Nat Rev Gastroenterol Hepatol 2011; 8(3): 169-177.10.1038/nrgastro.2011.421304475
  3. 3. ROMANA B.S., CHELA H., DAILEY F.E., NASSIR F., TAHAN V. Non-alcoholic fatty pancreas disease (NAFPD). A silent spectator or the fifth component of metabolic syndrome? A literature review. Endocrine Metab Immune Disord – Drug Targets 2018; 18(6): 547-554.10.2174/187153031866618032811130229595117
  4. 4. OU H.-Y., WANG C.-Y., YANG Y.-C., CHEN M.-F., CHANG C.-J. The association between nonalcoholic fatty pancreas disease and diabetes. PloSOne 2013; 8(5): e62561.10.1371/journal.pone.0062561364396223671610
  5. 5. OGILVIE R.F. The islands of langerhans in 19 cases of obesity. J. Pathol. Bacteriol. 1993; 37(3): 473-481.10.1002/path.1700370314
  6. 6. WANG C., OU H., CHEN M., CHANG T., CHANG C. Enigmatic ectopic fat: prevalence of nonalcoholic fatty pancreas disease and its associated factors in a Chinese population. J AmHeart Assoc 2014: 3(1): e000297.10.1161/JAHA.113.000297395970924572250
  7. 7. LESMANA C.R.A., PAKASI L.S., INGGRIANI S., AIDAWATI M.L., LESMANA L.A. Prevalence of non-alcoholic fatty pancreas disease (nafpd) and its risk factors among adult medical check-up patients in a private hospital: a large cross sectional study. BMCGastroenterol. 2015; 15: 174.10.1186/s12876-015-0404-1
  8. 8. ZHOU J., LI M.L., ZHANG D.D., LIN H.Y., DAI X.H., SUN X.L. et al. The correlation between pancreatic steatosis and metabolic syndrome in a Chinese population. Pancreatology 2016; 16(4): 578-83.10.1016/j.pan.2016.03.00827050733
  9. 9. UYGUN A, KADAYIFCI A, DEMIRCI H, SAGLAM M, SAKIN YS, OZTURK K et al. The effect of fatty pancreas on serum glucose parameters in patients with nonalcoholic steatohepatitis. Eur. J. Intern. Med 2015; 26(1): 37-41.10.1016/j.ejim.2014.11.007
  10. 10. AL-HADDAD M, KHASHAB M, ZYROMSKI N, PUNGPAPONG S, WALLACE MB, SCOLAPIO J et al. Risk factors for hyperechogenic pancreas on endoscopic ultrasound: a case-control study. Pancreas 2009; 36(6): 672-5.10.1097/MPA.0b013e3181a9d5af19506531
  11. 11. SCHWENZER NF, MACHANN J, MARTIROSIAN P, STEFAN N, SCHRAML C, FRITSCHE A et al. Quantification of pancreatic lipomatosis and liver steatosis by MRI: Comparison of in/opposed-phase and spectral-spatial excitation techniques. Invest. Radiol. 2008; 43(5): 330-337.10.1097/RLI.0b013e31816a88c6
  12. 12. HENI M, MACHANN J, STAIGER H, SCHWENZER NF, PETER A, SCHICK F et al. Pancreatic fat is negatively associated with insulin secretion in individuals with impaired fasting glucose and/or impaired glucose tolerance: a nuclear magnetic resonance study. Diabetes. Metab. Res. Rev. 2010; 26(3) 200-205.10.1002/dmrr.107320225188
  13. 13. GABORIT B, ABDESSELAM I, KOBER F, JACQUIER A, RONSIN O, EMUNGANIA O, et al. Ectopic fat storage in the pancreas using 1H-MRS: importance of diabetic status and modulation with bariatric surgery-induced weight loss. Int. J. Obes. 2015; 39(3): 480-487.10.1038/ijo.2014.126
  14. 14. VAN GEENEN E.-J.M., SMITS M. M., SCHREUDER T. C.M.A., VAN DER PEET D.L., BLOEMENA E., MULDER C.J.J. Nonalcoholic fatty liver disease is related to nonalcoholic fatty pancreas disease. Pancreas 2010; 39(8): 1185-1190.10.1097/MPA.0b013e3181f6fce220871475
  15. 15. PACIFICO L, DI MARTINO M, ANANIA C, ANDREOLI GM, BEZZI M, CATALANO C et al. Pancreatic fat and β-cell function in overweight/obese children with nonalcoholic fatty liver disease. World J. Gastroenterol. 2015; 21(15): 4688-4695.10.3748/wjg.v21.i15.4688
  16. 16. TARGHER G, ROSSI AP, ZAMBONI GA, FANTIN F, ANTONIOLI A, CORZATO F et al. Pancreatic fat accumulation and its relationship with liver fat content and other fat depots in obese individuals. J. Endocrinol. Invest. 2012; 35(8): 748-753.
