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Induction chemotherapy and concurrent chemoradiotherapy for larynx preservation in laryngeal and hypopharyngeal cancer Cover

Induction chemotherapy and concurrent chemoradiotherapy for larynx preservation in laryngeal and hypopharyngeal cancer

Open Access
|Oct 2025

References

  1. Singer S, Danker H, Guntinas-Lichius O, Oeken J, Pabst F, Schock J, et al. Quality of life before and after total laryngectomy: results of a multicenter prospective cohort study. Head Neck 2014; 36: 359-68. doi: org/10.1002/hed.23305
  2. Argiris A, Lefebvre JL. Laryngeal preservation strategies in locally advanced laryngeal and hypopharyngeal cancers. Front Oncol 2019; 9: 419. doi: org/10.3389/fonc.2019.00419
  3. Forastiere AA, Goepfert H, Maor M, Pajak TF, Weber R, Morrison W, et al. Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer. N Engl J Med 2003; 349: 2091-8. doi: 10.1056/NEJMoa031317
  4. Forastiere AA, Zhang Q, Weber RS, Maor MH, Goepfert H, Pajak TF, et al. Long-term results of RTOG 91-11: a comparison of three nonsurgical treatment strategies to preserve the larynx in patients with locally advanced larynx cancer. J Clin Oncol 2013; 31: 845-52. doi: org/10.1200/JCO.2012.43.6097
  5. Strojan P, Haigentz M Jr, Bradford CR, Wolf GT, Hartl DM, Langendijk JA, et al. Chemoradiotherapy vs. total laryngectomy for primary treatment of advanced laryngeal squamous cell carcinoma. Oral Oncol 2013; 49: 283-6. doi: org/10.1016/j.oraloncology.2012.11.002
  6. Kiong KL, de Souza NN, Sultana R, Iyer NG. Meta-analysis of induction chemotherapy as a selection marker for chemoradiation in the head and neck. Laryngoscope 2018; 128: 1594-601. doi: org/10.1002/lary.27011
  7. Forastiere AA, Ismaila N, Lewin JS, Nathan CA, Adelstein DJ, Eisbruch A, et al. Use of larynx-preservation strategies in the treatment of laryngeal cancer: American Society of Clinical Oncology Clinical Practice Guideline update. J Clin Oncol 2018; 36: 1143-69. doi: org/10.1200/JCO.2017.75.7385
  8. Vidal L, Ben Aharon I, Limon D, Cohen E, Popovtzer A. Role of induction chemotherapy prior to chemoradiation in head and neck squamous cell cancer - systematic review and meta-analysis. Cancer J 2017; 23: 79-83. doi: org/10.1097/PPO.0000000000000253
  9. Lefebvre JL, Pointreau Y, Rolland F, Alfonsi M, Baudoux A, Sire C, et al. Induction chemotherapy followed by either chemoradiotherapy or bioradiotherapy for larynx preservation: the TREMPLIN randomized phase II study. J Clin Oncol 2013; 31: 853-9. doi: org/10.1200/JCO.2012.42.3988
  10. Urba S, Wolf G, Eisbruch A, Worden F, Lee J, Bradford C, et al. Single-cycle induction chemotherapy selects patients with advanced laryngeal cancer for combined chemoradiation: a new treatment paradigm. J Clin Oncol 2006; 24: 593-8. doi: org/10.1200/JCO.2005.01.2047
  11. Wolf GT, Bellile E, Eisbruch A, Urba S, Bradford CR, Peterson L, et al. Survival rates using individualized bioselection treatment methods in patients with advanced laryngeal cancer. JAMA Otolaryngol Head Neck Surg 2017; 143: 355-66. doi: org/10.1001/jamaoto.2016.3669
