TABLE 1.
Clinicopathological characteristics of the younger and elderly group
| Young (< 70years) N = 229 | Elderly (≥ 70 years) N = 204 | P - value | ||
|---|---|---|---|---|
| N (%) | N (%) | |||
| Sex | Male | 169 (73.8) | 130 (63.7) | |
| Female | 60 (26.2) | 74 (36.3) | 0.024 | |
| ASA | ASA 1, ASA2 | 203 (88.6) | 127 (62.3) | |
| ASA 3, ASA 4 | 26 (11.4) | 77 (37.7) | < 0.001 | |
| Tumor site | Distal third | 81 (35.4) | 81 (39.7) | |
| Middle third | 85 (37.1) | 87 (42,6) | ||
| Upper third | 62 (27.1) | 34 (16.79 | ||
| Whole stomach | 1(0.4) | 2 (1) | 0.069 | |
| Lauren | Intestinal | 94 (48.2) | 105 (61.4) | |
| Diffuse | 39 (20.0) | 23 (13.5) | ||
| Mixed | 60 (30.8) | 42 (24.6) | 0.052 | |
| Missing data | 36 (15.7) | 34 (16.6) | ||
| Tumor grading | 0 | 1 (0.6) | 0 (0.0) | |
| 1 | 19(11.0) | 26 15.0) | ||
| 2 | 52 (30.1) | 59 (30.1) | ||
| 3 | 100 (57.8 | 84 (48.6) | 0.221 | |
| Missing data | 58 (25.3) | 35 (17.1) | ||
| Tumor diameter | mean | 46.3 mm (SD 29.9) | 53.2 mm(SD 32.1) | 0.418 |
TABLE 2.
Operation characteristics and postoperative outcome of the younger and elderly group
| Young (< 70years) N = 229 | Elderly (≥ 70 years) N = 204 | P - value | ||
|---|---|---|---|---|
| N (%) | N (%) | |||
| Type of resection | Subtotal | 38 (16.6) | 60 (29.4) | |
| Total | 132 (57.6) | 108 (52.9) | ||
| Total + distal oesophagecgtomy | 41 (17.9) | 22 (10.8) | ||
| Proximal resection | 14 (6.1) | 10 (4.9) | ||
| Stump resection | 2 (0.9) | 3 (1.5) | ||
| Wedge resection | 2 (0.9) | 0 (0.0) | ||
| Stomach + Whipple | 0 (0.0) | 1 (0.5) | 0.012 | |
| Splenectomy | No | 187 (81.7) | 175 (85.8) | |
| Yes | 42 (18.3) | 29 (14.2) | 0.247 | |
| Extent of lymphadenectomy | D 1 | 5 (2.2) | 16 (7.8) | |
| D 1.5 | 13 (5.7) | 16 (7.8) | ||
| D 2 | 209 (91.3) | 169 (82.8) | ||
| D 2.5 | 2 (0.9) | 3 (1.5) | 0.028 | |
| Residual tumour | R0 | 225 (98.3) | 200 (98.0) | |
| R1 | 2 (0.9) | 3 (0.9) | ||
| R2 | 2 (0.9) | 1 (0.5) | 0.178 | |
| Clavien-Dindo complications classification | < 3b | 206 (90.0) | 171 (83.8) | |
| 3 3b | 23 (10) | 33 (16.2) | 0.04 | |
| Treatment of complications | None | 176 (76.9) | 144 (70.6) | |
| Conservative | 21 (9.2) | 28 (13.7) | ||
| Interventions US guided, endoscopy | 14 (6.1) | 7 (3.4) | ||
| Surgery | 18 (7.9) | 25 (12.3) | 0.1 | |
| Mortality (30 days) | 5 (2.2) | 2 (1.0) | 0.275 | |
| Mortality (90 days) | 10 (4.4) | 17 (8.3) | 0.088 |
TABLE 3.