  17. 17. LINGVAYI, ESSER V, LEGENDRE JL, PRICE AL, WERTZ KM, ADAMS-HUET B et al. Noninvasive quantification of pancreatic fat in humans. J. Clin. Endocrinol. Metab. 2009; 94(10): 4070-4076.10.1210/jc.2009-0584
  18. 18. ROSSI AP, FANTIN F, ZAMBONI GA, MAZZALI G, RINALDI CA, DEL GIGLIO M. et al. Predictors of ectopic fat accumulation in liver and pancreas in obese men and women. Obesity (Silver Spring). 2011; 19(9): 1747-1754.10.1038/oby.2011.11421593811
  19. 19. WU W.-C., WANG C.-Y. Association between non-alcoholic fatty pancreatic disease (NAFPD) and the metabolic syndrome: case-control retrospective study. Cardiovasc. Diabetol. 2013; 12: 77.10.1186/1475-2840-12-77
  20. 20. LI S., SU L., LV G., ZHAO W., CHEN J. Transabdominal ultrasonography of the pancreas is superior to that of the liver for detection of ectopic fat deposits resulting from metabolic syndrome. Medicine (Baltimore) 2017; 96 (37): e8060.10.1097/MD.0000000000008060560467028906401
  21. 21. WENG S., ZHOU J., CHEN X., SUN Y., MAO Z., CHAI K. Prevalence and factors associated with nonalcoholic fatty pancreas disease and its severity in China. Medicine (Baltimore). 2018; 97 (26): e11293.10.1097/MD.0000000000011293603962729953011
  22. 22. LEE SE, JANG JY, LIM CS, KANG MJ, KIM SH, KIM MA et al. Measurement of pancreatic fat by magnetic resonance imaging: predicting the occurrence of pancreatic fistula after pancreatoduodenectomy. Ann. Surg. 2010; 51 (251): 932-936.10.1097/SLA.0b013e3181d65483
  23. 23. NAVINA S, ACHARYA C, DELANY JP, ORLICHENKO LS, BATY CJ, SHIVA SS et al. Lipotoxicity causes multisystem organ failure and exacerbates acute pancreatitis in obesity. Sci. Transl. Med 2011; 3 (107): 107ra110.10.1126/scitranslmed.3002573332136222049070
  24. 24. ACHARYA C, CLINE RA, JALIGAMA D, NOEL P, DELANY JP, BAE K et al. Fibrosis reduces severity of acute-on-chronic pancreatitis in humans. Gastroenterology 2013; 145 (2): 466-475.10.1053/j.gastro.2013.05.012396481623684709
  25. 25. SEPE PS, OHRI A, SANAKA S, BERZIN TM, SEKHON S, BENNETT G et al. A prospective evaluation of fatty pancreas by using EUS. Gastrointest. Endosc. 2011; 73 (5): 987-993.10.1016/j.gie.2011.01.015
  26. 26. ACHARYA C., NAVINA S., SINGH V.P. Role of pancreatic fat in the outcomes of pancreatitis. Pancreatology 2014; 14 (5): 403-408.10.1016/j.pan.2014.06.004418515225278311
  27. 27. ROSSO E, CASNEDI S, PESSAUX P, OUSSOULTZOGLOU E, PANARO F, MAHFUD M et al. The role of "fatty pancreas" and of BMI in the occurrence of pancreatic fistula after pancreaticoduodenectomy. J. Gastrointest. Surg., 2009; 13 (10): 1845-1851.10.1007/s11605-009-0974-8
  28. 28. TOMITA Y, AZUMA K, NONAKA Y, KAMADA Y, TOMOEDA M, KISHIDA M et al. Pancreatic fatty degeneration and fibrosis as predisposing factors for the development of pancreatic ductal adenocarcinoma. Pancreas 2014; 43 (7): 1032-1041.10.1097/MPA.000000000000015924991971
