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Comparison of two different doses of dexmedetomidine added to lignocaine in patients posted for upper limb orthopedic surgery under intravenous regional anaesthesia Cover

Comparison of two different doses of dexmedetomidine added to lignocaine in patients posted for upper limb orthopedic surgery under intravenous regional anaesthesia

Romanian Journal of Anaesthesia and Intensive Care
Volume 28 (2021): Issue 2 (December 2021)
By: ,  ,  ,   and    
Open Access
|Dec 2022
Figures & tables

Figures & Tables

Table 1

Comparison among groups according to demographic data.

Demographic dataGroup I: Control (n=30)Group II: Dex 0.25 μg/kg (n=30)Group III: Dex 0.50 μg/kg (n=30)Testp-value
Age (years)     
Range20-7021-7020-69  
   F = 0.9350.397
Mean ± SD41.54 ± 7.0639.04 ± 6.9240.60 ± 7.47  
Sex     
Male23 (76.7%)26 (86.7%)24 (80.0%)  
Female7 (23.3%)4 (13.3%)6 (20.0%)x2 = 1.0150.602
ASA     
I21 (70.0%)22 (73.3%)19 (63.3%)  
   x2 = 0.7260.696
II9 (30.0%)8 (26.7%)11 (36.7%)  
Duration of surgery     
(min)     
Range28-6025-5927-58  
   F = 0.9300.399
Mean ± SD43.84 ± 7.4541.21 ± 7.3042.86 ± 7.89  

[i] Using: F-One Way Analysis of Variance; x2: Chi-square test p-value>0.05 NS

Figure 1

Comparison between groups according to heart rate (beat/min).

Figure 2

Comparison between groups according to mean arterial blood pressure (mmHg).

Figure 3

Comparison between groups according to respiratory rate (b/min).

Table 2

Comparison between groups in terms of block and mean duration of tourniquet time.

Block (min)Group I: Control (n=30)Group II: Dex 0.25 μg/kg (n=30)Group III: Dex 0.50 μg/kg (n=30)Testp-value
Onset block of (min) sensory4.96 ± 0.903.92 ± 0.92a1.06 ± 0.35abF = 206.345<0.001**
Onset block of (min) motor12.80 ± 2.1610.69 ± 2.20a5.34 ± 1.16abF = 122.649<0.001**
Quality of block     
Excellent15 (50.0%)24 (80.0%)26 (86.7%)  
Good8 (26.7%)4 (13.3%)3 (10.0%)x2 = 13.2190.040*
Fair5 (16.7%)2 (6.7%)1 (3.3%)  
Poor2 (6.7%)0 (0.0%)0 (0.0%)  
Mean duration of tourniquet time (min)     
Mean ± SD52.77 ± 4.5855.06 ± 5.2054.28 ± 4.821.7120.187

Using: F-One Way Analysis of Variance; x2: Chi-square test Post HOC test, LSD: a: significant difference with group I: control; b: significant difference with Group II: Dex 0.25 p-value>0.05 NS;

* p-value <0.05 S;

** p-value <0.001 HS

Table 3

Comparison between groups according to sedation score (after tourniquet deflation), VAS score duration of analgesia, doses needed of analgesic and total dose of ketorolac.

Sedation score (after tourniquet deflation)Group I: Control (n=30)Group II: Dex 0.25 μg/ kg (n=30)Group III: Dex 0.50 μg/ kg (n=30)Testp-value
After 20 min2 (1-4)2 (1-4)2 (1-4)1.7130.207
After 40 min1 (1-3)1 (1-3)1 (1-3)1.1170.186
After 60 min1 (1-2)1 (1-2)1 (1-2)1.4400.173
VAS score     
After 1 hr1 (0-3)1 (0-2)0 (0-1)1.6790.201
After 2 hrs3 (1-5)2 (1-4)a1 (0-2)ab2.3380.016*
After 3 hrs5 (1-5)3 (1-4)a1 (1-2)ab2.1890.013*
After 4 hrs4 (2-6)3 (2-5)a2 (1-4)ab2.0990.012*
After 5 hrs5 (3-7)4 (3-5)a3 (1-4)ab2.0150.006*
Duration of analgesia   F-test 
Mean ± SD108.27 ± 55.00174.20 ± 67.08a331.53 ± 78.27ab86.746<0.001**
Doses needed of analgesic   1.7130.207
After 40 min1 (1-3)1 (1-3)1 (1-3)1.1170.186
After 60 min1 (1-2)1 (1-2)1 (1-2)1.4400.173
VAS score   x2 
1st dose30 (100.0%)30 (100.0%)30 (100.0%)0.0001.000
2nd dose30 (100.0%)26 (86.7%)17 (56.7%)19.291<0.001**
3rd dose18 (60.0%)12 (40.0%)0 (0.0%)25.200<0.001**
4th dose5 (16.7%)0 (0.0%)0 (0.0%)10.5880.005*
Total dose (Ketorolac mg/kg)   F-test 
Mean ± SD83.75 ± 7.5468.61 ± 6.18a47.42 ± 4.27ab264.587<0.001**

[i] Using: H-Kruskal Wallis test; p-value>0.05 NS

Table 4

Comparison between groups according to complications.

ComplicationsGroup I: Control (n=30)Group II: Dex 0.25 μg/kg (n=30)Group III: Dex 0.50 μg/kg (n=30)x2p-value
Dry mouth1 (3.3%)2 (6.7%)3 (10.0%)  
Bradycardia0 (0.0%)1 (3.3%)2 (6.7%)  
Tinnitus0 (0.0%)1 (3.3%)2 (6.7%)8.2800.407
Perioral numbness0 (0.0%)1 (3.3%)2 (6.7%)  
Nil29 (96.7%)25 (83.3%)21 (70.0%)  

[i] Using: x2: Chi-square test; p-value>0.05 NS

DOI: https://doi.org/10.2478/rjaic-2021-0011 | Journal eISSN: 2502-0307 | Journal ISSN: 2392-7518
Journal RSS Feed
Language: English
Page range: 63 - 70
Published on: Dec 29, 2022
Published by: Sciendo
In partnership with: Paradigm Publishing Services
Keywords:
Dexmedetomidine,
lignocaine,
upper limb orthopedic surgery,
intravenous regional anaesthesia
Related subjects:
Medicine,
Clinical medicine,
Clinical medicine, other,
Surgery,
Surgery, other,
Anaesthesiology,
Emergency medicine and intensive-care medicine

© 2022 Mostafa Saieed Mansour, Shebin El Kom, Mohamed Ahmed, Ayman Rady, Sadik Sadik, published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Volume 28 (2021): Issue 2 (December 2021)
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