Have a personal or library account? Click to login
Pyroglutamic Acidosis – An Underrecognised Entity Associated with Acetaminophen Use Cover

Pyroglutamic Acidosis – An Underrecognised Entity Associated with Acetaminophen Use

Open Access
|Apr 2023

References

  1. Mehta AN, Emmett JB, Emmett M. GOLD MARK: an anion gap mnemonic for the 21st century. Lancet 2008;372(9642):892. doi:10.1016/S0140-6736(08)61398-7
  2. Emmett M. Acetaminophen toxicity and 5-oxoproline (pyroglutamic acid): A tale of two cycles, one an ATP-depleting futile cycle and the other a useful cycle. Clin J Am Soc Nephrol 2014;9(1):191–200. doi:10.2215/CJN.07730713
  3. Creer MH, Lau BWC, Jones JD, Chan KM. Pyroglutamic acidemia in an adult patient. Clin Chem 1989;35(4):684–6. doi:10.1093/clinchem/35.4.684
  4. Pitt JJ, Hauser S. Transient 5-oxoprolinuria and high anion gap metabolic acidosis: Clinical and biochemical findings in eleven subjects. Clin Chem 1998;44(7):1497–1503. doi:10.1093/clinchem/44.7.1497
  5. Liss DB, Paden MS, Schwarz ES, Mullins ME. What is the clinical significance of 5-oxoproline (pyroglutamic acid) in high anion gap metabolic acidosis following paracetamol (acetaminophen) exposure? Clin Toxicol 2013;51(9):817–27. doi:10.3109/15563650.2013.844822
  6. Croal BL, Glen ACA, Kelly CJG, Logan RW. Transient 5-oxoprolinuria (pyroglutamic aciduria) with systemic acidosis in an adult receiving antibiotic therapy. Clin Chem 1998;44(2):336–340. doi:10.1093/clinchem/44.2.336
  7. Bonham JR, Rattenbury JM, Meeks A, Pollitt RJ. Pyroglutamicaciduria from vigabatrin. Lancet 1989;1(8652):1452–3. doi:10.1016/S0140-6736(89)90158-X
  8. Fenves AZ, Kirkpatrick HM, Patel VV, Sweetman L, Emmett M. Increased anion gap metabolic acidosis as a result of 5-oxoproline (pyroglutamic acid): a role for acetaminophen. Clin J Am Soc Nephrol 2006;1(3):441–7. doi:10.2215/CJN.01411005
  9. O’Brien LMN, Hooper M, Flemmer M, Marik PE. Chronic acetaminophen ingestion resulting in severe anion gap metabolic acidosis secondary to 5-oxoproline accumulation: An under diagnosed phenomenon. BMJ Case Rep [Internet] 2012:1–3. doi:10.1136/bcr.bcr.03.2012.6020
  10. Tummers S, Oei SDX, Nooteboom F, Meenks SD, Wilting RM. Severe metabolic acidosis induced by 5-oxoproline accumulation after paracetamol and flucloxacillin administration. Neth J Crit Care 2020;28.
  11. Wu SL, Wei TY, Lin SW, Su KY, Kuo CH. Metabolomics Investigation of voriconazole-induced hepatotoxicity in mice. Chem Res Toxicol 2019;32(9):1840–9. doi:10.1021/acs.chemrestox.9b00176
  12. Hoshitsuki K, Molinelli AR, Inaba H, Rubnitz JE, Barker PJ. Metabolic Acidosis in a pediatric patient with leukemia and fungal infection. Clin Chem 2020;66(4):518–22. doi:10.1093/CLINCHEM/HVZ035
  13. Mårtensson J, Gustafsson J, Larsson A. A therapeutic trial with N-acetylcysteine in subjects with hereditary glutathione synthetase deficiency (5-oxoprolinuria). J Inherit Metab Dis 1989;12(2):120–30. doi:10.1007/BF01800713
DOI: https://doi.org/10.2478/rjaic-2023-0004 | Journal eISSN: 2502-0307 | Journal ISSN: 2392-7518
Language: English
Page range: 26 - 30
Published on: Apr 20, 2023
Published by: Sciendo
In partnership with: Paradigm Publishing Services
Publication frequency: 2 issues per year

© 2023 Wincy Wing-Sze Ng, Hok-Fung Tong, Wai-Yan Ng, Joshua Ka-Ho Yeung, Joyce Kit-Yu Young, Raymond Kam-Wing Woo, Maureen Mo-Lin Wong, published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.