  29. 39. CATANZARO R., CUFFARI B., ITALIA A., MAROTTA F. Exploring the metabolic syndrome: Nonalcoholic fatty pancreas disease. World J. Gastroenterol. 2016; 22(34): 7660-7675.10.3748/wjg.v22.i34.7660
  30. 30. VIRTUE S., VIDAL-PUIG A. It’s not how fat you are, it’s what you do with it that counts. PLoS Biol. 2008; 6(9): e237.10.1371/journal.pbio.0060237255384318816166
  31. 31. SKURK T., ALBERTI-HUBER C., HERDER C., HAUNER H. Relationship between adipocyte size and adipokine expression and secretion. J. Clin. Endocrinol. Metab. 2007; 92(3):1023-1033.10.1210/jc.2006-1055
  32. 32. BLÜHER M. Adipose tissue dysfunction in obesity. Exp. Clin. Endocrinol. Diabetes 2009; 117 (06): 241-250.10.1055/s-0029-119204419358089
  33. 33. SCHA J.E. Lipotoxicity: when tissues overeat. Curr. Opin. Lipidol.2003; 14 (3): 281-287.10.1097/00041433-200306000-0000812840659
  34. 34. YE J. Mechanisms of insulin resistance in obesity. Front. Med. 2013; 7 (1): 14-24.10.1007/s11684-013-0262-6393601723471659
  35. 35. PINNICK K.E., COLLINS S.C., LONDOS C., GAUGUIER D., CLARK A., FIELDING B.A. Pancreatic ectopic fat is characterized by adipocyte infiltration and altered lipid composition. Obesity 2008; 16 (3): 522-530.10.1038/oby.2007.11018239594
  36. 36. MARKS W.M., FILLY R.A., CALLEN P.W. Ultrasonic evaluation of normal pancreatic echogenicity and its relationship to fat deposition. Radiology 1980; 137 (2): 475-9.10.1148/radiology.137.2.74336807433680
  37. 37. NGHIEM D.D., OLSON P.R., ORMOND D. The fatty pancreas allograf T anatomopathologic findings and clinical experience. Transplant. Proc. 2004; 36 (4): 1045-1047.10.1016/j.transproceed.2004.04.032
  38. 38. WALTERS M.N. Adipose atrophy of the exocrine pancreas. J. Pathol. Bacteriol. 1996; 92 (2): 547-557.10.1002/path.17009202325964381
  39. 39. WELLEN K.E., HOTAMISLIGIL G.S. Inflammation, stress, and diabetes. J. Clin. Invest 2005; 115 (5): 1111-1119.10.1172/JCI25102108718515864338
  40. 40. VAN RAALTE D.H., VAN DER ZIJL N.J., DIAMANT M. Pancreatic steatosis in humans: cause or marker of lipotoxicity? Curr. Opin. Clin. Nutr. Metab. Care 2010; 13 (4): 478-485.10.1097/MCO.0b013e32833aa1ef
  41. 41. TSATSOULIS A., MANTZARIS M.D., BELLOU S., ANDRIKOULA M. Insulin resistance: An adaptive mechanism becomes maladaptive in the current environment – An evolutionary perspective. Metabolism 2013; 62 (5): 622-633.10.1016/j.metabol.2012.11.00423260798
  42. 42. UNGER R.H., SCHERER P.E. Gluttony, sloth and the metabolic syndrome: a roadmap to lipotoxicity. Trends Endocrinol. Metab. 2010; 21 (6): 345-352.10.1016/j.tem.2010.01.009
  43. 43. LEE JS, KIM SH, JUN DW, HAN JH, JANG EC, PARK JY et al. Clinical implications of fatty pancreas: correlations between fatty pancreas and metabolic syndrome. World J. Gastroenterol. 2009; 15 (15): 1869-1875.10.3748/wjg.15.1869
  44. 44. Then and now: ATP III vs. IV – American College of Cardiology [Online]. Available: https://www.acc.org/latest-in-cardiology/articles/2014/07/18/16/03/then-and-now-atp-iii-vs-iv. [Accessed: 29-Nov-2018].