  12. Strojan P, Grašič Kuhar C, Žumer B, Kadivec M, Karner K, Fajdiga I, et al. TPF induction chemotherapy and concomitant irradiation with cisplatin and cetuximab in unresectable squamous cell carcinoma of the head and neck. Head Neck 2014; 36: 1555-61. doi: org/10.1002/hed.23506
  13. Grégoire V, Evans M, Le QT, Bourhis J, Budach V, Chen A, et al. Delineation of the primary tumour Clinical Target Volumes (CTV-P) in laryngeal, hypopharyngeal, oropharyngeal and oral cavity squamous cell carcinoma: AIRO, CACA, DAHANCA, EORTC, GEORCC, GORTEC, HKNPCSG, HNCIG, IAG-KHT, LPRHHT, NCIC CTG, NCRI, NRG Oncology, PHNS, SBRT, SOMERA, SRO, SSHNO, TROG consensus guidelines. Radiother Oncol 2018; 126: 3-24. doi: org/10.1016/j.radonc.2017.10.016
  14. Grégoire V, Ang K, Budach W, Grau C, Hamoir M, Langendijk JA, et al. Delineation of the neck node levels for head and neck tumors: a 2013 update. DAHANCA, EORTC, HKNPCSG, NCIC CTG, NCRI, RTOG, TROG consensus guidelines. Radiother Oncol 2015; 117: 83-90. doi: org/10.1016/j. radonc.2015.07.041
  15. Beitler JJ, Ridge JA, Vermorken JB, Bradford CR, Strojan P, Saba NF, et al. T4 laryngeal cancer with good function: should we be reluctant to treat without surgery? Int J Radiat Oncol Biol Phys 2018; 102: 400-3. doi: org/10.1016/j.ijrobp.2018.03.007
  16. Lefebvre JL, Ang KK. Larynx Preservation Consensus Panel. Larynx preservation clinical trial design: key issues and recommendations - a consensus panel summary. Head Neck 2009; 31: 429-41. doi: org/10.1002/hed.21081
  17. Wichmann G, Krüger A, Boehm A, Kolb M, Hofer M, Fischer M, et al. Induction chemotherapy followed by radiotherapy for larynx preservation in advanced laryngeal and hypopharyngeal cancer: outcome prediction after one cycle induction chemotherapy by a score based on clinical evaluation, computed tomography-based volumetry and 18F-FDG-PET/CT. Eur J Cancer 2017; 72: 144-55. doi: org/10.1016/j.ejca.2016.11.013
  18. Popovtzer A, Burnstein H, Stemmer S, Limon D, Hili O, Bachar G, et al. Phase II organ-preservation trial: concurrent cisplatin and radiotherapy for advanced laryngeal cancer after response to docetaxel, cisplatin, and 5-fluorouracil-based induction chemotherapy. Head Neck 2017; 39: 227-33. doi: org/10.1002/hed.24571
  19. Garcia GCTE, Gorphe P, Hartl D, Ammari S, Even C, Tao Y, et al. Computed tomography evaluation after induction chemotherapy for T3 laryngeal cancer: does response correlate with vocal cord mobility? Oral Oncol 2019; 90: 13-6. doi: 10.1016/j.oraloncology.2019.01.009
  20. Ferrari M, Mularoni F, Taboni S, Crosetti E, Pessina C, Carobbio ALC, et al. How reliable is assessment of true vocal cord-arytenoid unit mobility in patients affected by laryngeal cancer? A multi-institutional study on 366 patients from the ARYFIX collaborative group. Oral Oncol 2024; 152: 106744. doi: 10.1016/j.oraloncology.2024.106744
  21. de Bree R, Wolf GT, de Keizer B, Nixon IJ, Hartl DM, Forastiere AA, et al. Response assessment after induction chemotherapy for head and neck squamous cell carcinoma: from physical examination to modern imaging techniques and beyond. Head Neck 2017; 39: 2329-49. doi: 10.1002/hed.24883
  22. Xu J, Yang Y, Zhong Q, Hou L, Ma H, Zhang Y, et al. A study of peripheral blood parameters to predict response to induction chemotherapy and overall survival in advanced laryngeal squamous cell carcinoma. Curr Oncol 2022; 29: 6472-84. doi: 10.3390/curroncol29090509
