Epidural Naloxone Attenuates Fentanyl Induced PONV in Patients Undergoing Lower Limb Orthopaedic Surgeries. A Prospective Randomized Double-Blind Comparative Study

	GROUP N (23)	GROUP C (23)	P value
AGE	48.91(18.9)	56.22 (17.2)	0.179
SEX (M/F)	14 / 9	10/ 13	0.238
ASA STATUS (1/2/3)	14 / 9 / 0	13 / 8 / 2	0.351
HEIGHT (M)	164.04 (6.89)	162.09 (7.077)	0.348
WEIGHT (KG)	65.87 (7.7)	64.22 (6.8)	0.446
BMI (KG/M2)	23.34 (1.6)	24.4 (1.6)	0.900
PREV HISTORY OF PONV	5	4	0.738
MAXIMAL SENSORY BLOCK	T6 (T6–T8)	T6(T6–T8)	-
DURATION OF SURGERY	10.74 (18.15)	110.83 (27.8)	0.631

[i] Data expressed as Mean (standard deviation) or Number

Rescue antiemetic consumption. Number of patients on Y axis, Time in hours on X axis. *P < 0.05 in between group comparison considered statistically significant

Table 2

Comparison of PONV and WBS pain scores between groups

0		PONV Scores			P value 0	WBS PAIN Scores				P value

		1	2			1	2	3
6 HRS	GROUP N	21	2	0	0.011^*	18	5	0	0	0.007^*
6 HRS	GROUP C	12	8	3	0.011^*	9	14	0	0	0.007^*
12 HRS	GROUP N	18	3	2	0.026^*	5	15	3	0	0.403
12 HRS	GROUP C	9	9	5	0.026^*	2	16	5	0	0.403
18 HRS	GROUP N	17	3	3	0.060	3	10	9	1	0.991
18 HRS	GROUP C	12	10	1	0.060	3	9	10	1	0.991

* significant at the 0.05 level

Table 3

Comparison of Mean PONV score at 6, 12 and 18 hrs between Group N and Group C

	GROUP N	GROUP C	P VALUE
6 hrs	0.09 (0.288)	0.61 (0.722)	0.002^*
12 hrs	0.30 (0.635)	0.83 (0.778)	0.017^*
18 hrs	0.39 (0.722)	0.52 (0.593)	0.507

* significant at the 0.05 level.

** Data expressed as Mean (standard deviation)

Table 4

Comparison of Mean pain score at 6, 12 and 18 hrs between Group N and Group C

	GROUP N	GROUP C	P value
6 HOURS	0.22 (0.422)	0.61 (0.499)	0.006^*
12 HOURS	0.91 (0.596)	1.13 (0.548)	0.205
18 HOURS	1.35 (0.775)	1.39 (0.783)	0.851

* significant at the 0.05 level.

** Data expressed as Mean (standard deviation)

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DOI: https://doi.org/10.2478/rjaic-2020-0009 | Journal eISSN: 2502-0307 | Journal ISSN: 2392-7518

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Language: English

Page range: 23 - 28

Published on: Aug 10, 2020

Published by: Sciendo

In partnership with: Paradigm Publishing Services

Keywords:

PONV,

Related subjects:

Clinical medicine, other,

Surgery,

Surgery, other,

Anaesthesiology,

Emergency medicine and intensive-care medicine

© 2020 Zabrin Nimeeliya, Thomas Derlin, Sabah Rahman Kundil Alungal, George Kanjirathummoottil, published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Volume 27 (2020): Issue 1 (July 2020)

Epidural Naloxone Attenuates Fentanyl Induced PONV in Patients Undergoing Lower Limb Orthopaedic Surgeries. A Prospective Randomized Double-Blind Comparative Study

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