  45. 45. MATSUMOTO S, MORI H, MIYAKE H, TAKAKI H, MAEDA T, YAMADA Y et al. Uneven fatty replacement of the pancreas: evaluation with CT. Radiology 1995; 194(2): 453-458.10.1148/radiology.194.2.78247267824726
  46. 46. KÜHN JP, BERTHOLD F, MAYERLE J, VÖLZKE H, REEDER SB, RATHMANN W et al. Pancreatic steatosis demonstrated at MR imaging in the general population: clinical relevance. Radiology 2015; 276 (1):129-136.10.1148/radiol.15140446455420825658037
  47. 47. CHANTAROJANASIRI T., HIROOKA Y., RATANACHU-EK T., KAWASHIMA H., OHNO E., GOTO H. Evolution of pancreas in aging: degenerative variation or early changes of disease? J. Med. Ultrason.2015; 42 (2): 177-183.10.1007/s10396-014-0576-2
  48. 48. JEONG H.T., LEE M.S., KIM M.-J. Quantitative analysis of pancreatic echogenicity on transabdominal sonography: correlations with metabolic syndrome. J. Clin. Ultrasound 2015; 43 (2): 98-108.10.1002/jcu.22200
  49. 49. POLKOWSKI M, JENSSEN C, KAYE P, CARRARA S, DEPREZ P, GINES A et al. Technical aspects of endoscopic ultrasound (EUS)-guided sampling in gastroenterology: European Society of Gastrointestinal Endoscopy (ESGE) Technical guideline – March 2017. Endoscopy 2017; 49(10): 989-1006.10.1055/s-0043-11921928898917
  50. 50. CHOI CW, KIM GH, KANG DH, KIM HW, KIM DU, HEO J et al. Associated factors for a hyperechogenic pancreas on endoscopic ultrasound. World J. Gastroenterol. 2010; 16 (34): 4329-34.10.3748/wjg.v16.i34.4329
  51. 51. USTUNDAG Y., CEYLAN G., HEKIMOGLU K. Pancreatic hyperechogenicity on endoscopic ultrasound examination. World J. Gastroenterol. 2011; 17 (15): 2061-2062.10.3748/wjg.v17.i15.2061
  52. 52. COSGROVE D, PISCAGLIA F, BAMBER J, BOJUNGA J, CORREAS JM, GILJA OH et al. EFSUMB guidelines and recommendations on the clinical use of ultrasound elastography. Part 2: clinical applications. Ultraschall der Medizin – Eur. J. Ultrasound 2013; 34 (03): 238-253.10.1055/s-0033-1335375
  53. 53. KUWAHARA T, HIROOKA Y, KAWASHIMA H, OHNO E, YOKOYAMA Y, FUJII T et al. Usefulness of endoscopic ultrasonography-elastography as a predictive tool for the occurrence of pancreatic fistula after pancreatoduodenectomy. J. Hepatobiliary. Pancreat. Sci. 2017; 24 (12): 649-656.10.1002/jhbp.514
  54. 54. BARRETO S.G., DIRKZWAGER I., WINDSOR J.A., PANDANABOYANA S. Predicting post-operative pancreatic fistulae using preoperative pancreatic imaging: a systematic review. ANZ J. Surg. 2018 [Epub ahead of print].10.1111/ans.1489130306712
  55. 55. MATHUR A, HERNANDEZ J, SHAHEEN F, SHROFF M, DAHAL S, MORTON C et al. Preoperative computed tomography measurements of pancreatic steatosis and visceral fat: prognostic markers for dissemination and lethality of pancreatic adenocarcinoma. HPB (Oxford). 2011; 13(6): 404-10.10.1111/j.1477-2574.2011.00304.x310309721609373
  56. 56. TRANCHART H, GAUJOUX S, REBOURS V, VULLIERME MP, DOKMAK S, LEVY P et al. Preoperative CT scan helps to predict the occurrence of severe pancreatic fistula after pancreaticoduodenectomy. Ann. Surg. 2012; 256 (1): 139-145.10.1097/SLA.0b013e318256c32c
