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A Comparative Study of Palonosetron with Ondansetron for Prophylaxis of Postoperative Nausea and Vomiting (PONV) Following Laparoscopic Gynaecological Surgeries Cover

A Comparative Study of Palonosetron with Ondansetron for Prophylaxis of Postoperative Nausea and Vomiting (PONV) Following Laparoscopic Gynaecological Surgeries

Romanian Journal of Anaesthesia and Intensive Care
Volume 29 (2022): Issue 1 (July 2022)
By: Rohit Balyan,  Sachin Kumar,  K. Lalitha,  Sanjeev Aneja and  Jai S. George  
Open Access
|Jan 2023

Figures & Tables

Figure 1

Consort flow diagram.
Consort flow diagram.

Figure 2

Comparison of postoperative overall PONV score between group A [Ondansetron] and group B [Palonosetron]; 0–3 on x-axis denotes PONV scoring system used at various time intervals in postoperative period [Table 1].
Comparison of postoperative overall PONV score between group A [Ondansetron] and group B [Palonosetron]; 0–3 on x-axis denotes PONV scoring system used at various time intervals in postoperative period [Table 1].

Figure 3

Comparison of amount of ondansetron [first line rescue antiemetic drug] used between group A [ondansetron] and group B [palonosetron] [0,1,2,3 on x-axis denotes the number of times rescue antiemetic drug administered during a time interval in post-operativ.
Comparison of amount of ondansetron [first line rescue antiemetic drug] used between group A [ondansetron] and group B [palonosetron] [0,1,2,3 on x-axis denotes the number of times rescue antiemetic drug administered during a time interval in post-operativ.

Patient characteristics and duration of anaesthesia_

Group A [n=65]Group B [n=65]P-value
Age [years]37.40 ± 9.5939.51 ± 8.670.191
Weight [kg]64.90 ± 11.1065.10 ± 8.530.909
ASA grade [I/II]32/33 [49.2%/50.8%]39/26 [60%/40%]0.218
Duration of anaesthesia [min]150.85 ± 57.42145.08 ± 36.230.495
Morphine requirement in PACU [Number of patient/%]20 [30.76]16 [24.61]0.435

Postoperative nausea and vomiting (PONV) score_

Overall PONV scoreGroup A [n=65] Frequency [%]Group B [n=65] Frequency [%]P-value
0–2 h051 [78]48 [74]0.218
17 [11]14 [21]
22 [3]0 [0]
35 [8]3 [5]
2–24 h026 [40]41 [63]0.023*
122 [34]16 [25]
20 [0]0 [0]
317 [26]8 [12]
24–48 h058 [89]57 [88]0.177
16 [9]8 [12]
20 [0]0 [0]
31 [2]0 [0]

Scoring system used for assessing postoperative nausea, vomiting, and PONV_

ScorePostoperative nausea scorePostoperative vomiting scorePONV score
0NoneNoneNo nausea /vomiting /retching /no rescue antiemetic required
1Mild, intermittent nauseaOne vomit onlyNausea
2Constant, moderate nauseaSeveral vomitsRetching
3Severe nauseaRepeated retching/vomitingVomiting

Postoperative nausea score

Overall nausea scoreGroup A [n=65] Frequency [%]Group B [n=65] Frequency [%]P-value
0–2 h051 [78.4]50 [77]0.101
17 [10.8]13 [20]
20 [0]0 [0]
37 [10.8]2 [3]
2–24 h026 [40]43 [66]0.010*
124 [37]15 [23]
20 [0]0 [0]
315 [23]7 [11]
24–48 h058 [89]56 [86]0.593
17 [11]9 [14]
20 [0]0 [0]
30 [0]0 [0]

Amount of ondansetron [first line rescue antiemetic drug] used_

Amount of ondansetron [no. of doses]Group A [n=65] Frequency [%]Group B [n=65] Frequency [%]P-value
0–2 h051 [79]50 [77]0.833
114 [21]15 [23]
2–24 h029 [44]45 [69]0.012
124 [37]15 [23]
27 [11]5 [8]
35 [8]0 [0]
24–48 h056 [86]62 [95]0.102
16 [9]1 [2]
21 [2]2 [3]
32 [3]0 [0]

Postoperative vomiting score_

Overall vomiting scoreGroup A [n=65] Frequency [%]Group B [n=65] Frequency [%]P-value
0–2 h059 [91]61 [95]0.061
16 [9]1 [2]
20 [0]0 [0]
30 [0]2 [3]
2–24 h048 [74]56 [86]0.173
111 [17]7 [11]
20 [0]0 [0]
36 [9]2 [3]
24–48 h064 [98.5]65 [100]1.000
11 [1.5]0 [0]
20 [0]0 [0]
30 [0]0 [0]

Incidence of adverse events_

Adverse effectsGroup A Frequency [%]Group B Frequency [%]P-value
Headache10 [15]8 [12]0.800
Dizziness4 [6]8 [12]0.364
Drowsiness14 [22]17 [26]0.537
Constipation4 [6]14 [22]0.020
Allergic reaction0 [0]0 [0]-
ECG changes0 [0]0 [0]
DOI: https://doi.org/10.2478/rjaic-2022-0005 | Journal eISSN: 2502-0307 | Journal ISSN: 2392-7518
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Language: English
Page range: 32 - 40
Published on: Jan 14, 2023
Published by: Sciendo
In partnership with: Paradigm Publishing Services
Publication frequency: 2 issues per year
Keywords:
Palonosetron,
ondansetron,
postoperative nausea and vomiting,
laparoscopy,
gynaecological surgery,
general anaesthesia
Related subjects:
Medicine,
Clinical medicine,
Clinical medicine, other,
Surgery,
Surgery, other,
Anaesthesiology,
Emergency medicine and intensive-care medicine

© 2023 Rohit Balyan, Sachin Kumar, K. Lalitha, Sanjeev Aneja, Jai S. George, published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

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