FIGURE 1.
Example of imaging data acquisition of psoas muscle volume index (PMVI), psoas muscle index (PMI), skeletal muscle index (SMI), tumor burden score (TBS) and bone density
TABLE 1.
Baseline characteristics of the cohort
| Variable | All patients |
|---|---|
| Age, years, median (IQR) | 62 (55–71) |
| Sex, n (%) | |
| Female | 25 (28%) |
| Male | 63 (72%) |
| Temporal presentation n (%) | |
| Synchronous | 58 (66%) |
| Metachronous | 30 (34%) |
| Prior hepatic resection n (%) | |
| Yes | 72 (82%) |
| No | 16 (18%) |
| Mean time from CRC diagnosis to ablation, years, median (IQR) | 2 (1–4) |
| Mean CRLM count, median (IQR) | 1 (1–1) |
| Mean diameter of largest CRLM, cm, median (IQR) | 2 (1.5–2.6) |
TABLE 2.
Survival groups after thermal ablation
| Variable | Alive (first year) | Deceased (first year) |
|---|---|---|
| PMVI, cm3/m3, median (IQR) | 113.3 (99.17–129.55) | 101.34 (90.93–111.81) |
| PMI, cm2/m2, median (IQR) | 5.46 (4.6–6.24) | 4.74 (4.12–5.46) |
| SMI, cm2/m2, median (IQR) | 43.78 (40.77–51.96) | 40.74 (37.73–48.48) |
| Ll-density, HU, median (IQR) | 134.5 (112–156) | 141.5 (103.25–160.5) |
| Tumor burden score, median (IQR) | 2.3 (1.8–3.17) | 2.77 (2.19–3.35) |
FIGURE 2.
Boxplots of the survival group analysis.
PMI = psoas muscle index; PMVI = psoas muscle volume index
TABLE 3.
t-Test/Mann-Whitney-U-Test to show differences in survival groups
| Variable | Test | Test Statistic (t/W) | p-Value | Result |
|---|---|---|---|---|
| PMVI | t-Test (Welch) | t = 2.14 | 0.048 | Significant |
| PMI | Mann-Whitney U Test | W = 519 | 0.137 | Not significant |
| SMI | Mann-Whitney U Test | W = 521 | 0.107 | Not significant |
| L1-Density | Mann-Whitney U Test | W = 415.5 | 0.925 | Not significant |
| TBS | Mann-Whitney U Test | W = 308.5 | 0.182 | Not significant |
TABLE 4.
Univariate and multivariate Cox regression analysis of baseline clinical, psoas muscle volume index (PMVI), PMI = psoas muscle index (PMI), skeletal muscle index (SMI), L1-density and tumor burden score (TBS)
| Covariate | Univariate | Multivariate | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P-value | HR | 95% CI | P-value | |
| Age | 1.10 | 1.03–1.18 | 0.005 | 1.13 | 1.03–1.24 | 0.013 |
| Gender (female) | 1.58 | 0.46–5.39 | 0.467 | 3.30 | 0.56–19.5 | 0.189 |
| ECOG performance status | 1.88 | 0.5–7.00 | 0.347 | 1.39 | 0.33–5.96 | 0.654 |
| Temporal presentation CRLM (synchronous) | 0.61 | 0.19–2.00 | 0.417 | 1.33 | 0.30–5.90 | 0.705 |
| Chemotherapy (yes) | 1.2 | 032–4.52 | 0.789 | 2.79 | 0.56–13.9 | 0.209 |
| PMVI | 0.97 | 0.95–0.99 | 0.049 | 0.99 | 0.94–1.03 | 0.509 |
| PMI | 0.78 | 0.51–1.21 | 0.273 | 1.53 | 0.62–3.77 | 0.358 |
| SMI | 0.94 | 0.87–1.01 | 0.159 | 0.94 | 0.80–1.10 | 0.417 |
| L1 -density | 1.00 | 0.98–1.01 | 0.502 | 1.01 | 0.99–1.03 | 0.487 |
| TBS | 1.13 | 0.83–1.56 | 0.440 | 1.42 | 0.91–2.23 | 0.124 |
FIGURE 3.
Heatmap of the correlation between the variables.