  57. 57. ROBERTS K.J., STOREY R., HODSON J., SMITH A.M., MORRIS-STIFF G. Pre-operative prediction of pancreatic fistula: is it possible?, Pancreatology 2013; 13(4) 423-428.10.1016/j.pan.2013.04.32223890142
  58. 58. SAISHO Y, BUTLER AE, MEIER JJ, MONCHAMP T, ALLEN-AUERBACH M, RIZZA RA et al. Pancreas volumes in humans from birth to age one hundred taking into account sex, obesity, and presence of type-2 diabetes. Clin. Anat. 2007; 20(8): 933-942.10.1002/ca.20543
  59. 59. KIM SY, KIM H, CHO JY, LIM S, CHA K, LEE KH et al. Quantitative assessment of pancreatic fat by using unenhanced CT: pathologic correlation and clinical implications. Radiology 2014; 271 (1): 104-112.10.1148/radiol.1312288324475851
  60. 60. HU H.H., KIM H.-W., NAYAK K.S., GORAN M.I. Comparison of fat–water MRI and single-voxel MRS in the Assessment of hepatic and pancreatic fat fractions in humans. Obesity 2010; 18(4): 841-847.10.1038/oby.2009.352284703719834463
  61. 61. LIVINGSTONE RS, BEGOVATZ P, KAHL S, NOWOTNY B, STRASSBURGER K, GIANI G et al. Initial clinical application of modified Dixon with flexible echo times: hepatic and pancreatic fat assessments in comparison with 1H MRS. Magn. Reson. Mater. Physics. Biol. Med. 2014; 27(5): 397-405.10.1007/s10334-013-0421-4
  62. 62. MA J., SONG Z., YAN F. Detection of hepatic and pancreatic fat infiltration in type II diabetes mellitus patients with IDEAL-Quant using 3.0T MR: comparison with single-voxel proton spectroscopy. Chin. Med. J. (Engl). 2014; 127 (20): 3548-52.10.3760/cma.j.issn.0366-6999.20141178
  63. 63. OLSEN T.S. Lipomatosis of the pancreas in autopsy material and its relation to age and overweight. Acta Pathol. Microbiol. Scand. A. 1978; 86A(5): 367-73.10.1111/j.1699-0463.1978.tb02058.x716899
  64. 64. WONG VW, WONG GL, YEUNG DK, ABRIGO JM, KONG AP, CHAN RS et al. Fatty pancreas, insulin resistance, and β-cell function: a population study using fat-water magnetic resonance imaging. Am. J. Gastroenterol. 2014; 109 (4): 589-597.10.1038/ajg.2014.1
  65. 65. YAMAZAKI H, TSUBOYA T, KATANUMA A, KODAMA Y, TAUCHI S, DOHKE M et al. Lack of independent association between fatty pancreas and incidence of type 2 diabetes: 5-year Japanese cohort study. Diabetes Care2016; 39 (10): 1677-1683.10.2337/dc16-007427422578
  66. 66. KIM MK, CHUN HJ, PARK JH, YEO DM, BAEK KH, SONG KH et al. The association between ectopic fat in the pancreas and subclinical atherosclerosis in type 2 diabetes. Diabetes Res. Clin. Pract. 2014; 106 (3): 590-596.10.1016/j.diabres.2014.09.005
  67. 67. MATHUR A, PITT HA, MARINE M, SAXENA R, SCHMIDT CM, HOWARD TJ et al. Fatty pancreas. Ann. Surg. 2007; 246 (6): 1058-1064.10.1097/SLA.0b013e31814a6906
  68. 68. CAVALLINI G., FRULLONI L., VAONA B., DI FRANCESCO V., BOVO P. Is hyperamylasemia related to dyslipidemia? Gastroenterology 1997; 112 (3): 1058-059.10.1053/gast.1997.v112.agast971058
  69. 69. GULLO L., LUCREZIO L., MIGLIORI M., BASSI M., NESTICÒ V., COSTA P.L. Benign pancreatic hyperenzymemia or Gullo’s syndrome. Adv. Med. Sci. 2008; 53(1): 1-5.10.2478/v10039-008-0027-7
  70. 70. KHAN N.A., AMIN M.S., ISLAM M.Z. Pancreatic lipomatosis with massive steatorrhea. Mymensingh Med. J. 2011; 20 (4): 712-714.