Preoperative and postoperative chemotherapy between the groups of younger and elderly patients
| Young (< 70 years) N = 229 | Elderly (≥ 70 years) N = 204 | P - value | ||
|---|---|---|---|---|
| Neoadjuvant therapy | Candidate | 135 (59.0) | 58 (28.4) | |
| Not a candidate | 94 (41.0) | 146 (71.6) | < 0.001 | |
| Type of neoadjuvant therapy | None | 94 (41.0) | 146 (71.6) | |
| Chemo + RT | 14 (2.9) | 6 (4.6) | ||
| Chemo - FLOT | 74 (32.3) | 31 (15.2) | ||
| Chemo - EOX | 47 (20.5) | 21 (10.3) | < 0.001 | |
| Adjuvant therapy | Candidate | 176 (76.9) | 113 (55.4) | |
| Not a candidate | 53 (23.1) | 91 (44.6) | < 0.001 | |
| Type of adjuvant therapy | None | 83 (36.2) | 138 (67.6) | |
| Chemo | 121 (52.8) | 58 (28.4) | ||
| Chemo + RT | 25 (10.9) | 8 (3.9) | < 0.001 |
TABLE 4.
Histopathological findings between younger and elderly patients
| Young (< 70years) N = 229 | Elderly (≥ 70 years) N = 204 | P - value | ||
|---|---|---|---|---|
| N (%) | N (%) | |||
| Lymphocyte infiltration | None | 68 (32.7) | 60 (32.8) | |
| Mild | 74 (35.6) | 71 (38.8) | ||
| Moderate | 56 (26.9) | 39 (21.3) | ||
| Severe | 10 (4.8) | 13 (7.1) | 0.492 | |
| Missing data | 21 (9.1) | 21 (10.2) | ||
| Vascular invasion | None | 173 (77.9) | 138 (71.9) | |
| Present | 49 (22.1) | 54 (28.1) | 0.155 | |
| Missing data | 8 (3.4) | 12 (5.8) | ||
| Tumour thrombus | None | 184 (94.8) | 162 (91.0) | |
| Present | 10 (5.2) | 16 (9.0) | 0.160 | |
| Missing data | 35 (15.2) | 26 (12.7) | ||
| Extranodular infiltration | None | 185 (93.4) | 159 (87.8) | |
| Present | 13 (6.6) | 22 (12.2) | 0.060 | |
| Missing data | 31 8 (13.5) | 23 (11.27) | ||
| Perineura invasion | None | 112 (49.8) | 86 (43.4) | |
| Present | 113 (50.2) | 111 (56.1) | 0.257 | |
| Missing data | 4 (1.7) | 7 (3.43) | ||
| T stage | T0 | 6 (2.6) | 6 (2.9) | |
| Tx | 0 (0.0) | 1 (0.6) | ||
| Tis | 32 14.0) | 13 (6.4) | ||
| T1a | 11 (4.8) | 10 (4.9) | ||
| T1b | 10 (4.4) | 12 (5.9) | ||
| T2 | 23 (10.0) | 23 (11.3) | ||
| T3 | 91 (39.7) | 75 (36.8) | ||
| T4a | 44 (19.2) | 55 (27.0) | ||
| T4b | 12 (5.2) | 9 (4.49 | 0.200 | |
| Nodes | N0 | 110 (48.0) | 88 (43.1) | |
| N1 | 33 (14.4) | 26 (12.7) | ||
| N2 | 39 (17.0) | 37 (18.1) | ||
| N3a | 27 (11.8) | 23 (11.3) | ||
| N3b | 20 (8.7) | 30 (14.7) | 0.377 | |
| Negative nodes | 110(48.0) | 88 (43.1) | ||
| Positive nodes | 119 (52.0) | 116 (56.9) | 0.307 | |
| Metastases | None | 219 (95.6) | 191 (93.6) | |
| Present | 10 (4.4) | 13 (6.4) | 0.353 |
FIGURE 1.
Overall survival (OS) between the younger and elderly group of patients. 1.00 represents patients < 70, 2.00 represents patients > 70.