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The Impact of Anaesthesia on Hyperalgesia, Testosterone, Cortisol, C-Reactive Protein, and Glucose Levels After Spine Surgery: Prospective Randomised Controlled Trial Cover

The Impact of Anaesthesia on Hyperalgesia, Testosterone, Cortisol, C-Reactive Protein, and Glucose Levels After Spine Surgery: Prospective Randomised Controlled Trial

Romanian Journal of Anaesthesia and Intensive Care
AHEAD OF PRINT
By: Maksym Barsa and  Olha Filyk  
Open Access
|Apr 2023

Figures & Tables

Figure 1.

CONSORT follow-up diagram.
CONSORT follow-up diagram.

Figure 2.

A graphical representation of the statistical ranges of administered fentanyl and morphine hydrochloride in the study groups: (a) fentanyl during surgery in SG and CG; (b) morphine hydrochloride total amount after surgery in SG and CG.
A graphical representation of the statistical ranges of administered fentanyl and morphine hydrochloride in the study groups: (a) fentanyl during surgery in SG and CG; (b) morphine hydrochloride total amount after surgery in SG and CG.

Figure 3.

A graphical representation of the statistical ranges of mechanical pain thresholds: (a) in study group; (b) in control group.
A graphical representation of the statistical ranges of mechanical pain thresholds: (a) in study group; (b) in control group.

Figure 4.

A graphical representation of the statistic ranges of testosterone levels in SG: (a) Men 20–49 years old; (b) Men ≥50 years old; (c) Women 20–49 years old; (d) Women ≥50 years old.
A graphical representation of the statistic ranges of testosterone levels in SG: (a) Men 20–49 years old; (b) Men ≥50 years old; (c) Women 20–49 years old; (d) Women ≥50 years old.

Figure 5.

A graphical representation of the statistic ranges of testosterone levels in CG: (a) Men 20–49 years old; (b) Men ≥50 years old; (c) Women 20–49 years old; (d) Women ≥50 years old.
A graphical representation of the statistic ranges of testosterone levels in CG: (a) Men 20–49 years old; (b) Men ≥50 years old; (c) Women 20–49 years old; (d) Women ≥50 years old.

Figure 6.

A graphical representation of the statistical ranges of cortisol levels in the studied groups: (a) in SG; (b) in CG.
A graphical representation of the statistical ranges of cortisol levels in the studied groups: (a) in SG; (b) in CG.

Figure 7.

A graphical representation of the statistical ranges of CRP levels in the studied groups: (a) in SG; (b) in CG.
A graphical representation of the statistical ranges of CRP levels in the studied groups: (a) in SG; (b) in CG.

The baseline characteristics of patients_

SG (n=27)CG (n=26)
Men (n=26)
Age 20–49 years old (n)77
Age ≥50 years old (n)76
Women (n=24)
Age 20–49 years old (n)68
Age ≥50 years old (n)75
ASA
I (n)119
II (n)1617
BMI (kg/m2)26.6 (CI 95% 23.4–29.7)26.6 (CI 95% 23.4–29.7)

The average mechanical pain thresholds in SG and CG before surgery and after surgery_

Before SurgeryAfter Surgery
SG14.49 (95% CI 10.72–25.21) g/mm216.70 (95% CI 13.02–20.57) g/mm2
CG21.45 (95% CI 18.80–24.10) g/mm24.75 (95% CI 4.13–5.38) g/mm2

Reference values of serum testosterone, cortisol C-reactive protein, and glucose levels_

TESTOSTERONE
Men 20–49 years8.64–29.0 nmol/l
Men ≥50 years6.68–25.7 nmol/l
Women 20–49 years0.290–1.67 nmol/l
Women ≥50 years0.101–1.42 nmol/l
CORTISOL
AM 7:00–10:00171–536 nmol/l
PM 16:00–20:0064–327 nmol/l
C-REACTIVE PROTEIN
<5 mg/ml
GLUCOSE
4.11–6.05 mmol/l

The average testosterone levels in CG before surgery and after surgery_

General anaesthesia without BESPB (CG)
Before SurgeryAfter Surgery
Men 20–49 years old26.94 (95% CI 25.37–28.52)6.79 (95% CI 5.28–8.29)
Men 20–49 years old17.67 (95%CI 14.23–21.1)2.63 (95% CI 0.88–4.39)
Women 20–49 years old1.09 (95% CI 0.85–1.32)0.11 (95% CI 0.08–0.14)
Women ≥50 years old1.15 (95% CI 0.82–1.48)0.1 (95% CI 0.1–0.1)

The average testosterone levels in SG before surgery and after surgery_

General anaesthesia with BESPB (SG)
Before SurgeryAfter Surgery
Men 20–49 years old20.73 (95% CI 19.07–22.38)21.11 (95% CI 20.00 –22.23)
Men 20–49 years old19.38 (95% CI 13.11–25.65)16.35 (95% CI 8.21–24.49)
Women 20–49 years old0.65 (95% CI 0.20–1.16)0.62 (95% CI 0.11–1.13)
Women ≥50 years old0.55 (95% CI 0.04–1.07)0.71 (95% CI 0.07–1.35)

The average glucose levels in SG and CG before and after surgery_

Before SurgeryAfter Surgery
SG5.09 (95% CI 4.88–5.3)6.06 (95% CI 5.83–6.3)
CG5.2 (95% CI 4.9–5.5)9.23 (95% CI 8.63–9.83)

The average C-reactive protein levels in Groups 1 and 2 before and after surgery_

Before SurgeryAfter Surgery
SG1.95 (95% CI 1.48 to 2.42)2.34 (95% CI 1.88 to 2.81)
CG1.48 (95% CI 0.89 to 2.06)8.54 (95% CI 8 to 9.1)

The average cortisol levels in Groups 1 and 2 before and after surgery_

Before SurgeryAfter Surgery
SG291.6 (95%CI 265.74–317.46)322 (95% CI 290.35–353.65)
CG296.4 (95% CI 270.8–567.2)767.24 (95% CI 720.02–814.46)
DOI: https://doi.org/10.2478/rjaic-2023-0005 | Journal eISSN: 2502-0307 | Journal ISSN: 2392-7518
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Language: English
Published on: Apr 25, 2023
Published by: Sciendo
In partnership with: Paradigm Publishing Services
Publication frequency: 2 issues per year
Keywords:
erector spinae plane block,
hyperalgesia,
testosterone,
cortisol,
C-reactive protein
Related subjects:
Medicine,
Clinical medicine,
Clinical medicine, other,
Surgery,
Surgery, other,
Anaesthesiology,
Emergency medicine and intensive-care medicine

© 2023 Maksym Barsa, Olha Filyk, published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

AHEAD OF PRINT