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Dosimetric comparison of organs at risk in ultra-hypofractionated versus hypofractionated postoperative radiotherapy for early breast cancer: single center clinical study Cover

Dosimetric comparison of organs at risk in ultra-hypofractionated versus hypofractionated postoperative radiotherapy for early breast cancer: single center clinical study

Open Access
|Feb 2026

Figures & Tables

Dosimetric evaluation to the Lung

LungVGy(%)p-level
nmean ± SDmin–maxmedian (IQR)
UHF408.1 ± 4.10.2–15.57.95 (5.5–11.1)Z = 2.59**p = 0.0096
HF4011.8 ± 5.61.6–24.510.25 (7.5–16.2)

Tumor characteristics

VariablenUHFHFp-level
Tumor stage
     1b72 (5.26)5 (12.5)p = 0.185
     1c3718 (47.37)19 (47.5)
     1mi303 (7.5)
     23118 (47.37)13 (32.5)
     all783840
Tumor size
     mean ± SD 20.3 ± 8.216.3 ± 7.9t = 2.13*p = 0.037
     min-max 7–451–35
     median (IQR) 19 (15–22)15 (11.5–23)
Lymph nodes
     N07336 (94.74)37 (92.5)X2 = 0.0035p = 0.953
     N152 (5.26)3 (7.5)
Grade
     G1103 (8.11)7 (17.5)X2 = 191p = 0.384
     G25127 (72.97)24 (60)
     G3167 (18.92)9 (22.5)
Lymphovascular invasion
     LV 04221 (61.76)21 (56.76)X2 = 0.18p = 0.668
     LV 12913 (38.24)16 (43.24)
Histopathological type
     NST5629 (72.5)27 (67.5)p = 0.23
     lobular116 (15)5 (12.5)
     mixed42 (5)2 (5)
     other71 (2.5)6 (15)
     Tis22 (5)0
ER/HER2
     ER+ HER2+84 (10.53)4 (10)p = 0.344
     ER+ HER2-5931 (81.58)28 (70)
     ER-HER2+303 (7.5)
     ER-HER2-83 (7.89)5 (12.5)

Patients’ characteristics

VariablenUHFHFp-level
Age (years) mean ± SDmin-max
     UHF4060.8 ± 7.150–75t = 0.37
     HF4061.35± 6.250–74p = 0.712
Side
     Right3822 (55)16 (40)X2 = 1.8
     Center4218 (45)24 (60)p = 0.18
Chemotherapy
     No5024 (63.2)26 (65)X2 = 0.029
     Yes2814 (36.8)14 (35)p = 0.865
Hormonal therapy
     No82 (5.3)6 (15)X2 = 1.09
     Yes7036 (94.7)34 (85)p = 0.297
Target therapy
     No6532 (84.2)33 (82.5)X2 = 0.041
     Yes136 (15.8)7 (17.5)p = 0.839
Breast size
     < 1300 cm36836 (90)32 (80)X2 = 1.57
     > 1300 cm3124 (10)8 (20)p = 0.21

Dosimetric evaluation of PTV

PTV95%p-level
nmean ± SDmin–max
UHF4099.3 ± 0.697.4 – 100t = 4.9***p = 0.000006
HF4098.3 ± 1.295.2 – 99.9

Dosimetric evaluation of dose to the Heart

HeartV(%))p-level
nmean ± SDmin–maxmedian (IQR)
UHF197.7 ±4.00–16.37.5 (5.7–9.5)Z = 3.3**p = 0.0011
HF243.7 ± 2.90.03–10.03.1 (1.4–5.0)
DOI: https://doi.org/10.2478/raon-2026-0008 | Journal eISSN: 1581-3207 | Journal ISSN: 1318-2099
Language: English
Submitted on: Oct 14, 2025
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Accepted on: Dec 1, 2025
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Published on: Feb 6, 2026
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2026 Gordana Petkovska, Ivica Ratosa, Valentina Bojovska Trajanovska, Marina Iljovska, Albina Pupakovski Creslovnik, Emilija Lazareva, published by Association of Radiology and Oncology
This work is licensed under the Creative Commons Attribution 4.0 License.

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