  71. 71. LOZANO M, NAVARRO S, PÉREZ-AYUSO R, LLACH J, AYUSO C, GUEVARA MC et al. Lipomatosis of the pancreas: an unusual cause of massive steatorrhea. Pancreas 1988; 3(5): 580-582.10.1097/00006676-198810000-000123186686
  72. 72. AUBERT A, GORNET JM, HAMMEL P, LÉVY P, O’TOOLE D, RUSZNIEWSKI P et al. Diffuse primary fat replacement of the pancreas: an unusual cause of steatorrhea. Gastroenterol. Clin. Biol. 2007; 31 (3): 303-306.10.1016/S0399-8320(07)89379-1
  73. 73. AMBESH P., LAL H. Pancreatic lipomatosis: complete replacement of pancreas by fat. J. Clin. Diagn. Res. 2015; 9 (10): OL01.10.7860/JCDR/2015/15085.6653462527926557560
  74. 74. PRASANNA KUMAR H.R., GOWDAPPA H.B., HOSMANI T., URS T. Exocrine dysfunction correlates with endocrinal impairment of pancreas in type 2 diabetes mellitus. Indian J. Endocrinol. Metab. 2018; 22 (1): 121-125.10.4103/ijem.IJEM_139_17
  75. 75. HARDT PD, HAUENSCHILD A, NALOP J, MARZEION AM, JAEGER C, TEICHMANN J, et al. High prevalence of exocrine pancreatic insufficiency in diabetes mellitus. A multicenter study screening fecal elastase 1 concentrations in 1,021 diabetic patients. Pancreatology 2003; 3 (5): 395-402.10.1159/00007365514526149
  76. 76. ČABARKAPA V, DJERIĆ M, MITROVIĆ M, KOJIĆ-DAMJANOV S, ISAKOV I, VUKOVIĆ B et al. Fecal pancreatic elastase-1 and erythrocyte magnesium levels in diabetes type 1 and type 2. Magnes. Res. 2018; 31 (1): 1-10.10.1684/mrh.2018.0433
  77. 77. TERZIN V, VÁRKONYI T, SZABOLCS A, LENGYEL C, TAKÁCS T, ZSÓRI G et al. Prevalence of exocrine pancreatic insufficiency in type 2 diabetes mellitus with poor glycemic control. Pancreatology 2014; 14 (5): 356-60.10.1016/j.pan.2014.07.00425278304
  78. 78. ESPOSITO K., CHIODINI P., COLAO A., LENZI A., GIUGLIANO D. Metabolic syndrome and risk of cancer: a systematic review and meta-analysis. Diabetes Care 2012; 35 (11): 2402-2411.10.2337/dc12-0336
  79. 79. MENDONÇA FM, DE SOUSA FR, BARBOSA AL, MARTINS SC, ARAÚJO RL, SOARES R et al. Metabolic syndrome and risk of cancer: Which link? Metabolism, 2015; 64 (2): 182-189.10.1016/j.metabol.2014.10.008
  80. 80. XU M., JUNG X., HINES O.J., EIBL G., CHEN Y. Obesity and pancreatic cancer: overview of epidemiology and potential prevention by weight loss. Pancreas 2018; 47 (2): 158-162.10.1097/MPA.0000000000000974
  81. 81. MATHUR A, ZYROMSKI NJ, PITT HA, AL-AZZAWI H, WALKER JJ, SAXENA R et al. Pancreatic steatosis promotes dissemination and lethality of pancreatic cancer. J. Am. Coll. Surg., 2009; 208 (5): 989-94; discussion 994-996.10.1016/j.jamcollsurg.2008.12.026
  82. 82. MALVEZZI M, CARIOLI G, BERTUCCIO P, BOFFETTA P, LEVI F, LA VECCHIA C et al. European cancer mortality predictions for the year 2018 with focus on colorectal cancer. Ann. Oncol. Off. J. Eur. Soc. Med. Oncol. 2018; 29 (4): 1016-1022.10.1093/annonc/mdy033