  23. Tan C, Wang L, Yang Y, He S, Chen GG, Chan JY, et al. Construction of a novel six-gene signature to predict tumour response to induction chemotherapy and overall survival in locoregionally advanced laryngeal and hypopharyngeal carcinoma. Genes Dis 2023; 11: 101022. doi: 10.1016/j. gendis.2023.05.018
  24. Janoray G, Pointreau Y, Garaud P, Chapet S, Alfonsi M, Sire C, et al. Long-term results of a multicenter randomized phase III trial of induction chemotherapy with cisplatin, 5-fluorouracil, ± docetaxel for larynx preservation. J Natl Cancer Inst 2016; 108: djv368. doi: 10.1093/jnci/djv368
  25. Dietz A, Wichmann G, Kuhnt T, Pfreundner L, Hagen R, Scheich M, et al. Induction chemotherapy (IC) followed by radiotherapy (RT) versus cetuximab plus IC and RT in advanced laryngeal/hypopharyngeal cancer resectable only by total laryngectomy: final results of the larynx organ preservation trial DeLOS-II. Ann Oncol 2018; 29: 2105-14. doi: 10.1093/annonc/mdy332
  26. Sanabria A, Chaves ALF, Kowalski LP, Wolf GT, Saba NF, Forastiere AA, et al. Organ preservation with chemoradiation in advanced laryngeal cancer: the problem of generalizing results from randomized controlled trials. Auris Nasus Larynx 2017; 44: 18-25. doi: 10.1016/j.anl.2016.06.005
  27. Vermorken JB, Remenar E, van Herpen C, Gorlia T, Mesia R, Degardin M, et al; EORTC 24971/TAX 323 Study Group. Cisplatin, fluorouracil, and docetaxel in unresectable head and neck cancer. N Engl J Med 2007; 357: 1695-704. doi: 10.1056/NEJMoa071028
  28. Posner MR, Hershock DM, Blajman CR, Mickiewicz E, Winquist E, Gorbounova V, et al; TAX 324 Study Group. Cisplatin and fluorouracil alone or with docetaxel in head and neck cancer. N Engl J Med 2007; 357: 1705-15. doi: org/10.1056/NEJMoa070956
  29. Peng J, Luo G, Yu Y, Ning K, Liu X. Retrospective assessment of neoadjuvant camrelizumab combined with induction chemotherapy: efficacy in laryngeal preservation for advanced hypopharyngeal and laryngeal squamous cell carcinoma. Cancer Immunol Immunother 2024; 73: 54. doi: org/10.1007/s00262-023-03579-0
  30. Chow LQM. Head and neck cancer. N Engl J Med 2020; 382: 60-72. doi: org/10.1056/NEJMra1715715
  31. Janoray G, Pointreau Y, Alfonsi M, Sire C, Geoffrois L, de Raucourt D, et al. Induction chemotherapy followed by cisplatin or cetuximab concomitant to radiotherapy for laryngeal/hypopharyngeal cancer: long-term results of the TREMPLIN randomised GORTEC trial. Eur J Cancer 2020; 133: 86-93. doi: 10.1016/j.ejca.2020.04.009
DOI: https://doi.org/10.2478/raon-2025-0055 | Journal eISSN: 1581-3207 | Journal ISSN: 1318-2099
Language: English
Page range: 579 - 588
Submitted on: Jul 21, 2025
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Accepted on: Sep 5, 2025
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Published on: Oct 27, 2025
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2025 Primoz Strojan, Gaber Plavc, Robert Sifrer, Simona Jereb, Bostjan Lanisnik, Marko Kokalj, Ales Groselj, Cvetka Grasic Kuhar, published by Association of Radiology and Oncology
This work is licensed under the Creative Commons Attribution 4.0 License.