  83. 83. HONKA H, KOFFERT J, HANNUKAINEN JC, TUULARI JJ, KARLSSON HK, IMMONEN H et al. The effects of bariatric surgery on pancreatic lipid metabolism and blood flow. J. Clin. Endocrinol. Metab. 2015; 100 (5): 2015-023.10.1210/jc.2014-4236
  84. 84. HANSEN E.N., TORQUATI A., ABUMRAD N.N. Results of bariatric surgery. Annu. Rev. Nutr. 2006; 26 (1): 481-511.10.1146/annurev.nutr.26.061505.111242
  85. 85. CUMMINGS BP, STRADER AD, STANHOPE KL, GRAHAM JL, LEE J, RAYBOULD HE. et al. Ileal interposition surgery improves glucose and lipid metabolism and delays diabetes onset in the UCD-T2DM rat. Gastroenterology 2010; 138 (7): 2437-2446.e1.10.1053/j.gastro.2010.03.005
  86. 86. MALIN S.K., KASHYAP S.R. Effects of various gastrointestinal procedures on β-cell function in obesity and type 2 diabetes. Surg. Obes. Relat. Dis. 2016; 12 (6): 1213-1219.10.1016/j.soard.2016.02.035
  87. 87. MCCARTY M.F. Complementary measures for promoting insulin sensitivity in skeletal muscle. Med. Hypotheses 1998; 51 (6): 451-464.10.1016/S0306-9877(98)90065-2
  88. 88. WRÓBEL M.P., MAREK B., KAJDANIUK D., ROKICKA D., SZYMBORSKA-KAJANEK A., STROJEK K. Metformin – a new old drug. Endokrynol. Pol. 2017; 68 (4): 482-496.10.5603/EP.2017.0050
  89. 89. PIRO S., RABUAZZO A.M., RENIS M., PURRELLO F. Effects of metformin on oxidative stress, adenine nucleotides balance, and glucose-induced insulin release impaired by chronic free fatty acids exposure in rat pancreatic islets. J. Endocrinol. Invest. 2012; 35(5): 504-510.
  90. 90. TAJIMA K, SHIRAKAWA J, OKUYAMA T, KYOHARA M, YAMAZAKI S, TOGASHI Y et al. Effects of metformin on compensatory pancreatic β-cell hyperplasia in mice fed a high-fat diet. Am. J. Physiol. Metab. 2017; 313 (3): E367-E380.10.1152/ajpendo.00447.201628512156
  91. 91. REIMER R.A., GROVER G.J., KOETZNER L., GAHLER R.J., LYON M.R., WOOD S. Combining sitagliptin/metformin with a functional fiber delays diabetes progression in Zucker rats. J. Endocrinol. 2014; 220 (3): 361-373.10.1530/JOE-13-048424389593
  92. 92. LEBOVITZ H.E., BANERJI M.A. Insulin resistance and its treatment by thiazolidinediones. Recent Prog. Horm. Res.2001; 56: 265-294.10.1210/rp.56.1.265
  93. 93. DUPLOMB L, LEE Y, WANG MY, PARK BH, TAKAISHI K, AGARWAL AK et al. Increased expression and activity of 11beta-HSD-1 in diabetic islets and prevention with troglitazone. Biochem. Biophys. Res. Commun. 2004; 313 (3): 594-599.10.1016/j.bbrc.2003.11.160
  94. 94. SHIMABUKURO M., ZHOU Y.T., LEE Y., UNGER R.H. Troglitazone lowers islet fat and restores beta cell function of Zucker diabetic fatty rats. J. Biol. Chem. 1998; 273(6): 3547-3550.10.1074/jbc.273.6.3547
  95. 95. JIA D.M., FUKUMITSU K.I., TABARU A., AKIYAMA T., OTSUKI M. Troglitazone stimulates pancreatic growth in congenitally CCK-A receptor-deficient OLETF rats. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2001; 280 (5): R1332-40.10.1152/ajpregu.2001.280.5.R133211294751
  96. 96. ZHANG W., MIAO J., LI P., WANG Y., ZHANG Y. Up-regulation of components of the renin–angiotensin system in liver fibrosis in the rat induced by CCL4. Res. Vet. Sci. 2013; 95 (1): 54-58.10.1016/j.rvsc.2013.01.028
  97. 97. SOUZA-MELLO V. Hepatic structural enhancement and insulin resistance amelioration due to AT1 receptor blockade. World J. Hepatol. 2017; 9 (2): 74-79.10.4254/wjh.v9.i2.74524153128144388
  98. 98. SOUZA-MELLO V., GREGÓRIO B.M., CARDOSO-DE-LEMOS F.S., DE CARVALHO L., AGUILA M.B., MANDARIMDE-LACERDA C.A. Comparative effects of telmisartan, sitagliptin and metformin alone or in combination on obesity, insulin resistance, and liver and pancreas remodelling in C57BL/6 mice fed on a very high-fat diet. Clin. Sci. (Lond) 2010; 119 (6): 239-250.10.1042/CS20100061
  99. 99. SOUZA-MELLO V., GREGÓRIO B.M., RELVAS-LUCAS B., DA SILVA FARIA T., AGUILA M.B., MANDARIM-DELACERDA C.A. Pancreatic ultrastructural enhancement due to telmisartan plus sitagliptin treatment in diet-induced obese C57BL/6 mice. Pancreas 2011; 40 (5): 715-722.10.1097/MPA.0b013e318215392221602737
  100. 100. YU T, LIU R, LI M, LI X, QIANG O, HUANG W et al. Effects of octreotide on fatty infiltration of the pancreas in high-fat diet induced obesity rats. Wei Sheng Yan Jiu 2014; 43 (2): 186-92.
  101. 101. GOTOH K, INOUE M, SHIRAISHI K, MASAKI T, CHIBA S, MITSUTOMI K et al. Spleen-derived interleukin-10 downregulates the severity of high-fat diet-induced non-alcoholic fatty pancreas disease. PLoS One 2012; 7 (12): e53154.10.1371/journal.pone.0053154353234723285260
  102. 102. TURNER N, LI JY, GOSBY A, TO SW, CHENG Z, MIYOSHI H et al. Berberine and its more biologically available derivative, dihydroberberine, inhibit mitochondrial respiratory complex I: a mechanism for the action of berberine to activate AMP-activated protein kinase and improve insulin action. Diabetes 2008; 57 (5): 1414-1418.10.2337/db07-155218285556
  103. 103. ZHANG Z, ZHANG H, LI B, MENG X, WANG J, ZHANG Y et al. Berberine activates thermogenesis in white and brown adipose tissue. Nat. Commun. 2014; 5 (1): 5493.10.1038/ncomms6493
  104. 104. ZHANG Z, ZHANG H, LI B, MENG X, WANG J, ZHANG Y et al. Effects of berberine and cinnamic acid on palmitic acid-induced intracellular triglyceride accumulation in NIT-1 pancreatic β cells. Chin. J. Integr.Med.2016; 22 (7): 496-502.10.1007/s11655-014-1986-0
DOI: https://doi.org/10.2478/rjim-2019-0005 | Journal eISSN: 2501-062X | Journal ISSN: 1220-4749
Language: English
Page range: 209 - 219
Submitted on: Dec 30, 2018
Published on: Sep 9, 2019
Published by: N.G. Lupu Internal Medicine Foundation
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2019 Larisa Pinte, Daniel Vasile Balaban, Cristian Băicuş, Mariana Jinga, published by N.G. Lupu Internal Medicine Foundation
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.